In the present study, a statistical investigation is carried out to explore whether there is a relationship between the critical frequency （foEs） of the sporadic-E layer that is occasionally seen on the E region of ...In the present study, a statistical investigation is carried out to explore whether there is a relationship between the critical frequency （foEs） of the sporadic-E layer that is occasionally seen on the E region of the ionosphere and the quasi- biennial oscillation （QBO） that flows in the east-west direction in the equatorial stratosphere. Multiple regression model as a statistical tool was used to determine the relationship between variables. In this model, the stationarity of the variables （foEs and QBO） was firstly analyzed for each station （Cocos Island, Gibilmanna, Niue Island, and Tahiti）. Then, a co- integration test was made to determine the existence of a long-term relationship between QBO and foes. After verifying the presence of a long-term relationship between the variables, the magnitude of the relationship between variables was further determined using the multiple regression model. As a result, it is concluded that the variations in foEs were explainable with QBO measured at 10 hPa altitude at the rate of 69%, 94%, 79%, and 58% for Cocos Island, Gibilmanna, Niue Island, and Tahiti stations, respectively. It is observed that the variations in foes were explainable with QBO measured at 70 hPa altitude at the rate of 66%, 69%, 53%, and 47% for Cocos Island, Gibilmanna, Niue Island, and Tahiti stations, respectively.展开更多
Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that ...Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that the specialized pro-resolving lipid mediator resolvin E1 promotes relief of pathologic pain by binding to chemerin receptor 23 in the nervous system.However,whether the resolvin E1-chemerin receptor 23 axis is involved in exercise-induced analgesia in complex regional pain syndrome type-Ⅰ has not been demonstrated.In the present study,a mouse model of chronic post-ischemia pain was established to mimic complex regional pain syndrome type-Ⅰ and subjected to an intervention involving swimming at different intensities.Chronic pain was reduced only in mice that engaged in high-intensity swimming.The resolvin E1-chemerin receptor 23 axis was clearly downregulated in the spinal cord of mice with chronic pain,while high-intensity swimming restored expression of resolvin E1 and chemerin receptor 23.Finally,shRNA-mediated silencing of chemerin receptor 23in the spinal cord reve rsed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammato ry pola rization of microglia in the dorsal horn of the spinal cord.These findings suggest that high-intensity swimming can decrease chronic pain via the endogenous resolvin E1-chemerin receptor 23 axis in the spinal cord.展开更多
High yield is a major objective for peanut(Arachis hypogaea L.) breeding worldwide. However, fewer yield-related quantitative trait loci(QTL) have been reported in peanut than in other staple food crops such as rice(O...High yield is a major objective for peanut(Arachis hypogaea L.) breeding worldwide. However, fewer yield-related quantitative trait loci(QTL) have been reported in peanut than in other staple food crops such as rice(Oryza sativa), wheat(Triticum aestivum), and maize(Zea mays). This study aimed to identify stable major-effect QTL associated with pod yield per plant, hundred-pod weight for double-seeded pods,hundred-seed weight, shelling percentage, and pod number per plant, allowing us to predict candidate genes by means of transcriptome and genome sequencing. To this end, we used a population of recombinant inbred lines comprising 192 F9:11families derived from a JH6 × KX01-6 cross to construct a highresolution genetic map(1705.7 c M) consisting of 2273 polymorphic SNPs, with 0.75 c M(on average)between adjacent SNPs. We identified two high-confidence, yield-related QTL, qHYF_A08 and qHYF_B06, explaining 5.78%–31.40% of phenotypic variation and with LOD values of 5.10–24.48, in six environments. qHYF_A08 mainly explained the variation in shelling percentage, whereas qHYF_B06explained variation in hundred-pod weight and hundred-seed weight and accounted for 8.77%–31.40%of the variation in effective pod number per plant, pod number per plant, and shelling percentage. We narrowed down qHYF_B06 to an 890-kb interval using an advanced mapping population.Transcriptome and genome analyses revealed that only Arahy.129FS0 and Arahy.3R9A5K in the candidate mapping interval were differentially expressed between JH6 and KX01-6, with substantial structural variations in their promoter and coding regions. Genotypes of 208 peanut accessions determined using a diagnostic CAPS marker suggested that the two haplotypes of Arahy.3R9A5K were highly associated with hundred-seed weight and hundred-pod weight;this diagnostic CAPs marker could therefore be useful for selecting high-yielding lines during peanut breeding. Overall, our results provide valuable information for cloning alleles with favorable effects on peanut yield.展开更多
E层占优电离层是指E层的峰值电子密度大于F层的峰值电子密度(NmE>NmF)时的电离层,记为ELDI(E-Layer Dominated Ionosphere)。针对ELDI,利用2007—2010年的COSMIC(Constellation Observing System for Meteorolo-gy,Ionosphere,and Cl...E层占优电离层是指E层的峰值电子密度大于F层的峰值电子密度(NmE>NmF)时的电离层,记为ELDI(E-Layer Dominated Ionosphere)。针对ELDI,利用2007—2010年的COSMIC(Constellation Observing System for Meteorolo-gy,Ionosphere,and Climate satellite)掩星数据,在修正地磁纬度-磁地方时标系下统计分析了它在南北极区极夜期间(南北半球的冬至日前后30天)的分布特征,结果表明极夜期间电离层ELDI特征明显,其分布与极光椭圆位形基本一致,而且其在夜侧的发生率较高,特别是磁子夜之后,北极为70%左右,而南极为90%左右;另外南极的ELDI特征在磁纬度分布上要略宽于北极的分布范围。在ELDI高发区,电离层峰值电子密度要高于其两侧地区,特别是在夜侧,尤其是磁子夜前的峰值电子密度要接近甚至大于磁正午的峰值电子密度,在南极地区格外明显;而且ELDI高发区内的E层的电子含量(TECE)、电离层总电子含量(TECI)及TECE占TECI的比重(TECEI)都高于其两侧地区,北极TECE和TECI大于南极,而TECEI则是南极大于北极。这些现象主要是由于极夜期间极区高能粒子沉降引起底部电离层电离率增大所致;同时,由于地磁轴偏离地理轴的程度在南极要大于北极,使得极夜期间南极地区的电离层的电子密度,特别是在F层要相应地小于北极地区,从而导致了极夜期间南北半球极区电离层ELDI特征之间差异。展开更多
文摘In the present study, a statistical investigation is carried out to explore whether there is a relationship between the critical frequency （foEs） of the sporadic-E layer that is occasionally seen on the E region of the ionosphere and the quasi- biennial oscillation （QBO） that flows in the east-west direction in the equatorial stratosphere. Multiple regression model as a statistical tool was used to determine the relationship between variables. In this model, the stationarity of the variables （foEs and QBO） was firstly analyzed for each station （Cocos Island, Gibilmanna, Niue Island, and Tahiti）. Then, a co- integration test was made to determine the existence of a long-term relationship between QBO and foes. After verifying the presence of a long-term relationship between the variables, the magnitude of the relationship between variables was further determined using the multiple regression model. As a result, it is concluded that the variations in foEs were explainable with QBO measured at 10 hPa altitude at the rate of 69%, 94%, 79%, and 58% for Cocos Island, Gibilmanna, Niue Island, and Tahiti stations, respectively. It is observed that the variations in foes were explainable with QBO measured at 70 hPa altitude at the rate of 66%, 69%, 53%, and 47% for Cocos Island, Gibilmanna, Niue Island, and Tahiti stations, respectively.
基金National Key R&D Program of China,Nos.2019YFA0110300 (to LZ),2021YFA1201400 (to LZ)Natural Science Foundation of Shanghai,No.21ZR1468600 (to LZ)Open Fund of the Key Laboratory of Cellular Physiology (Shanxi Medical University),Ministry of Education,No.KLMEC/SXMU-201910 (to XJ)。
文摘Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that the specialized pro-resolving lipid mediator resolvin E1 promotes relief of pathologic pain by binding to chemerin receptor 23 in the nervous system.However,whether the resolvin E1-chemerin receptor 23 axis is involved in exercise-induced analgesia in complex regional pain syndrome type-Ⅰ has not been demonstrated.In the present study,a mouse model of chronic post-ischemia pain was established to mimic complex regional pain syndrome type-Ⅰ and subjected to an intervention involving swimming at different intensities.Chronic pain was reduced only in mice that engaged in high-intensity swimming.The resolvin E1-chemerin receptor 23 axis was clearly downregulated in the spinal cord of mice with chronic pain,while high-intensity swimming restored expression of resolvin E1 and chemerin receptor 23.Finally,shRNA-mediated silencing of chemerin receptor 23in the spinal cord reve rsed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammato ry pola rization of microglia in the dorsal horn of the spinal cord.These findings suggest that high-intensity swimming can decrease chronic pain via the endogenous resolvin E1-chemerin receptor 23 axis in the spinal cord.
基金jointly supported by the Earmarked Fund for CARS-13the Modern Agricultural Industrial Technology System of Hebei Province (HBCT2018090101 and HBCT2018090201)+3 种基金the Science and Technology Innovation Team of Modern Peanut Seed Industry (21326316D)the Technology Innovation Special Project(2022KJCXZX-LYS-11)the Basic Research Funds of Hebei Academy of Agriculture and Forestry Sciences (2021060201)the Talents Construction Project of Science and Technology Innovation,Hebei Academy of Agriculture and Forestry Sciences (C22R0311)。
文摘High yield is a major objective for peanut(Arachis hypogaea L.) breeding worldwide. However, fewer yield-related quantitative trait loci(QTL) have been reported in peanut than in other staple food crops such as rice(Oryza sativa), wheat(Triticum aestivum), and maize(Zea mays). This study aimed to identify stable major-effect QTL associated with pod yield per plant, hundred-pod weight for double-seeded pods,hundred-seed weight, shelling percentage, and pod number per plant, allowing us to predict candidate genes by means of transcriptome and genome sequencing. To this end, we used a population of recombinant inbred lines comprising 192 F9:11families derived from a JH6 × KX01-6 cross to construct a highresolution genetic map(1705.7 c M) consisting of 2273 polymorphic SNPs, with 0.75 c M(on average)between adjacent SNPs. We identified two high-confidence, yield-related QTL, qHYF_A08 and qHYF_B06, explaining 5.78%–31.40% of phenotypic variation and with LOD values of 5.10–24.48, in six environments. qHYF_A08 mainly explained the variation in shelling percentage, whereas qHYF_B06explained variation in hundred-pod weight and hundred-seed weight and accounted for 8.77%–31.40%of the variation in effective pod number per plant, pod number per plant, and shelling percentage. We narrowed down qHYF_B06 to an 890-kb interval using an advanced mapping population.Transcriptome and genome analyses revealed that only Arahy.129FS0 and Arahy.3R9A5K in the candidate mapping interval were differentially expressed between JH6 and KX01-6, with substantial structural variations in their promoter and coding regions. Genotypes of 208 peanut accessions determined using a diagnostic CAPS marker suggested that the two haplotypes of Arahy.3R9A5K were highly associated with hundred-seed weight and hundred-pod weight;this diagnostic CAPs marker could therefore be useful for selecting high-yielding lines during peanut breeding. Overall, our results provide valuable information for cloning alleles with favorable effects on peanut yield.
文摘E层占优电离层是指E层的峰值电子密度大于F层的峰值电子密度(NmE>NmF)时的电离层,记为ELDI(E-Layer Dominated Ionosphere)。针对ELDI,利用2007—2010年的COSMIC(Constellation Observing System for Meteorolo-gy,Ionosphere,and Climate satellite)掩星数据,在修正地磁纬度-磁地方时标系下统计分析了它在南北极区极夜期间(南北半球的冬至日前后30天)的分布特征,结果表明极夜期间电离层ELDI特征明显,其分布与极光椭圆位形基本一致,而且其在夜侧的发生率较高,特别是磁子夜之后,北极为70%左右,而南极为90%左右;另外南极的ELDI特征在磁纬度分布上要略宽于北极的分布范围。在ELDI高发区,电离层峰值电子密度要高于其两侧地区,特别是在夜侧,尤其是磁子夜前的峰值电子密度要接近甚至大于磁正午的峰值电子密度,在南极地区格外明显;而且ELDI高发区内的E层的电子含量(TECE)、电离层总电子含量(TECI)及TECE占TECI的比重(TECEI)都高于其两侧地区,北极TECE和TECI大于南极,而TECEI则是南极大于北极。这些现象主要是由于极夜期间极区高能粒子沉降引起底部电离层电离率增大所致;同时,由于地磁轴偏离地理轴的程度在南极要大于北极,使得极夜期间南极地区的电离层的电子密度,特别是在F层要相应地小于北极地区,从而导致了极夜期间南北半球极区电离层ELDI特征之间差异。
