Analyzing the Revitalization Strategies of Historical Fabric with the Approach of Endogenous Development Case Study (1, 2 &3 Regional of Zahedan City)

Internal development is applying of all the power and existing potential and actual capacities in the city to achieve sustainable and urban participation, and improves all social, physical, economic, and political structures to achieve a sustainable quality and quantity equilibrium. The policy of urban development in the world is to improve the productivity and optimization of land use and the possibility of infill development and improving access of city distressed fabric habitants to urban and social services. In this regard, the present study of Analysis of vitalization strategies of historical fabric with the approach of endogenous development Case study (1, 2 & 3 regional of Zahedan city). The research method is analytic-descriptive and based on library, documentary and field studies and VIKOR model has been also used for data analysis. Based on the results of VIKOR model, the 3 regional of Zahedan city with score 3 and the region 1 with a score of 0.436 were located on the highest and lowest rank. At the end, we suggested strategies according of the research result.

Commentary on “Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis”

This report,"Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis" by Li et al. is an important step forward in describing the factors that control tooth development in a large animal model. That many of the regulatory miRNA pathways have been elucidated in murine species have always begged the question as to how relevant they

An auxin‐responsive endogenous peptide regulates root development in Arabidopsis

Auxin plays critical roles in root formation and development. The components involved in this process, however, are not well understood. Here, we newly identified a peptide encoding gene, auxin-responsive endogenous polypeptide 1 （AREP1）, which is induced by auxin, and mediates root development in Arabidopsis. Expression of AREP1 was specific to the cotyledon and to root and shoot meristem tissues. Amounts of AREP1 transcripts and AREP1-green fluorescent protein fusion proteins were elevated in response to indoleacetic acid treatment. Suppression of AREP1 through RNAi silencing resulted in reduction of primary root length, increase of lateral root number, and expansion of adventitious roots, compared to the observations in wild-type plants in the presence of auxin. By contrast, transgenic plants overexpressing AREP1 showed enhanced growth of the primary root under auxin treatment. Additionally, rootmorphology, including lateral root number and adventitious roots, differed greatly between transgenic and wildtype plants. Further analysis indicated that the expression of auxin-responsive genes, such as IAA3, IAA7, IAA17, GH3.2, GH3.3, and SAUR-AC1, was significantly higher in AREP1 RNAi plants, and was slightly lower in AREP1 overexpressing plants than in wildtype plants. These results suggest that the novel endogenous peptide AREP1 plays an important role in the process of auxinmediated root development.

Novel Tuning Buttons in Tomato Fruit Ripening:miRNAs and siRNAs

Tomato has emerged as an emblematic model plants for fleshy fruit research and tomato fruit ripening is a complex and highly coordinated developmental process.The many physiology and biochemical processes associated with tomato fruit ripening require changes in the expression of hundreds to thousands of genes.Gene expression is regulated by transcriptional and post-transcriptional pathways,one of the recently discovered mechanisms in plants was small RNAs mediated gene silencing at post-transcriptional(PTGS) level.Intriguingly,several mi RNAs and endogenous si RNAs were revealed to be involved in the fruit ripening process which opened a new avenue in the field of fleshy fruit biology.This review compiled the most recent advances made in deciphering the regulation functions of mi RNAs and si RNAs in tomato fruit ripening.It also emphasized the new perspectives now possible in the small RNAs regulation research in tomato fruit ripening and senescence.

Decoding early myelopoiesis from dynamics of core endogenous network

A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network perspective. Indeed, there are numerical difficulties even for those who were determined to explore along this direction. Undeterred, seven years ago a group of Chinese scientists started a program aiming to obtain quantitative connections between tumors and network dynamics. Many interesting results have been obtained. In this paper we wish to test such idea from a different angle: the connection between a normal biological process and the network dynamics. We have taken early myelopoiesis as our biological model. A standard roadmap for the cell-fate diversification during hematopoiesis has already been well established experimentally, yet little was known for its underpinning dynamical mechanisms. Compounding this difficulty there were additional experimental challenges, such as the seemingly conflicting hematopoietic roadmaps and the cell-fate inter-conversion events. With early myeloid cell-fate determination in mind, we constructed a core molecular endogenous network from well-documented gene regulation and signal transduction knowledge. Turning the network into a set of dynamical equations, we found computationally several structurally robust states. Those states nicely correspond to known cell phenotypes. We also found the states connecting those stable states.They reveal the developmental routes—how one stable state would most likely turn into another stable state. Such interconnected network among stable states enabled a natural organization of cell-fates into a multi-stable state landscape. Accordingly, both the myeloid cell phenotypes and the standard roadmap were explained mechanistically in a straightforward manner. Furthermore,recent challenging observations were also explained naturally. Moreover, the landscape visually enables a prediction of a pool of additional cell states and developmental routes, including the non-sequential and cross-branch transitions, which are testable by future experiments. In summary, the endogenous network dynamics provide an integrated quantitative framework to understand the heterogeneity and lineage commitment in myeloid progenitors.

The Chinese Path to Rural Common Prosperity:Based on an Analysis of Jiangsu and Zhejiang Rural Demonstration Projects

Common prosperity in rural areas is integral to achieving common prosperity.This paper makes an in-depth analysis of Jiangsu and Zhejiang rural demonstration projects from a state-society interaction perspective.Pathway analysis is based on the framework of“high-level promotion-endogenous development”linked by the advancement of the building of the Communist Party of China and the Party’s leading role:high-level promotion,through multi-level responsibilization,ensures policy implementation,while endogenous development,driven by endogenous breakthroughs and economies of scale brought about by industrial integration,generates explosive dynamics through common interest bonding.By linking high-level promotion with endogenous development,the advancement of Party building and the Party’s leading role ensure benign interaction between state and society.The combined efforts of state and society creates a“common prosperity effect,”effectively solving the thorny problem of“weak society”in the welfare system of developing countries and that of the“welfare trap”in the welfare system of welfare states.This,in a sense,enables China to embark on the road to rural common prosperity.