Pudendal nerve plays an important role in urine storage and voiding.Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury...Pudendal nerve plays an important role in urine storage and voiding.Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury.We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve.This study explored the excitatory pudendal-to-bladder reflex in beagle dogs,with intact or injured spinal cord,by electrical stimulation of the pudendal nerve trunk.The optimal stimulation frequency was approximately 15–25 Hz.This excitatory effect was dependent to some extent on the bladder volume.We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function.展开更多
Voiding dysfunction,such as urge-frequency syndrome,urge incontinence,stress incontinence and unobstructive urinary retention,is often refractory to pharmacotherapy.Electrical neuromodulation has proved to be benefici...Voiding dysfunction,such as urge-frequency syndrome,urge incontinence,stress incontinence and unobstructive urinary retention,is often refractory to pharmacotherapy.Electrical neuromodulation has proved to be beneficial for these situations.Electroacupuncture pudendal nerve stimulation(EPNS),as one therapy of electrical neuromodulation,is beneficial for voiding dysfunction.The performance and application of EPNS will be introduced in this article.展开更多
基金supported by the Capital Medical Development Research Fund of China,No.2014-2-4141
文摘Pudendal nerve plays an important role in urine storage and voiding.Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury.We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve.This study explored the excitatory pudendal-to-bladder reflex in beagle dogs,with intact or injured spinal cord,by electrical stimulation of the pudendal nerve trunk.The optimal stimulation frequency was approximately 15–25 Hz.This excitatory effect was dependent to some extent on the bladder volume.We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function.
基金supported by Project of Shanghai Municipal Science and Technology Commission(09dZ1974900)Project of Shanghai Municipal Science and Technology Commission(12401904600)Project of Shanghai Municipal Health Bureau(ZYSNXD-CCZDYJ010)
文摘Voiding dysfunction,such as urge-frequency syndrome,urge incontinence,stress incontinence and unobstructive urinary retention,is often refractory to pharmacotherapy.Electrical neuromodulation has proved to be beneficial for these situations.Electroacupuncture pudendal nerve stimulation(EPNS),as one therapy of electrical neuromodulation,is beneficial for voiding dysfunction.The performance and application of EPNS will be introduced in this article.
