A single-center, open-label clinical study was conducted to evaluate the efficacy and safety of NEM<sup>®</sup> as a natural treatment for pain and stiffness associated with osteoarthritis of the k...A single-center, open-label clinical study was conducted to evaluate the efficacy and safety of NEM<sup>®</sup> as a natural treatment for pain and stiffness associated with osteoarthritis of the knee in an Italian population. NEM<sup>®</sup> brand eggshell membrane is a unique dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joints and connective tissues. Twenty-five subjects received oral NEM<sup>®</sup>, 500 mg once daily for four weeks. The primary outcome measure was to evaluate the mean effectiveness of NEM<sup>®</sup> in relieving general pain associated with moderate osteoarthritis of the knee at 10 and 30 days utilizing a 10-question, abbreviated questionnaire based on the WOMAC osteoarthritis questionnaire. Supplementation with NEM<sup>®</sup> produced a significant treatment response from baseline at both 10 days and 30 days for composite pain (40.6% reduction, p p p = 0.009;59.7% reduction, p < 0.001, respectively). There were no adverse events or serious adverse events reported during the study and the treatment was reported to be well tolerated by study participants. NEM<sup>®</sup> is an effective and safe natural therapeutic option for the treatment of both pain and stiffness associated with osteoarthritis of the knee. Supplementation with NEM<sup>®</sup>, 500 mg taken once daily, significantly reduced both pain and stiffness rapidly (10 days) and this effect continued to improve through 30 days. There was also a meaningful reduction in the amount of analgesic consumed on a weekly basis, which further enhanced patients’ safety.展开更多
文摘A single-center, open-label clinical study was conducted to evaluate the efficacy and safety of NEM<sup>®</sup> as a natural treatment for pain and stiffness associated with osteoarthritis of the knee in an Italian population. NEM<sup>®</sup> brand eggshell membrane is a unique dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joints and connective tissues. Twenty-five subjects received oral NEM<sup>®</sup>, 500 mg once daily for four weeks. The primary outcome measure was to evaluate the mean effectiveness of NEM<sup>®</sup> in relieving general pain associated with moderate osteoarthritis of the knee at 10 and 30 days utilizing a 10-question, abbreviated questionnaire based on the WOMAC osteoarthritis questionnaire. Supplementation with NEM<sup>®</sup> produced a significant treatment response from baseline at both 10 days and 30 days for composite pain (40.6% reduction, p p p = 0.009;59.7% reduction, p < 0.001, respectively). There were no adverse events or serious adverse events reported during the study and the treatment was reported to be well tolerated by study participants. NEM<sup>®</sup> is an effective and safe natural therapeutic option for the treatment of both pain and stiffness associated with osteoarthritis of the knee. Supplementation with NEM<sup>®</sup>, 500 mg taken once daily, significantly reduced both pain and stiffness rapidly (10 days) and this effect continued to improve through 30 days. There was also a meaningful reduction in the amount of analgesic consumed on a weekly basis, which further enhanced patients’ safety.
