Objective:The objective of this study is to explore the clinical effects of structured skin care plan of integrated Chinese and Western medicine in intervening elderly patients with incontinence-associated dermatitis(...Objective:The objective of this study is to explore the clinical effects of structured skin care plan of integrated Chinese and Western medicine in intervening elderly patients with incontinence-associated dermatitis(IAD).Materials and Methods:Totally,66 elderly patients with IAD were randomly divided into the experiment group(32 cases)and control group(34 cases).The control group was given routine nursing care,while the experiment group was given a structured skin care plan.The observational course was 2 weeks.The treatment efficiency and healing time were compared between the two groups.Results:After 2-week intervention,the total effective rate of the experiment group was higher than that of the control group(97.1%vs.78.1%,X^(2)=3.913,P=0.048).The skin assessment tool score of the experiment group was lower than that of the control group(0.56±1.58 vs.1.75±2.46,Z=−−2.401,P=0.016).The healing time of the experiment group was shorter than that of the control group(7.29±4.76 days vs.10.69±6.36 days,Z=−2.280,P=0.026).Conclusion:The structured skin care plan of integrated Chinese and Western medicine showed a good effect in elderly IAD patients,and provided a reference for clinical treatment and care of elderly patients with IAD.展开更多
Objective:To discuss the specific application of Zhuang Medicine Crystal Sugar Ye'An Decoction in senile skin pruritus and its effects on serum IgE detection level.Methods:90 patients with senile skin pruritus adm...Objective:To discuss the specific application of Zhuang Medicine Crystal Sugar Ye'An Decoction in senile skin pruritus and its effects on serum IgE detection level.Methods:90 patients with senile skin pruritus admitted to our hospital from February 2019 to April 2020 were randomly grouped.The general treatment effect,itching,secondary skin lesion severity,sernum IL-6,IgE level and adverse reactions between 45 patients treated with Chlorcyclizine Hydrochloride Tablets(The control group)and 45 patients treated with Crystal Sugar Ye'An Decoction were compared.Results:The total effective rate of the treatment in the observation group was 93.33%,much higher than that in the control group,75.56%.The difference was verified and statistically significant(P<0.05).Before the treatment,the itching area,frequency,duration and severity of secondary skin lesions were at the same level(P>0.05).After the treatment,the above data were all reduced,and the reduction of the observation group was more significant than that of the control group,indicating the difference was statistically significant(P<0.05).Before the treatment,there was no difference in serum IL-6 and IgE test data between the two groups(P>0.05).After the treatment,the tendency all declined,and that of the observation group was more obvious,indicating the difference was statistically significant(P<0.05).During the experiment,no obvious adverse reactions were observed in both groups.Conclusion:In the treatment of patients with senile pruritus,the application of Zhuang Medicine Crystal Sugar Ye’An Decoction is not only safe and reliable,but can promote the improvement of patients'symptoms,adjust the level of inflammatory factors,and enhance clinical efficacy.展开更多
Objective:This study aimed to evaluate the influence of advanced glycation end-product(AGE)accumulation on the prevalence and severity of overactive bladder(OAB)in community-dwelling elderly adults.Methods:We conducte...Objective:This study aimed to evaluate the influence of advanced glycation end-product(AGE)accumulation on the prevalence and severity of overactive bladder(OAB)in community-dwelling elderly adults.Methods:We conducted a cross-sectional study involving 269 Japanese community dwellers aged≥75 years in 2015.AGE accumulation was non-invasively measured via skin autofluorescence(SAF)values using AGE Reader.The primary and secondary outcomes were the presence and severity of OAB evaluated using the Overactive Bladder Symptom Score(OABSS).Individuals with an urgency score of≥2 and sum score of≥3 were considered to have OAB.The associations of SAF with the prevalence and severity of OAB were assessed using logistic and linear regression models,respectively,adjusted for clinically important confounders.Results:The median age of participants was 78 years.Of 269 participants,110(40.9%)were men and 75(27.9%)had OAB.The median SAF was 2.2 arbitrary units(AUs).Increasing median SAF was observed with increasing age.Multivariable analysis revealed that SAF was not associated with either the likelihood of having OAB(odds ratio per AU=0.77,95%confidence interval:0.37-1.62)or the natural log-transformed OABSS(0 per AU=-0.07,95%confidence interval:-0.26-0.12).Conclusions:In this study,AGE accumulation,as assessed by SAF,was not associated with the prevalence and severity of OAB in Japanese community-dwelling elderly people aged≥75 years.展开更多
目的:观察化痰散瘀汤治疗斑块型银屑病(痰瘀互结证)的临床疗效及临床作用机制。方法:将皮肤科斑块型银屑病(痰瘀互结证)患者80例按随机数字表法分为观察组与对照组各40例。对照组予阿维A胶囊+糠酸莫米松软膏治疗,观察组在此基础上予化...目的:观察化痰散瘀汤治疗斑块型银屑病(痰瘀互结证)的临床疗效及临床作用机制。方法:将皮肤科斑块型银屑病(痰瘀互结证)患者80例按随机数字表法分为观察组与对照组各40例。对照组予阿维A胶囊+糠酸莫米松软膏治疗,观察组在此基础上予化痰散瘀汤治疗。观察两组患者中医证候评分(皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错),银屑病皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分,皮肤病生活质量指数调查表(dermatology life quality index,DLQI)评分,血清免疫细胞因子干扰素γ(interferonγ,IFN-γ)、白细胞介素4(interleukin 4,IL-4)、白细胞介素17A(interleukin 17A,IL-17A)、白细胞介素10(interleukin-10,IL-10)、白细胞介素22(interleukin-22,IL-22)改善状况,并统计临床疗效及不良反应发生情况。结果:两组治疗后皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错积分均明显降低(P<0.05),且观察组治疗后中医证候积分明显低于对照组(P<0.05)。两组治疗后PASI及DLQI评分均明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。两组治疗后血清IFN-γ、IL-17A、IL-22水平均明显降低(P<0.05),IL-4及IL-10水平均明显升高(P<0.05),且观察组上述指标改善情况均优于对照组(P<0.05)。观察组总有效率[92.5%(37/40)]明显高于对照组[75.0%(30/40)](P<0.05)。两组治疗期间均未出现明显不良反应。结论:化痰散瘀汤能有效改善斑块型银屑病(痰瘀互结证)患者皮损状况,缓解瘙痒等临床症状,有助于提高生活质量,其可能与调节IFN-γ、IL-4、IL-17A、IL-10、IL-22等免疫细胞因子,纠正患者机体紊乱的免疫机能有关。展开更多
目的:系统评价中国2型糖尿病(T2DM)患者并发皮肤瘙痒的危险因素。方法:检索PubMed、Web of Science、中国知网、万方等数据库关于中国T2DM患者并发皮肤瘙痒危险因素的文献,检索时限从建库至2022年7月。采用RevMan 5.4、Stata 16.0软件进...目的:系统评价中国2型糖尿病(T2DM)患者并发皮肤瘙痒的危险因素。方法:检索PubMed、Web of Science、中国知网、万方等数据库关于中国T2DM患者并发皮肤瘙痒危险因素的文献,检索时限从建库至2022年7月。采用RevMan 5.4、Stata 16.0软件进行meta分析。结果:共纳入9篇文献,共计4681例患者。meta分析结果显示,高龄、病程长、高空腹血糖、高糖化血红蛋白、糖尿病视网膜病变、糖尿病周围神经病变的OR(95%CI)分别为1.08(1.04,1.12)、1.06(1.03,1.10)、1.62(1.30,2.03)、1.71(1.33,2.19)、1.26(1.18,1.35)、1.21(1.11,1.32)。结论:高龄、病程长、高空腹血糖、高糖化血红蛋白、糖尿病视网膜病变、糖尿病周围神经病变是中国T2DM患者并发皮肤瘙痒的危险因素。展开更多
基金This study is supported by the Young Teacher Project of Beijing University of Chinese Medicine(No.:2018-JYB-JS134).
文摘Objective:The objective of this study is to explore the clinical effects of structured skin care plan of integrated Chinese and Western medicine in intervening elderly patients with incontinence-associated dermatitis(IAD).Materials and Methods:Totally,66 elderly patients with IAD were randomly divided into the experiment group(32 cases)and control group(34 cases).The control group was given routine nursing care,while the experiment group was given a structured skin care plan.The observational course was 2 weeks.The treatment efficiency and healing time were compared between the two groups.Results:After 2-week intervention,the total effective rate of the experiment group was higher than that of the control group(97.1%vs.78.1%,X^(2)=3.913,P=0.048).The skin assessment tool score of the experiment group was lower than that of the control group(0.56±1.58 vs.1.75±2.46,Z=−−2.401,P=0.016).The healing time of the experiment group was shorter than that of the control group(7.29±4.76 days vs.10.69±6.36 days,Z=−2.280,P=0.026).Conclusion:The structured skin care plan of integrated Chinese and Western medicine showed a good effect in elderly IAD patients,and provided a reference for clinical treatment and care of elderly patients with IAD.
基金National Key R&D Program(N0:2017YFC1703903)Youth Fund Project of Guangxi First-Class Discipline Construction Projects(No.2019XK048)+2 种基金General Project of Guangxi First-Class Discipline Construction Projects(No.:Guijiao Scientific Research 2019XK043)Guangxi First-Class Discipline Construction Projects(No.:Gui Education Scientific Research[2018]12)The High-Level Talent Team Cultivation Project of Qihuang Engineering of the Guangxi University of Chinese Medicine(No.2018005)。
文摘Objective:To discuss the specific application of Zhuang Medicine Crystal Sugar Ye'An Decoction in senile skin pruritus and its effects on serum IgE detection level.Methods:90 patients with senile skin pruritus admitted to our hospital from February 2019 to April 2020 were randomly grouped.The general treatment effect,itching,secondary skin lesion severity,sernum IL-6,IgE level and adverse reactions between 45 patients treated with Chlorcyclizine Hydrochloride Tablets(The control group)and 45 patients treated with Crystal Sugar Ye'An Decoction were compared.Results:The total effective rate of the treatment in the observation group was 93.33%,much higher than that in the control group,75.56%.The difference was verified and statistically significant(P<0.05).Before the treatment,the itching area,frequency,duration and severity of secondary skin lesions were at the same level(P>0.05).After the treatment,the above data were all reduced,and the reduction of the observation group was more significant than that of the control group,indicating the difference was statistically significant(P<0.05).Before the treatment,there was no difference in serum IL-6 and IgE test data between the two groups(P>0.05).After the treatment,the tendency all declined,and that of the observation group was more obvious,indicating the difference was statistically significant(P<0.05).During the experiment,no obvious adverse reactions were observed in both groups.Conclusion:In the treatment of patients with senile pruritus,the application of Zhuang Medicine Crystal Sugar Ye’An Decoction is not only safe and reliable,but can promote the improvement of patients'symptoms,adjust the level of inflammatory factors,and enhance clinical efficacy.
基金supported by a Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research(KAKENHI)[Grant No.JP18K09975].
文摘Objective:This study aimed to evaluate the influence of advanced glycation end-product(AGE)accumulation on the prevalence and severity of overactive bladder(OAB)in community-dwelling elderly adults.Methods:We conducted a cross-sectional study involving 269 Japanese community dwellers aged≥75 years in 2015.AGE accumulation was non-invasively measured via skin autofluorescence(SAF)values using AGE Reader.The primary and secondary outcomes were the presence and severity of OAB evaluated using the Overactive Bladder Symptom Score(OABSS).Individuals with an urgency score of≥2 and sum score of≥3 were considered to have OAB.The associations of SAF with the prevalence and severity of OAB were assessed using logistic and linear regression models,respectively,adjusted for clinically important confounders.Results:The median age of participants was 78 years.Of 269 participants,110(40.9%)were men and 75(27.9%)had OAB.The median SAF was 2.2 arbitrary units(AUs).Increasing median SAF was observed with increasing age.Multivariable analysis revealed that SAF was not associated with either the likelihood of having OAB(odds ratio per AU=0.77,95%confidence interval:0.37-1.62)or the natural log-transformed OABSS(0 per AU=-0.07,95%confidence interval:-0.26-0.12).Conclusions:In this study,AGE accumulation,as assessed by SAF,was not associated with the prevalence and severity of OAB in Japanese community-dwelling elderly people aged≥75 years.
文摘目的:观察化痰散瘀汤治疗斑块型银屑病(痰瘀互结证)的临床疗效及临床作用机制。方法:将皮肤科斑块型银屑病(痰瘀互结证)患者80例按随机数字表法分为观察组与对照组各40例。对照组予阿维A胶囊+糠酸莫米松软膏治疗,观察组在此基础上予化痰散瘀汤治疗。观察两组患者中医证候评分(皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错),银屑病皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分,皮肤病生活质量指数调查表(dermatology life quality index,DLQI)评分,血清免疫细胞因子干扰素γ(interferonγ,IFN-γ)、白细胞介素4(interleukin 4,IL-4)、白细胞介素17A(interleukin 17A,IL-17A)、白细胞介素10(interleukin-10,IL-10)、白细胞介素22(interleukin-22,IL-22)改善状况,并统计临床疗效及不良反应发生情况。结果:两组治疗后皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错积分均明显降低(P<0.05),且观察组治疗后中医证候积分明显低于对照组(P<0.05)。两组治疗后PASI及DLQI评分均明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。两组治疗后血清IFN-γ、IL-17A、IL-22水平均明显降低(P<0.05),IL-4及IL-10水平均明显升高(P<0.05),且观察组上述指标改善情况均优于对照组(P<0.05)。观察组总有效率[92.5%(37/40)]明显高于对照组[75.0%(30/40)](P<0.05)。两组治疗期间均未出现明显不良反应。结论:化痰散瘀汤能有效改善斑块型银屑病(痰瘀互结证)患者皮损状况,缓解瘙痒等临床症状,有助于提高生活质量,其可能与调节IFN-γ、IL-4、IL-17A、IL-10、IL-22等免疫细胞因子,纠正患者机体紊乱的免疫机能有关。
文摘目的:系统评价中国2型糖尿病(T2DM)患者并发皮肤瘙痒的危险因素。方法:检索PubMed、Web of Science、中国知网、万方等数据库关于中国T2DM患者并发皮肤瘙痒危险因素的文献,检索时限从建库至2022年7月。采用RevMan 5.4、Stata 16.0软件进行meta分析。结果:共纳入9篇文献,共计4681例患者。meta分析结果显示,高龄、病程长、高空腹血糖、高糖化血红蛋白、糖尿病视网膜病变、糖尿病周围神经病变的OR(95%CI)分别为1.08(1.04,1.12)、1.06(1.03,1.10)、1.62(1.30,2.03)、1.71(1.33,2.19)、1.26(1.18,1.35)、1.21(1.11,1.32)。结论:高龄、病程长、高空腹血糖、高糖化血红蛋白、糖尿病视网膜病变、糖尿病周围神经病变是中国T2DM患者并发皮肤瘙痒的危险因素。
