Skin scar is unique to humans,the major significant negative outcome sustained after thermal injuries,traumatic injuries,and surgical procedures.Hypertrophic scar in human skin is investigated using non-linear spectra...Skin scar is unique to humans,the major significant negative outcome sustained after thermal injuries,traumatic injuries,and surgical procedures.Hypertrophic scar in human skin is investigated using non-linear spectral imaging microscopy.The high contrast images and spectroscopic intensities of collagen and elastic fibers extracted from the spectral imaging of normal skin tissue,and the normal skin near and far away from the hypertrophic scar tissues in a 10-year-old patient case are obtained.The results show that there are apparent differences in the morphological structure and spectral characteristics of collagen and elastic fibers when comparing the normal skin with the hypertrophic scar tissue.These differences can be good indicators to differentiate the normal skin and hypertrophic scar tissue and demonstrate that non-linear spectral imaging microscopy has potential to noninvasively investigate the pathophysiology of human hypertrophic scar.展开更多
盆底器官脱垂(pelvic organ prolapse,POP)是以盆底支持组织薄弱为特性的一类功能障碍性疾病,其发生是一个复杂的过程。盆底组织内弹性纤维结构或功能异常可直接导致POP的发生。类赖氨酰氧化酶-1(lysyl oxidase-like protein-1,LOXL-1)...盆底器官脱垂(pelvic organ prolapse,POP)是以盆底支持组织薄弱为特性的一类功能障碍性疾病,其发生是一个复杂的过程。盆底组织内弹性纤维结构或功能异常可直接导致POP的发生。类赖氨酰氧化酶-1(lysyl oxidase-like protein-1,LOXL-1)是弹性蛋白保持正常结构功能的关键酶。LOXL-1缺失或功能障碍,将导致弹性纤维功能紊乱,从而引起POP。本研究就LOXL-1在POP发生机制中的作用进行综述。展开更多
基金supported by the National Natural Science Foundation of China(No.60508017)the Natural Science Foundation of Fujian Province of China(2007J0007,C0720001)+1 种基金the Science and Technology Planning Key Program of Fujian Province(2008Y0037)the Program for New Century Excellent Talents in University(NCET-07-0191).
文摘Skin scar is unique to humans,the major significant negative outcome sustained after thermal injuries,traumatic injuries,and surgical procedures.Hypertrophic scar in human skin is investigated using non-linear spectral imaging microscopy.The high contrast images and spectroscopic intensities of collagen and elastic fibers extracted from the spectral imaging of normal skin tissue,and the normal skin near and far away from the hypertrophic scar tissues in a 10-year-old patient case are obtained.The results show that there are apparent differences in the morphological structure and spectral characteristics of collagen and elastic fibers when comparing the normal skin with the hypertrophic scar tissue.These differences can be good indicators to differentiate the normal skin and hypertrophic scar tissue and demonstrate that non-linear spectral imaging microscopy has potential to noninvasively investigate the pathophysiology of human hypertrophic scar.
文摘盆底器官脱垂(pelvic organ prolapse,POP)是以盆底支持组织薄弱为特性的一类功能障碍性疾病,其发生是一个复杂的过程。盆底组织内弹性纤维结构或功能异常可直接导致POP的发生。类赖氨酰氧化酶-1(lysyl oxidase-like protein-1,LOXL-1)是弹性蛋白保持正常结构功能的关键酶。LOXL-1缺失或功能障碍,将导致弹性纤维功能紊乱,从而引起POP。本研究就LOXL-1在POP发生机制中的作用进行综述。
