As important atmospheric circulation patterns in Northern Hemisphere(NH),the North Atlantic Oscillation(NAO)and the Western Pacific teleconnection(WP)affect the winter climate in Eurasia.In order to explore the combin...As important atmospheric circulation patterns in Northern Hemisphere(NH),the North Atlantic Oscillation(NAO)and the Western Pacific teleconnection(WP)affect the winter climate in Eurasia.In order to explore the combined effects of NAO and WP on East Asian(EA)temperature,the NAO and WP indices are divided into four phases from 1980−2021:the positive NAO and WP phase(NAO+/WP+),the negative NAO and WP phase(NAO−/WP−),the positive NAO and negative WP phase(NAO+/WP−),the negative NAO and positive WP phase(NAO−/WP+).In the phase of NAO+/WP+,the low geopotential height(GH)stays in north of EA at 50°−80°N;the surface air temperature anomaly(SATA)is 0.8−1℃lower than Southern Asian.In the phase of NAO−/WP−,the center of high temperature and GH locate in the northeast of EA;the cold air spreads to Southern Asia,causing the SATA decreases 1−1.5℃.In the phase of NAO+/WP−,the high GH belt is formed at 55°−80°N.Meanwhile,the center of high SATA locates in the north of Asia that increases 0.8−1.1℃.The cold airflow causes temperature dropping 0.5−1℃in the south of EA.The SATA improves 0.5−1.5℃in south of EA in the phase of NAO−/WP+.The belt of high GH is formed at 25°−50°N,and blocks the cold air which from Siberia.The NAO and WP generate two warped plate pressure structures in NH,and affect the temperature by different pressure configurations.NAO and WP form different GH,and GH acts to block and push airflow by affecting the air pressure,then causes the temperature to be different from the north and south of EA.Finally,the multiple linear regression result shows that NAO and WP are weakened by each other such as the phase of NAO+/WP+and NAO−/WP−.展开更多
We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably kn...We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably known from the fossil record. Most of these are woody (with two exceptions), and most are today either broadly East Asian, or more specifically confined to Sino-Japanese subcategory rather than being endemic to the Sino-Himalayan area. Of the "eastern Asian endemic" genera so far known from the fossil record, the majority formerly occurred in Europe and/or North America, indicating that eastern Asia served as a late Tertiary or Quaternary refugium for taxa. Hence, many of these genera may have originated in other parts of the Northern Hemisphere and expanded their ranges across continents and former sea barriers when tectonic and climatic conditions allowed, leading to their arrival in eastern Asia. Although clear evidence for paleoendemism is provided by the gymnosperms Amentotaxus, Cathaya, Cephalotaxus, Cunninghamia, Cryptomeria, Glyptostrobus, Ginkgo, Keteleeria, Metasequoia, Nothotsuga, Pseudolarix, Sciadopitys, and Taiwania, and the angiosperms Cercidiphyllum, Choerospondias, Corylopsis, Craigia, Cyclocarya, Davidia, Dipelta, Decaisnea, Diplopanax, Dipteronia, Emmenopterys, Eucommia, Euscaphis, Hemiptelea, Hovenia, Koelreuteria, Paulownia, Phellodendron, Platycarya, Pteroceltis, Rehderodendron, Sargentodoxa, Schizophragma, Sinomenium, Tapiscia, Tetracentron, Toricellia, Trapella, and Trochodendron, we cannot rule out the possibility that neoendemism plays an important role especially for herbaceous taxa in the present-day flora of Asia, particularly in the Sino-Himalayan region. In addition to reviewing paleobotanical occurrences from the literature, we document newly recognized fossil occurrences that expand the geographic and stratigraphic ranges previously known for Dipelta, Pteroceltis, and Toricellia.展开更多
The disjunct distribution of plants between eastern Asia(EA) and North America(NA) is one of the most well-known biogeographic patterns. However, the formation and historical process of this pattern have been long deb...The disjunct distribution of plants between eastern Asia(EA) and North America(NA) is one of the most well-known biogeographic patterns. However, the formation and historical process of this pattern have been long debated. Chamaecyparis is a good model to test previous hypotheses about the formation of this disjunct pattern as it contains six species disjunctly distributed in EA, western North America(WNA)and eastern North America(ENA). In this study, we applied ecological niche models to test the formation of the disjunct pattern of Chamaecyparis. The model calibrated with the EA species was able to predict the distribution of eastern NA species well, but not the western NA species. Furthermore, the eastern Asian species were shown to have higher niche overlap with the eastern North American species. The EA species were also shown to share more similar habitats with ENA species than with WNA species in the genus. Chamaecyparis species in WNA experienced a significant niche shift compared with congeneric species. Chamaecyparis had a low number of suitable regions in Europe and the middle and western NA during the Last Glacial Maximum(LGM) period, and became extinct in the former region whereas it retains residual distribution in the latter. The extirpations in western NA and Europe in response to the late Neogene and Quaternary climatic cooling and the more similar habitats between ENA and EA ultimately shaped the current intercontinental disjunct distribution of Chamaecyparis. Both current hypotheses may be also jointly applied to explain more eastern Asian and eastern North American disjunctions observed today.展开更多
The beginning of the XXI century was marked a new rising of the international tectonic cartography as a result of analysis and synthesis of a huge volume of geological information obtained for the territory of Asia e...The beginning of the XXI century was marked a new rising of the international tectonic cartography as a result of analysis and synthesis of a huge volume of geological information obtained for the territory of Asia es-pecially during the last 30 years. The previous tectonic maps for Asia were created in the 1960s-1970s of the last century. Since that time, the national geological surveys have compiled tectonic maps exclusively in the limits of their own state boundaries. The international cooperation of five countries since 2002 ( Russia, China, Mongolia, Kazakhstan and Republic of Korea) gave a unique possibility to join the data into a united cartog-raphic form as Atlas of Geological Maps (since 2002-Atlas of Geological Maps of Central Asia and since 2007- Atlas of Geological Maps of Northem-Central-Eastem Asia). Both atlases include four maps: geological, tecton-ic ,metallogenic, and energy resources. Tectonic Map of Northem-Central-Eastem Asia and Adjacent Areas at scale 1 : 2 500 000 was the key map for further compilation of the metallogenic and energy resources ( coal, oil and gas) maps. By this reason, special attention was given to showing the structure and composition of the Mes-ozoic sedimentary basins in Northern-Central- Eastern Asia as the most perspective structures for oil-and-gas and coal prospect.展开更多
Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South K...Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South Korea, Japan and China) has the highest incidence of gastric cancer in the world. There were 988 000 new cases of gastric cancer worldwide and 736 000 deaths in 2008. Approximately 60% of the cases of gastric cancer are found in East Asia (mainly China). We herein provide a brief review of the clinical applications of miRNA, which include the following aspects: (1) miRNA may serve as a potential new generation of tumor markers; (2) a complete miRNA expression profile is highly specific, can reflect the evolutionary lineage and differentiation of tumors, and be used to carry out diversity analysis; (3) detecting specific miRNA expression in peripheral blood will become a new method for diagnosis of gastric cancer; (4) miRNA can predict prognosis of gastric cancer; (5) miRNA has predictive value in determining chemotherapy and radiotherapy resistance; and (6) miRNA could be a type of innovative drug. Finally, we focus on assessing the value of miRNA from laboratory to clinical application and the challenges it faces in East Asia.展开更多
The study of the netlike earthquake distribution indicates that in the central-eastern part of Asia continent there are two network systems: the central-eastern Asia system and the southeastern China system.As interpr...The study of the netlike earthquake distribution indicates that in the central-eastern part of Asia continent there are two network systems: the central-eastern Asia system and the southeastern China system.As interpreted by the multilayer tectonic model,they might be a manifestation of the plastic-flow network systems in the lower lithosphere,including the lower crust and the mantle lid.Each network system is enclosed by different types of boundaries,including one driving boundary and some constraining and releasing boundaries.The two plastic-flow network systems with the Himalayan and Taiwan arcs as their driving boundaries play the role of controlling the intraplate tectonic deformation,stress field,seismicity,and subdivision of tectonic units.展开更多
From an angle of integrative analysis on historical-dynamic geotectonics, the formation mechanism of the Eastern Asia continental-margin and historical background of the evolution-movement of the crustobody are discus...From an angle of integrative analysis on historical-dynamic geotectonics, the formation mechanism of the Eastern Asia continental-margin and historical background of the evolution-movement of the crustobody are discussed. The pull-breaking-extending and thinning of the continental margin crustobody in the region result in the formation of the continental-margin extensional belt.Finally, the theoretical and practical significance of the study is pointed out.展开更多
There’re 4 types of crustobodies and total 6.Each has its own way of evolu-tion and movement. Their combination and separation depict a complex history of geotectonics.
Sheep have been one of the most important groups of animals since ancient times.However,the knowledge of their migration routes and genetic relationships is still poorly understood.To investigate sheep maternal migrat...Sheep have been one of the most important groups of animals since ancient times.However,the knowledge of their migration routes and genetic relationships is still poorly understood.To investigate sheep maternal migration histories alongside Eurasian communications routes,in this study,we obtain mitochondrial genomes(mitogenomes)from 17 sheep remains in 6 Chinese sites and 1 Uzbekistan site dated 4429–3100 years before present(BP).By obtaining the mitogenomes from the sheep(4429–3556 BP)found in the Tongtian Cave site in Xinjiang,Altai region of northwest China,our results support the emergence of haplogroup C sheep in Xinjiang as early as 4429–3556 BP.The combined phylogenetic analyses with extant ancient and modern sheep mitogenomes suggest that the Uzbekistan-Altai region may have been a migration hub for early sheep in eastern Asia.At least two migration events have taken place for sheep crossing Eurasia to China,one passing by Uzbekistan and Northwest China to the middle and lower reaches of the Yellow River at approximately 4000 BP and another following the Altai region to middle Inner Mongolia from 4429 BP to 2500 BP.Overall,this study provides further evidence for early sheep utilization and migration patterns in Eastern Asia.展开更多
Mammals have high dispersal ability,and many lineages can spread across the continents when a landbridge appears.Here,we summarize the dispersal of mammals between the Old and New World at the end of the Miocene.Our a...Mammals have high dispersal ability,and many lineages can spread across the continents when a landbridge appears.Here,we summarize the dispersal of mammals between the Old and New World at the end of the Miocene.Our analysis suggested that the three phases of dispersal represented the largest dispersal tide during the Neogene,and the direction of dispersal is dominated by being from the Old to New World.Judging from the components that crossed the dispersal corridor,the Arctic environment near the Beringia corridor in the first phase(~7.5 Ma)is a mixed environment,and in the second phase(~6.5 Ma)is an open environment,and in the third phase(~5.8 Ma and continue to the Pliocene)is a wooded(closed)environment.A clear trend of eastern Asian humidification driven by Asian monsoon and the global C4 grassland expansion explain this dispersal pattern.The boost of mammalian dispersals is controlled by the heterogeneity of environmental changes in different continents.展开更多
The Tibetan Plateau is a key factor for the pattern of the general circulation of the atmosphere (GCA) in eastern Asia. The pattern of the GCA after the uplift of the plateau is well known, while the pattern of the GC...The Tibetan Plateau is a key factor for the pattern of the general circulation of the atmosphere (GCA) in eastern Asia. The pattern of the GCA after the uplift of the plateau is well known, while the pattern of the GCA before the uplift of the plateau is lack of direct evidences. Based on the knowability of desert, a section recording wind directions across the Cretaceous northern hemisphere mid-low latitude desert belt is measured and the pattern of the GCA in the Cretaceous is revealed. The result shows that the eastern Asia was really controlled by the planetary circulation before the uplift of the plateau, i.e. westerlies in the north and northeast trades in the south. The convert belt between westerlies and trades had drifted northwards and southwards. The possibility of existence of paleo-monsoon is also dealt with and a possibly imposed paleo-monsoon is suggested.展开更多
The linkage between the Asian-Pacific oscillation (APO) and the precipitation over central eastern China in spring is preliminarily addressed by use of the observed data. Results show that they correlate very well, ...The linkage between the Asian-Pacific oscillation (APO) and the precipitation over central eastern China in spring is preliminarily addressed by use of the observed data. Results show that they correlate very well, with the positive (negative) phase of APO tending to increase (decrease) the precipitation over central eastern China. Such a relationship can be explained by the atmospheric circulation changes over Asia and the North Pacific in association with the anomalous APO. A positive phase of APO, characterized by a positive anomaly over Asia and a negative anomaly over the North Pacific in the upper-tropospheric temperature, corresponds to decreased low-level geopotential height (H) and increased high-level H over Asia, and these effects are concurrent with increased low-level H and decreased high-level H over the North Pacific. Meanwhile, an anticyclonic circulation anomaly in the upper troposphere and a cyclonic circulation anomaly in the lower troposphere are introduced in East Asia, and the low-level southerly wind is strengthened over central eastern China. These changes provide advantageous conditions for enhanced precipitation over central eastern China. The situation is reversed in the negative phase of APO, leading to reduced precipitation in this region.展开更多
Objective:There exist conflicting data on the efficacy and safety of ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome(ACS).We performed a meta-analysis to evaluate whether ticagrelor or c...Objective:There exist conflicting data on the efficacy and safety of ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome(ACS).We performed a meta-analysis to evaluate whether ticagrelor or clopidogrel produces better outcomes for East Asian patients with ACS.Methods:We searched for randomized controlled trials reporting associations between ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome in PubMed,EMBASE,web of science and Cochrane central register of controlled trials.Results:Ten studies involving 3715 participants were qualified for our analysis.The major adverse cardiovascular events(MACE)were significantly decreased in patients with ticagrelor treatment compared to those with clopidogrel(risk ratio[RR]:0.61;95%confidence interval[CI]:0.38-0.98;P=0.042).There was no significant difference in all-cause death(RR:0.89;95%CI:0.61-1.29;P=0.540),cardiovascular death(RR:0.86;95%CI:0.58-1.27;P=0.451),myocardial infarction(RR:0.91;95%CI:0.65-1.27;P=0.575)and stroke(RR:0.77;95%CI:0.44-1.36;P=0.372)between ticagrelor and clopidogrel.Ticagrelor was associated with a significantly higher risk of bleeding compared to clopidogrel(RR:1.71;95%CI:1.37-2.13;P=0.000).Conclusion:The present meta-analysis demonstrates that ticagrelor reduced the incidence of MACE in ACS patients from East Asia compared with clopidogrel.However,it increased the risk of bleeding.展开更多
The Tan-Lu Fault was once a transform fault in the Paleotethys, west of which was the Qinling-Dabie Ocean separating the Yangtze Craton from the North China Craton, and east of which was the Su-Lu Ocean separating the...The Tan-Lu Fault was once a transform fault in the Paleotethys, west of which was the Qinling-Dabie Ocean separating the Yangtze Craton from the North China Craton, and east of which was the Su-Lu Ocean separating the Su-Wan Block from the Jiao-Liao Craton. The Qinling-Dabie Ocean closed in the Indosinian orogeny, which created the China-Southeast Asia Subcontinent, with the Tan-Lu Fault becoming a marginal shear zone along the newly-formed amalgamated subcontinent. The Su-Lu Ocean subducted partly in the Indosinian.orogeny, but not closed. In the Jurassic and Early Cretaceous, the Su-Wan Block drifted northwards with subduction of the Su-Lu Ocean and moved westwards to converge the subcontinent by sinistral sheafing of the ENE-striking fractures. The Su-Lu Ocean finally closed and the Su-Wan Block collided with the Jiao-Liao Craton in the Early Cretaceous, which constituted a part of the magnificent interplate Yanshanides. The interplate orogeny rejuvenated the fossil sutures and deep fractures, as well as the Indosinian orogen, and the intraplate (intracontinental) Yanshanian orogeny occurred in the subcontinent. The East Asia Yanshanides, consisting of the interplate orogens in the outer side and the intraplate orogens in the inner side, collapsed quickly in the latest Early Cretaceous and Late Cretaceous. The eastern China area entered a tensile period from the Eogene, and the tectonic differentiation between the central and eastern China areas since the Jurassic was further strengthened.展开更多
基金The National Key Research and Development Program of China under contract No.2022YFE0140500the National Natural Science Foundation of China under contract Nos 41821004 and 42130406+2 种基金the National Natural Science Foundation of China-Shandong Joint Fund under contract No.U1906215the Open Fund of Key Laboratory of Ocean Circulation and Waves,Chinese Academy of Sciences under contract No.KLOCW2003the Project of Doctoral Found of Qingdao University of Science and Technology under contract No.210010022746.
文摘As important atmospheric circulation patterns in Northern Hemisphere(NH),the North Atlantic Oscillation(NAO)and the Western Pacific teleconnection(WP)affect the winter climate in Eurasia.In order to explore the combined effects of NAO and WP on East Asian(EA)temperature,the NAO and WP indices are divided into four phases from 1980−2021:the positive NAO and WP phase(NAO+/WP+),the negative NAO and WP phase(NAO−/WP−),the positive NAO and negative WP phase(NAO+/WP−),the negative NAO and positive WP phase(NAO−/WP+).In the phase of NAO+/WP+,the low geopotential height(GH)stays in north of EA at 50°−80°N;the surface air temperature anomaly(SATA)is 0.8−1℃lower than Southern Asian.In the phase of NAO−/WP−,the center of high temperature and GH locate in the northeast of EA;the cold air spreads to Southern Asia,causing the SATA decreases 1−1.5℃.In the phase of NAO+/WP−,the high GH belt is formed at 55°−80°N.Meanwhile,the center of high SATA locates in the north of Asia that increases 0.8−1.1℃.The cold airflow causes temperature dropping 0.5−1℃in the south of EA.The SATA improves 0.5−1.5℃in south of EA in the phase of NAO−/WP+.The belt of high GH is formed at 25°−50°N,and blocks the cold air which from Siberia.The NAO and WP generate two warped plate pressure structures in NH,and affect the temperature by different pressure configurations.NAO and WP form different GH,and GH acts to block and push airflow by affecting the air pressure,then causes the temperature to be different from the north and south of EA.Finally,the multiple linear regression result shows that NAO and WP are weakened by each other such as the phase of NAO+/WP+and NAO−/WP−.
基金supported in part by US National Science Foundation grants EAR 9220079,0174295INT 0074295 to SRM+4 种基金National Basic Research Program of China (973 Program No.2007CB411600)Chinese Academy of Sciences (KSCX2-YW-R-136) to CZDin part by Research Project of the National Museum of Nature of Science (20077005)the Monbusho Grant-in-Aid for Scientific Research (17540446) for KUsupported through SRM's participation in the NSF (NESCent)-sponsored Phytogeography of the Northern Hemisphere Working Group
文摘We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably known from the fossil record. Most of these are woody (with two exceptions), and most are today either broadly East Asian, or more specifically confined to Sino-Japanese subcategory rather than being endemic to the Sino-Himalayan area. Of the "eastern Asian endemic" genera so far known from the fossil record, the majority formerly occurred in Europe and/or North America, indicating that eastern Asia served as a late Tertiary or Quaternary refugium for taxa. Hence, many of these genera may have originated in other parts of the Northern Hemisphere and expanded their ranges across continents and former sea barriers when tectonic and climatic conditions allowed, leading to their arrival in eastern Asia. Although clear evidence for paleoendemism is provided by the gymnosperms Amentotaxus, Cathaya, Cephalotaxus, Cunninghamia, Cryptomeria, Glyptostrobus, Ginkgo, Keteleeria, Metasequoia, Nothotsuga, Pseudolarix, Sciadopitys, and Taiwania, and the angiosperms Cercidiphyllum, Choerospondias, Corylopsis, Craigia, Cyclocarya, Davidia, Dipelta, Decaisnea, Diplopanax, Dipteronia, Emmenopterys, Eucommia, Euscaphis, Hemiptelea, Hovenia, Koelreuteria, Paulownia, Phellodendron, Platycarya, Pteroceltis, Rehderodendron, Sargentodoxa, Schizophragma, Sinomenium, Tapiscia, Tetracentron, Toricellia, Trapella, and Trochodendron, we cannot rule out the possibility that neoendemism plays an important role especially for herbaceous taxa in the present-day flora of Asia, particularly in the Sino-Himalayan region. In addition to reviewing paleobotanical occurrences from the literature, we document newly recognized fossil occurrences that expand the geographic and stratigraphic ranges previously known for Dipelta, Pteroceltis, and Toricellia.
基金funded by grants from the Ministry of Science and Technology of China, Basic Research Project(No. 2013FY112600)the Talent Project of Yunnan Province(No. 2011CI042)
文摘The disjunct distribution of plants between eastern Asia(EA) and North America(NA) is one of the most well-known biogeographic patterns. However, the formation and historical process of this pattern have been long debated. Chamaecyparis is a good model to test previous hypotheses about the formation of this disjunct pattern as it contains six species disjunctly distributed in EA, western North America(WNA)and eastern North America(ENA). In this study, we applied ecological niche models to test the formation of the disjunct pattern of Chamaecyparis. The model calibrated with the EA species was able to predict the distribution of eastern NA species well, but not the western NA species. Furthermore, the eastern Asian species were shown to have higher niche overlap with the eastern North American species. The EA species were also shown to share more similar habitats with ENA species than with WNA species in the genus. Chamaecyparis species in WNA experienced a significant niche shift compared with congeneric species. Chamaecyparis had a low number of suitable regions in Europe and the middle and western NA during the Last Glacial Maximum(LGM) period, and became extinct in the former region whereas it retains residual distribution in the latter. The extirpations in western NA and Europe in response to the late Neogene and Quaternary climatic cooling and the more similar habitats between ENA and EA ultimately shaped the current intercontinental disjunct distribution of Chamaecyparis. Both current hypotheses may be also jointly applied to explain more eastern Asian and eastern North American disjunctions observed today.
基金the project of the Federal Agency for Scientific Organizations of the Ministry of Education and Science of the Russian Federation ( Registration Number 0135 -2014 -0065 )the support of the Russian Science Foundation ( Grant 16 -17 -10251 )
文摘The beginning of the XXI century was marked a new rising of the international tectonic cartography as a result of analysis and synthesis of a huge volume of geological information obtained for the territory of Asia es-pecially during the last 30 years. The previous tectonic maps for Asia were created in the 1960s-1970s of the last century. Since that time, the national geological surveys have compiled tectonic maps exclusively in the limits of their own state boundaries. The international cooperation of five countries since 2002 ( Russia, China, Mongolia, Kazakhstan and Republic of Korea) gave a unique possibility to join the data into a united cartog-raphic form as Atlas of Geological Maps (since 2002-Atlas of Geological Maps of Central Asia and since 2007- Atlas of Geological Maps of Northem-Central-Eastem Asia). Both atlases include four maps: geological, tecton-ic ,metallogenic, and energy resources. Tectonic Map of Northem-Central-Eastem Asia and Adjacent Areas at scale 1 : 2 500 000 was the key map for further compilation of the metallogenic and energy resources ( coal, oil and gas) maps. By this reason, special attention was given to showing the structure and composition of the Mes-ozoic sedimentary basins in Northern-Central- Eastern Asia as the most perspective structures for oil-and-gas and coal prospect.
文摘Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South Korea, Japan and China) has the highest incidence of gastric cancer in the world. There were 988 000 new cases of gastric cancer worldwide and 736 000 deaths in 2008. Approximately 60% of the cases of gastric cancer are found in East Asia (mainly China). We herein provide a brief review of the clinical applications of miRNA, which include the following aspects: (1) miRNA may serve as a potential new generation of tumor markers; (2) a complete miRNA expression profile is highly specific, can reflect the evolutionary lineage and differentiation of tumors, and be used to carry out diversity analysis; (3) detecting specific miRNA expression in peripheral blood will become a new method for diagnosis of gastric cancer; (4) miRNA can predict prognosis of gastric cancer; (5) miRNA has predictive value in determining chemotherapy and radiotherapy resistance; and (6) miRNA could be a type of innovative drug. Finally, we focus on assessing the value of miRNA from laboratory to clinical application and the challenges it faces in East Asia.
基金This Project was sponsored by the National Natural Science Foundation of China under No.49070196.
文摘The study of the netlike earthquake distribution indicates that in the central-eastern part of Asia continent there are two network systems: the central-eastern Asia system and the southeastern China system.As interpreted by the multilayer tectonic model,they might be a manifestation of the plastic-flow network systems in the lower lithosphere,including the lower crust and the mantle lid.Each network system is enclosed by different types of boundaries,including one driving boundary and some constraining and releasing boundaries.The two plastic-flow network systems with the Himalayan and Taiwan arcs as their driving boundaries play the role of controlling the intraplate tectonic deformation,stress field,seismicity,and subdivision of tectonic units.
文摘From an angle of integrative analysis on historical-dynamic geotectonics, the formation mechanism of the Eastern Asia continental-margin and historical background of the evolution-movement of the crustobody are discussed. The pull-breaking-extending and thinning of the continental margin crustobody in the region result in the formation of the continental-margin extensional belt.Finally, the theoretical and practical significance of the study is pointed out.
文摘There’re 4 types of crustobodies and total 6.Each has its own way of evolu-tion and movement. Their combination and separation depict a complex history of geotectonics.
基金funded by the National Key Research and Development Program of China(2021YFF1000701)the Young S&T Talent Training Program of Guangdong Provincial Association for S&T,China(SKXRC202205)+1 种基金the Foundation for the Creative Team and Key Laboratory in Higher Education of Guangdong(2019KCXTD006 and 2019KSYS011)the National Natural Science Foundations of China(31961133031)。
文摘Sheep have been one of the most important groups of animals since ancient times.However,the knowledge of their migration routes and genetic relationships is still poorly understood.To investigate sheep maternal migration histories alongside Eurasian communications routes,in this study,we obtain mitochondrial genomes(mitogenomes)from 17 sheep remains in 6 Chinese sites and 1 Uzbekistan site dated 4429–3100 years before present(BP).By obtaining the mitogenomes from the sheep(4429–3556 BP)found in the Tongtian Cave site in Xinjiang,Altai region of northwest China,our results support the emergence of haplogroup C sheep in Xinjiang as early as 4429–3556 BP.The combined phylogenetic analyses with extant ancient and modern sheep mitogenomes suggest that the Uzbekistan-Altai region may have been a migration hub for early sheep in eastern Asia.At least two migration events have taken place for sheep crossing Eurasia to China,one passing by Uzbekistan and Northwest China to the middle and lower reaches of the Yellow River at approximately 4000 BP and another following the Altai region to middle Inner Mongolia from 4429 BP to 2500 BP.Overall,this study provides further evidence for early sheep utilization and migration patterns in Eastern Asia.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(Grant Nos.XDB26000000 and XDA20070203)the National Natural Science Foundation of China(Grant Nos.42102001,41430102,41872001,41872005 and 41772018)+2 种基金Key Frontier Science Research Program of the Chinese Academy of Sciences(Grant Nos.QYZDY-SSW-DQC-22 and GJHZ1885)China Scholarship CouncilFrick Fund,Division of Vertebrate Paleontology,AMNH.
文摘Mammals have high dispersal ability,and many lineages can spread across the continents when a landbridge appears.Here,we summarize the dispersal of mammals between the Old and New World at the end of the Miocene.Our analysis suggested that the three phases of dispersal represented the largest dispersal tide during the Neogene,and the direction of dispersal is dominated by being from the Old to New World.Judging from the components that crossed the dispersal corridor,the Arctic environment near the Beringia corridor in the first phase(~7.5 Ma)is a mixed environment,and in the second phase(~6.5 Ma)is an open environment,and in the third phase(~5.8 Ma and continue to the Pliocene)is a wooded(closed)environment.A clear trend of eastern Asian humidification driven by Asian monsoon and the global C4 grassland expansion explain this dispersal pattern.The boost of mammalian dispersals is controlled by the heterogeneity of environmental changes in different continents.
基金the National Natural Science Foundation of China (Grant No. 49572113).
文摘The Tibetan Plateau is a key factor for the pattern of the general circulation of the atmosphere (GCA) in eastern Asia. The pattern of the GCA after the uplift of the plateau is well known, while the pattern of the GCA before the uplift of the plateau is lack of direct evidences. Based on the knowability of desert, a section recording wind directions across the Cretaceous northern hemisphere mid-low latitude desert belt is measured and the pattern of the GCA in the Cretaceous is revealed. The result shows that the eastern Asia was really controlled by the planetary circulation before the uplift of the plateau, i.e. westerlies in the north and northeast trades in the south. The convert belt between westerlies and trades had drifted northwards and southwards. The possibility of existence of paleo-monsoon is also dealt with and a possibly imposed paleo-monsoon is suggested.
基金supported by the National Basic Research Program of China (2009CB421407)the Special Fund for Public Welfare Industry(meteorology)(GYHY200906018)the National Natural Science Foundation of China(90711004 and 40921003)
文摘The linkage between the Asian-Pacific oscillation (APO) and the precipitation over central eastern China in spring is preliminarily addressed by use of the observed data. Results show that they correlate very well, with the positive (negative) phase of APO tending to increase (decrease) the precipitation over central eastern China. Such a relationship can be explained by the atmospheric circulation changes over Asia and the North Pacific in association with the anomalous APO. A positive phase of APO, characterized by a positive anomaly over Asia and a negative anomaly over the North Pacific in the upper-tropospheric temperature, corresponds to decreased low-level geopotential height (H) and increased high-level H over Asia, and these effects are concurrent with increased low-level H and decreased high-level H over the North Pacific. Meanwhile, an anticyclonic circulation anomaly in the upper troposphere and a cyclonic circulation anomaly in the lower troposphere are introduced in East Asia, and the low-level southerly wind is strengthened over central eastern China. These changes provide advantageous conditions for enhanced precipitation over central eastern China. The situation is reversed in the negative phase of APO, leading to reduced precipitation in this region.
基金National Natural Science Foundation of China(81830012,81900302,82070336).
文摘Objective:There exist conflicting data on the efficacy and safety of ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome(ACS).We performed a meta-analysis to evaluate whether ticagrelor or clopidogrel produces better outcomes for East Asian patients with ACS.Methods:We searched for randomized controlled trials reporting associations between ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome in PubMed,EMBASE,web of science and Cochrane central register of controlled trials.Results:Ten studies involving 3715 participants were qualified for our analysis.The major adverse cardiovascular events(MACE)were significantly decreased in patients with ticagrelor treatment compared to those with clopidogrel(risk ratio[RR]:0.61;95%confidence interval[CI]:0.38-0.98;P=0.042).There was no significant difference in all-cause death(RR:0.89;95%CI:0.61-1.29;P=0.540),cardiovascular death(RR:0.86;95%CI:0.58-1.27;P=0.451),myocardial infarction(RR:0.91;95%CI:0.65-1.27;P=0.575)and stroke(RR:0.77;95%CI:0.44-1.36;P=0.372)between ticagrelor and clopidogrel.Ticagrelor was associated with a significantly higher risk of bleeding compared to clopidogrel(RR:1.71;95%CI:1.37-2.13;P=0.000).Conclusion:The present meta-analysis demonstrates that ticagrelor reduced the incidence of MACE in ACS patients from East Asia compared with clopidogrel.However,it increased the risk of bleeding.
文摘The Tan-Lu Fault was once a transform fault in the Paleotethys, west of which was the Qinling-Dabie Ocean separating the Yangtze Craton from the North China Craton, and east of which was the Su-Lu Ocean separating the Su-Wan Block from the Jiao-Liao Craton. The Qinling-Dabie Ocean closed in the Indosinian orogeny, which created the China-Southeast Asia Subcontinent, with the Tan-Lu Fault becoming a marginal shear zone along the newly-formed amalgamated subcontinent. The Su-Lu Ocean subducted partly in the Indosinian.orogeny, but not closed. In the Jurassic and Early Cretaceous, the Su-Wan Block drifted northwards with subduction of the Su-Lu Ocean and moved westwards to converge the subcontinent by sinistral sheafing of the ENE-striking fractures. The Su-Lu Ocean finally closed and the Su-Wan Block collided with the Jiao-Liao Craton in the Early Cretaceous, which constituted a part of the magnificent interplate Yanshanides. The interplate orogeny rejuvenated the fossil sutures and deep fractures, as well as the Indosinian orogen, and the intraplate (intracontinental) Yanshanian orogeny occurred in the subcontinent. The East Asia Yanshanides, consisting of the interplate orogens in the outer side and the intraplate orogens in the inner side, collapsed quickly in the latest Early Cretaceous and Late Cretaceous. The eastern China area entered a tensile period from the Eogene, and the tectonic differentiation between the central and eastern China areas since the Jurassic was further strengthened.