Anti-tumor effect of matrine combined with cisplatin on rat models of cervical cancer

Objective:To observe the anti-tumor effect of matrine combined with cisplatin on U14 rat models of cervical cancer.Methods:A total of 80 female Kunming rats were used to establish U14 rat models of cervical cancer and then divided into groups Ⅰ,Ⅱ,Ⅲ and Ⅳ,with 20 rats in each.For Group Ⅰ,the control group,injection of normal saline was given around the tumors.For Group Ⅱ,injection of 2 mg/kg cisplatin was given around the tumors.For Group Ⅲ,injection of 75 mg/kg matrine was given around the tumors while the combined injection of matrine and cisplatin was given for Group Ⅳ with the same doses as Groups Ⅱand Ⅲ.The animals were sacrificed 10 d after the injection and tumors were taken out for the comparisons of tumor weights after injection and calculation of anti-tumor rates,while thymus and spleen were taken for thymus index and spleen index.Blood in eyeball was collected for determination of changes in serum creatinine and urea nitrogen levels.Sections of tumor issue were prepared and morphological changes in tumor tissue cells were observed by using immunohistochemistry technique.Results:After injection,the thymus index and spleen index in Groups Ⅲ and Ⅳ were significantly higher than those in Groups Ⅰ and Ⅱ(P<0.05)while the two indexes in Group Ⅱ were significantly lower than Group Ⅰ(P<0.05).The tumor weights in Groups Ⅱ and Ⅳ were significantly smaller than those in Groups Ⅰ and Ⅲ(P<0.05) with significantly higher anti-tumor rates than Groups Ⅰ and Ⅲ(P<0.05).The serum creatinine and urea nitrogen levels in Groups Ⅲ and Ⅳ were significantly lower than Group Ⅱ(P<0.05) and the two indicators in Group Ⅲ were significantly lower than those in Group Ⅳ(P<0.05).The observation under the histological microscope showed densely arranged tumor cells in Group Ⅰ,growing as a crumby structure and diffuse appearance,with hyperchromatic and large nuclei,and abundant cytoplasm.In the case of Group Ⅱ,it showed less tumor cells,with extensive degenerative necrosis,sparse arrangement and karyopyknosis as well as karyoclasis.For Group Ⅲ,necrosis of tumor cells in different sizes and heterogeneous color in nuclei were observed.For Group Ⅳ,the number of tumor cells was significantly smaller than Groups Ⅰ and Ⅲ and the tumor cells presented an appearance of crumby structure as cancer nests,with more proliferation of connective tissue.Conclusions:The treatment of matrine combined with cisplatin can significantly improve the anti-tumor effect on U14 rats with cervical cancer,which can be a new option for the treatment for cervical cancer.

Cooperative Principle and the Equivalent Effect in Translation

The cooperative principle is an important theory of pragmatics,concerning how to maximally achieve communicative goal.While translation serves as a communicative medium,it should also observe the conversational rules—cooperative principle to achieve the equivalent effect.This paper tries to explore the issue from the perspective of cooperative principle.

Birefringence Effect of Long-period Fiber Gratings Fabricated by SMF

The fabrication of LPFG in single mode fiber （SMF） was fabricated using amplitude mask writing techniques. The birefringence effect of LPFG for sensing the transverse strain was discussed in detail. The experimented results shou that it exhibits a very high sensitivity and a good linearity to transverse strain, with a sensitivity some hundred times greater than what has been achieved using FBG sensor.

STUDY ON THE MUTAGNENIC EFFECTS OF a-MOMORCHARIM

A basic glucoprotein named α-momorcharin(Mr:29000) that was isolated andpurified from the seeds of MomordicaCharantia was proved to have an obviousinhibitory effect on early pregnacy of

affect和effect

在高二英语课本中相继出现了 affect 和 effect。这两个词虽说都有“影响”之意,但词性不同,而且用法也各异。此外,由于它们发音相似而易于混淆。现辨异如下:一、affect 只用怍动词。使用时常有以下几个意义。1.表示“影响”,“对……有(产生)影响”。例如;Smoking affects health.吸烟影响健康。The war and the sufferinu that it caused affected him greatly.(SB Ⅱ p.105)这场战争及其所造成的苦难对他影响很大。

Intervention effect of mindfulness-based stress reduction for psychological health among nurses:A meta-analysis

Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindfulness-based stress reduction in nursing staff were retrieved from CNKI,WanFang,VIP,PubMed,Cochrane Library,Web of Science,EMBASE databases.The retrieval time was set from the establishment of the database to April 2020.The Review Manager 5.3 software were used for meta-analysis.Result:9 RCTs and 5 self-control trails were included with 1421,712 subjects in the experimental group and 709 subjects in the control group.The results of the meta-analysis showed that compared with the control group,mindfulness-based stress reduction therapy can effectively reduce the psychological symptoms of clinical nurses[SMD=-0.96,95%CI(-1.51,-0.38),P=0.001],reduces nurses'anxiety levels[SMD=-1.28,95%CI(-2.18,-0.38),P=0.005],relieve the nurse's depression[SMD=-1.08,95%CI(-2.15,-0.02),P=0.005],improve the mental resilience of nurse[SMD=7.05,95%CI(3.93,10.17),P=0.03],showing a statistical meaning.Conclusion:The mental health of nurses is often neglected by themselves and there is insufficient awareness that MBSR can improve mental health.There has been a debate about whether MBSR actually improves the mental health of nurses,so it is necessary to further explore this issue and seek better methods and opportunities for practice.

Assessment of Equivalent Radium Activity and Annual Effective Dose Due to Building Materials in Côte D’Ivoire by Gamma Spectrometry: Cases of Cement

Radioactivity is a natural phenomenon present in the universe. So, because of human life solidarity with a habitat, we are permanently in contact, especially through building materials. The objective of this work is the determination of the used cement radioactivity level in the buildings in Cote d'Ivoire. Thus, samples of grey and white cement currently used on Ivorian territory were taken. In order to determine the radioactivity level of this cement, samples were analyzed by using gamma spectrometry chain which contains a NaI (Tl) scintillation detector designed by the German manufacturer LD-DIDACTIC, coupled to a multichannel analyzer (AMC) using a Cassy Lab software. Thus, the specific activity of the primordial radionuclides 226Ra, 232Th and 40K, was able to be determined. The average values obtained are 29.66 Bq/kg, 34.88 Bq/kg and 178.424 Bq/kg respectively for 226Ra, 232Th and 40K. All average values are below the limit values recommended by UNSCEAR. However, we evaluated the radiological parameters such as the equivalent radium activity and the annual effective dose in order to translate the specific activity in terms of harmfulness. Values obtained for these parameters are below those recommended by ICRP and UNSCEAR. These results show that the risk incurred by the use of these different brands of cement is low.

On the γ' precipitates of the normal and inverse Portevin-Le Chatelier effect in a wrought Ni-base superalloy

The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that the γ' precipitates have a decisive influence on the transformation from normal to inverse PLC behavior, which is rarely proposed in other works. It is considered that the γ' precipitates play the same role in PLC effect as temperature and strain rate for the investigated wrought Ni-base superalloy.

Effect of Orientation on Stress-Rupture Property and Related Deformation Microstructure of a Ni-Base Re-containing Single-Crystal Superalloy at 900℃

Stress-rupture properties of a Ni-base Re-containing single-crystal superalloy with three orientations have been tested under 900℃/445 MPa.An obvious anisotropy of stress-rupture property is attributed to orientation reliant deformation microstructure.The good strength in[001]orientation is attributed to the rapid multiplication of dislocations active in horizontal channels and laterγ'cutting via dislocations pair coupled with anti-phase boundary.The microtwin formation largely limits the strength and plasticity as a result of the continuous shearing acrossγ/γ'microstructure by{111}112 slip activated in[011]orientation.The property in[111]orientation results mainly from the lateral cross-slip movements of the screw dislocations within connected matrix channels as well as the precipitate shearing by coplanar dislocations.Microcracks all initially originate from the interdendritic micropores in three orientations.The critical temperature of stress-rupture anisotropy could be increased by a high level of refractory solutes especially Re.

Predicting Effectiveness of Generate-and-Validate Patch Generation Systems Using Random Forest

One way to improve practicability of automatic program repair（APR） techniques is to build prediction models which can predict whether an application of a APR technique on a bug is effective or not. Existing prediction models have some limitations. First, the prediction models are built with hand crafted features which usually fail to capture the semantic characteristics of program repair task. Second, the performance of the prediction models is only evaluated on Genprog, a genetic-programming based APR technique. This paper develops prediction models, i.e., random forest prediction models for SPR, another kind of generate-and-validate APR technique, which can distinguish ineffective repair instances from effective repair instances. Rather than handcrafted features, we use features automatically learned by deep belief network（DBN） to train the prediction models. The empirical results show that compared to the baseline models, that is, all effective models, our proposed models can at least improve the F1 by 9% and AUC（area under the receiver operating characteristics curve） by 19%. At the same time, the prediction model using learned features at least outperforms the one using hand-crafted features in terms of F1 by 11%.

尾部风险、生产网络与行业增加值波动

建立包含行业尾部风险的多行业生产网络一般均衡模型,从中分解出行业尾部风险扩散导致增加值波动的技术扭曲网络效应和配置扭曲网络效应,然后采用ICIO数据库1998—2020年中国的投入产出数据,实证检验两种扭曲网络效应对行业增加值波动的影响。研究表明:生产网络会放大并传导行业尾部风险,形成技术扭曲网络效应、配置扭曲网络效应,其中配置扭曲网络效应对行业增加值波动的负面影响更强烈;下游行业的需求侧冲击会通过生产网络向上游传导,使技术扭曲网络效应对上游行业的冲击更强;高技术水平的工业、均衡的生产网络结构以及高中间品替代弹性行业更容易抵御风险冲击;在极端事件冲击时期,两种扭曲网络效应的负面冲击更显著。建议政府正视生产网络对风险的传导作用,做好风险防范与对冲,以实现经济平稳运转。

AN ANOMALOUS HALL EFFECT IN n-Ge SAMPLES

Although quite a few achievements have been made in the study of anomalous Hall effects, there is a great difference in the theoretical explanation of them. Recently this problem has been much studied both theoretically and experimentally.

RTAs框架下跨境数据流动规则对数字服务贸易的影响研究

文章基于2010—2021年全球50个代表性经济体的双边数字服务出口数据,采用引力模型实证检验了跨境数据流动规则的贸易创造效应。结果表明:缔约国之间签订的RTAs中,跨境数据流动规则的承诺水平越高,双边数字服务贸易规模越大,贸易创造效应越显著;将跨境数据流动规则细分为数据流动规则、数据本地化规则和数据保护规则后发现,数据本地化条款对数字服务贸易的促进作用更强;相较于其他部门,跨境数据流动规则对金融服务的贸易促进作用更强;缔约国整体的经济自由度水平越高,跨境数据流动规则对数字服务贸易的促进效应越小;缔约国之间的数据监管环境差距越大,跨境数据流动规则越能促进双边数字服务贸易发展。机制检验结果表明:跨境数据流动规则能够通过降低贸易成本、缩短制度距离和扩大出口国的双向FDI规模促进数字服务贸易发展。研究结论证实了跨境数据流动规则产生的贸易创造效应,为我国有效制定数字服务贸易开放政策、积极参与全球数字治理提供了经验证据。

PARP抑制剂治疗转移性去势抵抗性前列腺癌有效性及安全性的Meta分析

目的:系统评价PARPi治疗转移性去势抵抗性前列腺癌(mCRPC)的有效性及安全性,以期为临床决策供循证医学证据。方法:依据纳入和排除标准,网络检索2015年1月~2023年6月PubMed、Web of Science、Embace、Clinicial.gov中有关PARPi治疗mCRPC的随机对照试验文献,使用RevMan5.4及Stata17.0软件对数据进行Meta分析。结果:纳入7篇随机对照试验文献,共1888例患者。Meta分析结果表明,与非PARPi组比较,PARPi组(PARPi联合或不联合抗激素治疗)可提高mCRPC的放射学无进展生存期(HR=0.52,95%CI=0.34~0.78)和总生存期(HR=0.72,95%CI=0.60~0.86),差异均有统计学意义(P<0.05)。在安全性方面,PARPi组1~2级骨痛、背痛、贫血、中性粒细胞减少、恶心、呕吐、腹泻、乏力不良反应发生率明显高于非PARPi组,差异均有统计学意义(P<0.05);≥3级上述不良反应中与非PARPi组比较,PARPi组中只有恶心和贫血不良反应发生率较高,差异均有统计学意义(P<0.05),而骨痛、背痛、中性粒细胞减少、呕吐、腹泻、乏力两组间比较差异均无统计学意义(P>0.05)。结论:与非PARPi比较,PARPi联合或不联合抗激素治疗可提高mCRPC的放射学无进展生存期和总生存期,3级及以上不良反应发生率低,值得在临床上推广应用。

数实融合与区域协调发展:基于要素空间流动的视角

文章聚焦数实融合赋能欠发达地区,探讨数实融合对区域协调发展的直接影响、作用机制与空间效应,利用2011—2021年我国279个地级及以上城市的样本数据进行实证检验。结果表明:数实融合会通过矫正资源错配、促进数字技术创新与提高政府关注度来推动区域协调发展;数实融合在欠发达地区的经济增长带动作用更为显著,有利于缩小区域差距;考虑要素空间流动,数实融合不仅会产生对邻近地区的经济溢出效应,还会产生跨区域的经济开发效应。

兰姆波驱动微流体温度分布研究

该文应用压电陶瓷器件激发频率1 MHz的兰姆波在非压电基板上进行了微流体温度分布的研究。经理论分析表明,兰姆波向流体中辐射纵波以及兰姆波在介质中传播时的粘性摩擦损失产生了声热效应。采用红外摄像机观察液滴从兰姆波激发直至达到稳态时的热分布变化,发现液滴在兰姆波入射一侧的温度高于其他区域且高温区域有向顶部扩散的趋势。观察不同液体黏度液滴的声热现象,发现油滴的温度扩散更均匀,动力学行为更弱。采用有限元分析声流和声热效应,发现液滴在顶部区域声流速最大,在声流作用下,液滴的高温区域扩散至顶部。

宫腹腔镜联合肌瓣填充缝合术与宫腔镜电切术治疗子宫瘢痕憩室的疗效对比研究

目的:探讨宫腔镜电切术与宫腹腔镜联合肌瓣填充缝合术治疗子宫瘢痕憩室的临床疗效。方法:回顾分析2018年8月至2023年6月手术治疗的68例子宫瘢痕憩室患者的临床资料,根据手术方式分为两组,A组(n=38)行宫腔镜电切术,B组(n=30)行宫腹腔镜联合肌瓣填充缝合术。比较两组手术相关指标、临床疗效、术后3个月子宫前壁下端肌层厚度等。结果:两组术后经期均缩短,手术前后差异有统计学意义(P<0.05);A组术中出血量少于B组,手术时间、住院时间均短于B组,差异有统计学意义(P<0.05);术后3个月复查子宫前壁下端肌层厚度,A组手术前后差异无统计学意义,B组由术前的(2.09±0.48)mm增加至术后的(6.52±0.21)mm,差异有统计学意义(P<0.05)。结论:两种术式均能明显改善剖宫产术后子宫瘢痕憩室引起的异常子宫出血症状。宫腔镜电切术操作相对简单、创伤小、术中出血少、手术时间短,适于无生育要求、月经期延长影响生活质量、术前子宫憩室残存子宫肌层厚度≥3 mm的患者;宫腹腔镜联合肌瓣填充术不破坏子宫的完整性,术后避孕时间短,可增加术后子宫前壁肌层厚度,适于有生育要求的子宫憩室患者。

党政联合发文的行政司法效力研究——基于100份行政裁判文书的分析

党政联合发文因其兼具党内法规与行政法规的双重属性,对相关机关职责及公众权利义务可能产生重要影响,从而具备进入行政司法审判的可能性。对100份涉及党政联合发文的行政裁判文书进行分析发现,党政联合发文的纠纷常集中于信息公开与司法审查两方面,且在司法实践中党政联合发文通常不被纳入行政规范性文件之列,仅作为法官裁判说理时的参照依据。为了充分发挥党政联合文件的功能价值,缓解其与现行司法适用规则之间的紧张关系,有必要通过明确党政联合文件的法源地位,构建实质审查标准以及完善司法救济体系等方式,提升党政联合发文在行政司法实践中的合法性和规范性,从而推进国家治理体系和治理能力的现代化进程。

基于电法CT和地震CT的烧变岩含水层帷幕注浆效果评价

烧变岩水害严重影响煤矿安全生产,采取帷幕注浆治理烧变岩水害是目前效果较好的方式。以柠条塔煤矿烧变岩水害帷幕注浆工程为例,采用钻探取心验证、高清视频、电法CT和地震CT手段,综合评价了烧变岩含水层的帷幕注浆效果。结果表明,5个取心检查孔中的4个在风化基岩段均见到水泥浆液充填薄层,J5孔在120.8~121.2 m烧变岩处见浆液充填,且检查孔施工过程中均未出现漏水、掉钻现象。高清视频结果显示,检查孔孔壁光滑,无明显裂隙,局部明显可见原地层裂隙被浆液充填密实,无残余裂隙。跨孔电阻率CT结果显示,注浆后地层电阻率明显升高,其中强风化砂岩的电阻率值升高最为明显;强风化层所对应的深度范围地层电阻率均提升2~4倍,所有剖面地层电阻率均明显有效提升。孔间地震CT结果显示,注浆前中、强风化层所对应的速度范围主要分布在1600~2800 m/s,且横向速度变化较大;注浆后速度范围集中在1800~3800 m/s,其中速度在1600~2000 m/s的范围明显缩小,且大部分区域速度均在2200 m/s以上。以上4种指标均反映了本次注浆工程的效果整体较好。研究成果可为类似条件下烧变岩水害治理工程的效果评价提供参考。

沁水盆地煤层气低效井成因及治理措施效果

沁水盆地是我国煤层气开发生产主战场,但整体开发效果不佳,存在较多的低效井。本文以沁水盆地典型区块为例,开展低产低效井分析,确定了低产低效井原因。并结合近几年陆续开展的增产措施试验,进行效果评价,得出了储层改造类措施针对地质条件无问题,受到后期钻压、排采影响的低效井效果较好,其他类增产措施效果都不佳。后期对煤层气低效井治理应转变思路,开展井区加密调整,提高储量动用率,整体盘活低效井区。