Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol

A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.

A REPORT OF 300 CASES OF MIGRAINE TREATED WITH ACUPUNCTURE PLUS BLOOD-LETTING PUNCTURING AND CUPPING

Acupuncture combined with blood-letting puncturing and cupping Is quite effectivein treatment of migraine.The total effective rate of 300 cases is 95.7％.Combined treatment ofacupuncture and cupping can supplement each other in strengthening the therapeutic effect and is agood way for relieving headache.

BLOOD-LETTING PUNCTURING AND CUPPING FOR TREATMENT OF 56 CASES OF RHEUMATIC ARTHRITIS

Presented is a summary of 56 cases of rheumatic arthritis treated with blood-letting puncturing and cupping. Patients acupoints selected were pricked first with a three-edged needle and then cupped for 15 min. The treatment was conducted once every other day and six times constituted a therapeutic course. After treatment, out of the 56 cases, 45 cases were cured, 4 markedly effective,3 effective and 4 ineffective, with the total effective rate of 92%.

OBSERVATION OF 14 CASES OF LARYNGEAL CARBUNCLE TREATED BY WEI JIA'S BLOOD-LETTING THERAPY

The author used the pricking-blood therapy to treat 14 cases of laryngeal car-buncle.The pricking-blood therapy included clumpy pricking(local area),spot pricking(prickingSanshang points on the thumb and three points of the helix).The therapy has role of clearing awaypathogentic heat and toxic materials and promoting subsidence of swelling.It could avoid forming py-opoiesis and free from operating treatment.The treatment was given once daily,result:13 cases cured(93%),1 case failed(7%).In 14 cases,antero-upper type has 13 cases which cured,postero-uppertype has only 1 case which treated failure.It is because its imflammation was located on posterior totonsillae,exposed bad and pricked difficulty.So the therapy only used antero-upper type of laryngealcarbuncle and had a good effect.

Progress of blood-letting puncture on the treatment of psoriasis

Psoriasis is a chronic skin disease characterized by localized or wide spread squamous erythema or plaque. The pathogenesis is complicated. According to the TCM theory, psoriasis results from internal heat toxin and the deficiency of blood. And blood stasis exists throughout the disease, the treatment should focus on promoting blood circulation and removing blood stasis. Blood-letting puncture can balance Qi and blood through stimulating the meridians, forcing evil Qi to go out, so as to dispel pathogenic factors and dredge the meridians. This article briefly discusses the basic mechanisms and clinical researches of psoriasis with blood-letting puncture, in order to provide new ideas for the clinical treatment of psoriasis.

Combination Treatment with Gua Sha and Blood-letting Causes Attenuation of Systemic Inflammation,Activated Coagulation,Tissue Ischemia and Injury during Heatstroke in Rats

Objective： Gua Sha and Blood-letting at the acupoints were Chinese traditional therapies for heatstroke. The purpose of present study was to assess the therapeutic effect of Gua Sha on the DU Meridian and Bladder Meridian combined with Blood-letting acupoints at Shixuan （EX-UE 11） and Weizhong （BL 40） on heatstroke. Methods： Anesthetized rats, immediately after the onset of heatstroke, were divided into four major groups： Gua Sha group, Blood-letting group, Gua Sha combined with Blood-letting group and model group. They were exposed to ambient temperature of 43℃ to induce heatstroke. Another group of rats were exposed to room temperature （26℃） and used as normal control group. Their survival times were measured. In addition, their physiological and biochemical parameters were continuously monitored. Results： When rats underwent heatstroke, their survival time values were found to be 21-25 min. Treatment of Gua Sha combined with Blood- letting greatly improved the survival time （230 ± 22 rain） during heatstroke. All heatstoke animals displayed and activated coagulation evidenced by increased prothrombin time （PT）, activated partial thromboplastin time （aPTT）, D-dimer, and decreased platelet count, protein C. Furthermore, the animals displayed systemic inflammation evidenced by increased the serum levels of cytokines interleukin-1β （IL-1β）, tumor necrosis factor α （TNF-α） and malondialdehyde （MDA）. Biochemical markers evidenced by cellular ischemia and injury/dysfunction included increased plasma levels of blood urea nitrogen （BUN）, creatinine, serum glutamic oxaloacetic transaminase （SGOT）, serum glutamic pyruvic transaminase （SGPT）, and alkaline phosphatase （ALP） were all elevated during heatstroke. Core temperatures （Tco） were also increased during heatstroke. In contrast, the values of mean arterial pressure were significantly lower during heatstroke. These heatstroke reactions were all significantly suppressed by treatment of Gua Sha and Blood-letting, especially the combination therapy. Conclusion： Gua Sha combined with Blood-letting after heatstroke may improve survival by ameliorating systemic inflammation, hypercoagulable state, and tissue ischemia and injury in multiple organs.

REVIEW ON THE CLINICAL RESEARCH DEVELOPMENT IN ACUPUNCTURE AND MOXIBUSTION

The author read the clinical reports on stroke, coronary cardiopathy, prostatitis, acute mastitis, gastroduodenal ulcer and ulcerative colitis treated with acupuncture and articles about bloodletting puncturing method in recent 10 years, analysed generally recent research articles about the above diseases treated with acupuncture, summed up some effective prescription of acupuncture, and pointed out some shortcomings in clinical research, classified the clinical reports on blood-letting puncturing method into three aspects according to the effects of clearing away heat and toxic material, promoting blood circulation to remove blood stasis and alleviating pain, and rescuing emergency. These reports suggested that there was no analytic study on the contraindication and the amount of bleeding,and also the basic research was not enough. In the end, the author introduced their research workappling acupuncture to rescue the patients with central respiratory failure and arrhythmia caused by cardiac infarction.

Blood-Letting Therapy for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective:To evaluate the efficacy and safety of blood-letting therapy(BLT)in treatment of hypertension.Methods:A comprehensive electronic and manual bibliographic searches were performed in Cochrane Central Register of Controlled Trials,Excerpt Medica Database(EMBASE),PubMed,China National Knowledge Infrastructure,Chinese Scientific Journal Database,Chinese Biomedical Literature Database,and Wanfang Database to identify randomized controlled trials(RCTs)in which hypertensive patients were treated with BLT or BLT plus antihypertensive drugs(BPAD)against placebo,no treatment or antihypertensive drugs.The Cochrane Risk Assessment Tool was used to assess the methodological quality of trials.The Review Manager 5.3 software was used for meta-analysis.Results:A total of 7 RCTs with 637 hypertensive patients from 1989 to 2017 were identified.Compared with antihypertensive drugs,blood pressure was significantly reduced by BLT(RR=1.21,95%CI:1.01 to 1.44,P=0.03;heterogeneity:P=0.06,I^2=60%)and BPAD(RR=1.25,95%CI,1.02 to 1.53,P=0.03;heterogeneity:P=0.01,I^2=71%).Moreover,a significant improvement in Chinese medicine syndrome by BLT(RR=1.32;95%CI:1.14 to 1.53,P=0.0002;heterogeneity:P=0.53,I^2=0%)and BPAD(RR=1.47;95%CI:1.06 to 2.04,P=0.02;heterogeneity:P=0.13,I^2=56%)was identified.The reported adverse effects were well tolerated.Conclusions:Although some positive findings were identified,no definite conclusions regarding the efficacy and safety of BLT as complementary and alternative approach for treatment of hypertension could be drew due to the generally poor methodological design,significant heterogeneity,and insufficient clinical data.Further rigorously designed trials are warranted to confirm the results.

TREATMENT OF 102 CASES OF ACUTE ABDOMEN BY BLOODLETTING PUNCTURE AND CUPPING THERAPY

102 cases of the acute abdominal disease were treated with the blood-lettingpuncture and cupping. 56 cases were cured, 22 markedly effective, 17 improved and 7 ineffective.Total effective rate was 93.1%.

106 CASES OF SCIATICA TREATED BY BLOOD LETTING AND CUPPINTG

The blood letting and cupping treatment can treat sciatica. The authors treated 106cases, of whom 76 cases were cured (71. 7%), 22 were improved (20.7%) and 8 didn’t show ef-fect (7. 6% ). The total effective rate is 92. 4%. This therapy has advantages of shorter course,less suffering, simple to practise, quick effect and less expense. It is a unique therapy and easy tobe popularized.

针刺加刺络与卡马西平治疗偏头痛效应差异的观察

Objective:To observe the clinical therapeutic effect on migraine treated with acupuncture combined with blood-letting therapy.Methods:A total of 90 patients of migraine were included in compliance with the requirement and divided into a blood-letting therapy group,a western medication group,an acupuncture plus blood-letting therapy group,30 cases in each one according to the random number table.In the two control groups,the simple blood-letting therapy was exerted at Dàzhuī(大椎GV14)and the oral administration with carbamazepine were provided respectively.In the acupuncture plus blood-letting therapy group,acupuncture was exerted at Bǎihuì(百会GV20)and other points,with blood-letting therapy combined.The treatment was given once daily and 12 treatments were as one course.After 2 courses of treatment,the score of therapeutic effect on symptoms and signs,pain score of visual analogue scale(VAS)and clinical therapeutic effect were compared among the three groups before and after treatment.Results:At the end of treatment,the scores for symptoms and signs and VAS score were reduced obviously as compared with those before treatment in the three groups(all P<0.01).Compared with the blood-letting therapy group and the medication group,the scores for symptoms and signs and VAS score were all reduced more obviously in the acupuncture plus blood-letting therapy group respectively(all P<0.01)and the differences were not significant between the blood-letting therapy group and the medication group(P>0.05).The total effective rate in the acupuncture plus blood-letting therapy group was higher obviously than either the blood-letting therapy group or the medication group(both P<0.05).Conclusion:Acupuncture combined with blood-letting therapy achieves a better clinical therapeutic effect on migraine as compared with either simple blood-letting therapy or medication.Such combined treatment obtains a satisfactory therapeutic results and deserves to be promoted in clinical application.

刺络放血拔罐结合电针围刺治疗带状疱疹后神经痛临床观察

Objective:To explore the clinical efficacy of collateral-pricking and blood-letting cupping combined with surrounding needling technique electroacupuncture in the treatment of post-herpetic neuralgia(PHN).Methods:Seventy-two patients with post-herpetic neuralgia were randomized into observation group and control group.Of the 72 cases,12 cases fell off,so finally 30 cases in each group.The observation group was treated with collateral-pricking and blood-letting cupping combined with surrounding needling technique electroacupuncture,while the control group was treated simply with pregabalin capsules for 20 consecutive days.On the basis of the western medication pregabalin capsules,the same as that of the control group,collateral-pricking and blood-letting cupping combined with electroacupuncture in a surrounding needling technique,was adopted for the observation group,once every two days,ten days as one course of treatment,a total of two courses.The immediate visual analogue scale(VAS)before and after treatment were observed in the two groups,and their clinical effects were compared.Results:The VAS scores of PHN patients in the two groups after treatment were lower than those before treatment(both P<0.01),and the scores of observation group were lower than those of control group(P<0.05).The total effective rate of the observation group was 86.7%,higher than 73.3% of the control group.Conclusion:The clinical effect of collateral-pricking and blood-letting cupping combined with electroacupuncture is relatively satisfactory in the treatment of post-herpetic neuralgia.

电针“肘灵”,阿是穴配合刺络拔罐治疗肱骨外上髁炎30例临床观察

Objective:To observe the clinical effect of electroacupuncture(EA)at Zhouling(Extra)and Ashi points in combination with blood-letting cupping for the treatment of external humeral epicondylitis(EHE).Methods:Thirty EHE patients were treated with EA at Zhouling(Extra)and Ashi points in combination with blood-letting cupping,once every 2 days,twice a week,4 times as one course of treatment,and2 successive courses of treatment were given.Before treatment,after 1 course of treatment,and after 2 courses of treatment,the visual analogue scale(VAS)score and Mayo elbow performance score(MEPS)were adopted to evaluate the curative effect.Results:Before treatment,the VAS score of patients was 7.81±1.39.After 1 course of treatment and after 2 courses of treatment,it was 4.77±1.56 and 2.95±1.23 respectively,lowered than before treatment,and the difference was statistically significant(both P<0.01).Before treatment,the Mayo score of patients was 32.17±19.31.After 1 course of treatment and after 2 courses of treatment,it was 47.39±19.85 and85.21±20.47 respectively,increased than before treatment,and the difference was statistically significant(both P<0.01).Of the 30 patients,5 were cured,accounting for 16.67%;14 cases obviously effective,accounting for 46.67%;8 cases effective,accounting for 26.67%;3 cases ineffective,accounting for 10.00%,and the total effective rate was 90.00%.Conclusion:EA at Zhouling(Extra)and Ashi points and blood-letting cupping used in combination are remarkably effective in the treatment of EHE,being worthy for popularization.