BACKGROUND Early postoperative inflammatory small bowel obstruction(EPISBO)is easy to be complicated after colorectal cancer surgery.Both intestinal obstruction catheter and meglumine can treat EPISBO.AIM To investiga...BACKGROUND Early postoperative inflammatory small bowel obstruction(EPISBO)is easy to be complicated after colorectal cancer surgery.Both intestinal obstruction catheter and meglumine can treat EPISBO.AIM To investigate the efficacy of an intestinal obstruction tube combined with meg-lumine diazo in treating EPISBO of colorectal cancer.METHODS Data from 60 patients with colorectal cancer and intestinal obstruction admitted to the Proctology Department of our hospital from April 2018 to May 2022 were collected and analyzed and divided into three cohorts according to different treatment regimens.Cohort A(n=20)received a transnasal intestinal obstruction catheter with panumglumine,and cohort B(n=20)received a transnasal intestinal obstruction catheter with liquid paraffin.Cohort C(n=20)received oral treatment with meglumine.The clinical efficacy,first exhaust/defecation time,length of hospital stay,gastrointestinal decompression time,relief time of abdo-minal pain,and relief time of abdominal distension were compared among the three cohorts.The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1),serum albumin,and transferrin were compared among the three cohorts before and after treatment.The occurrence of adverse reactions in the three cohorts was compared.RESULTS Compared with cohort C,the successful treatment rate of cohort A was signi-ficantly higher.There were statistically significant variations in the time of first exhaust/defecation,length of hospital stays,gastrointestinal decompression time,relief time of abdominal pain,and relief time of abdominal distention among the three cohorts.Compared with cohort C,cohort A’s first exhaust/defecation time,hospitalization time,gastrointestinal decompression time,abdominal pain relief time,and abdominal distension relief time was reduced(P<0.05).After treatment,serum CRP,TNF-α,IL-6,and MCP-1 expression levels increased,and serum albumin and serum transferrin levels increased in the three cohorts.The serum albumin level in cohort A was higher than in cohort C.Compared with cohort B and cohort C,the serum transferrin level in cohort A increased(P<0.05).Compared with cohort C,the total incidence of adverse reactions in cohorts A and B was significantly higher(P<0.05).The incidence of adverse reactions was similar between cohort A and cohort B.CONCLUSION Using an ileus tube combined with meglumine diatrizoate can effectively treat postoperative inflammatory ileus obstructions after surgery colorectal cancer and improve prognosis,inflammatory response,and nutritional status.展开更多
Inflammatory bowel diseases(IBD),Crohns disease and ulcerative colitis,are chronic conditions associated with high morbidity and healthcare costs.The natural history of IBD is variable and marked by alternating period...Inflammatory bowel diseases(IBD),Crohns disease and ulcerative colitis,are chronic conditions associated with high morbidity and healthcare costs.The natural history of IBD is variable and marked by alternating periods of flare and remission.Even though the use of newer therapeutic targets has been associated with higher rates of mucosal healing,a great proportion of IBD patients remain symptomatic despite effective control of inflammation.These symptoms may include but not limited to abdominal pain,dyspepsia,diarrhea,urgency,fecal incontinence,constipation or bloating.In this setting,commonly there is an overlap with gastrointestinal(GI)motility and absorptive disorders.Early recognition of these conditions greatly improves patient care and may decrease the risk of mistreatment.Therefore,in this review we describe the prevalence,diagnosis and treatment of GI motility and absorptive disorders that commonly affect patients with IBD.展开更多
目的:探讨六磨汤联合芒硝外敷对术后早期炎性肠梗阻(EPISBO)患者肠道屏障功能及血清血管活性肠肽(VIP)水平的影响。方法:选取2021年11月—2022年11月我院收治的符合标准的98例EPISBO患者,采用随机数字表法分为对照组(n=49)及研究组(n=49...目的:探讨六磨汤联合芒硝外敷对术后早期炎性肠梗阻(EPISBO)患者肠道屏障功能及血清血管活性肠肽(VIP)水平的影响。方法:选取2021年11月—2022年11月我院收治的符合标准的98例EPISBO患者,采用随机数字表法分为对照组(n=49)及研究组(n=49)。对照组进行常规治疗,研究组在对照组的基础上给予六磨汤联合芒硝外敷治疗。比较两组临床疗效、治疗前后胃肠功能恢复时间、胃肠激素水平、血清炎症因子水平和不良反应发生率。结果:研究组总有效率高于对照组(91.84%vs 75.51%,P<0.05)。研究组腹部症状缓解时间、肠鸣音恢复时间以及肛门排气时间均低于对照组(6.37±0.97 vs 8.56±1.29,5.31±0.76 vs 7.16±0.93,6.37±1.09 vs 8.16±1.16,P<0.05)。治疗前,两组的血清VIP、胃动素(MOT)、胃泌素(GAS)水平无统计学差异(31.76±5.87 vs 31.08±5.63,187.29±26.39 vs 186.32±25.97,108.67±21.76 vs 111.62±26.89,P>0.05),治疗后,两组的血清VIP水平都有所降低,MOT、GAS水平都有所升高,相对而言,研究组的血清VIP水平降低更多,MOT、GAS水平升高更多(16.23±3.66 vs 20.75±4.37,289.67±38.52 vs 231.56±31.26,179.65±39.55 vs 142.34±31.76,P<0.05)。治疗前,两组的血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平无差异(65.19±7.83 vs 63.13±7.56,67.59±9.27 vs 67.11±8.96,59.13±8.52 vs 58.77±8.78,P>0.05),治疗后,两组的血清TNF-α、CRP、IL-6水平都有所降低,且研究组的血清TNF-α、CRP、IL-6水平降低更多(19.37±3.65 vs 29.82±5.23,17.26±3.25 vs 27.51±4.16,15.56±2.44 vs 23.41±3.53,P<0.05)。结论:六磨汤联合芒硝外敷可有效改善EPISBO患者的临床症状,降低胃肠功能恢复的时间,调节胃肠激素水平和血清炎症因子,且具有一定的安全性。展开更多
文摘BACKGROUND Early postoperative inflammatory small bowel obstruction(EPISBO)is easy to be complicated after colorectal cancer surgery.Both intestinal obstruction catheter and meglumine can treat EPISBO.AIM To investigate the efficacy of an intestinal obstruction tube combined with meg-lumine diazo in treating EPISBO of colorectal cancer.METHODS Data from 60 patients with colorectal cancer and intestinal obstruction admitted to the Proctology Department of our hospital from April 2018 to May 2022 were collected and analyzed and divided into three cohorts according to different treatment regimens.Cohort A(n=20)received a transnasal intestinal obstruction catheter with panumglumine,and cohort B(n=20)received a transnasal intestinal obstruction catheter with liquid paraffin.Cohort C(n=20)received oral treatment with meglumine.The clinical efficacy,first exhaust/defecation time,length of hospital stay,gastrointestinal decompression time,relief time of abdo-minal pain,and relief time of abdominal distension were compared among the three cohorts.The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1),serum albumin,and transferrin were compared among the three cohorts before and after treatment.The occurrence of adverse reactions in the three cohorts was compared.RESULTS Compared with cohort C,the successful treatment rate of cohort A was signi-ficantly higher.There were statistically significant variations in the time of first exhaust/defecation,length of hospital stays,gastrointestinal decompression time,relief time of abdominal pain,and relief time of abdominal distention among the three cohorts.Compared with cohort C,cohort A’s first exhaust/defecation time,hospitalization time,gastrointestinal decompression time,abdominal pain relief time,and abdominal distension relief time was reduced(P<0.05).After treatment,serum CRP,TNF-α,IL-6,and MCP-1 expression levels increased,and serum albumin and serum transferrin levels increased in the three cohorts.The serum albumin level in cohort A was higher than in cohort C.Compared with cohort B and cohort C,the serum transferrin level in cohort A increased(P<0.05).Compared with cohort C,the total incidence of adverse reactions in cohorts A and B was significantly higher(P<0.05).The incidence of adverse reactions was similar between cohort A and cohort B.CONCLUSION Using an ileus tube combined with meglumine diatrizoate can effectively treat postoperative inflammatory ileus obstructions after surgery colorectal cancer and improve prognosis,inflammatory response,and nutritional status.
文摘Inflammatory bowel diseases(IBD),Crohns disease and ulcerative colitis,are chronic conditions associated with high morbidity and healthcare costs.The natural history of IBD is variable and marked by alternating periods of flare and remission.Even though the use of newer therapeutic targets has been associated with higher rates of mucosal healing,a great proportion of IBD patients remain symptomatic despite effective control of inflammation.These symptoms may include but not limited to abdominal pain,dyspepsia,diarrhea,urgency,fecal incontinence,constipation or bloating.In this setting,commonly there is an overlap with gastrointestinal(GI)motility and absorptive disorders.Early recognition of these conditions greatly improves patient care and may decrease the risk of mistreatment.Therefore,in this review we describe the prevalence,diagnosis and treatment of GI motility and absorptive disorders that commonly affect patients with IBD.
文摘目的:探讨六磨汤联合芒硝外敷对术后早期炎性肠梗阻(EPISBO)患者肠道屏障功能及血清血管活性肠肽(VIP)水平的影响。方法:选取2021年11月—2022年11月我院收治的符合标准的98例EPISBO患者,采用随机数字表法分为对照组(n=49)及研究组(n=49)。对照组进行常规治疗,研究组在对照组的基础上给予六磨汤联合芒硝外敷治疗。比较两组临床疗效、治疗前后胃肠功能恢复时间、胃肠激素水平、血清炎症因子水平和不良反应发生率。结果:研究组总有效率高于对照组(91.84%vs 75.51%,P<0.05)。研究组腹部症状缓解时间、肠鸣音恢复时间以及肛门排气时间均低于对照组(6.37±0.97 vs 8.56±1.29,5.31±0.76 vs 7.16±0.93,6.37±1.09 vs 8.16±1.16,P<0.05)。治疗前,两组的血清VIP、胃动素(MOT)、胃泌素(GAS)水平无统计学差异(31.76±5.87 vs 31.08±5.63,187.29±26.39 vs 186.32±25.97,108.67±21.76 vs 111.62±26.89,P>0.05),治疗后,两组的血清VIP水平都有所降低,MOT、GAS水平都有所升高,相对而言,研究组的血清VIP水平降低更多,MOT、GAS水平升高更多(16.23±3.66 vs 20.75±4.37,289.67±38.52 vs 231.56±31.26,179.65±39.55 vs 142.34±31.76,P<0.05)。治疗前,两组的血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平无差异(65.19±7.83 vs 63.13±7.56,67.59±9.27 vs 67.11±8.96,59.13±8.52 vs 58.77±8.78,P>0.05),治疗后,两组的血清TNF-α、CRP、IL-6水平都有所降低,且研究组的血清TNF-α、CRP、IL-6水平降低更多(19.37±3.65 vs 29.82±5.23,17.26±3.25 vs 27.51±4.16,15.56±2.44 vs 23.41±3.53,P<0.05)。结论:六磨汤联合芒硝外敷可有效改善EPISBO患者的临床症状,降低胃肠功能恢复的时间,调节胃肠激素水平和血清炎症因子,且具有一定的安全性。
