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基于EPOCHS的数字化电力通信光传输网络的优化
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作者 陈飞 汪政 《科学技术创新》 2024年第17期86-89,共4页
为解决数字化电力通信光传输网络中存在的信号衰减与干扰、网络容量限制以及设备老化与故障问题,本文依托EPOCHS仿真平台,结合实际优化工程,针对具体问题,提出了利用EPOCHS平台的解决措施,最后通过效果分析证明了所采取措施的有效性,实... 为解决数字化电力通信光传输网络中存在的信号衰减与干扰、网络容量限制以及设备老化与故障问题,本文依托EPOCHS仿真平台,结合实际优化工程,针对具体问题,提出了利用EPOCHS平台的解决措施,最后通过效果分析证明了所采取措施的有效性,实现了数字化电力通信光传输网络性能的优化,以此为相关行业人员提供实践参考。 展开更多
关键词 epochs 数字化电力通信光传输网络 信号衰减 网络容量 设备老化
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基于EPOCHS平台的智能配电网通信系统仿真 被引量:19
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作者 黄飞 王晓茹 +1 位作者 董雪源 王睿 《电力系统自动化》 EI CSCD 北大核心 2013年第11期81-86,共6页
快速、可靠、集成的通信系统是实现智能配电网的关键环节。在当前配电自动化通信系统分析的基础上,对智能配电网通信需求及其业务流量建模,提出了基于IP通信网络的智能配电网通信体系结构。在电力和通信同步仿真(EPOCHS)平台上建立了智... 快速、可靠、集成的通信系统是实现智能配电网的关键环节。在当前配电自动化通信系统分析的基础上,对智能配电网通信需求及其业务流量建模,提出了基于IP通信网络的智能配电网通信体系结构。在电力和通信同步仿真(EPOCHS)平台上建立了智能配电网通信仿真模型,仿真研究了多种数据流业务背景下一种基于通用面向对象变电站事件(GOOSE)的馈线自动化算法通信交互过程,仿真结果表明所提通信体系结构能够满足智能配电网的通信需求。 展开更多
关键词 智能配电网 通信网络 电力和通信同步仿真(epochs)平台 馈线自动化 通用面向对象变电站事件(GOOSE)
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基于EPOCHS平台的IEC 61850采样值传输仿真 被引量:11
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作者 丁力 王晓茹 童晓阳 《电力系统自动化》 EI CSCD 北大核心 2008年第20期67-72,共6页
采样值传输是IEC61850变电站自动化系统过程层与间隔层之间通信的主要部分。在电力和通信系统同步仿真(EPOCHS)平台上提出IEC61850变电站通信仿真框架,针对具体变电站构建IEC61850通信模型。在NS2中添加虚拟局域网(VLAN)IEEE802.1Q协议... 采样值传输是IEC61850变电站自动化系统过程层与间隔层之间通信的主要部分。在电力和通信系统同步仿真(EPOCHS)平台上提出IEC61850变电站通信仿真框架,针对具体变电站构建IEC61850通信模型。在NS2中添加虚拟局域网(VLAN)IEEE802.1Q协议代码,实现VLAN多播报文的仿真。对交换式以太网和共享式以太网、接收不同数目合并单元采样值报文的保护设备进行了比较。结果表明:100Mbit/s交换式以太网完全满足标准要求,而100Mbit/s共享式以太网采样值报文时延和时延抖动较大,导致工频保护测量值波形畸变;接收多个采样值报文的保护设备存在链路瓶颈问题,对此提出了多通信插件的解决方案。 展开更多
关键词 IEC 61850 采样值传输 虚拟局域网(VLAN)多播 电力和通信系统同步仿真(epochs)平台 NS2
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基于EPOCHS平台的监控网与GOOSE网合一的网络仿真分析 被引量:1
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作者 王义军 李晨曦 +1 位作者 秦思远 王喜 《电测与仪表》 北大核心 2015年第17期44-47,共4页
通用面向对象的变电站事件(GOOSE)是IEC 61850标准中用于满足变电站自动化系统快速报文需求的机制。针对监控网与GOOSE网合一的网络结构,运用电力通信同步仿真平台(EPOCHS)进行通信网络动态仿真。通过对GOOSE及采样值(SAV)实时性的仿真... 通用面向对象的变电站事件(GOOSE)是IEC 61850标准中用于满足变电站自动化系统快速报文需求的机制。针对监控网与GOOSE网合一的网络结构,运用电力通信同步仿真平台(EPOCHS)进行通信网络动态仿真。通过对GOOSE及采样值(SAV)实时性的仿真分析,其结果为报文优先级、网络带宽及组网的创新拓展提供了依据。 展开更多
关键词 GOOSE MMS epochs SAV 实时性
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基于EPOCHS的数字化电力通信光传输网络的优化改造 被引量:1
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作者 卢嘉斌 《数字技术与应用》 2018年第11期36-37,共2页
将EPOCHS仿真软件应用电力通信网络中,能够有效克服存在的弊端,使电力通信网络效果得到显著增强。基于此,本文将对EPOCHS在电力传输网络中的优化仿真实验进行分析与研究。
关键词 epochs仿真软件 电力通信 数字化
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Formation of Glaciation Epochs
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作者 Sanghee Shin George V. Chilingar +1 位作者 Oleg Sorokhtin Nikolai O. Sorokhtin 《Journal of Environmental Protection》 2013年第6期516-521,共6页
The effect of Earth precession angle on a climate is presented here. It is shown that the glaciation epochs occurred only when the precession angle was low. After the continental glaciation formed in the Northern hemi... The effect of Earth precession angle on a climate is presented here. It is shown that the glaciation epochs occurred only when the precession angle was low. After the continental glaciation formed in the Northern hemisphere, Earth’s spherecal symmetry was disrupted and its precession angle increased drastically. As a result, a drastic and rapid climate warm-up occurred, the glaciers melted down and an interglacial stadial1 began. Subsequently, affected by the Lunar-Solar gravity pull on the Earth’s equatorial swelling, the precession angle gradually decreased and a new cooling-down phase occurred. As a result, there was nonlinear oscillation of Earth’s climate with periods on the order of 100 - 120 MY. 展开更多
关键词 Earth’s PRECESSION GLACIATION epochs CLIMATE Evolution CLIMATE Change GLOBAL WARMING GLOBAL COOLING
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GOLD METALLOGENETIC EPOCHS IN GEODOME STRUCTURES
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《Geotectonica et Metallogenia》 1994年第Z2期91-93,共3页
关键词 GOLD METALLOGENETIC epochs IN GEODOME STRUCTURES
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The Asymmetrical Behaviour of the SqH Current System during the Prenoon-Postnoon Epochs at African Longitudes
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作者 Charles Owolabi Babatunde Rabiu Kayode Oluyo 《Journal of Aerospace Science and Technology》 2015年第1期9-17,共9页
This study examines the prenoon-postnoon asymmetrical behaviour and latitudinal dependence of Sq (solar quiet) current system using data of quiet-time daily variations of the geomagnetic field intensity from twelve ... This study examines the prenoon-postnoon asymmetrical behaviour and latitudinal dependence of Sq (solar quiet) current system using data of quiet-time daily variations of the geomagnetic field intensity from twelve geomagnetic observatories along the African Meridian. The dataset of each month during 2009 (noted for empirically low solar activity with average sunspot number Rz = 3.1) was treated for non-cyclic correction. From a blend of spatial contour maps and graphical analyses, our results show that Sq current system exhibits in the daytime unstable tendency. A consistent diurnal variation of solar quiet variation in the horizontal component of earth magnetic field (SqH) was observed which exhibits synoptic pre-noon and post-noon mean values of 59 nT and 33 nT with ranges of 33 nT and 24 nT, respectively. The centre of circulation of overhead electric current is observed to exhibit both pre-noon and post-noon epoch's asymmetric variations. This is noted to indicate the dynamic heterogeneous genesis of the mechanism responsible for the observation. The spatial contour mapping result depicts SqH behaviour switch twice a year around March and September with similar spatial distribution in January up to March and then October up to December. A similar distribution was noted for the months of April to September. Prenoon values of SqH have higher magnitudes across the latitudes in comparison with the post noon values just as is the case at noontime. 展开更多
关键词 solar quiet variation pre-noon epoch ionospheric current system variability.
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Reduced Dynamic Orbit Determination Using Differenced Phase in Adjacent Epochs for Spaceborne Dual-frequency GPS 被引量:4
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作者 GU Defeng YI Dongyun 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2011年第6期789-796,共8页
We study on reduced dynamic orbit determination using differenced phase in adjacent epochs for spacebome dual-frequency GPS. This method not only overcomes the shortcomings that the epoch-difference kinematic method c... We study on reduced dynamic orbit determination using differenced phase in adjacent epochs for spacebome dual-frequency GPS. This method not only overcomes the shortcomings that the epoch-difference kinematic method cannot be used when observation geometry is poor or observations are insufficient, but also avoids solving the ambiguity in the zero-difference reduced dynamic method. As the epoch-difference method is not sensitive to the impact of phase cycle slips, it can lower the difficulty of slip detection in phase observation preprocessing. In the solution strategies, we solve the high-dimensional matrix computation problems by decomposing the long observation arc into a number of short arcs. By gravity recovery and climate experiment (GRACE) satellite orbit determination and compared with GeoForschungsZentrum (GFZ) post science orbit, for epoch-difference reduced dynamic method, the root mean squares (RMSs) of radial, transverse and normal components are 1.92 cm, 3.83 cm and 3.80 cm, and the RMS in three dimensions is 5.76 cm. The solution's accuracy is comparable to the zero-difference reduced dynamic method. 展开更多
关键词 dual-frequency GPS phase difference in adjacent epochs SATELLITE reduced dynamic orbit determination
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精准给药策略联合预见性护理在接受R⁃EPOCH方案治疗的非霍奇金淋巴瘤病人中的应用 被引量:1
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作者 牛润花 杨佳 +1 位作者 赵新娜 郝晓丽 《护理研究》 北大核心 2024年第2期349-353,共5页
目的:探讨精准给药策略联合预见性护理在接受R⁃EPOCH方案治疗的非霍奇金淋巴瘤病人中的应用效果。方法:采用便利抽样法,选取2021年1月—2022年12月山西省某三级甲等医院血液科住院并采用R⁃EPOCH方案治疗的非霍奇金淋巴瘤病人为研究对象,... 目的:探讨精准给药策略联合预见性护理在接受R⁃EPOCH方案治疗的非霍奇金淋巴瘤病人中的应用效果。方法:采用便利抽样法,选取2021年1月—2022年12月山西省某三级甲等医院血液科住院并采用R⁃EPOCH方案治疗的非霍奇金淋巴瘤病人为研究对象,将2021年住院的70例病人作为对照组,将2022年住院的73例病人作为观察组。对照组实施常规护理,观察组实施精准给药策略联合预见性护理。比较两组护士实际给药时间、病人焦虑情况及生命质量。结果:研究过程中对照组有2例病人失访,观察组有3例病人失访,最终对照组68例病人完成研究,观察组70例病人完成研究。观察组护士实际给药总时间为(96.16±9.45)h,短于对照组[(99.77±10.22)h],差异有统计学意义(P<0.05),且观察组护士实际给药总时间更接近指南要求(持续输注96 h)。随着时间变化,非霍奇金淋巴瘤病人汉密尔顿焦虑量表(HAMA)得分有变化(P<0.05),不同组别的非霍奇金淋巴瘤病人HAMA得分不同(P<0.05),干预时间与干预方法间存在交互效应(P<0.05)。干预后,观察组病人癌症病人生命质量测定量表(FACT⁃G)总体及各维度得分均高于对照组,差异均有统计学意义(P<0.05)。结论:将精准给药策略联合预见性护理应用于接受R⁃EPOCH方案治疗的非霍奇金淋巴瘤病人,可以提高病人给药时间的准确性,改善病人焦虑状况,提高病人生活质量。 展开更多
关键词 非霍奇金淋巴瘤 R⁃EPOCH方案 精准给药 预见性护理 化疗 护理
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Statistical Properties and Cosmological Applications of Fast Radio Bursts
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作者 Qin Wu Fa-Yin Wang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第11期241-260,共20页
Fast radio burst(FRB)is a type of extragalactic radio signal characterized by millisecond duration,extremely high brightness temperature,and large dispersion measure.It remains a mystery in the universe.Advancements i... Fast radio burst(FRB)is a type of extragalactic radio signal characterized by millisecond duration,extremely high brightness temperature,and large dispersion measure.It remains a mystery in the universe.Advancements in instrumentation have led to the discovery of 816 FRB sources and 7622 bursts from 67 repeating FRBs(https://blinkverse.alkaidos.cn/).This field is undergoing rapid development,rapidly advancing our understanding of the physics of FRBs as new observational data accumulates.The accumulation of data has also promoted exploration of our universe.In this review,we summarize the statistical analysis and cosmological applications using large samples of FRBs,including the energy functions,the waiting time distributions of repeating FRBs,probe of missing baryons and circumgalactic medium in the universe,measurements of cosmological parameters,exploration of the epoch of re-ionization history,and research of the gravitational lensing of FRBs. 展开更多
关键词 GALACTIC UNIVERSE EPOCH
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广域后备保护多代理系统的仿真建模与实现 被引量:11
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作者 童晓阳 王晓茹 +1 位作者 Kenneth Hopkinson 汤俊 《中国电机工程学报》 EI CSCD 北大核心 2008年第19期111-117,共7页
针对广域后备保护多代理系统分布式协作的特点,为广域后备保护代理构造了环境感知、情景感知、综合决策等智能模块和接口,设计了多代理系统的容错性处理措施。EPOCHS是将电力系统电磁暂态仿真软件EMTDC/PSCAD、机电动态仿真软件PSLF、... 针对广域后备保护多代理系统分布式协作的特点,为广域后备保护代理构造了环境感知、情景感知、综合决策等智能模块和接口,设计了多代理系统的容错性处理措施。EPOCHS是将电力系统电磁暂态仿真软件EMTDC/PSCAD、机电动态仿真软件PSLF、网络通信仿真软件NS2、Agent集成的电力和通信同步仿真环境,将保护代理映射到EPOCHS予以仿真设计和实现,构造了电网的EMDTC/PSCAD模型和SDH通信网络的NS2仿真模型。通过仿真系统可观察保护代理的内部活动和多代理间的交互过程,从而评价广域保护算法及策略。通过3个仿真实例证明广域后备保护多代理仿真系统的代理设计是正确的。仿真试验能够有效地检验在电力系统故障、保护代理失效、断路器失灵等多种情景下多代理推演带来的整体性能。 展开更多
关键词 广域后备保护 多代理系统 仿真设计 epochs
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An Exploration of the Three Dimensions and Epochal Strengths of Building a Human Community With a Shared Future
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作者 Jiang Ruibing Liu Zongling 《Contemporary Social Sciences》 2024年第3期120-138,共19页
The idea of a human community with a shared future was proposed by the Communist Party of China(CPC)Central Committee with Comrade Xi Jinping at its core for the future development of human beings to face up to the mo... The idea of a human community with a shared future was proposed by the Communist Party of China(CPC)Central Committee with Comrade Xi Jinping at its core for the future development of human beings to face up to the most important question in today's world:“What is happening to the world and what should we do?”It profoundly answers the question of the world,history,and the times.The theory of a human community with a shared future is an innovative theory with a multidimensional formation logic that guides humanity toward continually seeking common interests and values.This paper dives into the profound motivations behind building a human community with a shared future from historical,cultural,and practical dimensions and analyzes its epochal value from both domestic and international perspectives.This not only helps exert China's role in the international community,contributing Chinese strength to the construction of a peaceful,stable,and prosperous human society,but also enhances the influence of the idea of a human community with a shared future in the international community,accelerating the building of a human community with a shared future that considers the legitimate concerns of all countries,and aiding in solving the crises facing the world. 展开更多
关键词 a human community with a shared future historical dimension cultural dimension practical dimension epochal strength
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JWST Discoveries and the Hypersphere World-Universe Model: Transformative New Cosmology
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作者 Vladimir S. Netchitailo 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第4期1806-1834,共29页
Twenty-six years ago, a small committee report built upon earlier studies to articulate a compelling and poetic vision for the future of astronomy. This vision called for an infrared-optimized space telescope with an ... Twenty-six years ago, a small committee report built upon earlier studies to articulate a compelling and poetic vision for the future of astronomy. This vision called for an infrared-optimized space telescope with an aperture of at least four meters. With the support of their governments in the US, Europe, and Canada, 20,000 people brought this vision to life as the 6.5-meter James Webb Space Telescope (JWST). The telescope is working perfectly, delivering much better image quality than expected [1]. JWST is one hundred times more powerful than the Hubble Space Telescope and has already captured spectacular images of the distant universe. A view of a tiny part of the sky reveals many well-formed spiral galaxies, some over thirteen billion light-years away. These observations challenge the standard Big Bang Model (BBM), which posits that early galaxies should be small and lack well-formed spiral structures. JWST’s findings are prompting scientists to reconsider the BBM in its current form. Throughout the history of science, technological advancements have led to new results that challenge established theories, sometimes necessitating their modification or even abandonment. This happened with the geocentric model four centuries ago, and the BBM may face a similar reevaluation as JWST provides more images of the distant universe. In 1937, P. Dirac proposed the Large Number Hypothesis and the Hypothesis of Variable Gravitational Constant, later incorporating the concept of Continuous Creation of Matter in the universe. The Hypersphere World-Universe Model (WUM) builds on these ideas, introducing a distinct mechanism for matter creation. WUM is proposed as an alternative to the prevailing BBM. Its main advantage is the elimination of the “Initial Singularity” and “Inflation”, offering explanations for many unresolved problems in Cosmology. WUM is presented as a natural extension of Classical Physics with the potential to bring about a significant transformation in both Cosmology and Classical Physics. Considering JWST’s discoveries, WUM’s achievements, and 87 years of Dirac’s proposals, it is time to initiate a fundamental transformation in Astronomy, Cosmology, and Classical Physics. The present paper is a continuation of the published article “JWST Discoveries—Confirmation of World-Universe Model Predictions” [2] and a summary of the paper “Hypersphere World-Universe Model: Digest of Presentations John Chappell Natural Philosophy Society” [3]. Many results obtained there are quoted in the current work without full justification;interested readers are encouraged to view the referenced papers for detailed explanations. 展开更多
关键词 World-Universe Model JWST Discoveries Universe-Created Matter Gravity GRAVITOMAGNETISM Wave-Particle Duality Hubble Tension Stretching of World Dark Epoch Luminous Epoch Axis of Evil
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拜登主义与美国外交政策的转型
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作者 王浩 《China International Studies》 2024年第2期69-95,共27页
It is an American tradition to name the guiding principles of any new foreign policy as a president’s doctrine during his incumbency.Realizing that it was facing epochal global changes and needed adjustments in its f... It is an American tradition to name the guiding principles of any new foreign policy as a president’s doctrine during his incumbency.Realizing that it was facing epochal global changes and needed adjustments in its foreign policy to face evolving new challenges,the Joe Biden administration embarked on a comprehensive and significant adjustment to American foreign policy under the guidance of new strategic concepts. 展开更多
关键词 美国外交政策 POLICY EPOCH
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Epoché as the Breakthrough of the Natural Attitude
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作者 Maurizio Trudu 《Philosophy Study》 2024年第3期138-144,共7页
The following contribution aims to interpret the methodical device of Husserl’s epochéin light of the concept of breakthrough.Since the epochéis a theoretical device directed towards the suspension of the n... The following contribution aims to interpret the methodical device of Husserl’s epochéin light of the concept of breakthrough.Since the epochéis a theoretical device directed towards the suspension of the natural attitude,I will first attempt to define the concept of natural attitude.Subsequently,I will seek to understand the rich meaning of the concept of epoché.Finally,I will explore how this element is related to the concept of breakthrough.In other words,I will endeavour to clarify how the epochédetermines a breakthrough of the natural attitude,which is not to be understood as“annihilation”or“destruction”but as a traversal. 展开更多
关键词 Edmund Husserl epoché natural attitude PHENOMENOLOGY
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剂量调整的EPOCH方案治疗初治血管免疫母T细胞淋巴瘤的前瞻性研究 被引量:6
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作者 仲凯励 苏航 +6 位作者 肖秀斌 刘静 鲁云 陈喜林 达永 路春蕾 张伟京 《中国肿瘤临床》 CAS CSCD 北大核心 2014年第19期1229-1233,共5页
目的:前瞻性研究剂量调整的EPOCH方案对初治血管免疫母T细胞淋巴瘤(AITL)患者的疗效及不良反应。方法:选择2008年9月至2012年9月中国军事医学科学院附属307医院确诊的初治AITL患者9例。全组患者均接受剂量调整的EPOCH方案一线化疗... 目的:前瞻性研究剂量调整的EPOCH方案对初治血管免疫母T细胞淋巴瘤(AITL)患者的疗效及不良反应。方法:选择2008年9月至2012年9月中国军事医学科学院附属307医院确诊的初治AITL患者9例。全组患者均接受剂量调整的EPOCH方案一线化疗。结果:全组患者发病中位年龄54岁,男∶女为2∶1,88.9%为Ann-Arbor stageⅢ~Ⅳ期,77.8%合并B症状。初诊时伴有贫血的患者占66.7%,LDH或β2微球蛋白升高占55.6%。EPOCH方案近期疗效CR率22.2%,总反应率66.7%。中位随访20个月,4年PFS和OS分别为11.1%和33.3%,中位生存时间19个月。EPOCH方案化疗主要不良反应为血液学毒性,3~4度粒细胞减少和血小板减少分别为77.8%和33.3%,44.4%的患者出现粒细胞缺乏伴发热。结论:剂量调整的EPOCH方案一线治疗AITL患者较传统CHOP方案未见明显生存获益。主要不良反应为血液学毒性,并可以耐受。 展开更多
关键词 血管免疫母T细胞淋巴瘤 EPOCH方案 初治 化疗
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GELOX与EPOCH方案化疗序贯放疗一线治疗ⅠE/ⅡE期结外NK/T细胞淋巴瘤的疗效比较 被引量:5
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作者 吴肖志军 王华 +3 位作者 王科峰 陈晓勤 夏忠军 李苏 《广东医学》 CAS CSCD 北大核心 2013年第6期864-866,共3页
目的比较GELOX(吉西他滨、奥沙利铂、左旋门冬酰胺酶)与EPOCH方案(依托泊苷、泼尼松、长春新碱、环磷酰胺、阿霉素)化疗序贯放疗一线治疗ⅠE/ⅡE期结外NK/T细胞淋巴瘤的近期疗效、远期生存及安全性。方法共计63例初诊患者经影像学检查... 目的比较GELOX(吉西他滨、奥沙利铂、左旋门冬酰胺酶)与EPOCH方案(依托泊苷、泼尼松、长春新碱、环磷酰胺、阿霉素)化疗序贯放疗一线治疗ⅠE/ⅡE期结外NK/T细胞淋巴瘤的近期疗效、远期生存及安全性。方法共计63例初诊患者经影像学检查、病理学诊断确诊为ⅠE/ⅡE期结外NK/T细胞淋巴瘤,其中27例接受GELOX化疗,36例接受EPOCH化疗,化疗完成后行侵犯野放射治疗。结果化疗后GELOX组完全缓解(CR)率为70.4%,总体有效率(ORR)为85.2%,均显著高于EPOCH组的41.7%与61.1%(PCR=0.024,PORR=0.036);两组有效率差异无统计学意义(P>0.05)。GELOX组的远期生存则表现出较明显的优势:GELOX组与EPOCH组3年无进展生存率分别为77.8%和47.6%,差异有统计学意义(P=0.011);3年总生存率分别为88.5%、56.6%,差异有统计学意义(P=0.012)。EPOCH组的血液学毒性更严重,GELOX组中15例(55.6%)患者出现纤维蛋白原下降,但均较轻微且无严重不良事件,其余毒性均较轻微。结论与EPOCH方案相比,GELOX方案具有较好的近期疗效,提高了远期生存,且不良反应较轻,安全性更高。 展开更多
关键词 结外NK T细胞淋巴瘤 GELOX EPOCH 化学治疗 近期疗效 远期生存
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EPOCH方案和CHOP方案一线治疗非特殊性外周T细胞淋巴瘤回顾性临床对照研究 被引量:5
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作者 王轶楠 刘卫东 +4 位作者 马守东 肖建波 李海丽 王志武 岳海淑 《现代肿瘤医学》 CAS 2014年第2期420-422,共3页
目的:比较EPOCH方案和CHOP方案一线治疗非特殊性外周T细胞淋巴瘤(PTCL-U)的疗效及不良反应。方法:A组:2008年1月至2010年4月,24例经病理确诊的PTCL-U患者,采用EPOCH方案化疗:足叶已甙50mg/(m2·d),长春新碱0.4mg/(m2·d),表阿霉... 目的:比较EPOCH方案和CHOP方案一线治疗非特殊性外周T细胞淋巴瘤(PTCL-U)的疗效及不良反应。方法:A组:2008年1月至2010年4月,24例经病理确诊的PTCL-U患者,采用EPOCH方案化疗:足叶已甙50mg/(m2·d),长春新碱0.4mg/(m2·d),表阿霉素15mg/(m2·d),上述三种药物持续静脉滴注96h,环磷酰胺750mg/m2,静脉滴注,d5;强的松60mg/(m2·d),口服,d1-5。每3周为1周期。B组:2005年1月至2007年4月PTCL-U患者35例,采用CHOP方案化疗:环磷酰胺750mg/m2,静脉滴注,d1,表阿霉素75mg/m2,静脉滴注,d1,长春新碱1.4mg/m2,静脉滴注,d1,强的松60mg/(m2·d),口服,d1-5,每3周为1周期。对两组的近期疗效、疾病进展时间、不良反应进行分析比较。结果:A组和B组的完全缓解效率分别为66.7%(16/24)和40.0%(14/35),有显著性差异(P=0.0441),有效率分别为79.2%(19/24)和65.7%(23/35),无显著差异(P=0.2624)。A组和B组的中位疾病进展时间12.0月(1-27月)、10月(1-28月)(P=0.2045)。主要不良反应白细胞减少、神经毒性、脱发、心脏毒性等指标均无显著性差异(P>0.05)。轻度口腔炎的发生率A组高于B组:24.8%∶13%(P<0.05)。结论:一线治疗PTCL-U,EPOCH方案近期疗效较CHOP方案具有一定的优势,不良反应相近,耐受性好。 展开更多
关键词 外周T细胞淋巴瘤 化学治疗 EPOCH方案 CHOP方案 药物持续静脉滴注
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Hyper-CVAD/MA与EPOCH方案治疗侵袭性非霍奇金淋巴瘤临床效果比较 被引量:4
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作者 朱太岗 董毅 +2 位作者 李月红 张飞虎 汤继春 《安徽医学》 2014年第6期770-773,共4页
目的比较Hyper-CVAD/MA与EPOCH两种方案治疗侵袭性非霍奇金淋巴瘤的临床效果。方法 35例侵袭性非霍奇金淋巴瘤初治患者随机分为Hyper-CVAD/MA组(17例)与EPOCH组(18例),按各自的方案给药,评估其疗效和不良反应。结果 Hyper-CVAD/MA组总... 目的比较Hyper-CVAD/MA与EPOCH两种方案治疗侵袭性非霍奇金淋巴瘤的临床效果。方法 35例侵袭性非霍奇金淋巴瘤初治患者随机分为Hyper-CVAD/MA组(17例)与EPOCH组(18例),按各自的方案给药,评估其疗效和不良反应。结果 Hyper-CVAD/MA组总有效率为64.71%,EPOCH组总有效率为72.22%。两种方案治疗的患者均出现不同程度骨髓抑制,消化道反应、脱发、神经毒性、黏膜炎等,两种方案的不良反应差异无统计学意义(P>0.05)。结论 Hyper-CVAD/MA与EPOCH两种方案治疗侵袭性非霍奇金淋巴瘤的临床效果与不良反应相当,两者均为治疗侵袭性淋巴瘤的合理化疗方案。 展开更多
关键词 非霍奇金淋巴瘤 Hyper-CVAD/MA方案 EPOCH方案 临床效果 不良反应
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