Under the catalysis of only 3 mol% of Br2 at room temperature, indoles reacted rapidly with isatins to form bio- logically important 3,3-bis（indole-3-yl）indoline-2-（1H）-ones with high efficiency and wide substrate...Under the catalysis of only 3 mol% of Br2 at room temperature, indoles reacted rapidly with isatins to form bio- logically important 3,3-bis（indole-3-yl）indoline-2-（1H）-ones with high efficiency and wide substrate scope. More- over, we demonstrated that p-toluenesulfonic acid （TsOH） could serve as a surrogate to catalyze this transformation.展开更多
Determination of halogen-specific total organic halogen（TOX） is vital for studies of disinfection of waters containing bromide, since total organic bromine（TOBr） is likely to be more problematic than total organic...Determination of halogen-specific total organic halogen（TOX） is vital for studies of disinfection of waters containing bromide, since total organic bromine（TOBr） is likely to be more problematic than total organic chlorine. Here, we present further halogen-specific TOX method optimisation and validation, focusing on measurement of TOBr. The optimised halogen-specific TOX method was validated based on the recovery of model compounds covering different classes of disinfection by-products（haloacetic acids, haloacetonitriles,halophenols and halogenated benzenes） and the recovery of total bromine（mass balance of TOBr and bromide concentrations） during disinfection of waters containing dissolved organic matter and bromide. The validation of a halogen-specific TOX method based on the mass balance of total bromine has not previously been reported. Very good recoveries of organic halogen from all model compounds were obtained, indicating high or complete conversion of all organic halogen in the model compound solution through to halide in the absorber solution for ion chromatography analysis. The method was also successfully applied to monitor conversion of bromide to TOBr in a groundwater treatment plant. An excellent recovery（101%）of total bromine was observed from the raw water to the post-chlorination stage. Excellent recoveries of total bromine（92%–95%） were also obtained from chlorination of a synthetic water containing dissolved organic matter and bromide, demonstrating the validity of the halogen-specific TOX method for TOBr measurement. The halogen-specific TOX method is an important tool to monitor and better understand the formation of halogenated organic compounds, in particular brominated organic compounds, in drinking water systems.展开更多
文摘Under the catalysis of only 3 mol% of Br2 at room temperature, indoles reacted rapidly with isatins to form bio- logically important 3,3-bis（indole-3-yl）indoline-2-（1H）-ones with high efficiency and wide substrate scope. More- over, we demonstrated that p-toluenesulfonic acid （TsOH） could serve as a surrogate to catalyze this transformation.
基金the Australian Research Council (ARC LP100100285)Water Corporation of Western Australia+3 种基金Curtin Universitythe Swiss Federal Institute for Aquatic Science and Technology (Eawag)Water Research Australiathe Australian Government through The Department of Foreign Affairs and Trade for providing a PhD scholarship under the Australian Award Scholarship (AAS) scheme for M.Langsa
文摘Determination of halogen-specific total organic halogen（TOX） is vital for studies of disinfection of waters containing bromide, since total organic bromine（TOBr） is likely to be more problematic than total organic chlorine. Here, we present further halogen-specific TOX method optimisation and validation, focusing on measurement of TOBr. The optimised halogen-specific TOX method was validated based on the recovery of model compounds covering different classes of disinfection by-products（haloacetic acids, haloacetonitriles,halophenols and halogenated benzenes） and the recovery of total bromine（mass balance of TOBr and bromide concentrations） during disinfection of waters containing dissolved organic matter and bromide. The validation of a halogen-specific TOX method based on the mass balance of total bromine has not previously been reported. Very good recoveries of organic halogen from all model compounds were obtained, indicating high or complete conversion of all organic halogen in the model compound solution through to halide in the absorber solution for ion chromatography analysis. The method was also successfully applied to monitor conversion of bromide to TOBr in a groundwater treatment plant. An excellent recovery（101%）of total bromine was observed from the raw water to the post-chlorination stage. Excellent recoveries of total bromine（92%–95%） were also obtained from chlorination of a synthetic water containing dissolved organic matter and bromide, demonstrating the validity of the halogen-specific TOX method for TOBr measurement. The halogen-specific TOX method is an important tool to monitor and better understand the formation of halogenated organic compounds, in particular brominated organic compounds, in drinking water systems.
