Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic fields.In these collisions,highly charged fast-moving ions carry strong electromagnetic fields that...Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic fields.In these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon fluxes.The exchange of photons can induce photonuclear and two-photon interactions and excite ions.This excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other particles.Additionally,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ions.Consequently,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted neutrons.Using a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.展开更多
We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,inc...We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including microglia.To examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 months.We conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain tissue.We confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-βdeposition.The expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed group.Subsequently,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated group.Both radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by PLX3397.These results showed that radiofrequency electromagnetic fields ameliorated amyloid-βpathology and cognitive impairment by suppressing amyloid-βdeposition-induced microgliosis and their key regulator,CSF1R.展开更多
Recent decades have seen rapid advances in the field of electrical engineering, such that our environment has become a sea of electrical and magnetic signals, raising questions about the possible effects of low-freque...Recent decades have seen rapid advances in the field of electrical engineering, such that our environment has become a sea of electrical and magnetic signals, raising questions about the possible effects of low-frequency electromagnetic fields on the environment and which are capable of modifying and destroying our ecosystem. Particular interest was given in this article due to a massive influx of population living near high voltage lines. The analysis and simulation of the influence of low frequency electromagnetic fields on living beings in the vicinity of high voltage sources 132 kV and 220 kV in urban areas in DR Congo is the subject of our research with a view to estimating the level of exposure of humans to low frequency electromagnetic fields. To carry out our research, we used the classic method of analyzing the field produced near a high voltage line based on Maxwell’s image theory, the Maxwell-Gauss theorem and Maxwell-Ampère theorem to model and quantify low-frequency electromagnetic fields in the vicinity of high-voltage lines. The 2D FDTD numerical formulation was developed from telegraphers’ equations and allowed us to obtain models of current and voltage induced by electromagnetic fields on living beings below and near HV lines. The different simulations carried out on the proposed models illustrate the effects of the electrical and geometric parameters of the pylons on the distribution of the electromagnetic field in the vicinity of the HV lines. The results obtained were compared to the safety limits recommended by the standards.展开更多
Bone marrow-derived mesenchymal stem cells(BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field(PEMF) reportedly promotes the proliferation and neuronal differe...Bone marrow-derived mesenchymal stem cells(BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field(PEMF) reportedly promotes the proliferation and neuronal differentiation of BMSCs. Low-frequency PEMF can induce the neuronal differentiation of BMSCs in the absence of nerve growth factors. This study was designed to investigate the effects of low-frequency PEMF pretreatment on the proliferation and function of BMSCs and the effects of low-frequency PEMF pre-treated BMSCs on the regeneration of injured peripheral nerve using in vitro and in vivo experiments. In in vitro experiments, quantitative DNA analysis was performed to determine the proliferation of BMSCs, and reverse transcription-polymerase chain reaction was performed to detect S100(Schwann cell marker), glial fibrillary acidic protein(astrocyte marker), and brain-derived neurotrophic factor and nerve growth factor(neurotrophic factors) m RNA expression. In the in vivo experiments, rat models of crush-injured mental nerve established using clamp method were randomly injected with low-frequency PEMF pretreated BMSCs, unpretreated BMSCs or PBS at the injury site(1 × 106 cells). Di I-labeled BMSCs injected at the injury site were counted under the fluorescence microscope to determine cell survival. One or two weeks after cell injection, functional recovery of the injured nerve was assessed using the sensory test with von Frey filaments. Two weeks after cell injection, axonal regeneration was evaluated using histomorphometric analysis and retrograde labeling of trigeminal ganglion neurons. In vitro experiment results revealed that low-frequency PEMF pretreated BMSCs proliferated faster and had greater m RNA expression of growth factors than unpretreated BMSCs. In vivo experiment results revealed that compared with injection of unpretreated BMSCs, injection of low-frequency PEMF pretreated BMSCs led to higher myelinated axon count and axon density and more Di I-labeled neurons in the trigeminal ganglia, contributing to rapider functional recovery of injured mental nerve. These findings suggest that low-frequency PEMF pretreatment is a promising approach to enhance the efficacy of cell therapy for peripheral nerve injury repair.展开更多
Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly understood.In this s...Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly understood.In this study, we established rat models of middle cerebral artery occlusion/reperfusion.One day after modeling, a group of rats were treated with ELF-EMF(50 Hz, 1 mT) for 2 hours daily on 28 successive days.Our results showed that rats treated with ELF-EMF required shorter swimming distances and latencies in the Morris water maze test than those of untreated rats.The number of times the platform was crossed and the time spent in the target quadrant were greater than those of untreated rats.The number of BrdU~+/NeuN~+ cells, representing newly born neurons, in the hippocampal subgranular zone increased more in the treated than in untreated rats.Up-regulation in the expressions of Notch1, Hes1, and Hes5 proteins, which are the key factors of the Notch signaling pathway, was greatest in the treated rats.These findings suggest that ELF-EMF can enhance hippocampal neurogenesis of rats with cerebral ischemia, possibly by affecting the Notch signaling pathway.The study was approved by the Institutional Ethics Committee of Sichuan University, China(approval No.2019255A) on March 5, 2019.展开更多
The combined electromagnetic fields were achieved by the application of an alternating magnetic field and a stationary magnetic field and were used during direct chill(DC) casting process to control the microstructure...The combined electromagnetic fields were achieved by the application of an alternating magnetic field and a stationary magnetic field and were used during direct chill(DC) casting process to control the microstructure and macrosegregation of an Al-Zn-Mg-Cu alloy. Ingot microstructures were analyzed under an optical microscope(Leica DMR). The composition at different locations in the ingots was measured with inductively coupled plasma mass spectrometry(ICP) method. The results showed that the grain structure is transformed from dendrite to equiaxed structure and significantly refined with the application of combined electromagnetic fields. The uniformity of microstructure is also greatly improved. The combined electromagnetic fields show a significant effect on the distribution of elements. The negative macrosegregation in the centre area of the ingot is obviously reduced.展开更多
CuNi10Fe1Mn alloy billet under rotating electromagnetic field (REF) was characterized in this work. The change of the crystal orientation was first explored by X-ray diffraction (XRD) and scanning election microscope ...CuNi10Fe1Mn alloy billet under rotating electromagnetic field (REF) was characterized in this work. The change of the crystal orientation was first explored by X-ray diffraction (XRD) and scanning election microscope (SEM); the corrosion resistance was done by three electrodes system, and the natural sea water was used as corrosion medium. The results demonstrate that the strongest crystal orientation is transformed from crystal plane (200) to (111); moreover, the crystal plane (111) whose intensity is the strongest on the cross section and vertical section with REF causes the tubes be rolled easily, and the corrosion resistance of the billet is increasing with REF. As a result, properties of CuNi10Fe1Mn alloy tubes can be improved by REF.展开更多
In order to resolve direction finding problems in the impulse noise,a direction of arrival(DOA)estimation method is proposed.The proposed DOA estimation method can restrain the impulse noise by using infinite norm exp...In order to resolve direction finding problems in the impulse noise,a direction of arrival(DOA)estimation method is proposed.The proposed DOA estimation method can restrain the impulse noise by using infinite norm exponential kernel covariance matrix and obtain excellent performance via the maximumlikelihood(ML)algorithm.In order to obtain the global optimal solutions of this method,a quantum electromagnetic field optimization(QEFO)algorithm is designed.In view of the QEFO algorithm,the proposed method can resolve the difficulties of DOA estimation in the impulse noise.Comparing with some traditional DOA estimation methods,the proposed DOA estimation method shows high superiority and robustness for determining the DOA of independent and coherent sources,which has been verified via the Monte-Carlo experiments of different schemes,especially in the case of snapshot deficiency,low generalized signal to noise ratio(GSNR)and strong impulse noise.Beyond that,the Cramer-Rao bound(CRB)of angle estimation in the impulse noise and the proof of the convergence of the QEFO algorithm are provided in this paper.展开更多
It is shown that the non-equilibrium electrically neutral and relativistically invariant vacuum-like state with the negative energy density and positive pressure may exist at the non-zero temperature in the system of ...It is shown that the non-equilibrium electrically neutral and relativistically invariant vacuum-like state with the negative energy density and positive pressure may exist at the non-zero temperature in the system of spinor particles, antiparticles, and random electromagnetic field generated by particle-particle, particle-antiparticle, and antiparticle-antiparticle transitions. At the temperature of the order of 10 <sup>-5</sup> K, the energy density of its state corresponds to the dark energy density in absolute magnitude. The cosmological constant for such material medium turns out to be negative.展开更多
Objective This study aimed to investigate the effect of exposure to a 900 MHz electromagnetic field(EMF)on the cervical spinal cord(CSC)of rats and the possible protective effect of luteolin(LUT)against CSC tissue dam...Objective This study aimed to investigate the effect of exposure to a 900 MHz electromagnetic field(EMF)on the cervical spinal cord(CSC)of rats and the possible protective effect of luteolin(LUT)against CSC tissue damage.Methods Quantitative data were obtained via stereological,biochemical,immunohistochemical,and histopathological techniques.We investigated morphometric value,superoxide dismutase(SOD)level,and the expression of high-mobility group box 1 protein molecules,as well as histological changes.Results The total number of motor neurons in the EMF group significantly decreased in comparison with that in the control group(P<0.05).In the EMF+LUT group,we found a significant increase in the total number of motor neurons compared with that in the EMF group(P<0.05).SOD enzyme activity in the EMF group significantly increased in comparison with that in the control group(P<0.05).By contrast,the EMF+LUT group exhibited a decrease in SOD level compared with the EMF group(P<0.05).Conclusion Our results suggested that exposure to EMF could be deleterious to CSC tissues.Furthermore,the protective efficacy of LUT against SC damage might have resulted from the alleviation of oxidative stress caused by EMF.展开更多
The observed correlation of the angular momenta L<sup>ik</sup> and magnetic moments μ<sub>lm</sub> of celestial bodies (the Sun, planets and stars) was discussed by many au...The observed correlation of the angular momenta L<sup>ik</sup> and magnetic moments μ<sub>lm</sub> of celestial bodies (the Sun, planets and stars) was discussed by many authors but without any explanation. In this paper, a possible explanation of this phenomenon is suggested. It is shown that the function satisfies Maxwell equations and can be considered as a function which determines the electro-magnetic properties of rotating heavy bodies. The R<sub>iklm</sub> is the Riemann tensor, which determines the gravitational field of the body, r<sub>g</sub> is the gravitational radius of the body, and η is the constant which has to be determined by observations. The field Φ<sub>lm</sub> describes the observed correlation. It explains the stability of magnetic field of white dwarfs and neutron stars despite the ohmic dissipation. The function Φ<sub>l0</sub><sub></sub> describes the electric field created by rotating heavy bodies. The presented theory does not contradict any existed experiments and observations.展开更多
Objective:The aim of this study was to investigate the biological effects of occupational extremely low-frequency electromagnetic field(ELF-EMF)exposure on the thyroid gland.Methods:We conducted a prospective analysis...Objective:The aim of this study was to investigate the biological effects of occupational extremely low-frequency electromagnetic field(ELF-EMF)exposure on the thyroid gland.Methods:We conducted a prospective analysis of 85 workers(exposure group)exposed to an ELF-EMF(100μT,10-100 Hz)produced by the electromagnetic aircraft launch system and followed up on thyroid function indices,immunological indices,and color Doppler images for 3 years.Additionally,116 healthy volunteers were randomly selected as controls(control group),the thyroid function of whom was compared to the exposure group.Results:No significant difference was observed in thyroid function between the exposure and control groups.During the follow-up of the exposure group,the serum free triiodothyronine(FT3)level was found to slowly decrease and free thyroxine(FT4)level slowly increase with increasing exposure time.However,no significant difference was found in thyroid-stimulating hormone(TSH)over the three years,and no significant difference was observed in the FT3,FT4 and TSH levels between different exposure subgroups.Furthermore,no significant changes were observed in thyroid autoantibody levels and ultrasound images between subgroups or over time.Conclusion:Long-term exposure to ELF-EMF may promote thyroid secretion of T4 and inhibit deiodination of T4 to T3.ELF-EMF has no significant effect on thyroid immune function and morphology.展开更多
Modern technology has witnessed milestone achievements in the telecommunication industry.However,the widespread application of telecommunication technology is believed to heighten electromagnetic field(EMF)‘pollution...Modern technology has witnessed milestone achievements in the telecommunication industry.However,the widespread application of telecommunication technology is believed to heighten electromagnetic field(EMF)‘pollution’in our environment[1]and subject living organisms to various sources of electromagnetic emissions.These emissions include;microwaves.展开更多
The invariance of several new component electromagnetic-field vectors with respect to the Lorentz transformation has been demonstrated in the paper. The formalism of the classical relativistic mechanics has been appli...The invariance of several new component electromagnetic-field vectors with respect to the Lorentz transformation has been demonstrated in the paper. The formalism of the classical relativistic mechanics has been applied in examining both the time-square variable of the field, as well as the square-values of the position coordinates of a moving particle.展开更多
Although the rate of patients reporting satisfaction is generally high after joint replacement surgery, up to 23% after total hip replacement and 34% after total knee arthroplasty of treated subjects report discomfort...Although the rate of patients reporting satisfaction is generally high after joint replacement surgery, up to 23% after total hip replacement and 34% after total knee arthroplasty of treated subjects report discomfort or pain 1 year after surgery. Moreover, chronic or subacute inflammation is reported in some cases even a long time after surgery. Another open and debated issue in prosthetic surgery is implant survivorship, especially when related to good prosthesis bone ingrowth. Pulsed Electro Magnetic Fields(PEMFs) treatment, although initially recommended after total joint replacement to promote bone ingrowth and to reduce inflammation and pain, is not currently part of usual clinical practice. The purpose of this review was to analyze existing literature on PEMFs effects in joint replacement surgery and to report results of clinical studies and current indications. We selected all currently available prospective studies or RCT on the use of PEMFs in total joint replacement with the purpose of investigating effects of PEMFs on recovery, pain relief and patients’ satisfaction following hip, knee or shoulder arthroplasty. All the studies analyzed reported no adverse effects, and good patient compliance to the treatment. The available literature shows that early control of joint inflammation process in the first days after surgery through the use of PEMFs should be considered an effective completion of the surgical procedure to improve the patient’s functional recovery.展开更多
BACKGROUND Pulsed electromagnetic field(PEMF)therapy is widely used to treat myofascial pain syndrome(MPS).Damp-clearing and pain-reducing paste(DPP)comprises medical herbs and has been a traditional method of reducin...BACKGROUND Pulsed electromagnetic field(PEMF)therapy is widely used to treat myofascial pain syndrome(MPS).Damp-clearing and pain-reducing paste(DPP)comprises medical herbs and has been a traditional method of reducing myofascial pain in China for a long time,and it is usually administered with heating.However,the synergistic effect of PEMF therapy on heating-DPP in patients with MPS is unclear.AIM To investigate the synergistic effect of PEMF therapy plus heating-DPP in lumbar MPS.METHODS This double-blind,randomized,placebo-controlled trial was conducted on 120 patients with lumbar MPS who were randomly divided into an experimental group(EG,n=60)and a control group(CG,n=60).Patients in both groups were treated with heating-DPP combined with PEMF therapy;however,the electromagnetic function of the therapeutic apparatus used in the CG was disabled.Each treatment lasted for 20 min and was applied five times a week for two weeks.The short-form McGill Pain Questionnaire was applied at five time points:pretest,end of the first and second weeks of treatment,and end of the first and fourth week after completing treatment.Visual analog scale(VAS),present pain intensity index(PPI),and pain rating index(PRI;total,affective pain,and sensory pain scores)scores were then analyzed.RESULTS Compared with the CG,the VAS,PPI and PRI scores(total,affective pain and sensory pain scores)in the EG were significantly lower after treatment and during follow-up.CONCLUSION PEMF therapy combined with heating-DPP showed better efficacy than heating-DPP alone in reducing the overall intensity of pain and sensory and affective pain.展开更多
As the essential material for high temperature industrial production and technological development such as metallurgy,refractory has an important influence on the safety and efficiency of production for high-quality s...As the essential material for high temperature industrial production and technological development such as metallurgy,refractory has an important influence on the safety and efficiency of production for high-quality steels.Slag corrosion is one of the main reasons causing the wear of refractories.The slag resistance of refractories can be enhanced by regulation and control of the composition and structure,while applying the external electromagnetic field can achieve the good performance.Electromagnetic field can not only change the thermo physical properties of slags,but also have a significant effect on the slag resistance of refractories.Suitable electric field can slow down the slag corrosion while the influence of conductivity of refractories is obvious;The magnetic field with millitesla level have a significant impact on the high temperature properties of the slags,and the alternating magnetic field can accelerate the slag corrosion of the refractories,while the static magnetic field has a promising potential to improve the slag resistance of the refractories.Furthermore,the interaction mechanism between refractories and slags under magnetic field needs to be clarified in order to develop the magnetic resistance against slag corrosion of refractories.展开更多
The propagation of the lightning-radiated electromagnetic field along the real irregular terrain around Yangzhou Direction Finder(DF)site(119°42′E,32°39′N)and Nanjing DF site(118°46′E,32°03′N)o...The propagation of the lightning-radiated electromagnetic field along the real irregular terrain around Yangzhou Direction Finder(DF)site(119°42′E,32°39′N)and Nanjing DF site(118°46′E,32°03′N)of Jiangsu Province in China is estimated.The results show that the rough irregular terrain results in the rapid magnitude attenuation and the increase of the rise-time of the field waveform.For example,for the Yangzhou DF site as the circumference of a radius of 45 km,the root-mean-squared height(RMSH)of the real irregular terrain varies from 7 to 33 m;the extra field attenuation relative to the ideal ground surface ranges from 1%to 11%,and the extra rise-time increment varies from 0.1 to 0.6μs.Therefore,the extracted current peak of lightning return stroke may be underestimated from the remotely measured electromagnetic field,and the error varies along with different azimuths.展开更多
A new method for the unification of gravitational and electromagnetic forces is proposed. Previously, Kaluza-Klein theory dealt with the unification, but it has not yet been established as a complete theory. The main ...A new method for the unification of gravitational and electromagnetic forces is proposed. Previously, Kaluza-Klein theory dealt with the unification, but it has not yet been established as a complete theory. The main reason for this is that Kaluza-Klein theory has various contradictions due to the use of a 5-dimensional metric tensor. In this paper, unlike the conventional method, various equations related to gravitational and electromagnetic force are derived without any contradiction by processing equations having gauge symmetry within a 4-dimensional range. In this process, we propose that Maxwell’s equations for the electromagnetic force are expressed more simply and implicitly than the existing tensor form. Using the gauge symmetry, it shows that electromagnetic force can exist in single metric tensor along with gravity. In addition, since geodesic equations can be derived in the form of coordinate transformation, it has been shown that they are consistent with the existing equations. As a result, it has shown that they are consistent with the existing physical equations without contradiction.展开更多
Electron vortex beams(EVBs)have potential applications in nanoscale magnetic probes of condensed matter and nanoparticle manipulation as well as radiation physics.Recently,a relativistic electron vortex beam(REVB)has ...Electron vortex beams(EVBs)have potential applications in nanoscale magnetic probes of condensed matter and nanoparticle manipulation as well as radiation physics.Recently,a relativistic electron vortex beam(REVB)has been proposed[Phys.Rev.Lett.107174802(2011)].Compared with EVBs,except for orbital angular momentum,an REVB has intrinsic relativistic effect,i.e.,spin angular momentum and spin-orbit coupling.We study the electromagnetic field of an REVB analytically.We show that the electromagnetic field can be separated into two parts,one is only related to orbital quantum number,and the other is related to spin-orbit coupling effect.Exploiting this separation property,the difference between the electromagnetic fields of the REVB in spin-up and spin-down states can be used as a demonstration of the relativistic quantum effect.The linear momentum and angular momentum of the generated electromagnetic field have been further studied and it is shown that the linear momentum is weakly dependent on the spin state;while the angular momentum is evidently dependent on the spin state and linearly increases with the topological charge of electron vortex beam.The electromagnetic and mechanical properties of the REVB could be useful for studying the interaction between REVBs and materials.展开更多
基金This work is supported in part by the National Key Research and Development Program of China(Nos.2022YFA1604900)the Guangdong Major Project of Basic and Applied Basic Research(No.2020B0301030008)+3 种基金the National Natural Science Foundation of China(Nos.12275053,12025501,11890710,11890714,12147101,12075061,and 12225502)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB34030000)Shanghai National Science Foundation(No.20ZR1404100)STCSM(No.23590780100).
文摘Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic fields.In these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon fluxes.The exchange of photons can induce photonuclear and two-photon interactions and excite ions.This excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other particles.Additionally,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ions.Consequently,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted neutrons.Using a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.
基金Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by Korea government(MSIT),Nos.2017-0-00961 and 2019-0-00102(to HDC)。
文摘We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including microglia.To examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 months.We conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain tissue.We confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-βdeposition.The expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed group.Subsequently,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated group.Both radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by PLX3397.These results showed that radiofrequency electromagnetic fields ameliorated amyloid-βpathology and cognitive impairment by suppressing amyloid-βdeposition-induced microgliosis and their key regulator,CSF1R.
文摘Recent decades have seen rapid advances in the field of electrical engineering, such that our environment has become a sea of electrical and magnetic signals, raising questions about the possible effects of low-frequency electromagnetic fields on the environment and which are capable of modifying and destroying our ecosystem. Particular interest was given in this article due to a massive influx of population living near high voltage lines. The analysis and simulation of the influence of low frequency electromagnetic fields on living beings in the vicinity of high voltage sources 132 kV and 220 kV in urban areas in DR Congo is the subject of our research with a view to estimating the level of exposure of humans to low frequency electromagnetic fields. To carry out our research, we used the classic method of analyzing the field produced near a high voltage line based on Maxwell’s image theory, the Maxwell-Gauss theorem and Maxwell-Ampère theorem to model and quantify low-frequency electromagnetic fields in the vicinity of high-voltage lines. The 2D FDTD numerical formulation was developed from telegraphers’ equations and allowed us to obtain models of current and voltage induced by electromagnetic fields on living beings below and near HV lines. The different simulations carried out on the proposed models illustrate the effects of the electrical and geometric parameters of the pylons on the distribution of the electromagnetic field in the vicinity of the HV lines. The results obtained were compared to the safety limits recommended by the standards.
基金supported by a grant of the Korea Health Technology R & D Project through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HI15C1535)
文摘Bone marrow-derived mesenchymal stem cells(BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field(PEMF) reportedly promotes the proliferation and neuronal differentiation of BMSCs. Low-frequency PEMF can induce the neuronal differentiation of BMSCs in the absence of nerve growth factors. This study was designed to investigate the effects of low-frequency PEMF pretreatment on the proliferation and function of BMSCs and the effects of low-frequency PEMF pre-treated BMSCs on the regeneration of injured peripheral nerve using in vitro and in vivo experiments. In in vitro experiments, quantitative DNA analysis was performed to determine the proliferation of BMSCs, and reverse transcription-polymerase chain reaction was performed to detect S100(Schwann cell marker), glial fibrillary acidic protein(astrocyte marker), and brain-derived neurotrophic factor and nerve growth factor(neurotrophic factors) m RNA expression. In the in vivo experiments, rat models of crush-injured mental nerve established using clamp method were randomly injected with low-frequency PEMF pretreated BMSCs, unpretreated BMSCs or PBS at the injury site(1 × 106 cells). Di I-labeled BMSCs injected at the injury site were counted under the fluorescence microscope to determine cell survival. One or two weeks after cell injection, functional recovery of the injured nerve was assessed using the sensory test with von Frey filaments. Two weeks after cell injection, axonal regeneration was evaluated using histomorphometric analysis and retrograde labeling of trigeminal ganglion neurons. In vitro experiment results revealed that low-frequency PEMF pretreated BMSCs proliferated faster and had greater m RNA expression of growth factors than unpretreated BMSCs. In vivo experiment results revealed that compared with injection of unpretreated BMSCs, injection of low-frequency PEMF pretreated BMSCs led to higher myelinated axon count and axon density and more Di I-labeled neurons in the trigeminal ganglia, contributing to rapider functional recovery of injured mental nerve. These findings suggest that low-frequency PEMF pretreatment is a promising approach to enhance the efficacy of cell therapy for peripheral nerve injury repair.
基金supported by the National Natural Science Foundation of China,No.81201513 (to QG)。
文摘Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly understood.In this study, we established rat models of middle cerebral artery occlusion/reperfusion.One day after modeling, a group of rats were treated with ELF-EMF(50 Hz, 1 mT) for 2 hours daily on 28 successive days.Our results showed that rats treated with ELF-EMF required shorter swimming distances and latencies in the Morris water maze test than those of untreated rats.The number of times the platform was crossed and the time spent in the target quadrant were greater than those of untreated rats.The number of BrdU~+/NeuN~+ cells, representing newly born neurons, in the hippocampal subgranular zone increased more in the treated than in untreated rats.Up-regulation in the expressions of Notch1, Hes1, and Hes5 proteins, which are the key factors of the Notch signaling pathway, was greatest in the treated rats.These findings suggest that ELF-EMF can enhance hippocampal neurogenesis of rats with cerebral ischemia, possibly by affecting the Notch signaling pathway.The study was approved by the Institutional Ethics Committee of Sichuan University, China(approval No.2019255A) on March 5, 2019.
基金supported by the National Natural Science Foundation of China(51374067)the Outstanding Young Scholars'Growth Plan in the Colleges and Universities of Liaoning Province(LJQ2014032)the National Basic Research Program of China(2012CB619506)
文摘The combined electromagnetic fields were achieved by the application of an alternating magnetic field and a stationary magnetic field and were used during direct chill(DC) casting process to control the microstructure and macrosegregation of an Al-Zn-Mg-Cu alloy. Ingot microstructures were analyzed under an optical microscope(Leica DMR). The composition at different locations in the ingots was measured with inductively coupled plasma mass spectrometry(ICP) method. The results showed that the grain structure is transformed from dendrite to equiaxed structure and significantly refined with the application of combined electromagnetic fields. The uniformity of microstructure is also greatly improved. The combined electromagnetic fields show a significant effect on the distribution of elements. The negative macrosegregation in the centre area of the ingot is obviously reduced.
基金financially supported by the Fundamental Research Fund for the Zhejiang Provincial Laboratory of Testing and Deep Processing for Measuring and Cutting Tools(No.ZD201202)
文摘CuNi10Fe1Mn alloy billet under rotating electromagnetic field (REF) was characterized in this work. The change of the crystal orientation was first explored by X-ray diffraction (XRD) and scanning election microscope (SEM); the corrosion resistance was done by three electrodes system, and the natural sea water was used as corrosion medium. The results demonstrate that the strongest crystal orientation is transformed from crystal plane (200) to (111); moreover, the crystal plane (111) whose intensity is the strongest on the cross section and vertical section with REF causes the tubes be rolled easily, and the corrosion resistance of the billet is increasing with REF. As a result, properties of CuNi10Fe1Mn alloy tubes can be improved by REF.
基金supported by the National Natural Science Foundation of China(61571149)the Natural Science Foundation of Heilongjiang Province(LH2020F017)+1 种基金the Initiation Fund for Postdoctoral Research in Heilongjiang Province(LBH-Q19098)the Heilongjiang Province Key Laboratory of High Accuracy Satellite Navigation and Marine Application Laboratory(HKL-2020-Y01).
文摘In order to resolve direction finding problems in the impulse noise,a direction of arrival(DOA)estimation method is proposed.The proposed DOA estimation method can restrain the impulse noise by using infinite norm exponential kernel covariance matrix and obtain excellent performance via the maximumlikelihood(ML)algorithm.In order to obtain the global optimal solutions of this method,a quantum electromagnetic field optimization(QEFO)algorithm is designed.In view of the QEFO algorithm,the proposed method can resolve the difficulties of DOA estimation in the impulse noise.Comparing with some traditional DOA estimation methods,the proposed DOA estimation method shows high superiority and robustness for determining the DOA of independent and coherent sources,which has been verified via the Monte-Carlo experiments of different schemes,especially in the case of snapshot deficiency,low generalized signal to noise ratio(GSNR)and strong impulse noise.Beyond that,the Cramer-Rao bound(CRB)of angle estimation in the impulse noise and the proof of the convergence of the QEFO algorithm are provided in this paper.
文摘It is shown that the non-equilibrium electrically neutral and relativistically invariant vacuum-like state with the negative energy density and positive pressure may exist at the non-zero temperature in the system of spinor particles, antiparticles, and random electromagnetic field generated by particle-particle, particle-antiparticle, and antiparticle-antiparticle transitions. At the temperature of the order of 10 <sup>-5</sup> K, the energy density of its state corresponds to the dark energy density in absolute magnitude. The cosmological constant for such material medium turns out to be negative.
文摘Objective This study aimed to investigate the effect of exposure to a 900 MHz electromagnetic field(EMF)on the cervical spinal cord(CSC)of rats and the possible protective effect of luteolin(LUT)against CSC tissue damage.Methods Quantitative data were obtained via stereological,biochemical,immunohistochemical,and histopathological techniques.We investigated morphometric value,superoxide dismutase(SOD)level,and the expression of high-mobility group box 1 protein molecules,as well as histological changes.Results The total number of motor neurons in the EMF group significantly decreased in comparison with that in the control group(P<0.05).In the EMF+LUT group,we found a significant increase in the total number of motor neurons compared with that in the EMF group(P<0.05).SOD enzyme activity in the EMF group significantly increased in comparison with that in the control group(P<0.05).By contrast,the EMF+LUT group exhibited a decrease in SOD level compared with the EMF group(P<0.05).Conclusion Our results suggested that exposure to EMF could be deleterious to CSC tissues.Furthermore,the protective efficacy of LUT against SC damage might have resulted from the alleviation of oxidative stress caused by EMF.
文摘The observed correlation of the angular momenta L<sup>ik</sup> and magnetic moments μ<sub>lm</sub> of celestial bodies (the Sun, planets and stars) was discussed by many authors but without any explanation. In this paper, a possible explanation of this phenomenon is suggested. It is shown that the function satisfies Maxwell equations and can be considered as a function which determines the electro-magnetic properties of rotating heavy bodies. The R<sub>iklm</sub> is the Riemann tensor, which determines the gravitational field of the body, r<sub>g</sub> is the gravitational radius of the body, and η is the constant which has to be determined by observations. The field Φ<sub>lm</sub> describes the observed correlation. It explains the stability of magnetic field of white dwarfs and neutron stars despite the ohmic dissipation. The function Φ<sub>l0</sub><sub></sub> describes the electric field created by rotating heavy bodies. The presented theory does not contradict any existed experiments and observations.
基金supported by.the National Military Research Project of China(No.JGXM201507).
文摘Objective:The aim of this study was to investigate the biological effects of occupational extremely low-frequency electromagnetic field(ELF-EMF)exposure on the thyroid gland.Methods:We conducted a prospective analysis of 85 workers(exposure group)exposed to an ELF-EMF(100μT,10-100 Hz)produced by the electromagnetic aircraft launch system and followed up on thyroid function indices,immunological indices,and color Doppler images for 3 years.Additionally,116 healthy volunteers were randomly selected as controls(control group),the thyroid function of whom was compared to the exposure group.Results:No significant difference was observed in thyroid function between the exposure and control groups.During the follow-up of the exposure group,the serum free triiodothyronine(FT3)level was found to slowly decrease and free thyroxine(FT4)level slowly increase with increasing exposure time.However,no significant difference was found in thyroid-stimulating hormone(TSH)over the three years,and no significant difference was observed in the FT3,FT4 and TSH levels between different exposure subgroups.Furthermore,no significant changes were observed in thyroid autoantibody levels and ultrasound images between subgroups or over time.Conclusion:Long-term exposure to ELF-EMF may promote thyroid secretion of T4 and inhibit deiodination of T4 to T3.ELF-EMF has no significant effect on thyroid immune function and morphology.
文摘Modern technology has witnessed milestone achievements in the telecommunication industry.However,the widespread application of telecommunication technology is believed to heighten electromagnetic field(EMF)‘pollution’in our environment[1]and subject living organisms to various sources of electromagnetic emissions.These emissions include;microwaves.
文摘The invariance of several new component electromagnetic-field vectors with respect to the Lorentz transformation has been demonstrated in the paper. The formalism of the classical relativistic mechanics has been applied in examining both the time-square variable of the field, as well as the square-values of the position coordinates of a moving particle.
文摘Although the rate of patients reporting satisfaction is generally high after joint replacement surgery, up to 23% after total hip replacement and 34% after total knee arthroplasty of treated subjects report discomfort or pain 1 year after surgery. Moreover, chronic or subacute inflammation is reported in some cases even a long time after surgery. Another open and debated issue in prosthetic surgery is implant survivorship, especially when related to good prosthesis bone ingrowth. Pulsed Electro Magnetic Fields(PEMFs) treatment, although initially recommended after total joint replacement to promote bone ingrowth and to reduce inflammation and pain, is not currently part of usual clinical practice. The purpose of this review was to analyze existing literature on PEMFs effects in joint replacement surgery and to report results of clinical studies and current indications. We selected all currently available prospective studies or RCT on the use of PEMFs in total joint replacement with the purpose of investigating effects of PEMFs on recovery, pain relief and patients’ satisfaction following hip, knee or shoulder arthroplasty. All the studies analyzed reported no adverse effects, and good patient compliance to the treatment. The available literature shows that early control of joint inflammation process in the first days after surgery through the use of PEMFs should be considered an effective completion of the surgical procedure to improve the patient’s functional recovery.
基金Supported by the Project of Capacity Building for Sustainable Utilization of Precious Traditional Chinese Medicine Resources,No.2060302.
文摘BACKGROUND Pulsed electromagnetic field(PEMF)therapy is widely used to treat myofascial pain syndrome(MPS).Damp-clearing and pain-reducing paste(DPP)comprises medical herbs and has been a traditional method of reducing myofascial pain in China for a long time,and it is usually administered with heating.However,the synergistic effect of PEMF therapy on heating-DPP in patients with MPS is unclear.AIM To investigate the synergistic effect of PEMF therapy plus heating-DPP in lumbar MPS.METHODS This double-blind,randomized,placebo-controlled trial was conducted on 120 patients with lumbar MPS who were randomly divided into an experimental group(EG,n=60)and a control group(CG,n=60).Patients in both groups were treated with heating-DPP combined with PEMF therapy;however,the electromagnetic function of the therapeutic apparatus used in the CG was disabled.Each treatment lasted for 20 min and was applied five times a week for two weeks.The short-form McGill Pain Questionnaire was applied at five time points:pretest,end of the first and second weeks of treatment,and end of the first and fourth week after completing treatment.Visual analog scale(VAS),present pain intensity index(PPI),and pain rating index(PRI;total,affective pain,and sensory pain scores)scores were then analyzed.RESULTS Compared with the CG,the VAS,PPI and PRI scores(total,affective pain and sensory pain scores)in the EG were significantly lower after treatment and during follow-up.CONCLUSION PEMF therapy combined with heating-DPP showed better efficacy than heating-DPP alone in reducing the overall intensity of pain and sensory and affective pain.
基金the National Natural Science Foundation of China(Grant No.U1908227 and U1860205)the Special Project of Central Government for Local Science and Technology Development of Hubei Province(2019ZYYD076).
文摘As the essential material for high temperature industrial production and technological development such as metallurgy,refractory has an important influence on the safety and efficiency of production for high-quality steels.Slag corrosion is one of the main reasons causing the wear of refractories.The slag resistance of refractories can be enhanced by regulation and control of the composition and structure,while applying the external electromagnetic field can achieve the good performance.Electromagnetic field can not only change the thermo physical properties of slags,but also have a significant effect on the slag resistance of refractories.Suitable electric field can slow down the slag corrosion while the influence of conductivity of refractories is obvious;The magnetic field with millitesla level have a significant impact on the high temperature properties of the slags,and the alternating magnetic field can accelerate the slag corrosion of the refractories,while the static magnetic field has a promising potential to improve the slag resistance of the refractories.Furthermore,the interaction mechanism between refractories and slags under magnetic field needs to be clarified in order to develop the magnetic resistance against slag corrosion of refractories.
基金Supported by the Application of the Forecasting Warning System for Lightning Disaster in Yunan Plateau(YNKJXM20190733)National Natural Science Foundation of China(41775006,41575004).
文摘The propagation of the lightning-radiated electromagnetic field along the real irregular terrain around Yangzhou Direction Finder(DF)site(119°42′E,32°39′N)and Nanjing DF site(118°46′E,32°03′N)of Jiangsu Province in China is estimated.The results show that the rough irregular terrain results in the rapid magnitude attenuation and the increase of the rise-time of the field waveform.For example,for the Yangzhou DF site as the circumference of a radius of 45 km,the root-mean-squared height(RMSH)of the real irregular terrain varies from 7 to 33 m;the extra field attenuation relative to the ideal ground surface ranges from 1%to 11%,and the extra rise-time increment varies from 0.1 to 0.6μs.Therefore,the extracted current peak of lightning return stroke may be underestimated from the remotely measured electromagnetic field,and the error varies along with different azimuths.
文摘A new method for the unification of gravitational and electromagnetic forces is proposed. Previously, Kaluza-Klein theory dealt with the unification, but it has not yet been established as a complete theory. The main reason for this is that Kaluza-Klein theory has various contradictions due to the use of a 5-dimensional metric tensor. In this paper, unlike the conventional method, various equations related to gravitational and electromagnetic force are derived without any contradiction by processing equations having gauge symmetry within a 4-dimensional range. In this process, we propose that Maxwell’s equations for the electromagnetic force are expressed more simply and implicitly than the existing tensor form. Using the gauge symmetry, it shows that electromagnetic force can exist in single metric tensor along with gravity. In addition, since geodesic equations can be derived in the form of coordinate transformation, it has been shown that they are consistent with the existing equations. As a result, it has shown that they are consistent with the existing physical equations without contradiction.
基金the National Natural Science Foundation of China(Grant Nos.11574085,91536218,and 11834003)the 111 Project,China(Grant No.B12024)+1 种基金the National Key Research and Development Program of China(Grant No.2017YFA0304201)the Innovation Program of Shanghai Municipal Education Commission,China(Grant No.2019-01-07-00-05-E00079)。
文摘Electron vortex beams(EVBs)have potential applications in nanoscale magnetic probes of condensed matter and nanoparticle manipulation as well as radiation physics.Recently,a relativistic electron vortex beam(REVB)has been proposed[Phys.Rev.Lett.107174802(2011)].Compared with EVBs,except for orbital angular momentum,an REVB has intrinsic relativistic effect,i.e.,spin angular momentum and spin-orbit coupling.We study the electromagnetic field of an REVB analytically.We show that the electromagnetic field can be separated into two parts,one is only related to orbital quantum number,and the other is related to spin-orbit coupling effect.Exploiting this separation property,the difference between the electromagnetic fields of the REVB in spin-up and spin-down states can be used as a demonstration of the relativistic quantum effect.The linear momentum and angular momentum of the generated electromagnetic field have been further studied and it is shown that the linear momentum is weakly dependent on the spin state;while the angular momentum is evidently dependent on the spin state and linearly increases with the topological charge of electron vortex beam.The electromagnetic and mechanical properties of the REVB could be useful for studying the interaction between REVBs and materials.