Objective: To study the epidemiological, histological and therapeutic characteristics of endometrial cancer in the Gynecology-Obstetrics department of the Donka National Hospital, CHU of Conakry. Methods: We conducted...Objective: To study the epidemiological, histological and therapeutic characteristics of endometrial cancer in the Gynecology-Obstetrics department of the Donka National Hospital, CHU of Conakry. Methods: We conducted a retrospective descriptive study of 86 patients with endometrial cancer treated in the Gynecology-Obstetrics department of the Donka National Hospital from January 1, 2011, to December 31, 2021, based on their medical records. We analysed the epidemiological, histological and therapeutic aspects of the disease. Results: Endometrial cancer accounted for 3.1% of the 2793 gynecological pathology cases registered in the department during the study period, ranking third. The mean age of the patients was 63 ± 5 years. Most of them were uneducated (59.3%), postmenopausal (91.9%), nulliparous (30.2%), obese (65.1%) and hypertensive (77.1%). More than half of the patients (53.4%) were diagnosed at stage I. Endometrioid adenocarcinoma was the predominant histological type (68.6%). Surgery was performed in 96.6% of the patients, and chemotherapy in 14.0%. After a mean follow-up of 15 months, 84.5% of the patients were alive. Conclusion: Endometrial cancer is a common gynecological malignancy in our department. Endometrioid adenocarcinoma is the most frequent histological subtype. Surgery is the main treatment modality.展开更多
The human endometrial adenocarcinoma cell liueIskikawa cells suspended either in Matrigel or MEM buffer medium were injected subcutaneously to nude mice (N=10 mice/group);and the fresh human cervical cancer tissues ob...The human endometrial adenocarcinoma cell liueIskikawa cells suspended either in Matrigel or MEM buffer medium were injected subcutaneously to nude mice (N=10 mice/group);and the fresh human cervical cancer tissues obtained directly from the surgery were coated by Matrigel and transplanted into nude mouse. The purpose of these studies were to see if Matrigel could enhance the human uteriue cancers' proliferation and differentiation in vivo.The results showed that when cancer cells or tissues implanted into nude mice in Matrigel, the xenografts could turn out earlier, proliferate faster and kept the original differentiation better.It is suggested that Matrigel is an ideal agent in establishing animal models of human uterine cancer.展开更多
Endometrial cancer (EC) is the most frequent cancer of the female genital tract, especially in developed countries and the seventh most common cause of death from cancer in women in Western Europe. Major prognostic fa...Endometrial cancer (EC) is the most frequent cancer of the female genital tract, especially in developed countries and the seventh most common cause of death from cancer in women in Western Europe. Major prognostic factors related to endometrial cancer are stage, grade, and depth of myometrial invasion and the presences of lymho-vascular space invasion. Standard treatment of EC consist of surgical and then adjuvant therapy on the basis of pathological prognostic factors. Standard surgical approach for stage I-II endomerial cancer is total hysterectomy and bilateral salpingo-oophorectomy with or without staging. Without question a comprehensive surgical staging procedure similar to that for ovarian carcinoma should be performed for non-endometrioid EC (uterine papiller serous carcinoma and clear cell adenocarcinoma) due to the aggressive clinical behavior. In contrast, there are some controversial issues in the surgical management-staging of EC and the role of ommentectomy and lymphadenectomy are the issues of current debate.展开更多
目的分析43例术后病理提示子宫内膜癌患者的病例资料。方法收集并分析43例术前、术后诊断不一致而术后病理提示子宫内膜癌患者的临床病例资料,包括年龄、绝经与否、术前诊断方式、治疗等。结果43例患者平均年龄为56.23岁;绝经20例(46.5...目的分析43例术后病理提示子宫内膜癌患者的病例资料。方法收集并分析43例术前、术后诊断不一致而术后病理提示子宫内膜癌患者的临床病例资料,包括年龄、绝经与否、术前诊断方式、治疗等。结果43例患者平均年龄为56.23岁;绝经20例(46.5%),未绝经23例(53.5%);症状:异常子宫出血33例(76.7%),下腹痛伴或不伴阴道排液5例(11.6%),内膜增厚2例(4.7%),其他3例(7.0%);术前内膜厚度:内膜厚度>4 mm 36例(83.7%),内膜厚度≤4 mm 4例(9.3%),未进行相关检查3例(7.0%);手术方式:全子宫双附件切除术32例(74.4%),全子宫双输卵管切除术3例(7.0%),全子宫切除术4例(9.3%),全子宫双附件切除术+盆腔淋巴结清扫术1例(2.3%),全子宫双附件切除术+盆腔淋巴结腹主动脉旁淋巴结清扫术+大网膜阑尾切除术3例(7.0%);肿瘤分化程度:高分化12例(27.9%),中分化27例(62.8%),低分化4例(9.3%);组织病理学类型:子宫内膜样癌40例(93.0%),非子宫内膜样癌3例(7.0%);特殊病史:乳腺癌病史1例(2.3%),结肠癌病史1例(2.3%),贲门癌及内膜癌家族史1例(2.3%),高血压8例(18.6%),糖尿病4例(9.3%)。14例患者进行术前诊刮术,16例患者进行术前宫腔镜诊刮术,13例患者直接手术,术后3例患者补充手术治疗,9例患者补充放化疗。结论对于有异常子宫出血的围绝经期或绝经后女性,病理提示子宫内膜非典型增生者,仍需警惕子宫内膜癌可能性。展开更多
文摘Objective: To study the epidemiological, histological and therapeutic characteristics of endometrial cancer in the Gynecology-Obstetrics department of the Donka National Hospital, CHU of Conakry. Methods: We conducted a retrospective descriptive study of 86 patients with endometrial cancer treated in the Gynecology-Obstetrics department of the Donka National Hospital from January 1, 2011, to December 31, 2021, based on their medical records. We analysed the epidemiological, histological and therapeutic aspects of the disease. Results: Endometrial cancer accounted for 3.1% of the 2793 gynecological pathology cases registered in the department during the study period, ranking third. The mean age of the patients was 63 ± 5 years. Most of them were uneducated (59.3%), postmenopausal (91.9%), nulliparous (30.2%), obese (65.1%) and hypertensive (77.1%). More than half of the patients (53.4%) were diagnosed at stage I. Endometrioid adenocarcinoma was the predominant histological type (68.6%). Surgery was performed in 96.6% of the patients, and chemotherapy in 14.0%. After a mean follow-up of 15 months, 84.5% of the patients were alive. Conclusion: Endometrial cancer is a common gynecological malignancy in our department. Endometrioid adenocarcinoma is the most frequent histological subtype. Surgery is the main treatment modality.
文摘The human endometrial adenocarcinoma cell liueIskikawa cells suspended either in Matrigel or MEM buffer medium were injected subcutaneously to nude mice (N=10 mice/group);and the fresh human cervical cancer tissues obtained directly from the surgery were coated by Matrigel and transplanted into nude mouse. The purpose of these studies were to see if Matrigel could enhance the human uteriue cancers' proliferation and differentiation in vivo.The results showed that when cancer cells or tissues implanted into nude mice in Matrigel, the xenografts could turn out earlier, proliferate faster and kept the original differentiation better.It is suggested that Matrigel is an ideal agent in establishing animal models of human uterine cancer.
文摘Endometrial cancer (EC) is the most frequent cancer of the female genital tract, especially in developed countries and the seventh most common cause of death from cancer in women in Western Europe. Major prognostic factors related to endometrial cancer are stage, grade, and depth of myometrial invasion and the presences of lymho-vascular space invasion. Standard treatment of EC consist of surgical and then adjuvant therapy on the basis of pathological prognostic factors. Standard surgical approach for stage I-II endomerial cancer is total hysterectomy and bilateral salpingo-oophorectomy with or without staging. Without question a comprehensive surgical staging procedure similar to that for ovarian carcinoma should be performed for non-endometrioid EC (uterine papiller serous carcinoma and clear cell adenocarcinoma) due to the aggressive clinical behavior. In contrast, there are some controversial issues in the surgical management-staging of EC and the role of ommentectomy and lymphadenectomy are the issues of current debate.
文摘目的分析43例术后病理提示子宫内膜癌患者的病例资料。方法收集并分析43例术前、术后诊断不一致而术后病理提示子宫内膜癌患者的临床病例资料,包括年龄、绝经与否、术前诊断方式、治疗等。结果43例患者平均年龄为56.23岁;绝经20例(46.5%),未绝经23例(53.5%);症状:异常子宫出血33例(76.7%),下腹痛伴或不伴阴道排液5例(11.6%),内膜增厚2例(4.7%),其他3例(7.0%);术前内膜厚度:内膜厚度>4 mm 36例(83.7%),内膜厚度≤4 mm 4例(9.3%),未进行相关检查3例(7.0%);手术方式:全子宫双附件切除术32例(74.4%),全子宫双输卵管切除术3例(7.0%),全子宫切除术4例(9.3%),全子宫双附件切除术+盆腔淋巴结清扫术1例(2.3%),全子宫双附件切除术+盆腔淋巴结腹主动脉旁淋巴结清扫术+大网膜阑尾切除术3例(7.0%);肿瘤分化程度:高分化12例(27.9%),中分化27例(62.8%),低分化4例(9.3%);组织病理学类型:子宫内膜样癌40例(93.0%),非子宫内膜样癌3例(7.0%);特殊病史:乳腺癌病史1例(2.3%),结肠癌病史1例(2.3%),贲门癌及内膜癌家族史1例(2.3%),高血压8例(18.6%),糖尿病4例(9.3%)。14例患者进行术前诊刮术,16例患者进行术前宫腔镜诊刮术,13例患者直接手术,术后3例患者补充手术治疗,9例患者补充放化疗。结论对于有异常子宫出血的围绝经期或绝经后女性,病理提示子宫内膜非典型增生者,仍需警惕子宫内膜癌可能性。
