Elephantopus tomentosus,belonging to the genus Elephantopus,is widely distributed in the coastal areas of southern China and tropical regions,used locally as traditional folk medicine.Previous phytochemistry studies o...Elephantopus tomentosus,belonging to the genus Elephantopus,is widely distributed in the coastal areas of southern China and tropical regions,used locally as traditional folk medicine.Previous phytochemistry studies on Elephantopus tomentosus led to the isolation of sesquiterpenoids,triterpenoids,flavonoids and other compounds.Research has shown that these compounds possess multiple biological activities,which have attracted great attention of researchers worldwide.This study reviews the chemical constituents and biological activities of the Elephantopus tomentosus in order to better explore and utilize Elephantopus tomentosus.展开更多
Liver cancer is the leading cause of cancer-related death.As the clinical treatment for this disease is not satisfactory,it is urgent to discover new medications to treat liver cancer.Elephantopus tomentosus L.is a tr...Liver cancer is the leading cause of cancer-related death.As the clinical treatment for this disease is not satisfactory,it is urgent to discover new medications to treat liver cancer.Elephantopus tomentosus L.is a traditional whole grass herb,which contains sesquiterpene lactones,triterpenoids,aldehyde caffeic with good anti-tumor effect.In this study,molecular docking and network analysis were carried out to identify the active compounds,and predict the potential targets of E.tomentosus for the treatment of liver cancer.These attempts may provide insights for finding novel lead compounds for the treatment of liver cancer.展开更多
Phytochemical investigation on the whole plant of Elephantopus tomentosus Linn. led to the isolation of two new sesquiterpene lactones, tomenphantopin E （1） and tomenphantopin F （2）. The new compounds were complet...Phytochemical investigation on the whole plant of Elephantopus tomentosus Linn. led to the isolation of two new sesquiterpene lactones, tomenphantopin E （1） and tomenphantopin F （2）. The new compounds were completely elucidated using a combination of 1D, 2D NMR technique （COSY, HSQC, HMBC and NOSEY）, and HREIMS analysis.展开更多
文摘Elephantopus tomentosus,belonging to the genus Elephantopus,is widely distributed in the coastal areas of southern China and tropical regions,used locally as traditional folk medicine.Previous phytochemistry studies on Elephantopus tomentosus led to the isolation of sesquiterpenoids,triterpenoids,flavonoids and other compounds.Research has shown that these compounds possess multiple biological activities,which have attracted great attention of researchers worldwide.This study reviews the chemical constituents and biological activities of the Elephantopus tomentosus in order to better explore and utilize Elephantopus tomentosus.
基金This work was supported by the National Natural Science Foundation of China(82104037)Project funded by China Postdoctoral Science Foundation(2020M680987)the Scientific Research Fund Project of Liaoning Provincial Department of Education(LJKZ0937).
文摘Liver cancer is the leading cause of cancer-related death.As the clinical treatment for this disease is not satisfactory,it is urgent to discover new medications to treat liver cancer.Elephantopus tomentosus L.is a traditional whole grass herb,which contains sesquiterpene lactones,triterpenoids,aldehyde caffeic with good anti-tumor effect.In this study,molecular docking and network analysis were carried out to identify the active compounds,and predict the potential targets of E.tomentosus for the treatment of liver cancer.These attempts may provide insights for finding novel lead compounds for the treatment of liver cancer.
文摘Phytochemical investigation on the whole plant of Elephantopus tomentosus Linn. led to the isolation of two new sesquiterpene lactones, tomenphantopin E （1） and tomenphantopin F （2）. The new compounds were completely elucidated using a combination of 1D, 2D NMR technique （COSY, HSQC, HMBC and NOSEY）, and HREIMS analysis.
