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Isolation and identification of chemical constituents from Elephantopus scaber Linn.
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作者 Wei Xu Ming Bai Xiaoxiao Huang 《Asian Journal of Traditional Medicines》 CAS 2021年第2期98-104,共7页
Elephantopus scaber L.,as a popular Chinese medicinal herb of the Compositae family,is widely distributed in America,Africa and Asia.In the present study,five compounds were isolated from the 70%EtOH extract of the wh... Elephantopus scaber L.,as a popular Chinese medicinal herb of the Compositae family,is widely distributed in America,Africa and Asia.In the present study,five compounds were isolated from the 70%EtOH extract of the whole herb from Elephantopus scaber L.,including two lignans and three flavones.Their chemical structures were identified based on NMR spectroscopic analysis and comparison with the data reported in literature.It is noteworthy that compounds 1-5 were isolated from Elephantopus scaber L.for the first time and their chemotaxonomic significance was discussed. 展开更多
关键词 elephantopus scaber L. separation and purification chemical constituents structural elucidation
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Effect of Elephantopus scaber L.Extract on Acute Pleurisy in Rats
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作者 Yan ZHANG Jianting GAO +2 位作者 Xinchao SHI Hailong LIU Xin HE 《Medicinal Plant》 2024年第1期48-50,56,共4页
[Objectives]To study the anti-inflammatory effect of Elephantopus scaber L.extract on acute pleurisy induced by carrageenan in rats,and to explore its anti-inflammatory mechanism.[Methods]The active sites of E.scaber ... [Objectives]To study the anti-inflammatory effect of Elephantopus scaber L.extract on acute pleurisy induced by carrageenan in rats,and to explore its anti-inflammatory mechanism.[Methods]The active sites of E.scaber L.were extracted by ethanol reflux method.The extracts of different concentrations of E.scaber L.were used as the study object,and dexamethasone was used as the positive control drug.The anti-inflammatory effects of E.scaber L.extracts were studied by measuring the levels of malondialdehyde(MDA),prostaglandin E_(2)(PGE_(2)),tumor necrosis factor(TNF-α),interleukin-1β(IL-1β)in pleural fluid and serum nitric oxide(NO),MDA,PEG_(2),TNF-α,IL-1βin rats with acute pleurisy induced by carrageenan.[Results]E.scaber L.extracts in three doses could reduce the levels of inflammatory factors in pleural fluid and serum,and inhibit acute pleurisy in rats.It was speculated that the anti-inflammatory mechanism was related to the inhibition of the release of inflammatory factors and the antioxidant effect of extracts of three doses of E.scaber L.[Conclusions]This experiment provides a basis for the development and application of E.scaber L. 展开更多
关键词 elephantopus scaber L. EXTRACT Acute pleurisy ANTI-INFLAMMATORY
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Effect of Elephantopus scaber Linn on community acquired pneumonia through TLR4/NF-κB signaling pathway
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作者 Pan-Hong Jia Qi Li +3 位作者 Xiao-Man Xiong Ying Liu Meng-Zhe Jia Xiang-Dong Zhou 《Journal of Hainan Medical University》 2020年第24期10-13,共4页
Objective:To observe the effect of Elephantopus scaber Linn on community-acquired pneumonia and its relationship with the expression of TLR4/NF-κB pathway and the downstream inflammatory cytokines IL-6,IL-8,TNF-α.an... Objective:To observe the effect of Elephantopus scaber Linn on community-acquired pneumonia and its relationship with the expression of TLR4/NF-κB pathway and the downstream inflammatory cytokines IL-6,IL-8,TNF-α.and to explore its molecular mechanism for the treatment of community-acquired pneumonia,so as to provide new ideas and theoretical basis for the treatment of community-acquired pneumonia.Methods:140 patients with community-acquired pneumonia were randomly divided into observation group and control group,with 70 cases in each group.Observation group:Elephantopus scaber Linn+NS atomized inhalation+intravenous injection of ceftazidine;Control group:intravenous injection of ceftazidine;Meanwhile,70 healthy subjects were selected as the healthy control group.The expressions of TLR4,NF-kB,IL-6,IL-8 and TNF-αin serum of observation group,control group before and after treatment and healthy control group were detected by enzyme linked immunosorbent assay(ELISA),and the efficacy of Elephantopus scaber Linn in the treatment of community acquired pneumonia was observed.Results:Compared with the control group,the observation group was significantly better than the control group in recovery rate,total effective rate,number of days for the disappearance of symptoms such as fever,cough,expectoration,with statistical significance(P<0.05);Compared with the healthy control group,the serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere significantly different(P<0.05)between the observation group and the control group;Serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere significantly different(P<0.05)in the observation group before and after treatment with Elephantopus scaber Linn;Compared with the control group after treatment,there were significantly different(P<0.05)in serum TLR4,NF-κB,IL-6,IL-8 and TNF-αin the observation group after treatment.Conclusion:Serum TLR4,NF-κB,IL-6,IL-8,TNF-αwere highly expressed in patients with community-acquired pneumonia,Elephantopus scaber Linn can decreased the expression of TLR4 and NF-κB in blood,and its downstream inflammatory factors also decreased significantly.There were significantly different(P<0.05)in blood TLR4 and NF-κB between the observation group and the control group after treatment.It is suggested that Elephantopus scaber Linn may inhibit TLR4/NF-kB signal pathway to exert anti-inflammatory effect.Elephantopus scaber Linn has a definite effect and can significantly improve the clinical symptoms,and effectively shorten the treatment cycle. 展开更多
关键词 elephantopus scaber linn Community acquired pneumonia Toll-like receptor 4 Nuclear factor-kappa B Atomization inhalation
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Sesquiterpene Lactones from Elephantopus scaber 被引量:6
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作者 Qiao Li LIANG Zhi Da MIN 《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第4期343-344,共2页
A new germacranolide sesquiterpene lactone, isoscabertopin, was isolated from Elephantopus scaber together with the known scabertopin. Their structures were determined by spectroscopic methods.
关键词 elephantopus scaber COMPOSITAE germacranolide sesquiterpene lactone isoscabertopin.
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Antineoplastic effects of deoxyelephantopin,a sesquiterpene lactone from Elephantopusscaber, on lung adenocarcinoma (A549) cells 被引量:5
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作者 Farha A. Kabeer Geetha B. Sreedevi +4 位作者 Mangalam S. Nair Dhanya S. Rajalekshmi LathaP. Gopalakrishnan Sujathan Kunjuraman Remani Prathapan 《Journal of Integrative Medicine》 SCIE CAS CSCD 2013年第4期269-277,共9页
OBJECTIVE: Deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, showed inhibition of the growth of various tumor cells in vitro. In the present study, we investigated the cytotoxicity and apoptosis-in... OBJECTIVE: Deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, showed inhibition of the growth of various tumor cells in vitro. In the present study, we investigated the cytotoxicity and apoptosis-inducing capacity of deoxyelephantopin on lung adenocarcinoma (A549) cells. METHODS: The cytotoxic effect of deoxyelephantopin on A549 cells and normal lymphocytes was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and 50% inhibitory concentration (IC50) value was determined. The self-renewal and proliferating potential of A549 cells after treatment with deoxyelephantopin were examined by colony formation assay. Cellular morphology of deoxyelephantopin-treated cells was observed using phase- contrast microscopy. The induction of apoptosis was evaluated using acddine orange and ethidium bromide staining, Hoechst 33342 staining, terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end-labeling (TUNEL) assay, DNA fragmentation analysis and Annexin V-fluorescein isothiocyanate staining by flow cytometry. Activation of caspases was detected using fluorogenic substrate specific to caspases 2, 3, 8 and 9 and flow cytometric analysis. The total cellular DNA content and expression of cleaved poly (ADP-ribose) polymerase was also analyzed. RESULTS: Deoxyelephantopin exhibited cytotoxicity to A549 cells (IC50 = 12.287 μg/mL), however, there was no toxicity towards normal human lymphocytes. Deoxyelephantopin suppressed the colony-forming ability of A549 cells in a dose-dependent manner. Acridine orange, ethidium bromide and Hoechst 33342 staining showed cell shrinkage, chromosomal condensation and nuclear fragmentation, indicating induction of apoptosis. Deoxyelephantopin increased apoptosis of A549 cells, as evidenced by more TUNEL-positive cells. DNA fragmentation and Annexin V staining revealed late-stage apoptotic cell population. Deoxyelephantopin inhibited A549 cell growth by cell cycle arrest at G2/M phase and induced apoptosis through both extrinsic and intrinsic pathways. CONCLUSION: These results suggest that deoxyelephantopin has great potential as a new chemotherapeutic agent to be developed further for the treatment of lung cancer. 展开更多
关键词 herbal medicine lung neoplasms elephantopus scaber deoxyelephantopin APOPTOSIS CASPASES cell line tumor A549 cells
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Phenolic compounds from Elephantopus scaber L.
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作者 Yijie Zhang Ming Bai +2 位作者 Weiyu Zhou Xiaoxiao Huang Shaojiang Song 《Asian Journal of Traditional Medicines》 CAS 2020年第3期121-126,共6页
Eight compounds,(+)-syringaresinol(1),apigenin(2),3,5-dimethoxy-4-hydxyphenylpropanol(3),3,4,5-trimethoxy benzoic acid,(4)ferulaic acid(5),trans-p-hydroxycinnamic methyl ester(6),4-hydroxy-3-methoxybenz-oic acid(7)and... Eight compounds,(+)-syringaresinol(1),apigenin(2),3,5-dimethoxy-4-hydxyphenylpropanol(3),3,4,5-trimethoxy benzoic acid,(4)ferulaic acid(5),trans-p-hydroxycinnamic methyl ester(6),4-hydroxy-3-methoxybenz-oic acid(7)and p-methoxy benzoic acid(8)were isolated from the 70%ethanol extract of the whole herb of Elephantopus scaber L.The structures of all compounds were identified by spectral data analysis.All compounds were obtained for the first time from Elephantopus scaber L.. 展开更多
关键词 elephantopus scaber L. separation and purification structural analysis phenolic compounds
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Research review on the main chemical constituents and pharmacological effects of Elephantopus scaber L.
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作者 Shuhui Dong Ming Bai +1 位作者 Xiaoxiao Huang Shaojiang Song 《Asian Journal of Traditional Medicines》 2019年第4期202-212,共11页
Elephantopus scaber L.belongs to Elephantopus plant of Compositae,is widely used as the common Chinese herbal medicine in folk.Phytochemical investigations of the E.scaber have resulted in the isolation of triterpenno... Elephantopus scaber L.belongs to Elephantopus plant of Compositae,is widely used as the common Chinese herbal medicine in folk.Phytochemical investigations of the E.scaber have resulted in the isolation of triterpennoids,sesquiterpene lactones,sesquiterpene phenols,steroids,flavones,anthraquinones,peptides,lipid compounds and aryl compounds.It possesses the effects of antibacterial,clearing away heat and detoxification,detumescence and diuresis,and is used for treating lung cancer,cervical cancer,liver cancer,nasopharyngeal cancer,breast cancer,anemia and diarrhea.The research progress in the chemical constituents ofE scaber and pharmacological effects are reviewed for better explore and utilize theE scaber resource. 展开更多
关键词 elephantopus scaber L. CHEMICAL COMPOSITIONS PHARMACOLOGICAL EFFECTS research REVIEW
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Virtual screening of active ingredients,potential targets and pathways from Elephantopus scaber L.against liver cancer based on network pharmacology
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作者 Shuhui Dong Ming Bai +1 位作者 Xiaoxiao Huang Shaojiang Song 《Asian Journal of Traditional Medicines》 2019年第6期260-267,共8页
Elephantopus scaber L.,belonging to Elephantopus plant of Compositae,is widely used as the common Chinese herbal medicine in folk.According to the phytochemical investigations,E.scaber is used to treat several cancers... Elephantopus scaber L.,belonging to Elephantopus plant of Compositae,is widely used as the common Chinese herbal medicine in folk.According to the phytochemical investigations,E.scaber is used to treat several cancers,anemia and diarrhea on account of the property of the complex components and multi-targets.However,the underlying molecular mechanisms of herb remain unclear.In this report,network pharmacology method is used to analyze the relation among the small-molecule compounds of E.scaber,target proteins,biological pathways and liver cancer.The potential active compounds from the E.scaber,potential target proteins and the key pathways were predicted by network pharmacology models.We believe that our present study is useful to find novel lead compounds for liver cancer. 展开更多
关键词 elephantopus scaber L. network pharmacology liver cancer
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基于网络药理学和分子对接技术探究地胆草治疗溃疡性结肠炎的作用机制
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作者 慕娜娜 廖彬彬 +4 位作者 李镇 李吉品 李伊花 王莹 陈旭冰 《山东科学》 CAS 2023年第6期48-55,共8页
基于网络药理学和分子对接技术,研究地胆草治疗溃疡性结肠炎(ulcerative colitis,UC)的分子机制。根据文献调研确定地胆草的化学成分,利用SwissADME数据库筛选活性成分、SwissTargetPrediction数据库预测其作用靶点。通过GeneCards、Dis... 基于网络药理学和分子对接技术,研究地胆草治疗溃疡性结肠炎(ulcerative colitis,UC)的分子机制。根据文献调研确定地胆草的化学成分,利用SwissADME数据库筛选活性成分、SwissTargetPrediction数据库预测其作用靶点。通过GeneCards、Disgenet、PharmGKB和TTD数据库获取UC的相关靶点,并进行拓扑分析,采用Metascape数据库对候选靶点进行GO(gene ontology)功能和KEGG(Kyoto encyclopedia of genes and genomes)生物通路富集分析,最后结合RCSB PDB数据库及Chemdraw、PyMoL、AutoDock 4.2.6对核心成分和关键靶点进行分子对接验证并进行可视化分析。从地胆草中筛选出34个调控UC的潜在靶点,对关键靶点作GO功能和KEGG通路富集分析,显示地胆草可能通过对系统过程的调节、外部刺激反应的负面调节、凋亡信号通路的调节以及机械刺激的反应等生物学过程调节MAPK3、PIK3CA、STAT3和JAK2等关键靶点的表达,从而参与调控癌症信号通路、PI3K-Akt信号通路、NF-κB信号通路、幽门螺旋杆菌感染的上皮细胞信号传导和钙信号传导通路等多个KEGG信号通路,从而达到治疗UC的目的。分子对接结果显示,各活性成分与关键靶点的亲和力较好。研究认为地胆草治疗UC的作用机制可能与抑制MAPK3、PIK3CA、STAT3等靶点的表达,缓解结肠组织炎症反应有关。 展开更多
关键词 地胆草 溃疡性结肠炎 网络药理学 分子对接
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UPLC-MS/MS同时测定地胆草中黄酮类成分含量
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作者 雒江菡 《化学工程师》 CAS 2023年第11期16-20,共5页
地胆草中黄酮成分经乙醇溶液提取后,通过大孔树脂纯化,以Waters BEH C18柱分离。以1%甲酸的水溶液和1%甲酸的乙腈溶液为流动相,流速为0.2m L·min^(-1),柱温为30℃,进样体积为1μL。采用UPLC/MS/MS电喷雾电离,多反应监测模式检测,... 地胆草中黄酮成分经乙醇溶液提取后,通过大孔树脂纯化,以Waters BEH C18柱分离。以1%甲酸的水溶液和1%甲酸的乙腈溶液为流动相,流速为0.2m L·min^(-1),柱温为30℃,进样体积为1μL。采用UPLC/MS/MS电喷雾电离,多反应监测模式检测,以保留时间和子离子比定性,外标法定量。在该色谱条件下,地胆草中的5种黄酮类成分能得到较好的分离并检测。结果表明,地胆草中木犀草素平均含量为8.75g·kg^(^(-1)),山奈酚平均含量为0.86g·kg^(-1),儿茶素平均含量为4.29g·kg^(-1),芹菜素平均含量为2.43g·kg^(-1),芦丁平均含量为10.71g·kg^(-1)。地胆草中黄酮类化合物种类丰富,含量较高,该研究为地胆草黄酮类化合物的含量测定及中草药地胆草的进一步开发应用提供理论依据。 展开更多
关键词 地胆草 黄酮类化合物 超高效液相色谱串联质谱 含量测定
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地胆草化学成分的研究 被引量:16
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作者 黄婷 吴霞 +2 位作者 王英 叶文才 李药兰 《暨南大学学报(自然科学与医学版)》 CAS CSCD 北大核心 2009年第5期553-555,共3页
采用硅胶、葡聚糖凝胶SephadexLH-20和十八烷基硅烷键合硅胶(ODS)等多种色谱技术,对地胆草根部的化学成分进行分离纯化,从地胆草醇提物的乙酸乙酯萃取部位中分离了9个化合物,通过理化性质和波谱数据鉴定化合物1-9的化学结构分别为:大黄... 采用硅胶、葡聚糖凝胶SephadexLH-20和十八烷基硅烷键合硅胶(ODS)等多种色谱技术,对地胆草根部的化学成分进行分离纯化,从地胆草醇提物的乙酸乙酯萃取部位中分离了9个化合物,通过理化性质和波谱数据鉴定化合物1-9的化学结构分别为:大黄素甲醚(1),异香草酸(2),香豆酸(3),对羟基苯甲酸(4),阿魏酸(5),3-甲氧基-4-羟基-桂皮醛(6),豆甾醇-3-O-β-D-葡萄糖(7),豆甾醇(8),吲唑(9).化合物1、2、4、5、6、9为首次从该种植物中分离得到,其中化合物9为一新的天然产物. 展开更多
关键词 地胆草 化学成分 酚类化合物 吲唑
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地胆草三萜成分的研究 被引量:28
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作者 梁侨丽 龚祝南 闵知大 《中国药学杂志》 CAS CSCD 北大核心 2007年第7期494-496,共3页
目的分离鉴定地胆草的化学成分,为PC-12细胞活性筛选提供样品。方法用体积分数80%工业酒精提取,硅胶柱色谱分离纯化,根据理化性质和光谱分析确定结构。结果分得8个三萜类成分,分别为无羁萜酮(friedlin,E-6),表无羁萜醇(epifriedlinol,E-... 目的分离鉴定地胆草的化学成分,为PC-12细胞活性筛选提供样品。方法用体积分数80%工业酒精提取,硅胶柱色谱分离纯化,根据理化性质和光谱分析确定结构。结果分得8个三萜类成分,分别为无羁萜酮(friedlin,E-6),表无羁萜醇(epifriedlinol,E-7),羽扇豆醇(lupeol,E-8),羽扇豆醇乙酸酯(lupeol acetate,E-9),乌苏酸(ursolic acid,E-10),乌苏-12-烯-3β-十七酸酯(ursa-12-ene-3β-heptadecanoate,E-11),桦木酸(betulinic acid,E-12),30-羟基羽扇豆醇(30-hydroxylupeol,E-13)。结论化合物E-11为一个新的天然产物;化合物E-6,E-10,E-12,E-13为首次从该属植物中得到。 展开更多
关键词 地胆草 三萜 乌苏酸 桦木酸
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地胆草倍半萜内酯化合物体外抗肿瘤作用的研究 被引量:24
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作者 梁侨丽 龚祝南 +1 位作者 绪广林 赵烨 《天然产物研究与开发》 CAS CSCD 2008年第3期436-439,共4页
采用四甲基偶氮唑盐比色法和琼脂糖凝胶电泳法等研究地胆草倍半萜内酯化合物scabertopin(1)和isodeoxyelephantopin(2)在体外对SMMC-7721、Hela和Caco-2三种肿瘤细胞增殖的影响。发现这两个化合物在1~100 μM浓度内对三种肿瘤细胞... 采用四甲基偶氮唑盐比色法和琼脂糖凝胶电泳法等研究地胆草倍半萜内酯化合物scabertopin(1)和isodeoxyelephantopin(2)在体外对SMMC-7721、Hela和Caco-2三种肿瘤细胞增殖的影响。发现这两个化合物在1~100 μM浓度内对三种肿瘤细胞增殖有显著的抑制作用,且呈一定剂量依赖关系。二者抑制SMMC-7721细胞增殖的IC50值分别为29.27和9.54 μM;抑制Hela细胞增殖的IC50值分别为22.19和25.39 μM;抑制Caco-2细胞增殖的IC50值分别为35.99和25.76 μM。时效性实验还显示2对Hela细胞增殖的抑制作用呈时间依赖关系。2浓度 100 μM作用Hela细胞48 h琼脂糖凝胶电泳显示明显的细胞凋亡“梯状”条带(DNA ladder),提示isodeoxyelephantopin抑制Hela细胞作用是通过诱导其凋亡。 展开更多
关键词 地胆草 倍半萜内酯化合物 肿瘤细胞 凋亡
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地胆草的化学成分研究 被引量:16
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作者 郭妍 陈晨 +2 位作者 高纯 袁丹 付宏征 《天然产物研究与开发》 CAS CSCD 北大核心 2016年第7期1051-1054,共4页
对地胆草全草的化学成分进行研究。采用硅胶柱色谱、SephadexLH-20以及半制备型高效液相色谱技术进行分离纯化,通过1D、2DNMR,MS等方法鉴定化合物的结构。结果从地胆草95%乙醇提取物中分离并鉴定了9个化合物,分别为1-[(2R*,3.S... 对地胆草全草的化学成分进行研究。采用硅胶柱色谱、SephadexLH-20以及半制备型高效液相色谱技术进行分离纯化,通过1D、2DNMR,MS等方法鉴定化合物的结构。结果从地胆草95%乙醇提取物中分离并鉴定了9个化合物,分别为1-[(2R*,3.S*)-3-ethoxy-2,3-dihydro-6-hydroxy-2一(1-methylethenyl)-1-benzofuran-5-y1]ethanone(1)、7-hydroxy-6.acetyl-2.methylchromone(2)、matriisobenzofrrran(3)、桦木酸(betulinicacid,4)、木犀草素(1uteolin,S)、木犀草素-7-D-β-D-葡萄糖苷(1uteolin-7-01B-D—ghcoside,6)、对香豆酸(P-coumaricacid,7)、3,4-二羟基苯甲醛(3,4-dihydroxybenzaldehyde,8)、豆甾醇-3-O-β-D-葡萄糖苷(stigmasterol-3-O-β-D—ghcoside,9)。其中化合物1—3均为首次从该属植物中分离得到,化合物3在国内未见从其它植物中分离报道。 展开更多
关键词 菊科 地胆草 化学成分 结构鉴定
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遮光与定植方式对地胆草生长及产量的影响 被引量:7
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作者 郑定华 谢学方 +3 位作者 高宏华 余树华 范高俊 张以山 《中药材》 CAS CSCD 北大核心 2015年第3期433-437,共5页
目的:了解地胆草在不同光照条件下的生长与产量表现,为地胆草的人工种植提供参考。方法:以全光照的露地栽培为对照,对遮光率分别为42%、50%、60%、69%、85%的遮光处理下穴播、苗植两种方式种植的地胆草生长状况及产量进行了研究。结... 目的:了解地胆草在不同光照条件下的生长与产量表现,为地胆草的人工种植提供参考。方法:以全光照的露地栽培为对照,对遮光率分别为42%、50%、60%、69%、85%的遮光处理下穴播、苗植两种方式种植的地胆草生长状况及产量进行了研究。结果:适度遮光促进地胆草株高、叶片数、根系长度的增加并提高根冠比;随遮光率的增加,地胆草由定植到抽薹盛期、开花盛期所需时间减少;单位面积地胆草种子产量、全草产量、根头产量均为全光照的最高,并随遮光率增加而下降,各处理单位面积种子产量在8.46-31.10 kg/667 m^2之间,全草干品产量在327.28-800.95 kg/667 m^2之间,根头干品产量在30.65-70.72 kg/667 m^2之间。结论:地胆草对光照的适应能力较强,属偏喜阳,但可耐受较大程度的荫蔽;人工种植地胆草以穴播方式为好,在热带经济林下间种建议荫蔽度不超过60%为宜。 展开更多
关键词 地胆草 遮光处理 定植方式 主要性状 产量
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地胆草与白花地胆草脂溶性成分的GC-MS分析及抑菌活性研究 被引量:6
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作者 王蓓 梅文莉 +3 位作者 左文健 曾艳波 刘国道 戴好富 《天然产物研究与开发》 CAS CSCD 北大核心 2012年第B12期23-27,共5页
采用溶剂萃取法提取地胆草(Elephantopusscaber Linn.)和白花地胆草(Elephantopustomentosus Linn.)的脂溶性成分,经GC-MS分析,从地胆草中鉴定出44种化学成分,占总脂溶性成分的93.72%;从白花地胆草中鉴定出25种化学成分,占总脂溶性成分... 采用溶剂萃取法提取地胆草(Elephantopusscaber Linn.)和白花地胆草(Elephantopustomentosus Linn.)的脂溶性成分,经GC-MS分析,从地胆草中鉴定出44种化学成分,占总脂溶性成分的93.72%;从白花地胆草中鉴定出25种化学成分,占总脂溶性成分的82.08%。地胆草和白花地胆草在萜类成分含量具有显著性差异。通过滤纸片琼脂扩散法测试其抗菌活性,结果表明地胆草与白花地胆草的脂溶性成分对耐甲氧西林金黄色葡萄球菌(MRSA)和金黄色葡萄球菌均有抑制活性,且白花地胆草的抑菌活性强于地胆草。 展开更多
关键词 地胆草 白花地胆草 GC-MS 脂溶性成分 抑菌活性
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地胆草中的两个寡肽 被引量:20
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作者 梁侨丽 闵知大 成亮 《中国药科大学学报》 CAS CSCD 北大核心 2002年第3期178-180,共3页
目的 对地胆草的化学成分进行研究。方法 通过理化性质和波谱分析方法对结构进行鉴定并通过二维核磁共振技术 (1H 1HCOSY ,HMQC ,HMBC)对aurantiamideacetate的所有氢和碳的核磁共振化学位移进行了归属。结果 从地胆草中首次分得两... 目的 对地胆草的化学成分进行研究。方法 通过理化性质和波谱分析方法对结构进行鉴定并通过二维核磁共振技术 (1H 1HCOSY ,HMQC ,HMBC)对aurantiamideacetate的所有氢和碳的核磁共振化学位移进行了归属。结果 从地胆草中首次分得两个二肽衍生物。结论 鉴定其结构分别为 :N (N1 benzoyl S phenylalani lyl) S phenylalaninol (aurantiamide)及其乙酸酯 (aurantiamideacetate)。 展开更多
关键词 地胆草 二肽 aurantiamide aurantiamide ACETATE 化学成分
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地胆头化学成分及其生理活性的研究 被引量:8
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作者 范琼 邓爱妮 +3 位作者 朱玉龙 周聪 赵敏 叶海辉 《热带作物学报》 CSCD 北大核心 2017年第6期1138-1142,共5页
研究地胆头提取液中总多酚和类黄酮含量及其生理活性。测定了不同地胆头提取液的总多酚含量、类黄酮含量及其清除DPPH自由基的能力,并比较了不同料液比的地胆头提取液对血管紧张素转化酶(ACE)的抑制率。结果表明:不同提取剂提取的地胆... 研究地胆头提取液中总多酚和类黄酮含量及其生理活性。测定了不同地胆头提取液的总多酚含量、类黄酮含量及其清除DPPH自由基的能力,并比较了不同料液比的地胆头提取液对血管紧张素转化酶(ACE)的抑制率。结果表明:不同提取剂提取的地胆头总多酚和类黄酮含量不同,其中,丙酮提取液中总多酚和类黄酮含量分别为12.27 mg/g、7.50 mg/g,均高于乙醇、甲醇、水提取液中的总多酚和类黄酮含量;地胆头丙酮、甲醇、乙醇提取液对DPPH自由基的清除率分别为94.60%、93.41%、90.87%,均高于人工合成氧化剂BHT(89.15%)和地胆头水提取液(62.75%);地胆头提取液对ACE的抑制效果随着料液比的增加而越明显,其中,1∶10的料液比下,乙醇地胆头提取液对ACE抑制率达到96.67%。通过本研究得出,在地胆头乙醇、甲醇、水、丙酮4种提取液中,丙酮提取液的总多酚和类黄酮含量最高,且其抗氧化性效果最佳,乙醇地胆头提取液的抗高血压能力最强。地胆头提取液具有明显的抗氧化性和抗高血压等生理活性,在功能食品及中草药领域里具有良好的开发应用前景。 展开更多
关键词 地胆头 化学成分 生物活性 抗氧化性 抗高血压
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遮光对地胆草根系浸出物及黄酮和灰分含量影响研究初报 被引量:2
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作者 郑定华 袁淑娜 +4 位作者 陈俊明 李娟 黄坚雄 潘剑 周立军 《热带作物学报》 CSCD 北大核心 2016年第1期15-19,共5页
为初步了解不同遮光强度对地胆草根系品质的影响,对采收自5种不同遮光栽培处理下地胆草根系的浸出物、黄酮及灰分含量进行比较研究。结果表明,3种类型的地胆草根系浸出物得率为:水溶性浸出物>醇溶性浸出物>乙醚浸出物,其中,水热... 为初步了解不同遮光强度对地胆草根系品质的影响,对采收自5种不同遮光栽培处理下地胆草根系的浸出物、黄酮及灰分含量进行比较研究。结果表明,3种类型的地胆草根系浸出物得率为:水溶性浸出物>醇溶性浸出物>乙醚浸出物,其中,水热浸法得率、水冷浸法得率与遮光率间的相关性均不显著,醇热浸法得率、醇冷浸法得率与遮光率间均呈极显著(p<0.01)负相关,乙醚浸出物得率与遮光率间也呈显著负相关(p<0.05),而根系黄酮、粗灰分、酸不溶性灰分含量与遮光率间的相关性均不显著。初步认为,生长环境的遮光强度会对地胆草根系的品质产生影响,高遮光率可能有利于地胆草根系水溶性浸出物的获得,而不利于醇溶性浸出物及乙醚浸出物的累积,但遮光率对地胆草根系黄酮含量及粗灰分、酸不溶性灰分含量的影响相对较小。 展开更多
关键词 遮光率 地胆草 根系 浸出物 黄酮 灰分
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地胆头提取物的急性和亚急性毒性研究 被引量:3
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作者 林红英 陈进军 +1 位作者 吴秋霞 陈惠湘 《动物医学进展》 CSCD 2005年第11期69-71,共3页
采用650 mL/L乙醇热回流浸提结合冰冻干燥法,制备了地胆头提取物。分别给昆明种雄性小鼠腹腔注射不同剂量的地胆头提取物,研究该提取物对小鼠的急性毒性和亚急性毒性试验。结果表明,地胆头提取物对供试小鼠腹腔注射的LD50为2 123.24mg/k... 采用650 mL/L乙醇热回流浸提结合冰冻干燥法,制备了地胆头提取物。分别给昆明种雄性小鼠腹腔注射不同剂量的地胆头提取物,研究该提取物对小鼠的急性毒性和亚急性毒性试验。结果表明,地胆头提取物对供试小鼠腹腔注射的LD50为2 123.24mg/kg,95%可信限为1 742.86 mg/kg^2 503.62 mg/kg,地胆头提取物对供试小鼠属于低毒。亚急性毒性试验结果表明,地胆头提取物未引起供试小鼠临床表现和体重异常,未引起心、肺和肾等脏器的病理变化,但高剂量的地胆头提取物能够导致肝脏中央静脉轻度充血。 展开更多
关键词 地胆头提取物 急性毒性 亚急性毒 小鼠
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