EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine tar...EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.展开更多
Robust-by-design(RbD)is a design strategy that uses adversary emulation to strengthen the security of an information and communication infrastructure.It relies on two key components:the security twin and the threat ac...Robust-by-design(RbD)is a design strategy that uses adversary emulation to strengthen the security of an information and communication infrastructure.It relies on two key components:the security twin and the threat actor twins.The security twin is a detailed database that outlines the different parts of the infrastructure,how they are connected,and their vulnerabilities.It also highlights the types of attacks each part could enable.On the other hand,the twin of a threat actor describes its potential attack surface,the attacks it can carry out,its strategy,and its ultimate goal,if any.This information comes from threat intelligence.RbD conducts independent simulations of various threat actors against the security twin to identify all possible attack paths they could exploit.Three types of analysis use this information to improve the robustness and resilience of the infrastructure.The first analysis fills in the gaps in threat intelligence by extending in-formation on threat actors and vulnerabilities.The second analysis focuses on selecting countermeasures aimed at eliminating attack paths or at least reducing their chances of success.Possible countermeasures include patching vulnerabilities,adjusting firewall rules,and implementing network segmentation.Information on attack paths guides the choice and configuration of these countermeasures.Once the infrastructure twin is updated to reflect countermeasure deployment,RbD performs further simulations to uncover any new attack paths that could be exploited and to identify additional coun-termeasures.The final analysis seeks to address the risks associated with any remaining unaddressed attack paths.展开更多
Based on the research on the solidification of twin-roll continuous casting aluminum thin strip, the analytical model of heterogeneous nucleation, the growth kinetics of tip （KGT） and columnar dendrite transformatio...Based on the research on the solidification of twin-roll continuous casting aluminum thin strip, the analytical model of heterogeneous nucleation, the growth kinetics of tip （KGT） and columnar dendrite transformation to equiaxed dendrite （CET） of twin-roll continuous casting aluminum thin strip solidification was established by means of the principle of metal solidification and modem computer emulational technology. Meantime, based on the cellular automaton, the emulational model of twin-roll continuous casting aluminum thin strip, solidification was established. The foundation for the emulational simulation of twin-roll casting thin strip solidification structure was laid. Meanwhile, the mathematical simulation feasibility was confirmed by using the solidification process of twin-roll continuous casting aluminum thin strip.展开更多
eMule是建立在点对点(peer to peer)技术上,以eDonkey协议为基础的文件共享软件。eMule的集中程度是混合性的,并非是完全无中心服务器。文章从协议的角度论述了eMule是如何实现文件共享,分析了客户端到服务器端、客户端到客户端之间的TC...eMule是建立在点对点(peer to peer)技术上,以eDonkey协议为基础的文件共享软件。eMule的集中程度是混合性的,并非是完全无中心服务器。文章从协议的角度论述了eMule是如何实现文件共享,分析了客户端到服务器端、客户端到客户端之间的TCP通讯、UDP通讯的原理及相关的信息序列图。展开更多
A dynamic marine propeller simulation system was developed, which is utilized for meeting the experimental requirement of theory research and engineering design of marine electric propulsion system. By applying an act...A dynamic marine propeller simulation system was developed, which is utilized for meeting the experimental requirement of theory research and engineering design of marine electric propulsion system. By applying an actual ship parameter and its accurate propeller J＇ -KT＇ and J＇ - Kp＇ curve data, functional experiments based on the simulation system were carried out. The experiment results showed that the system can correctly emulate the propeller characteristics, produce the dynamic and steady performances of the propeller under different navigation modes, and present actual load torque for electric propulsion motor.展开更多
文摘EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.
文摘Robust-by-design(RbD)is a design strategy that uses adversary emulation to strengthen the security of an information and communication infrastructure.It relies on two key components:the security twin and the threat actor twins.The security twin is a detailed database that outlines the different parts of the infrastructure,how they are connected,and their vulnerabilities.It also highlights the types of attacks each part could enable.On the other hand,the twin of a threat actor describes its potential attack surface,the attacks it can carry out,its strategy,and its ultimate goal,if any.This information comes from threat intelligence.RbD conducts independent simulations of various threat actors against the security twin to identify all possible attack paths they could exploit.Three types of analysis use this information to improve the robustness and resilience of the infrastructure.The first analysis fills in the gaps in threat intelligence by extending in-formation on threat actors and vulnerabilities.The second analysis focuses on selecting countermeasures aimed at eliminating attack paths or at least reducing their chances of success.Possible countermeasures include patching vulnerabilities,adjusting firewall rules,and implementing network segmentation.Information on attack paths guides the choice and configuration of these countermeasures.Once the infrastructure twin is updated to reflect countermeasure deployment,RbD performs further simulations to uncover any new attack paths that could be exploited and to identify additional coun-termeasures.The final analysis seeks to address the risks associated with any remaining unaddressed attack paths.
基金Project (u0837601) supported by the New Joint Fund of National Natural Science Foundation of ChinaProject (50874054) supported by the National Natural Science Foundation of China
文摘Based on the research on the solidification of twin-roll continuous casting aluminum thin strip, the analytical model of heterogeneous nucleation, the growth kinetics of tip （KGT） and columnar dendrite transformation to equiaxed dendrite （CET） of twin-roll continuous casting aluminum thin strip solidification was established by means of the principle of metal solidification and modem computer emulational technology. Meantime, based on the cellular automaton, the emulational model of twin-roll continuous casting aluminum thin strip, solidification was established. The foundation for the emulational simulation of twin-roll casting thin strip solidification structure was laid. Meanwhile, the mathematical simulation feasibility was confirmed by using the solidification process of twin-roll continuous casting aluminum thin strip.
文摘eMule是建立在点对点(peer to peer)技术上,以eDonkey协议为基础的文件共享软件。eMule的集中程度是混合性的,并非是完全无中心服务器。文章从协议的角度论述了eMule是如何实现文件共享,分析了客户端到服务器端、客户端到客户端之间的TCP通讯、UDP通讯的原理及相关的信息序列图。
基金supported by the Fund of Shanghai Committee of Science and Technology(Grant No.11170501700)the International Cooperation and Exchange Projects of the Ministry of Science and Technology(Grant No.2012DFG71850)
文摘A dynamic marine propeller simulation system was developed, which is utilized for meeting the experimental requirement of theory research and engineering design of marine electric propulsion system. By applying an actual ship parameter and its accurate propeller J＇ -KT＇ and J＇ - Kp＇ curve data, functional experiments based on the simulation system were carried out. The experiment results showed that the system can correctly emulate the propeller characteristics, produce the dynamic and steady performances of the propeller under different navigation modes, and present actual load torque for electric propulsion motor.
