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Experimental Study and Fragility Analysis of Effective-Length Factors in Column Buckling
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作者 Brannan Shepherd Tadeh Zirakian 《Journal of Building Material Science》 2023年第1期9-16,共8页
The design of columns relies heavily on the basis of Leonhard Euler’s Theory of Elastic Buckling.However,to increase the accuracy in determining the maximum critical load a column can withstand before buckling,a cons... The design of columns relies heavily on the basis of Leonhard Euler’s Theory of Elastic Buckling.However,to increase the accuracy in determining the maximum critical load a column can withstand before buckling,a constant was introduced.This dimensionless coefficient is K,also known as the effective-length factor.This constant is often found in building design codes and varies in value depending on the type of column support that is applied.This paper presents experimental and analytical studies on the determination of the effective-length factor in the buckling stability of columns with partially-fixed support conditions.To this end,the accurate K value of the columns tested by the Instron Testing Machine(ITM)at California State University,Northridge’s(CSUN’s)Mechanics Laboratory is determined.The ITM is used in studying the buckling of columns where the supports are neither pinned nor fixed,and the material cross-section rather rests upon the machine while loading is applied axially.Several column specimens were tested and the experimental data were analyzed in order to estimation of the accurate effective-length factor.The calculations from the tested results as well as the conducted probabilistic analysis shed light on how a fragility curve may aid in predicting the effective-length value of future tests. 展开更多
关键词 Column buckling Fragility curve Critical loading effective length factor Fixity
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Novel method to determine effective length of quantum confinement using fractional-dimension space approach 被引量:2
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作者 Hua Li Bing-Can Liu +2 位作者 Bing-Xin Shi Si-Yu Dong Qiang Tian 《Frontiers of physics》 SCIE CSCD 2015年第4期97-102,共6页
The binding energy and effective mass of a polaron confined in a GaAs film deposited on an AlGal-xAs substrate are investigated, for different film thickness values and aluminum concentra- tions and within the framewo... The binding energy and effective mass of a polaron confined in a GaAs film deposited on an AlGal-xAs substrate are investigated, for different film thickness values and aluminum concentra- tions and within the framework of the fractional-dimensional space approach. Using this scheme, we propose a new method to define the effective length of the quantum confinement. The limita- tions of the definition of the original effective well width are discussed, and the binding energy and effective mass of a polaron confined in a GaAs film are obtained. The fl-actional-dimensional theo- retical results are shown to be in good agreement with previous, more detailed calculations based on second-order perturbation theory. 展开更多
关键词 fractional-dimensional approach effective length of quantum confinement polaron effect GaAs film
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A Soft Bionic Gripper with Variable Effective Length 被引量:13
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作者 Yufei Hao Zheyuan Gong +4 位作者 Zhexin Xie Shaoya Guan Xingbang Yang Tianmiao Wang Li Wen 《Journal of Bionic Engineering》 SCIE EI CSCD 2018年第2期220-235,共16页
This article presented a four-fingered soft bionic robotic gripper with variable effective actuator lengths. By combining approaches of finite element analysis, quasi-static analytical modeling, and experimental measu... This article presented a four-fingered soft bionic robotic gripper with variable effective actuator lengths. By combining approaches of finite element analysis, quasi-static analytical modeling, and experimental measurements, the deformation of the single soft actuator as a function of air pressure input in free space was analyzed. To investigate the effect of the effective actuator length on the gripping per- formance of the gripper, we conducted systematical experiments to evaluate the pull-off force, the actuation speed, the precision and error tolerance of the soft gripper while grasping objects of various sizes and shapes. A combination of depressurization and pressurization in actuation as well as applying variable effective actuator length enhanced the gripper's performance significantly, with no sensors. For example, with tunable effective actuator length, the gripper was able to grasp objects ranging from 2 mm 170 mm robustly. Under the optimal length, the gripper could generate the maximum pull-off force for the corresponding object size; the precision and the error tolerance of the gripper were also significantly improved compared to those of the gripper with full-length. Our soft robotic prototype exhibits a simple control and low-cost approach of gripping a wide range of objects and may have wide leverage for future industrial operations. 展开更多
关键词 soft robotics pneumatic control soft bionic gripper variable effective actuator length
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Determination of large diameter bored pile's effective length based on Mindlin's solution
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作者 Zhijun Zhou Duanduan Wang +1 位作者 Lipeng Zhang Weisi Ma 《Journal of Traffic and Transportation Engineering(English Edition)》 2015年第6期422-428,共7页
The calculation equation of large diameter bored pile's effective length is connected with its distribution of pile shaft resistance. Thus, there is a great difference between the calculation results under the differ... The calculation equation of large diameter bored pile's effective length is connected with its distribution of pile shaft resistance. Thus, there is a great difference between the calculation results under the different distributions of pile shaft resistance. Primarily, this paper summarizes the conceptualized mode of pile shaft resistance under the circum- stance that the soil surrounding the piles presents different layer distributions. Secondly, based on Mindlin's displacement solution and in consideration of the effect of pile diam- eter, the calculation equation is optimized with the assumption that the pile shaft resis- tance has a parabolic distribution. The influencing factors are analyzed according to the calculation result of effective pile length. Finally, combined with an engineering example, the calculation equation deduced in this paper is analyzed and verified. The result shows that both the Poisson ratio of soil and pile diameter have impacted the effective pile length. Compared with the Poisson ratio of soil, the effect of pile diameter is more significant. If the pile diameter remains the same, the effect of the Poisson ratio of soil to the effective pile length decreases as the ratio of pile elastic modulus and soil share modulus increases. If the Poisson ratio of soil remains the same, the effect of the pile diameter to the effective pile length increases as the ratio of pile elastic modulus and soil share modulus increases. Thus the optimized calculation result of pile effective length under the consideration of pile diameter effect is more close to the actual situation of engineering and reasonably practicable. 展开更多
关键词 Large diameter bored pile Pile shaft resistance Parabolic distribution Mindlin's solution Effect of pile diameter effective pile length
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Mathematical modeling and numerical computation of the effective interfacial conditions for Stokes flow on an arbitrarily rough solid surface
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作者 A.T.TRAN H.LE QUANG +1 位作者 Q.C.HE D.H.NGUYEN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2021年第5期721-746,共26页
The present work is concerned with a two-dimensional(2D)Stokes flow through a channel bounded by two parallel solid walls.The distance between the walls may be arbitrary,and the surface of one of the walls can be arbi... The present work is concerned with a two-dimensional(2D)Stokes flow through a channel bounded by two parallel solid walls.The distance between the walls may be arbitrary,and the surface of one of the walls can be arbitrarily rough.The main objective of this work consists in homogenizing the heterogeneous interface between the rough wall and fluid so as to obtain an equivalent smooth slippery fluid/solid interface characterized by an effective slip length.To solve the corresponding problem,two efficient numerical approaches are elaborated on the basis of the method of fundamental solution(MFS)and the boundary element methods(BEMs).They are applied to different cases where the fluid/solid interface is periodically or randomly rough.The results obtained by the proposed two methods are compared with those given by the finite element method and some relevant ones reported in the literature.This comparison shows that the two proposed methods are particularly efficient and accurate. 展开更多
关键词 effective slip length method of fundamental solution(MFS) boundary element method(BEM) Stokeslet MICRO-CHANNEL fluid/solid interface
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Maximum Momentum,Minimal Length and Quantum Gravity Effects of Compact Star Cores
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作者 张修明 付伟 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第1期14-18,共5页
Based on the generalized uncertainty principle with maximum momentum arid minimal length, we discuss the equation of state of ideal ultra-relativistic Fermi gases at zero temperature. Maximum momentum avoids the probl... Based on the generalized uncertainty principle with maximum momentum arid minimal length, we discuss the equation of state of ideal ultra-relativistic Fermi gases at zero temperature. Maximum momentum avoids the problem that the Fermi degenerate pressure blows up since the increase of the Fermi energy is not limited. Applying this equation of state to the Tolman-Oppenheimer Volkoff (TOV) equation, the quantum gravitational effects on the cores of compact stars are discussed. In the center of compact stars, we obtain the singularity-free solution of the metric component, gtt ~-(1 + 0.2185×r^2). By numerically solving the TOV equation, we find that quantum gravity plays an important role in the region r~10^4α0(△x)min. Current observed masses of neutron stars indicate that the dimensionless parameter α0 cannot exceed 10^19. 展开更多
关键词 of on it Maximum Momentum Minimal length and Quantum Gravity Effects of Compact Star Cores in that is
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Effect of day length and temperature on the pollen fertility in photo(thermo)-sensitive genic male-sterile rice
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作者 HUANG Qinglui and TANG Xihua,Shanghai Inst of Piant physiology,Acad Sinica,Xhanghai 200032,China 《Chinese Rice Research Newsletter》 1996年第2期4-5,共2页
The effect of day length and temperature on the pollen fertility of five photoperiod-sensitive genic male-sterile japonica rice lines (PGMSR) and three temperature-sensitive genic malesterile indica rice lines (TGMSR)... The effect of day length and temperature on the pollen fertility of five photoperiod-sensitive genic male-sterile japonica rice lines (PGMSR) and three temperature-sensitive genic malesterile indica rice lines (TGMSR) were investigated in phytotron. The light source used for illumination was xenon lamp, and the light intensity which plant accepted on the leaf surface was 300—350μmol photons ms. The results indicated that pollens of PGMSR 7001S and E47S aborted completely whereas a little part of 31116S pollens appeared normal under long day photoperiod (LD,25℃,15h) (Table 1). High temperature (HT, 30℃, 12h) and lower temperature (LT, 展开更多
关键词 length Effect of day length and temperature on the pollen fertility in photo sensitive genic male-sterile rice THERMO
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实际接地系统的冲击特性试验研究(英文) 被引量:4
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作者 N.Harid M.Ahmeda +1 位作者 H.Griffiths A.Haddad 《高电压技术》 EI CAS CSCD 北大核心 2011年第11期2721-2726,共6页
In this work,the results of an experimental study of the impulse characteristic of practical ground electrodes consisting of horizontal conductors of various lengths and full-scale tower footings were reported.These e... In this work,the results of an experimental study of the impulse characteristic of practical ground electrodes consisting of horizontal conductors of various lengths and full-scale tower footings were reported.These electrodes were installed at an outdoor test site having nonuniform soil,with equipment facilities for generating low-and high-magnitude impulse currents.The tests on the horizontal electrode were used to determine the effective length,the voltage and current distribution along the electrode length and the effect of the injection point along the electrode.The tests on the tower footings were used to determine impulse resistance and demonstrate its non-linear variation with current magnitude.Computer simulations of the test electrodes using the electromagnetic field method showed good agreement with the measured result. 展开更多
关键词 ground electrode impulse current ground impedance effective length horizontal electrode tower footing soil ionisation impulse resistance
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The Curing Process and Elastic Modulus of HTPB-Containing Polyurethanes
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作者 ZHENG Fu-an (East China Science and Technology University, Shanghai, 200237)SUN Jia-zhong (Institute of Theoretical Chemistry, Jilin University, Changchun, 130023)LUO Kui-de (Red Star Institute of Chemistry, Xiangfan, 441003) 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1993年第4期345-350,共6页
By means of the functionality distribution deduced and weight averaged functionality a and molecular size vb2, the sol-gel distribution equations of HTPB(Hydroxyl terminated polybutadiene) + TDI (Toluene-2, 4-diisocya... By means of the functionality distribution deduced and weight averaged functionality a and molecular size vb2, the sol-gel distribution equations of HTPB(Hydroxyl terminated polybutadiene) + TDI (Toluene-2, 4-diisocyanate) expressed by the model of Aai-B2 type polycondensation were solved and the elastic modulus were calculated. The experimental results of HTPB+TDI curing process indicate that a, vb2 and functionality distribution function are available basically. 展开更多
关键词 Curing process Functionality distribution Weight average functionality effective length of bond
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The Effect of Elevated Temperature on Bond Performance of Alkali-activated GGBFS Paste 被引量:2
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作者 郑文忠 朱晶 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2013年第4期721-725,共5页
The main reaction products were investigated by analysis of microstructure of alkali-activated ground granulated blast furnace slag (GGBFS) paste. An experimental research was performed on bond performance of alkali... The main reaction products were investigated by analysis of microstructure of alkali-activated ground granulated blast furnace slag (GGBFS) paste. An experimental research was performed on bond performance of alkali-activated GGBFS paste as a construction adhesive after exposure to 20-500℃. Through XRD analysis, a few calcium silicate hydrate, hydrotalcite and tetracalcium aluminate hydrate were determined as end products, and they were filled and packed each other at room temperature. In addition, akermanite dramatically increased at 800 ~C and above. The two key parameters, the ultimate load Pu.T and effective bond length Le, were determined using test data of carbon fiber-reinforced polymer (CFRP)-to-concrete bonded joints at elevated temperature. The experimental results indicate that the ultimate load Pu.T remains relatively stable initially and then decreases with increasing temperature. The effective bond length Le increases with increasing temperature except at 300℃. The proposed temperature-dependent effective bond length formula is shown to closely represent the test data. 展开更多
关键词 alkali-activated GGBFS paste MICROSTRUCTURE BOND effective bond length elevatedtemperature
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非均匀地表类型有效粗糙度的计算和特征分析 被引量:1
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作者 钟中 赵鸣 +1 位作者 苏炳凯 汤剑平 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2003年第1期71-76,共6页
A new method is proposed for the effective roughness length (ERL) in heterogeneous terrain based on the principle of equalisation of momentum or heat fluxes calculated by the drag coefficient parameterization scheme u... A new method is proposed for the effective roughness length (ERL) in heterogeneous terrain based on the principle of equalisation of momentum or heat fluxes calculated by the drag coefficient parameterization scheme used in the ECMWF numerical model. Compared with the area-weighted logarithmically averaged ERL (drag coefficient), the newly calculated ERL (drag coefficient) is about 40% (16%) larger with a roughness step of 2.3. These differences reach their maximum values when the ratio of smooth to rough surface is 60% to 40%. Since the determination by this method is not sensitive to the atmospheric stratification, it is suitable for use in climate models. 展开更多
关键词 heterogeneous terrain effective roughness length turbulent flux climate model
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Preliminary research on the relationship between long-range correlations and predictability 被引量:1
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作者 张志森 龚志强 +2 位作者 支蓉 封国林 胡经国 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第1期23-32,共10页
By establishing the Markov model for a long-range correlated time series (LRCS) and analysing its evolutionary characteristics, this paper defines a physical effective correlation length (ECL) T, which reflects th... By establishing the Markov model for a long-range correlated time series (LRCS) and analysing its evolutionary characteristics, this paper defines a physical effective correlation length (ECL) T, which reflects the predictability of the LRCS. It also finds that the ECL has a better power law relation with the long-range correlated exponent γ of the LRCS: T = Kexp(-γ/0.3) + Y, (0 〈 γ〈 1) the predictability of the LRCS decays exponentially with the increase of γ It is then applied to a daily maximum temperature series (DMTS) recorded at 740 stations in China between the years 1960-2005 and calculates the ECL of the DMTS. The results show the remarkable regional distributive feature that the ECL is about 10-14 days in west, northwest and northern China, and about 5-10 days in east, southeast and southern China. Namely, the predictability of the DMTS is higher in central-west China than in east and southeast China. In addition, the ECL is reduced by 1-8 days in most areas of China after subtracting the seasonal oscillation signal of the DMTS from its original DMTS; however, it is only slightly altered when the decadal linear trend is removed from the original DMTS. Therefore, it is shown that seasonal oscillation is a significant component of daily maximum temperature evolution and may provide a basis for predicting daily maximum temperatures. Seasonal oscillation is also significant for guiding general weather predictions, as well as seasonal weather predictions. 展开更多
关键词 long-range correlation information entropy effective correlation length PREDICTABILITY
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DESIGN OF DIGITAL IMPACTING FILTER IN CP-EBPSK WITH RANDOM-POLAR COMMUNICATION SYSTEM 被引量:4
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作者 Jin Yi Wu Lenan +1 位作者 Chen Yifang Yu Jing 《Journal of Electronics(China)》 2012年第3期328-333,共6页
To solve the difficulty of designing digital impacting filter in the receiver of random-polar modulated Extended Binary Phase Shift Keying with Continuous Phase (CP-EBPSK), a design method based on Quantum-behaved Par... To solve the difficulty of designing digital impacting filter in the receiver of random-polar modulated Extended Binary Phase Shift Keying with Continuous Phase (CP-EBPSK), a design method based on Quantum-behaved Particle Swarm Optimization (QPSO) algorithm is proposed. Firstly, QPSO is introduced elaborately, and the basic flow of QPSO is also given. Then, the demodulation principle of digital impacting filter in the communication system of CP-EBPSK with random-polar is demonstrated, and QPSO is utilized to design the digital impacting filter, which also takes the effect of finite word length into consideration when implemented by hardware. Finally, the proposed method is simulated. Simulation results show that the digital impacting filter designed by new method can derive satisfied demodulation performance. 展开更多
关键词 Extended Binary Phase Shift Keying with Continuous Phase (CP-EBPSK) Digital impacting filter Quantum-behaved Particle Swarm Optimization algorithm (QPSO) DEMODULATION Effect of finite word length
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Anisotropic nanocomposite soft/hard multilayer magnets 被引量:1
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作者 刘伟 张志东 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第11期26-50,共25页
Experimental and theoretical researches on nanostructured exchange coupled magnets have been carried out since about 1988. Here, we review the structure and magnetic properties of the anisotropic nanocomposite soft/ha... Experimental and theoretical researches on nanostructured exchange coupled magnets have been carried out since about 1988. Here, we review the structure and magnetic properties of the anisotropic nanocomposite soft/hard multilayer magnets including some new results and phenomena from an experimental point of view. According to the different component of the oriented hard phase in the nanocomposite soft/hard multilayer magnets, three types of magnets will be discussed:1) anisotropic Nd2Fe(14)B based nanocomposite multilayer magnets, 2) anisotropic SmCo5 based nanocomposite multilayer magnets, and 3) anisotropic rare-earth free based nanocomposite multilayer magnets. For each of them, the formation of the oriented hard phase, exchange coupling, coercivity mechanism, and magnetic properties of the corresponding anisotropic nanocomposite multilayer magnets are briefly reviewed, and then the prospect of realization of bulk magnets on new results of anisotropic nanocomposite multilayer magnets will be carried out. 展开更多
关键词 anisotropic multilayer magnets exchange coupling effective interaction length coercivity mechanism
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The Effects of Fatigue Cracks on Fastener Loads during Cyclic Loading and on the Stresses Used for Crack Growth Analysis in Classical Linear Elastic Fracture Mechanics Approaches
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作者 Claudiu Gudas 《Materials Sciences and Applications》 2020年第7期505-551,共47页
High strength threaded fasteners are widely used in the aircraft industry, and service experience shows that for structures where shear loading of the joints is significant, like skin splices, fuselage joints or spar ... High strength threaded fasteners are widely used in the aircraft industry, and service experience shows that for structures where shear loading of the joints is significant, like skin splices, fuselage joints or spar caps-web attachments, more cracks are initiated and grow from the edges of the fastener holes than from features like fillets radii and corners or from large access holes. The main causes of this cracking are the stress concentrations introduced by the fastener holes and by the threaded fasteners themselves, with the most common damage site being at the edge of the fastener holes. Intuitively, it is easy to visualize that after the crack initiation, during the growth stages, some of the load transferred initially by the fastener at the cracked hole will decrease, and it will be shed to the adjacent fasteners that will carry higher loads than in uncracked condition. Using currently available computer software, the method presented in this paper provides a relatively quick and quantitatively defined solution to account for the effects of crack length on the fastener loads transfer, and on the far field and bypass loads at each fastener adjacent to the crack. At each location, these variations are determined from the 3-dimensional distribution of stresses in the joint, and accounting for secondary bending effects and fastener tilt. Two cases of a typical skins lap splice with eight fasteners in a two rows configuration loaded in tension are presented and discussed, one representative for wing or fuselage skins configurations, and the second case representative for cost effective laboratory testing. Each case presents five cracking scenarios, with the cracks growing from approx. 0.03 inch to either the free edge, next hole or both simultaneously. 展开更多
关键词 Fasteners Load Transfer Functions Fatigue Life Multi-Site Fatigue Damage Fasteners Modelling Effects of Crack length on Adjacent Fasteners Secondary Bending Crack Growth Analysis
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Minimal length effects on motion of a particle in Rindler space
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作者 郭晓波 梁康楷 +2 位作者 木本荣 王鹏广 杨明焘 《Chinese Physics C》 SCIE CAS CSCD 2021年第2期270-281,共12页
Various quantum theories of gravity predict the existence of a minimal measurable length.In this paper,we study effects of the minimal length on the motion of a particle in the Rindler space under a harmonic potential... Various quantum theories of gravity predict the existence of a minimal measurable length.In this paper,we study effects of the minimal length on the motion of a particle in the Rindler space under a harmonic potential.This toy model captures key features of particle dynamics near a black hole horizon and allows us to make three observations.First,we find that chaotic behavior becomes stronger with increases in minimal length effects,leading predominantly to growth in the maximum Lyapunov characteristic exponents,while the KAM curves on Poincarésurfaces of a section tend to disintegrate into chaotic layers.Second,in the presence of the minimal length effects,it can take a finite amount of Rindler time for a particle to cross the Rindler horizon,which implies a shorter scrambling time of black holes.Finally,the model shows that some Lyapunov characteristic exponents can be greater than the surface gravity of the horizon,violating the recently conjectured universal upper bound.In short,our results reveal that quantum gravity effects may make black holes prone to more chaos and faster scrambling. 展开更多
关键词 CHAOS Rindler space minimal length effects
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A Series of Soluble Planar Oligorylenes up to Hexarylene
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作者 Ryuichi Fujita Shoko Yoshida +4 位作者 Haruka Kano Kyohei Matsuo Hironobu Hayashi Hiroko Yamada Naoki Aratani 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2023年第9期1023-1027,共5页
Preparation of large rylenes often needs the use of solubilizing groups along the rylene backbone,which results in the distortion of the skeleton and thus broadening of the absorption spectrum.In this work,we successf... Preparation of large rylenes often needs the use of solubilizing groups along the rylene backbone,which results in the distortion of the skeleton and thus broadening of the absorption spectrum.In this work,we successfully synthesized 2,5,8,16,19,22-hexakis[2,6-bis(tri-fluoromethyl)phenyl]hexarylene(H)by using an oxidative fusion reaction of perylene trimer in 5%yield.The product is soluble in common organic solvents and could be purified with column chromatography.Single-crystal X-ray diffraction analysis revealed that the hexarylene core is not disturbed by the substituents very much and is almost planar.The longest absorption of H exhibits a sharp peak at 831 nm and an on-set at 875 nm in toluene with a small full-width-at-half-maximum(FWHM)of 660 cm^(-1).The molar extinction coefficient is as large as 131,000 M^(-1)cm^(-1).The substituents could not perturb the electronic properties of the hexarylene because aryl groups are perpendicular to the hexarylene core and the carbon atoms at 2,5,16,19-positions have negligible coeffi-cients on its HOMO and LUMO,estimated by theoretical calculations.As a result,the hexarylene having less absorption at the visible light region was stable enough in solution under the LED room light for more than 1 week.This strategy gives a useful guideline to establish the near-infrared materials that exhibit stability under ambient conditions. 展开更多
关键词 Oligorylenes Undistorted skeleton Near infrared absorption Crystal structure effective conjugation length
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LIMK2 is required for membrane cytoskeleton reorganization of contracting airway smooth muscle
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作者 Yeqiong Li Yuwei Zhou +12 位作者 Pei Wang Tao Tao Lisha Wei Ye Wang Wei Wang Yanyan Zheng Zhihui Jiang Tiantian Qiu Wei Zhao Jie Sun Xin Chen Xue-Na Zhang Min-Sheng Zhu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2021年第6期452-462,共11页
Airway smooth muscle(ASM)has developed a mechanical adaption mechanism by which it transduces force and responds to environmental forces,which is essential for periodic breathing.Cytoskeletal reorganization has been i... Airway smooth muscle(ASM)has developed a mechanical adaption mechanism by which it transduces force and responds to environmental forces,which is essential for periodic breathing.Cytoskeletal reorganization has been implicated in this process,but the regulatory mechanism remains to be determined.We here observe that ASM abundantly expresses cytoskeleton regulators Limk1 and Limk2,and their expression levels are further upregulated in chronic obstructive pulmonary disease(COPD)animals.By establishing mouse lines with deletions of Limk1 or Limk2,we analyse the length-sensitive contraction,F/Gactin dynamics,and F-actin pool of mutant ASM cells.As LIMK1 phosphorylation does not respond to the contractile stimulation,LIMK1-deficient ASM develops normal maximal force,while LIMK2 or LIMK1/LIMK2 deficient ASMs show approximately 30%inhibition.LIMK2 deletion causes a significant decrease in cofilin phosphorylation along with a reduced F/G-actin ratio.As LIMK2 functions independently of cross-bridge movement,this observation indicates that LIMK2 is necessary for F-actin dynamics and hence force transduction.Moreover,LIMK2-deficient ASMs display abolishes stretching-induced suppression of 5-hydroxytryptamine(5-HT)but not acetylcholine-evoks force,which is due to the differential contraction mechanisms adopted by the agonists.We propose that LIMK2-mediated cofilin phosphorylation is required for membrane cytoskeleton reorganization that is necessary for ASM mechanical adaption including the 5-HT-evoked length-sensitive effect. 展开更多
关键词 Smooth muscle LIM kinases COFILIN CYTOSKELETON length sensitive effect
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Performance analysis of InSb based QWFET for ultra high speed applications
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作者 T.D.Subash T.Gnanasekaran C.Divya 《Journal of Semiconductors》 EI CAS CSCD 2015年第1期60-63,共4页
An indium antimonide based QWFET(quantum well field effect transistor) with the gate length down to 50 nm has been designed and investigated for the first time for L-band radar applications at 230 GHz. QWFETs are de... An indium antimonide based QWFET(quantum well field effect transistor) with the gate length down to 50 nm has been designed and investigated for the first time for L-band radar applications at 230 GHz. QWFETs are designed at the high performance node of the International Technology Road Map for Semiconductors(ITRS)requirements of drive current(Semiconductor Industry Association 2010). The performance of the device is investigated using the SYNOPSYS CAD(TCAD) software. In Sb based QWFET could be a promising device technology for very low power and ultra-high speed performance with 5–10 times low DC power dissipation. 展开更多
关键词 QWFET InSb gate length cut-off frequency short-channel effects
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