目的探讨微粒体环氧化物水解酶（EPHX1）编码基因多态性与泌尿系恶性肿瘤的遗传易感性的关系。方法按照制定的检索策略,检索相关数据库中的文献,获取有关EPHX1基因多态性与泌尿系恶性肿瘤易感性的病例-对照研究,提取相关数据进行Meta分...目的探讨微粒体环氧化物水解酶（EPHX1）编码基因多态性与泌尿系恶性肿瘤的遗传易感性的关系。方法按照制定的检索策略,检索相关数据库中的文献,获取有关EPHX1基因多态性与泌尿系恶性肿瘤易感性的病例-对照研究,提取相关数据进行Meta分析。以病例组和对照组基因型分布的比值比（OR）及其95%可信区间（CI）作为效应指标。结果共纳入EPHX1 Y113H多态位点的6篇文献,累计病例806例,对照1 156例。纳入的结果使用Meta分析显示EPHX1 Y113H基因多态性与泌尿系恶性肿瘤易感性无相关性[（CC vs TT：OR=1.33,95%CI：0.87~2.05,P〉0.05）;（CT vs TT：OR=1.11,95%CI：0.93~1.33,P〉0.05）;（CC/CT vs TT：OR=1.11,95%CI：0.95~1.30,P〉0.05）;（CC vs CT/TT：OR=1.24,95%CI：0.86~1.78,P〉0.05）]。EPHX1 H139R多态位点共4篇文献,累计病例491例,对照760例。Meta分析显示EPHX1 H139R基因多态性与泌尿系恶性肿瘤易感性无相关性[（GG vs AA：OR=0.74,95%CI：0.40~1.08,P〉0.05）;（AG vs AA：OR=1.04,95%CI：0.83~1.32,P〉0.05）;（GG/AG vs AA：OR=1.00,95%CI：0.79~1.27,P〉0.05）;（GG vs AG/AA：OR=0.72,95%CI：0.41~1.27,P〉0.05）]。结论 EPHX1 Y113H或H139R基因多态性与泌尿系恶性肿瘤易感性无明显相关性。展开更多
AIM: To summarize the relationship between p.Tyr113His and p.His139Arg polymorphisms in microsomal epoxide hydrolase (EPHX1) and risk for esophageal cancer (EC).
Microsomal epoxide hydrolase (EPHX1) is involved in the activation and detoxification of exogenous chemicals. Genetic polymorphisms in EPHX1 have been associated with the development of leukemia. To investigate an ass...Microsomal epoxide hydrolase (EPHX1) is involved in the activation and detoxification of exogenous chemicals. Genetic polymorphisms in EPHX1 have been associated with the development of leukemia. To investigate an association between single-nucleotide polymorphisms (SNPs) of EPHX1 and risk factors for childhood acute lymphoblastic leukemia (ALL) in Korean children, we genotyped two SNPs, Tyr113His (rs1051740) and His139Arg (rs2234922) in 185 childhood ALL cases and 536 healthy controls. Genotyping for these two SNPs was performed by simplex pyrosequencing assay and high-resolution melt analysis, respectively. We found that the Tyr113His genotype was associated with a decreased risk of childhood ALL (odds ratio, OR = 0.64, 95% confidence interval, CI = 0.43 - 0.93;p = 0.02). There was no association between His139Arg and the combined genotypes and the risk of childhood ALL. These results suggest that the EPHX1 113TyrHis genotype may protect against leukemogenesis in childhood.展开更多
Objective To explore the difference of mRNA,protein expression levels and the indexes of peripheral blood antioxidant capacity in peripheral blood lymphocytes of different EPHX1 genotypes in chronic obstructive pulmon...Objective To explore the difference of mRNA,protein expression levels and the indexes of peripheral blood antioxidant capacity in peripheral blood lymphocytes of different EPHX1 genotypes in chronic obstructive pulmonary disease(COPD).Methods A case-control study was conducted to collect peripheral blood samples of 220 stable chronic COPD patients with smoking history and 230 healthy smokers(control group)from October 2016 to February 2018 in the First Affiliated Hospital of Kunming Medical University,and the genetic testing was carried out according to the operation instructions of BigDye Terminator v1.1 DNA Sequencing Kit.展开更多
文摘目的探讨微粒体环氧化物水解酶（EPHX1）编码基因多态性与泌尿系恶性肿瘤的遗传易感性的关系。方法按照制定的检索策略,检索相关数据库中的文献,获取有关EPHX1基因多态性与泌尿系恶性肿瘤易感性的病例-对照研究,提取相关数据进行Meta分析。以病例组和对照组基因型分布的比值比（OR）及其95%可信区间（CI）作为效应指标。结果共纳入EPHX1 Y113H多态位点的6篇文献,累计病例806例,对照1 156例。纳入的结果使用Meta分析显示EPHX1 Y113H基因多态性与泌尿系恶性肿瘤易感性无相关性[（CC vs TT：OR=1.33,95%CI：0.87~2.05,P〉0.05）;（CT vs TT：OR=1.11,95%CI：0.93~1.33,P〉0.05）;（CC/CT vs TT：OR=1.11,95%CI：0.95~1.30,P〉0.05）;（CC vs CT/TT：OR=1.24,95%CI：0.86~1.78,P〉0.05）]。EPHX1 H139R多态位点共4篇文献,累计病例491例,对照760例。Meta分析显示EPHX1 H139R基因多态性与泌尿系恶性肿瘤易感性无相关性[（GG vs AA：OR=0.74,95%CI：0.40~1.08,P〉0.05）;（AG vs AA：OR=1.04,95%CI：0.83~1.32,P〉0.05）;（GG/AG vs AA：OR=1.00,95%CI：0.79~1.27,P〉0.05）;（GG vs AG/AA：OR=0.72,95%CI：0.41~1.27,P〉0.05）]。结论 EPHX1 Y113H或H139R基因多态性与泌尿系恶性肿瘤易感性无明显相关性。
文摘AIM: To summarize the relationship between p.Tyr113His and p.His139Arg polymorphisms in microsomal epoxide hydrolase (EPHX1) and risk for esophageal cancer (EC).
文摘Microsomal epoxide hydrolase (EPHX1) is involved in the activation and detoxification of exogenous chemicals. Genetic polymorphisms in EPHX1 have been associated with the development of leukemia. To investigate an association between single-nucleotide polymorphisms (SNPs) of EPHX1 and risk factors for childhood acute lymphoblastic leukemia (ALL) in Korean children, we genotyped two SNPs, Tyr113His (rs1051740) and His139Arg (rs2234922) in 185 childhood ALL cases and 536 healthy controls. Genotyping for these two SNPs was performed by simplex pyrosequencing assay and high-resolution melt analysis, respectively. We found that the Tyr113His genotype was associated with a decreased risk of childhood ALL (odds ratio, OR = 0.64, 95% confidence interval, CI = 0.43 - 0.93;p = 0.02). There was no association between His139Arg and the combined genotypes and the risk of childhood ALL. These results suggest that the EPHX1 113TyrHis genotype may protect against leukemogenesis in childhood.
文摘Objective To explore the difference of mRNA,protein expression levels and the indexes of peripheral blood antioxidant capacity in peripheral blood lymphocytes of different EPHX1 genotypes in chronic obstructive pulmonary disease(COPD).Methods A case-control study was conducted to collect peripheral blood samples of 220 stable chronic COPD patients with smoking history and 230 healthy smokers(control group)from October 2016 to February 2018 in the First Affiliated Hospital of Kunming Medical University,and the genetic testing was carried out according to the operation instructions of BigDye Terminator v1.1 DNA Sequencing Kit.
