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Potential therapeutic interventions based on the role of the endoplasmic reticulum stress response in progressive neurodegenerative diseases
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作者 Basant K.Puri Gerwyn Morris 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第11期1887-1889,共3页
In 1945,Porter et al.published an electon microscopy study of cultured chick fibroblasts in which they observed:'a granular background and details of a darker lacelike reticulum which in places appears to be made up... In 1945,Porter et al.published an electon microscopy study of cultured chick fibroblasts in which they observed:'a granular background and details of a darker lacelike reticulum which in places appears to be made up of chains of"vesicles"'(Porter et al.,1945).This constituted the first published observation of the endoplasmic reticulum(ER)and,while it was not evident at that time,this cytoplasmic system of interconnecting membrane-lined channels, comprising vesicles, tubules and cisternae, has numerous important functions. 展开更多
关键词 Potential therapeutic interventions based on the role of the endoplasmic reticulum stress response in progressive neurodegenerative diseases UPR NAC
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