To quantify the relative contributions of Arctic sea ice and unforced atmospheric internal variability to the “warm Arctic, cold East Asia”(WACE) teleconnection, this study analyses three sets of large-ensemble simu...To quantify the relative contributions of Arctic sea ice and unforced atmospheric internal variability to the “warm Arctic, cold East Asia”(WACE) teleconnection, this study analyses three sets of large-ensemble simulations carried out by the Norwegian Earth System Model with a coupled atmosphere–land surface model, forced by seasonal sea ice conditions from preindustrial, present-day, and future periods. Each ensemble member within the same set uses the same forcing but with small perturbations to the atmospheric initial state. Hence, the difference between the present-day(or future) ensemble mean and the preindustrial ensemble mean provides the ice-loss-induced response, while the difference of the individual members within the present-day(or future) set is the effect of atmospheric internal variability. Results indicate that both present-day and future sea ice loss can force a negative phase of the Arctic Oscillation with a WACE pattern in winter. The magnitude of ice-induced Arctic warming is over four(ten) times larger than the ice-induced East Asian cooling in the present-day(future) experiment;the latter having a magnitude that is about 30% of the observed cooling. Sea ice loss contributes about 60%(80%) to the Arctic winter warming in the present-day(future) experiment. Atmospheric internal variability can also induce a WACE pattern with comparable magnitudes between the Arctic and East Asia. Ice-lossinduced East Asian cooling can easily be masked by atmospheric internal variability effects because random atmospheric internal variability may induce a larger magnitude warming. The observed WACE pattern occurs as a result of both Arctic sea ice loss and atmospheric internal variability, with the former dominating Arctic warming and the latter dominating East Asian cooling.展开更多
Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab vs.docetaxel as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian patients.Methods: Key...Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab vs.docetaxel as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian patients.Methods: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT population.Results: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel arm.Conclusions: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.展开更多
Unraveling the phylogeographic histories of species remains a key endeavor for comprehending the evolutionary processes contributing to the rich biodiversity and high endemism found in East Asia.In this study,we explo...Unraveling the phylogeographic histories of species remains a key endeavor for comprehending the evolutionary processes contributing to the rich biodiversity and high endemism found in East Asia.In this study,we explored the phylogeographic patterns and demographic histories of three endemic fishfly and dobsonfly species(Neochauliodes formosanus,Protohermes costalis,and Neoneuromus orientalis)belonging to the holometabolan order Megaloptera.These species,which share a broad and largely overlapping distribution,were analyzed using comprehensive mitogenomic data.Our findings revealed a consistent influence of vicariance on the population isolation of Neoc.formosanus and P.costalis between Hainan,Taiwan,and the East Asian mainland during the early Pleistocene,potentially hindering subsequent colonization of the later diverged Neon.orientalis to these islands.Additionally,we unveiled the dual function of the major mountain ranges in East Asia,serving both as barriers and conduits,in shaping the population structure of all three species.Notably,we demonstrated that these co-distributed species originated from Southwest,Southern,and eastern Central China,respectively,then subsequently migrated along multi-directional routes,leading to their sympatric distribution on the East Asian mainland.Furthermore,our results highlighted the significance of Pleistocene land bridges along the eastern coast of East Asia in facilitating the dispersal of mountain-dwelling insects with low dispersal ability.Overall,this study provides novel insight into the synergistic impact of Pleistocene geological and climatic events in shaping the diversity and distribution of aquatic insects in East Asia.展开更多
Drought events have become more frequent and intense over East Asia in recent decades,leading to huge socioeconomic impacts.Although the droughts have been studied extensively by cases or for individual regions,their ...Drought events have become more frequent and intense over East Asia in recent decades,leading to huge socioeconomic impacts.Although the droughts have been studied extensively by cases or for individual regions,their leading variability and associated causes remain unclear.Based on the Standardized Precipitation Evapotranspiration Index(SPEI)and ERA5 reanalysis product from 1979 to 2020,this study evealuates the severity of spring droughts in East Asia and investigates their variations and associated drivers.The results indicate that North China and Mongolia have experienced remarkable trends toward dryness during spring in recent decades,while southwestern China has witnessed an opposite trend toward wetness.The first Empirical Orthogonal Function mode of SPEI variability reveals a similar seesawing pattern,with more severe dryness in northwestern China,Mongolia,North China,South Korea,and Japan but increased wetness in Southwestern China and southeast Asia.Further investigation reveals that the anomalously dry(wet)surface in North(Southwestern)China is significantly associated with anomalously high(low)temperature,less(more)precipitation,and reduced(increased)soil moisture during the previous winter and early spring,regulated by an anomalous anticyclone(cyclone)and thus reduced(increased)water vapor convergence.The spring dry-wet pattern in East Asia is also linked to cold sea surface temperature anomalies in the central-eastern Pacific.The findings of this study have important implications for improving the prediction of spring drought events in East Asia.展开更多
A double-plume convective parameterization scheme is revised to improve the precipitation simulation of a global model(Global-to-Regional Integrated Forecast System;GRIST).The improvement is achieved by considering th...A double-plume convective parameterization scheme is revised to improve the precipitation simulation of a global model(Global-to-Regional Integrated Forecast System;GRIST).The improvement is achieved by considering the effects of large-scale dynamic processes on the trigger of deep convection.The closure,based on dynamic CAPE,is improved accordingly to allow other processes to consume CAPE under the more restricted convective trigger condition.The revised convective parameterization is evaluated with a variable-resolution model setup(110–35 km,refined over East Asia).The Atmospheric Model Intercomparison Project(AMIP)simulations demonstrate that the revised convective parameterization substantially delays the daytime precipitation peaks over most land areas,leading to an improved simulated diurnal cycle,evidenced by delayed and less frequent afternoon precipitation.Meanwhile,changes to the threshold of the trigger function yield a small impact on the diurnal amplitude of precipitation because of the consistent setting of dCAPE-based trigger and closure.The simulated mean precipitation remains reasonable,with some improvements evident along the southern slopes of the Tibetan Plateau.The revised scheme increases convective precipitation at the lower levels of the windward slope and reduces the large-scale precipitation over the upper slope,ultimately shifting the rainfall peak southward,which is in better agreement with the observations.展开更多
It was generally accepted that manuscript maps,as distinct from printed maps,exhibited no signs of printing and were entirely hand-drawn.Western scholars Christopher Terrell and Tony Campbell were the first to break t...It was generally accepted that manuscript maps,as distinct from printed maps,exhibited no signs of printing and were entirely hand-drawn.Western scholars Christopher Terrell and Tony Campbell were the first to break this stereotype in 1987,followed by Catherine Delano-Smith and Chet Van Duzer who discovered a few Renaissance maps and two Qing dynasty maps that showed use of hand stamps.Inspired by these findings,this paper explores the stamped map signs in ten Chinese maps,three Japanese maps,and three Korean maps.By analyzing each map and each type of stamp,this paper provides more examples of this research,broadens the research horizons and geographical area,and demonstrates that use of stamps in manuscript maps was invented independently among people of different regions and civilizations as a result of human nature.展开更多
Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for societies.By using network analysis,the present study managed to identify significant nearly-simultaneous occurren...Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for societies.By using network analysis,the present study managed to identify significant nearly-simultaneous occurrences of heatwaves between the grid cells in East Asia and Eastern Europe,even though they are geographically far away from each other.By further composite analysis,this study revealed that hot events first occurred in Eastern Europe,typically with a time lag of3-4 days before the East Asian heatwave events.An eastward propagating atmospheric wave train,known as the circumglobal teleconnection(CGT)pattern,bridged the sequent occurrences of extreme events in these two remote regions.Atmospheric blockings,amplified by surface warming over Eastern Europe,not only enhanced local heat extremes but also excited a CGT-like pattern characterized by alternative anomalies of high and low pressures.Subsequent downstream anticyclones in the middle and upper troposphere reduced local cloud cover and increased downward solar radiation,thereby facilitating the formation of heatwaves over East Asia.Nearly half of East Asian heatwave events were preceded by Eastern European heatwave events in the 10-day time range before East Asian heatwave events.This investigation of heatwave teleconnection in the two distant regions exhibits strong potential to improve the prediction accuracy of East Asian heatwaves.展开更多
The interannual meridional displacement of the upper-tropospheric westerly jet over the eastern portion of East Asia in summer has been well documented.This study,however,investigates the interannual meridional displa...The interannual meridional displacement of the upper-tropospheric westerly jet over the eastern portion of East Asia in summer has been well documented.This study,however,investigates the interannual meridional displacement of the westerly jet over the western portion of East Asia in summer,which is distinct from its eastern counterpart.The results show that the meridional displacement of the western East Asian jet shows a clear asymmetric feature;that is,there are remarkable differences between the southward and northward displacement of the jet.The southward displacement of the jet corresponds to suppressed convection in the tropical western North Pacific and Maritime Continent and enhanced convection in the equatorial Pacific,which can be explained by the warmer sea surfaces found in the northern Indian Ocean and equatorial eastern Pacific.These tropical anomalies somewhat resemble those associated with the eastern East Asian jet variability.However,the northward displacement of the western East Asian jet does not correspond to significant convection and SST anomalies in the entire tropics;instead,the northward displacement of the jet corresponds well to the positive phase of the Arctic Oscillation.Furthermore,the meridional displacement of the western jet has asymmetric impacts on rainfall and surface air temperatures in East Asia.When the western jet shifts northward,more precipitation is found over South China and Northeast China,and higher temperatures appear in northern China.By contrast,when the jet shifts southward,more precipitation appears over the East Asian rainy belt,including the Yangtze River valley,South Korea,and southern and central Japan and warmer temperatures are found South and Southeast Asia.展开更多
The 2024 election is a pivotal and highly contested event in the United States.Donald Trump is expected to compete against Joe Biden without any doubts.A potential return of Trump to the White House would likely cause...The 2024 election is a pivotal and highly contested event in the United States.Donald Trump is expected to compete against Joe Biden without any doubts.A potential return of Trump to the White House would likely cause significant reactions in East Asia,particularly among the three major countries in the region.This analysis will explore the detailed implications of Trump’s return.展开更多
Studying the significant impacts on vegetation of drought due to global warming is crucial in order to understand its dynamics and interrelationships with temperature,rainfall,and normalized difference vegetation inde...Studying the significant impacts on vegetation of drought due to global warming is crucial in order to understand its dynamics and interrelationships with temperature,rainfall,and normalized difference vegetation index(NDVI).These factors are linked to excesses drought frequency and severity on the regional scale,and their effect on vegetation remains an important topic for climate change study.East Asia is very sensitive and susceptible to climate change.In this study,we examined the effect of drought on the seasonal variations of vegetation in relation to climate variability and determined which growing seasons are most vulnerable to drought risk;and then explored the spatio-temporal evolution of the trend in drought changes in East Asia from 1982 to 2019.The data were studied using a series of several drought indexes,and the data were then classified using a heat map,box and whisker plot analysis,and principal component analysis.The various drought indexes from January to August improved rapidly,except for vegetation health index(VHI)and temperature condition index(TCI).While these indices were constant in September,they increased again in October,but in December,they showed a descending trend.The seasonal and monthly analysis of the drought indexes and the heat map confirmed that the East Asian region suffered from extreme droughts in 1984,1993,2007,and 2012among the study years.The distribution of the trend in drought changes indicated that more severe drought occurred in the northwestern region than in the southeastern area of East Asia.The drought tendency slope was used to describe the changes in drought events during 1982–2019 in the study region.The correlations among monthly precipitation anomaly percentage(NAP),NDVI,TCI,vegetation condition index(VCI),temperature vegetation drought index(TVDI),and VHI indicated considerably positive correlations,while considerably negative correlations were found among the three pairs of NDVI and VHI,TVDI and VHI,and NDVI and TCI.This ecological and climatic mechanism provides a good basis for the assessment of vegetation and drought-change variations within the East Asian region.This study is a step forward in monitoring the seasonal variation of vegetation and variations in drought dynamics within the East Asian region,which will serve and contribute to the better management of vegetation,disaster risk,and drought in the East Asian region.展开更多
The East Asian Summer Monsoon(EASM)provides the majority of annual rainfall to countries in East Asia.Although state-of-the-art models broadly project increased EASM rainfall,the spread of projections is large and sim...The East Asian Summer Monsoon(EASM)provides the majority of annual rainfall to countries in East Asia.Although state-of-the-art models broadly project increased EASM rainfall,the spread of projections is large and simulations of present-day rainfall show significant climatological biases.Systematic evapotranspiration biases occur locally over East Asia,and globally over land,in simulations both with and without a coupled ocean.This study explores the relationship between evapotranspiration and EASM precipitation biases.First,idealized model simulations are presented in which the parameterization of land evaporation is modified,while sea surface temperature is fixed.The results suggest a feedback whereby excessive evapotranspiration over East Asia results in cooling of land,a weakened monsoon low,and a shift of rainfall from the Philippine Sea to China,further fueling evapotranspiration.Cross-model regressions against evapotranspiration over China indicate a similar pattern of behavior in Atmospheric Model Intercomparison Project(AMIP)simulations.Possible causes of this pattern are investigated.The feedback is not explained by an overly intense global hydrological cycle or by differences in radiative processes.Analysis of land-only simulations indicates that evapotranspiration biases are present even when models are forced with prescribed rainfall.These are strengthened when coupled to the atmosphere,suggesting a role for land-model errors in driving atmospheric biases.Coupled atmosphere-ocean models are shown to have similar evapotranspiration biases to those in AMIP over China,but different precipitation biases,including a northward shift in the ITCZ over the Pacific and Atlantic Oceans.展开更多
Based on the EAP (East Asia/Pacific) teleconnection in the summer circulation anomalies over the Northern Hemisphere, an index measuring the strength of the East Asian summer monsoon, i.e., the so-called EAP index, is...Based on the EAP (East Asia/Pacific) teleconnection in the summer circulation anomalies over the Northern Hemisphere, an index measuring the strength of the East Asian summer monsoon, i.e., the so-called EAP index, is defined in this paper. From the analyses of observed data, it is clearly shown that the EAP index defined in this study can well describe the interannual variability of summer rainfall and surface air temperature in East Asia, especially in the Yangtze River valley and the Huaihe River valley, Korea, and Japan. Moreover, this index can also reflect the interannual variability of the East Asian summer monsoon system including the monsoon horizontal circulation and the vertical-meridional circulation cell over East Asia. From the composite analyses of climate and monsoon circulation anomalies for high EAP index and for low EAP index, respectively, it is well demonstrated that the EAP index proposed in this study can well measure the strength of the East Asian summer monsoon.展开更多
The simulation and prediction of the climatology and interannual variability of the East Asia winter monsoon(EAWM),as well as the associated atmospheric circulation,was investigated using the hindcast data from Global...The simulation and prediction of the climatology and interannual variability of the East Asia winter monsoon(EAWM),as well as the associated atmospheric circulation,was investigated using the hindcast data from Global Seasonal Forecast System version 5(GloSea5),with a focus on the evolution of model bias among different forecast lead times.While GloSea5 reproduces the climatological means of large-scale circulation systems related to the EAWM well,systematic biases exist,including a cold bias for most of China’s mainland,especially for North and Northeast China.GloSea5 shows robust skill in predicting the EAWM intensity index two months ahead,which can be attributed to the performance in representing the leading modes of surface air temperature and associated background circulation.GloSea5 realistically reproduces the synergistic effect of El Niño–Southern Oscillation(ENSO)and the Arctic Oscillation(AO)on the EAWM,especially for the western North Pacific anticyclone(WNPAC).Compared with the North Pacific and North America,the representation of circulation anomalies over Eurasia is poor,especially for sea level pressure(SLP),which limits the prediction skill for surface air temperature over East Asia.The representation of SLP anomalies might be associated with the model performance in simulating the interaction between atmospheric circulations and underlying surface conditions.展开更多
Based on near-term climate simulations for IPCC-AR5 (The Fifth Assessment Report), probabilistic multimodel ensemble prediction (PMME) of decadal variability of surface air temperature in East Asia (20°-50...Based on near-term climate simulations for IPCC-AR5 (The Fifth Assessment Report), probabilistic multimodel ensemble prediction (PMME) of decadal variability of surface air temperature in East Asia (20°-50°N, 100°- 145°E) was conducted using the multivariate Gaussian ensemble kernel dressing (GED) methodology. The ensemble system exhibited high performance in hindcasting the deeadal (1981-2010) mean and trend of temperature anomalies with respect to 1961-90, with a RPS of 0.94 and 0.88 respectively. The interpretation of PMME for future decades (2006-35) over East Asia was made on the basis of the bivariate probability density of the mean and trend. The results showed that, under the RCP4.5 (Representative Concentration Pathway 4.5 W m-2) scenario, the annual mean temperature increases on average by about 1.1-1.2 K and the temperature trend reaches 0.6-0.7 K (30 yr)-1. The pattern for both quantities was found to be that the temperature increase will be less intense in the south. While the temperature increase in terms of the 30-yr mean was found to be virtually certain, the results for the 30-yr trend showed an almost 25% chance of a negative value. This indicated that, using a multimodel ensemble system, even if a longer-term warming exists for 2006-35 over East Asia, the trend for temperature may produce a negative value. Temperature was found to be more affected by seasonal variability, with the increase in temperature over East Asia more intense in autumn (mainly), faster in summer to the west of 115°E, and faster still in autumn to the east of 115°E.展开更多
The regional climate change index (RCCI) is employed to investigate hot-spots under 21st century global warming over East Asia. The RCCI is calculated on a 1-degree resolution grid from the ensemble of CMIP3 simulat...The regional climate change index (RCCI) is employed to investigate hot-spots under 21st century global warming over East Asia. The RCCI is calculated on a 1-degree resolution grid from the ensemble of CMIP3 simulations for the B1, AIB, and A2 IPCC emission scenarios. The RCCI over East Asia exhibits marked sub-regional variability. Five sub-regional hot-spots are identified over the area of investigation: three in the northern regions (Northeast China, Mongolia, and Northwest China), one in eastern China, and one over the Tibetan Plateau. Contributions from different factors to the RCCI are discussed for the sub-regions. Analysis of the temporal evolution of the hot-spots throughout the 21st century shows different speeds of response time to global warming for the different sub-regions. Hot-spots firstly emerge in Northwest China and Mongolia. The Northeast China hot-spot becomes evident by the mid of the 21st century and it is the most prominent by the end of the century. While hot-spots are generally evident in all the 5 sub-regions for the A1B and A2 scenarios, only the Tibetan Plateau and Northwest China hot-spots emerge in the B1 scenario, which has the lowest greenhouse gas (GHG) concentrations. Our analysis indicates that subregional hot-spots show a rather complex spatial and temporal dependency on the GHG concentration and on the different factors contributing to the RCCI.展开更多
The East Asian geological setting has a long duration related to the superconvergence of the Paleo-Asian, Tethyan and Paleo-Pacific tectonic domains. The Triassic Indosinian Movement contributed to an unified passive ...The East Asian geological setting has a long duration related to the superconvergence of the Paleo-Asian, Tethyan and Paleo-Pacific tectonic domains. The Triassic Indosinian Movement contributed to an unified passive continental margin in East Asia. The later ophiolites and I-type granites associated with subduction of the Paleo-Pacific Plate in the Late Triassic, suggest a transition from passive to active continental margins. With the presence of the ongoing westward migration of the Paleo-Pacific Subduction Zone, the sinistral transpressional stress field could play an important role in the intraplate deformation in East Asia during the Late Triassic to Middle Jurassic, being characterized by the transition from the E-W-trending structural system controlled by the Tethys and Paleo-Asian oceans to the NE-trending structural system caused by the Paleo-Pacific Ocean subduction. The continuously westward migration of the subduction zones resulted in the transpressional stress field in East Asia marked by the emergence of the Eastern North China Plateau and the formation of the Andean-type active continental margin from late Late Jurassic to Early Cretaceous (160-135 Ma), accompanied by the development of a small amount of adakites. In the Late Cretaceous (135-90 Ma), due to the eastward retreat of the Paleo-Pacific Subduction Zone, the regional stress field was replaced from sinistral transpression to transtension. Since a large amount of late-stage adakites and metamorphic core complexes developed, the Andean-type active continental margin was destroyed and the Eastern North China Plateau started to collapse. In the Late Cretaceous, the extension in East Asia gradually decreased the eastward retreat of the Paleo-Pacific subduction zones. Futhermore, a significant topographic inversion had taken place during the Cenozoic that resulted from a rapid uplift of the Tibet Plateau resulting from the India-Eurasian collision and the formation of the Bohai Bay Basin and other basins in the East Asian continental margin. The inversion caused a remarkable eastward migration of deformation, basin formation and magmatism. Meanwhile, the basins that mainly developed in the Paleogene resulted in a three-step topography which typically appears to drop eastward in altitude. In the Neogene, the basins underwent a rapid subsidence in some depressions after basin-controlled faulting, as well as the intracontinental extensional events in East Asia, and are likely to be a contribution to the uplift of the Tibetan Plateau.展开更多
基金supported by the Chinese-Norwegian Collaboration Projects within Climate Systems jointly funded by the National Key Research and Development Program of China (Grant No.2022YFE0106800)the Research Council of Norway funded project MAPARC (Grant No.328943)+2 种基金the support from the Research Council of Norway funded project BASIC (Grant No.325440)the Horizon 2020 project APPLICATE (Grant No.727862)High-performance computing and storage resources were performed on resources provided by Sigma2 - the National Infrastructure for High-Performance Computing and Data Storage in Norway (through projects NS8121K,NN8121K,NN2345K,NS2345K,NS9560K,NS9252K,and NS9034K)。
文摘To quantify the relative contributions of Arctic sea ice and unforced atmospheric internal variability to the “warm Arctic, cold East Asia”(WACE) teleconnection, this study analyses three sets of large-ensemble simulations carried out by the Norwegian Earth System Model with a coupled atmosphere–land surface model, forced by seasonal sea ice conditions from preindustrial, present-day, and future periods. Each ensemble member within the same set uses the same forcing but with small perturbations to the atmospheric initial state. Hence, the difference between the present-day(or future) ensemble mean and the preindustrial ensemble mean provides the ice-loss-induced response, while the difference of the individual members within the present-day(or future) set is the effect of atmospheric internal variability. Results indicate that both present-day and future sea ice loss can force a negative phase of the Arctic Oscillation with a WACE pattern in winter. The magnitude of ice-induced Arctic warming is over four(ten) times larger than the ice-induced East Asian cooling in the present-day(future) experiment;the latter having a magnitude that is about 30% of the observed cooling. Sea ice loss contributes about 60%(80%) to the Arctic winter warming in the present-day(future) experiment. Atmospheric internal variability can also induce a WACE pattern with comparable magnitudes between the Arctic and East Asia. Ice-lossinduced East Asian cooling can easily be masked by atmospheric internal variability effects because random atmospheric internal variability may induce a larger magnitude warming. The observed WACE pattern occurs as a result of both Arctic sea ice loss and atmospheric internal variability, with the former dominating Arctic warming and the latter dominating East Asian cooling.
基金funded by F. Hoffmann-La Roche Ltd. F. Hoffmann-La Roche Ltd sponsored the IMpower210 study。
文摘Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab vs.docetaxel as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian patients.Methods: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT population.Results: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel arm.Conclusions: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.
基金supported by the National Natural Science Foundation of China(32170448,32130012,32300374)Beijing Natural Science Foundation(5212011)2115 Talent Development Program of China Agricultural University,and National Animal Collection Resource Center,China。
文摘Unraveling the phylogeographic histories of species remains a key endeavor for comprehending the evolutionary processes contributing to the rich biodiversity and high endemism found in East Asia.In this study,we explored the phylogeographic patterns and demographic histories of three endemic fishfly and dobsonfly species(Neochauliodes formosanus,Protohermes costalis,and Neoneuromus orientalis)belonging to the holometabolan order Megaloptera.These species,which share a broad and largely overlapping distribution,were analyzed using comprehensive mitogenomic data.Our findings revealed a consistent influence of vicariance on the population isolation of Neoc.formosanus and P.costalis between Hainan,Taiwan,and the East Asian mainland during the early Pleistocene,potentially hindering subsequent colonization of the later diverged Neon.orientalis to these islands.Additionally,we unveiled the dual function of the major mountain ranges in East Asia,serving both as barriers and conduits,in shaping the population structure of all three species.Notably,we demonstrated that these co-distributed species originated from Southwest,Southern,and eastern Central China,respectively,then subsequently migrated along multi-directional routes,leading to their sympatric distribution on the East Asian mainland.Furthermore,our results highlighted the significance of Pleistocene land bridges along the eastern coast of East Asia in facilitating the dispersal of mountain-dwelling insects with low dispersal ability.Overall,this study provides novel insight into the synergistic impact of Pleistocene geological and climatic events in shaping the diversity and distribution of aquatic insects in East Asia.
基金National Natural Science Foundation of China(42230603,42275020)Guangdong Major Project of Basic and Applied Basic Research(2020B0301030004)+3 种基金Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies(2020B1212060025)Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(311021001)Open Fund of State Key Laboratory of Satellite Ocean Environment Dynamics,Second Institute of Oceanography,MNR(QNHX2310)Future Earth Early-Career Fellowship of the Future Earth Global Secretariat Hub China。
文摘Drought events have become more frequent and intense over East Asia in recent decades,leading to huge socioeconomic impacts.Although the droughts have been studied extensively by cases or for individual regions,their leading variability and associated causes remain unclear.Based on the Standardized Precipitation Evapotranspiration Index(SPEI)and ERA5 reanalysis product from 1979 to 2020,this study evealuates the severity of spring droughts in East Asia and investigates their variations and associated drivers.The results indicate that North China and Mongolia have experienced remarkable trends toward dryness during spring in recent decades,while southwestern China has witnessed an opposite trend toward wetness.The first Empirical Orthogonal Function mode of SPEI variability reveals a similar seesawing pattern,with more severe dryness in northwestern China,Mongolia,North China,South Korea,and Japan but increased wetness in Southwestern China and southeast Asia.Further investigation reveals that the anomalously dry(wet)surface in North(Southwestern)China is significantly associated with anomalously high(low)temperature,less(more)precipitation,and reduced(increased)soil moisture during the previous winter and early spring,regulated by an anomalous anticyclone(cyclone)and thus reduced(increased)water vapor convergence.The spring dry-wet pattern in East Asia is also linked to cold sea surface temperature anomalies in the central-eastern Pacific.The findings of this study have important implications for improving the prediction of spring drought events in East Asia.
基金supported by the National Key R&D Program of China on the Monitoring,Early Warning,and Prevention of Major Natural Disasters(Grant Nos.2018YFC1507005 and 02017YFC1502202)。
文摘A double-plume convective parameterization scheme is revised to improve the precipitation simulation of a global model(Global-to-Regional Integrated Forecast System;GRIST).The improvement is achieved by considering the effects of large-scale dynamic processes on the trigger of deep convection.The closure,based on dynamic CAPE,is improved accordingly to allow other processes to consume CAPE under the more restricted convective trigger condition.The revised convective parameterization is evaluated with a variable-resolution model setup(110–35 km,refined over East Asia).The Atmospheric Model Intercomparison Project(AMIP)simulations demonstrate that the revised convective parameterization substantially delays the daytime precipitation peaks over most land areas,leading to an improved simulated diurnal cycle,evidenced by delayed and less frequent afternoon precipitation.Meanwhile,changes to the threshold of the trigger function yield a small impact on the diurnal amplitude of precipitation because of the consistent setting of dCAPE-based trigger and closure.The simulated mean precipitation remains reasonable,with some improvements evident along the southern slopes of the Tibetan Plateau.The revised scheme increases convective precipitation at the lower levels of the windward slope and reduces the large-scale precipitation over the upper slope,ultimately shifting the rainfall peak southward,which is in better agreement with the observations.
文摘It was generally accepted that manuscript maps,as distinct from printed maps,exhibited no signs of printing and were entirely hand-drawn.Western scholars Christopher Terrell and Tony Campbell were the first to break this stereotype in 1987,followed by Catherine Delano-Smith and Chet Van Duzer who discovered a few Renaissance maps and two Qing dynasty maps that showed use of hand stamps.Inspired by these findings,this paper explores the stamped map signs in ten Chinese maps,three Japanese maps,and three Korean maps.By analyzing each map and each type of stamp,this paper provides more examples of this research,broadens the research horizons and geographical area,and demonstrates that use of stamps in manuscript maps was invented independently among people of different regions and civilizations as a result of human nature.
基金Guangdong Major Project of Basic and Applied Basic Research (2020B0301030004)National Natural Science Foundation of China (42275020)+1 种基金Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (311021001)Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies (2020B1212060025)。
文摘Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for societies.By using network analysis,the present study managed to identify significant nearly-simultaneous occurrences of heatwaves between the grid cells in East Asia and Eastern Europe,even though they are geographically far away from each other.By further composite analysis,this study revealed that hot events first occurred in Eastern Europe,typically with a time lag of3-4 days before the East Asian heatwave events.An eastward propagating atmospheric wave train,known as the circumglobal teleconnection(CGT)pattern,bridged the sequent occurrences of extreme events in these two remote regions.Atmospheric blockings,amplified by surface warming over Eastern Europe,not only enhanced local heat extremes but also excited a CGT-like pattern characterized by alternative anomalies of high and low pressures.Subsequent downstream anticyclones in the middle and upper troposphere reduced local cloud cover and increased downward solar radiation,thereby facilitating the formation of heatwaves over East Asia.Nearly half of East Asian heatwave events were preceded by Eastern European heatwave events in the 10-day time range before East Asian heatwave events.This investigation of heatwave teleconnection in the two distant regions exhibits strong potential to improve the prediction accuracy of East Asian heatwaves.
基金supported by the National Natural Science Foundation of China(Grant Nos.42130504 and 42275031)。
文摘The interannual meridional displacement of the upper-tropospheric westerly jet over the eastern portion of East Asia in summer has been well documented.This study,however,investigates the interannual meridional displacement of the westerly jet over the western portion of East Asia in summer,which is distinct from its eastern counterpart.The results show that the meridional displacement of the western East Asian jet shows a clear asymmetric feature;that is,there are remarkable differences between the southward and northward displacement of the jet.The southward displacement of the jet corresponds to suppressed convection in the tropical western North Pacific and Maritime Continent and enhanced convection in the equatorial Pacific,which can be explained by the warmer sea surfaces found in the northern Indian Ocean and equatorial eastern Pacific.These tropical anomalies somewhat resemble those associated with the eastern East Asian jet variability.However,the northward displacement of the western East Asian jet does not correspond to significant convection and SST anomalies in the entire tropics;instead,the northward displacement of the jet corresponds well to the positive phase of the Arctic Oscillation.Furthermore,the meridional displacement of the western jet has asymmetric impacts on rainfall and surface air temperatures in East Asia.When the western jet shifts northward,more precipitation is found over South China and Northeast China,and higher temperatures appear in northern China.By contrast,when the jet shifts southward,more precipitation appears over the East Asian rainy belt,including the Yangtze River valley,South Korea,and southern and central Japan and warmer temperatures are found South and Southeast Asia.
文摘The 2024 election is a pivotal and highly contested event in the United States.Donald Trump is expected to compete against Joe Biden without any doubts.A potential return of Trump to the White House would likely cause significant reactions in East Asia,particularly among the three major countries in the region.This analysis will explore the detailed implications of Trump’s return.
基金supported by the National Natural Science Foundation of China[grant numbers 41991280 and 42025502]the Guangdong Major Project of Basic and Applied Basic Research[grant number 2020B0301030004]the State Scholarship Fund by China Scholarship Council[grant number 202109045003].
基金the Basic Research Project of Zhejiang Normal University,China(ZC304022952)the China Postdoctoral Science Foundation Funding(2018M642614)the Natural Science Foundation Youth Proj ect of S h andong Provi nce,C hina(ZR2020QF281)。
文摘Studying the significant impacts on vegetation of drought due to global warming is crucial in order to understand its dynamics and interrelationships with temperature,rainfall,and normalized difference vegetation index(NDVI).These factors are linked to excesses drought frequency and severity on the regional scale,and their effect on vegetation remains an important topic for climate change study.East Asia is very sensitive and susceptible to climate change.In this study,we examined the effect of drought on the seasonal variations of vegetation in relation to climate variability and determined which growing seasons are most vulnerable to drought risk;and then explored the spatio-temporal evolution of the trend in drought changes in East Asia from 1982 to 2019.The data were studied using a series of several drought indexes,and the data were then classified using a heat map,box and whisker plot analysis,and principal component analysis.The various drought indexes from January to August improved rapidly,except for vegetation health index(VHI)and temperature condition index(TCI).While these indices were constant in September,they increased again in October,but in December,they showed a descending trend.The seasonal and monthly analysis of the drought indexes and the heat map confirmed that the East Asian region suffered from extreme droughts in 1984,1993,2007,and 2012among the study years.The distribution of the trend in drought changes indicated that more severe drought occurred in the northwestern region than in the southeastern area of East Asia.The drought tendency slope was used to describe the changes in drought events during 1982–2019 in the study region.The correlations among monthly precipitation anomaly percentage(NAP),NDVI,TCI,vegetation condition index(VCI),temperature vegetation drought index(TVDI),and VHI indicated considerably positive correlations,while considerably negative correlations were found among the three pairs of NDVI and VHI,TVDI and VHI,and NDVI and TCI.This ecological and climatic mechanism provides a good basis for the assessment of vegetation and drought-change variations within the East Asian region.This study is a step forward in monitoring the seasonal variation of vegetation and variations in drought dynamics within the East Asian region,which will serve and contribute to the better management of vegetation,disaster risk,and drought in the East Asian region.
基金supported by the UK–China Research and Innovation Partnership Fund, through the Met Office Climate Science for Service Partnership (CSSP) China, as part of the Newton Fund
文摘The East Asian Summer Monsoon(EASM)provides the majority of annual rainfall to countries in East Asia.Although state-of-the-art models broadly project increased EASM rainfall,the spread of projections is large and simulations of present-day rainfall show significant climatological biases.Systematic evapotranspiration biases occur locally over East Asia,and globally over land,in simulations both with and without a coupled ocean.This study explores the relationship between evapotranspiration and EASM precipitation biases.First,idealized model simulations are presented in which the parameterization of land evaporation is modified,while sea surface temperature is fixed.The results suggest a feedback whereby excessive evapotranspiration over East Asia results in cooling of land,a weakened monsoon low,and a shift of rainfall from the Philippine Sea to China,further fueling evapotranspiration.Cross-model regressions against evapotranspiration over China indicate a similar pattern of behavior in Atmospheric Model Intercomparison Project(AMIP)simulations.Possible causes of this pattern are investigated.The feedback is not explained by an overly intense global hydrological cycle or by differences in radiative processes.Analysis of land-only simulations indicates that evapotranspiration biases are present even when models are forced with prescribed rainfall.These are strengthened when coupled to the atmosphere,suggesting a role for land-model errors in driving atmospheric biases.Coupled atmosphere-ocean models are shown to have similar evapotranspiration biases to those in AMIP over China,but different precipitation biases,including a northward shift in the ITCZ over the Pacific and Atlantic Oceans.
基金supported jointly by the National Key Basic Research Development Program(Grant No.G1999043403)the Knowledge Innovation Project of the Chinese Academy of Sciences(CAS)(Grant No.KZCX3-SW-218)+1 种基金the National Natural Science Foundation of China project for young scientists fund(No.40305012) the Western Project of the CAS (KZCX1-10-07).
文摘Based on the EAP (East Asia/Pacific) teleconnection in the summer circulation anomalies over the Northern Hemisphere, an index measuring the strength of the East Asian summer monsoon, i.e., the so-called EAP index, is defined in this paper. From the analyses of observed data, it is clearly shown that the EAP index defined in this study can well describe the interannual variability of summer rainfall and surface air temperature in East Asia, especially in the Yangtze River valley and the Huaihe River valley, Korea, and Japan. Moreover, this index can also reflect the interannual variability of the East Asian summer monsoon system including the monsoon horizontal circulation and the vertical-meridional circulation cell over East Asia. From the composite analyses of climate and monsoon circulation anomalies for high EAP index and for low EAP index, respectively, it is well demonstrated that the EAP index proposed in this study can well measure the strength of the East Asian summer monsoon.
基金supported by the State Key Program of the National Natural Science of China(Grant No.41730964)the National Key Research and Development Program on Monitoring,Early Warning and Prevention of Major Natural Disaster(2018YFC1506000)+2 种基金the National Natural Science Foundation of China(Grant Nos.41975091 and 42175047)National Basic Research Program of China(2015CB453203)UK-China Research&Innovation Partnership Fund through the Met Office Climate Science for Service Partnership(CSSP)China as part of the Newton Fund.
文摘The simulation and prediction of the climatology and interannual variability of the East Asia winter monsoon(EAWM),as well as the associated atmospheric circulation,was investigated using the hindcast data from Global Seasonal Forecast System version 5(GloSea5),with a focus on the evolution of model bias among different forecast lead times.While GloSea5 reproduces the climatological means of large-scale circulation systems related to the EAWM well,systematic biases exist,including a cold bias for most of China’s mainland,especially for North and Northeast China.GloSea5 shows robust skill in predicting the EAWM intensity index two months ahead,which can be attributed to the performance in representing the leading modes of surface air temperature and associated background circulation.GloSea5 realistically reproduces the synergistic effect of El Niño–Southern Oscillation(ENSO)and the Arctic Oscillation(AO)on the EAWM,especially for the western North Pacific anticyclone(WNPAC).Compared with the North Pacific and North America,the representation of circulation anomalies over Eurasia is poor,especially for sea level pressure(SLP),which limits the prediction skill for surface air temperature over East Asia.The representation of SLP anomalies might be associated with the model performance in simulating the interaction between atmospheric circulations and underlying surface conditions.
基金supported by the National Key Basic Research and Development (973) Program of China (Grant No. 2012CB955204)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)the Research open-fund of Jiangsu Meteorology Bureau (Grant Nos. Q201205, KM201107, and K201009)
文摘Based on near-term climate simulations for IPCC-AR5 (The Fifth Assessment Report), probabilistic multimodel ensemble prediction (PMME) of decadal variability of surface air temperature in East Asia (20°-50°N, 100°- 145°E) was conducted using the multivariate Gaussian ensemble kernel dressing (GED) methodology. The ensemble system exhibited high performance in hindcasting the deeadal (1981-2010) mean and trend of temperature anomalies with respect to 1961-90, with a RPS of 0.94 and 0.88 respectively. The interpretation of PMME for future decades (2006-35) over East Asia was made on the basis of the bivariate probability density of the mean and trend. The results showed that, under the RCP4.5 (Representative Concentration Pathway 4.5 W m-2) scenario, the annual mean temperature increases on average by about 1.1-1.2 K and the temperature trend reaches 0.6-0.7 K (30 yr)-1. The pattern for both quantities was found to be that the temperature increase will be less intense in the south. While the temperature increase in terms of the 30-yr mean was found to be virtually certain, the results for the 30-yr trend showed an almost 25% chance of a negative value. This indicated that, using a multimodel ensemble system, even if a longer-term warming exists for 2006-35 over East Asia, the trend for temperature may produce a negative value. Temperature was found to be more affected by seasonal variability, with the increase in temperature over East Asia more intense in autumn (mainly), faster in summer to the west of 115°E, and faster still in autumn to the east of 115°E.
基金supported by the National Basic Research Program(2009CB421407,2006CB403707,and 2007BAC03A01)the R & D Special Fund for Public Welfare Industry(meteorol-ogy)(GYHY200806010)Chinese Academy of Sciences(Grant NOKZCX2-YW-Q1-02)
文摘The regional climate change index (RCCI) is employed to investigate hot-spots under 21st century global warming over East Asia. The RCCI is calculated on a 1-degree resolution grid from the ensemble of CMIP3 simulations for the B1, AIB, and A2 IPCC emission scenarios. The RCCI over East Asia exhibits marked sub-regional variability. Five sub-regional hot-spots are identified over the area of investigation: three in the northern regions (Northeast China, Mongolia, and Northwest China), one in eastern China, and one over the Tibetan Plateau. Contributions from different factors to the RCCI are discussed for the sub-regions. Analysis of the temporal evolution of the hot-spots throughout the 21st century shows different speeds of response time to global warming for the different sub-regions. Hot-spots firstly emerge in Northwest China and Mongolia. The Northeast China hot-spot becomes evident by the mid of the 21st century and it is the most prominent by the end of the century. While hot-spots are generally evident in all the 5 sub-regions for the A1B and A2 scenarios, only the Tibetan Plateau and Northwest China hot-spots emerge in the B1 scenario, which has the lowest greenhouse gas (GHG) concentrations. Our analysis indicates that subregional hot-spots show a rather complex spatial and temporal dependency on the GHG concentration and on the different factors contributing to the RCCI.
基金the financial supports received from the National Key Research and Development Program of China (Grants 2017YFC0601401 and 2016YFC0601002)National Natural Science Foundation of China (Grant Nos. 41325009, U1606401)+2 种基金National Science and Technology Major Project (Grant 2016ZX05004001003)National Ocean Bureau Program (GASI-GEOGE-1)the financial supports of Aoshan Elite Scientist Plan (2015ASTP-0S10) of Qingdao National Laboratory for Marine Science and Technology to Prof
文摘The East Asian geological setting has a long duration related to the superconvergence of the Paleo-Asian, Tethyan and Paleo-Pacific tectonic domains. The Triassic Indosinian Movement contributed to an unified passive continental margin in East Asia. The later ophiolites and I-type granites associated with subduction of the Paleo-Pacific Plate in the Late Triassic, suggest a transition from passive to active continental margins. With the presence of the ongoing westward migration of the Paleo-Pacific Subduction Zone, the sinistral transpressional stress field could play an important role in the intraplate deformation in East Asia during the Late Triassic to Middle Jurassic, being characterized by the transition from the E-W-trending structural system controlled by the Tethys and Paleo-Asian oceans to the NE-trending structural system caused by the Paleo-Pacific Ocean subduction. The continuously westward migration of the subduction zones resulted in the transpressional stress field in East Asia marked by the emergence of the Eastern North China Plateau and the formation of the Andean-type active continental margin from late Late Jurassic to Early Cretaceous (160-135 Ma), accompanied by the development of a small amount of adakites. In the Late Cretaceous (135-90 Ma), due to the eastward retreat of the Paleo-Pacific Subduction Zone, the regional stress field was replaced from sinistral transpression to transtension. Since a large amount of late-stage adakites and metamorphic core complexes developed, the Andean-type active continental margin was destroyed and the Eastern North China Plateau started to collapse. In the Late Cretaceous, the extension in East Asia gradually decreased the eastward retreat of the Paleo-Pacific subduction zones. Futhermore, a significant topographic inversion had taken place during the Cenozoic that resulted from a rapid uplift of the Tibet Plateau resulting from the India-Eurasian collision and the formation of the Bohai Bay Basin and other basins in the East Asian continental margin. The inversion caused a remarkable eastward migration of deformation, basin formation and magmatism. Meanwhile, the basins that mainly developed in the Paleogene resulted in a three-step topography which typically appears to drop eastward in altitude. In the Neogene, the basins underwent a rapid subsidence in some depressions after basin-controlled faulting, as well as the intracontinental extensional events in East Asia, and are likely to be a contribution to the uplift of the Tibetan Plateau.