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Relationship of Inflammation and Endothelial Dysfunction with Risks to Cardiovascular Disease among People in Inner Mongolia of China 被引量:15
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作者 PENG Hao HAN Shu Hai +3 位作者 LIU Hai Ying Vasisht CHANDNI CAI Xiao Qing ZHANG Yong Hong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第10期792-800,共9页
Objective To explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease (CVD). Methods Blood pressure, body weight, body height, waist circumference and lifestyle risk ... Objective To explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease (CVD). Methods Blood pressure, body weight, body height, waist circumference and lifestyle risk factors were measured and studied among 2589 participants in Inner Mongolia of China, and biomarkers of inflammation and endothelial dysfunction including high-sensitivity C-reactive protein (hsCRP), soluble inter-cellular adhesion molecule-1 (slCAM-1), soluble E-selectin (sE-selectin), and angiotensin II were investigated. Results Subjects with metabolic risk factors for CVD had higher levels of hsCRP, sE-selectin and slCAM-1 than those without such risk factors (all P〈O.05). Levels of all biomarkers positively and significantly increased with aggregation of the metabolic risk factors among the subjects (all P for trend 〈0.001). Data from the multivariate analysis showed that participants with high levels of hsCRP [odds ratio (OR}: 1.96, 95% confidence interval (CI): 1.52-2.53], sE-selectin (OR: 1.35, 95% Cl: 1.05-1.72), and angiotensin II (OR: 1.81, 95% CI" 1.40-2.33) were more likely to develop hypertension; participants with high levels of hsCRP (OR: 2.33, 95% CI: 1.85-2.94), sE-selectin (OR: 1.24, 95% CI: 1.00-1.54), and slCAM-1 (OR: 1.70, 95% CI: 1.30-2.22) were more likely to develop dyslipidemia, and those with high levels of hsCRP (OR: 2.95, 95% CI: 2.27-3.83) and slCAM-I(OR: 2.80, 95% CI: 2.06-3.80) were more likely to develop hyperglycemia. Conclusion Biomarkers of inflammation and endothelial dysfunction were separately associated with relevant metabolic risk factors for CVD. And appropriate measures should be taken to control inflammation and improve endothelial function among individuals with different metabolic risk factors for CVD. 展开更多
关键词 cardiovascular disease endothelial dysfunction INFLAMMATION Risk factors
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Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes 被引量:5
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作者 Marcello C Bertoluci Gislaine V Cé +3 位作者 Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales 《World Journal of Diabetes》 SCIE CAS 2015年第5期679-692,共14页
Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effec... Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. 展开更多
关键词 endothelial dysfunction Type 1 DIABETES cardiovascular DISEASE
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Advanced glycation end products:Key mediator and therapeutic target of cardiovascular complications in diabetes 被引量:5
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作者 Savita Bansal Archana Burman Asok Kumar Tripathi 《World Journal of Diabetes》 SCIE 2023年第8期1146-1162,共17页
The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns.Cardiovascular complications associated with diabetes are the leading cause o... The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns.Cardiovascular complications associated with diabetes are the leading cause of morbidity and mortality.The cardiovascular diseases that accompany diabetes include angina,myocardial infarction,stroke,peripheral artery disease,and congestive heart failure.Among the various risk factors generated secondary to hyperglycemic situations,advanced glycation end products(AGEs)are one of the important targets for future diagnosis and prevention of diabetes.In the last decade,AGEs have drawn a lot of attention due to their involvement in diabetic pathophysiology.AGEs can be derived exogenously and endogenously through various pathways.These are a nonhomogeneous,chemically diverse group of compounds formed nonenzymatically by condensation between carbonyl groups of reducing sugars and free amino groups of protein,lipids,and nucleic acid.AGEs mediate their pathological effects at the cellular and extracellular levels by multiple pathways.At the cellular level,they activate signaling cascades via the receptor for AGEs and initiate a complex series of intracellular signaling resulting in reactive oxygen species generation,inflammation,cellular proliferation,and fibrosis that may possibly exacerbate the damaging effects on cardiac functions in diabetics.AGEs also cause covalent modifications and cross-linking of serum and extracellular matrix proteins;altering their structure,stability,and functions.Early diagnosis of diabetes may prevent its progression to complications and decrease its associated comorbidities.In the present review,we recapitulate the role of AGEs as a crucial mediator of hyperglycemia-mediated detrimental effects in diabetes-associated complications.Furthermore,this review presents an overview of future perspectives for new therapeutic interventions to ameliorate cardiovascular complications in diabetes. 展开更多
关键词 Type 2 diabetes mellitus cardiovascular complications HYPERGLYCEMIA Advanced glycation end products Reactive oxygen species Oxidative stress endothelial cells Receptor of advanced glycation end products Anti-advanced glycation end products strategies
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Prognostic value of endothelial dysfunction in type 1 diabetes mellitus 被引量:2
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作者 Ana Marice Ladeia Raphael Ribeiro Sampaio +1 位作者 Maiara CostaHita Luis F Adan 《World Journal of Diabetes》 SCIE CAS 2014年第5期601-605,共5页
Patients with diabetes mellitus are at high risk of developing atherosclerosis, associated with higher rates of micro and macro vascular involvement such as coronary artery disease and renal disease. The role of hyper... Patients with diabetes mellitus are at high risk of developing atherosclerosis, associated with higher rates of micro and macro vascular involvement such as coronary artery disease and renal disease. The role of hyperglycemia to induce synthesis of reactive oxygen species by the oxidation of glucose, leading to an increased production of advanced glycosylation end products, as well as inflammation and oxidative stress has been proposed as a possible mechanism in the pathogenesis of endothelial dysfunction(ED). The interaction between C-peptide- the connecting segment of pro-insulin-and nitric oxide in vasodilation is also discussed. Therefore, endothelial dysfunction has been identified as an early marker of vascular disorder in type 1 and type 2 diabetes mellitus. In some other diseases, ED has been considered an independent predictor of vascular disease, regardless of the method used. Studies have demonstrated the importance of endothelial dysfunction as an useful tool for identifying the risk of vascular complications in patients with type 1 diabetes mellitus, particularly as regards to renal impairment. The aim of this review is to clarify the prognostic value of endothelial dysfunction as a marker of vascular disease in these subjects. 展开更多
关键词 endothelial dysfunction Type1 DIABETES PROGNOSTIC cardiovascular disease PATHOGENESIS
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Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk
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作者 Fiore Pelliccione Anatolia D'ngeli +7 位作者 Settimio D'ndrea Arcangelo Barbonetti Alfonso Pezzella Stefano Necozione Stefano Falone Fernanda Amicarelli Felice Francavilla Sandro Francavilla 《Asian Journal of Andrology》 SCIE CAS CSCD 2014年第2期290-294,I0011,共6页
The number of the circulating angiogenic cells (CACs) and colony forming units (CFUs) derived from cultured circulating mononuclear cells (MNCs) represents a laboratory surrogate for endothelial cell repair abil... The number of the circulating angiogenic cells (CACs) and colony forming units (CFUs) derived from cultured circulating mononuclear cells (MNCs) represents a laboratory surrogate for endothelial cell repair ability. The serum of men with erectile dysfunction (ED) and vascular risk factors (VRFs) showed an increased level of endothelial cell damage/dysfunction markers and reduced the numbers of CACs and CFUs derived from the cells of healthy men. We analyzed whether treating men with ED and VRFs with the selective phosphodiesterase type 5 inhibitor tadalafil improved the endothelial cell repair ability and reduced the levels of the serum markers of endothelial cell damage/dysfunction. MNCs from healthy men were cultured with 20% serum from 36 ED patients to obtain CACs and CFUs. The ED patients were evaluated before and after 4weeks of treatment with tadalafil (20 mg every other day) or with a placebo. The tadalafil treatment improved erectile function (P = 0.0028), but had no effect on the inhibitory effects of serum from ED patients on the CACs and CFUs derived from healthy men. The levels of endothelin-1 (P = 0.011) and tissue type plasminogen activator (P = 0.005) were reduced after treatment compared to baseline and those of the placebo group, whereas no changes were observed in the E-selectin levels. The tadalafil treatment in the ED patients with VRFs resulted in only a modest effect on the laboratory measures of the endothelial cell damage/dysfunction and repair ability. The proposed beneficial effect of phosphodiesterase type 5 inhibition on vascular homeostasis requires further analysis. 展开更多
关键词 cardiovascular risk circulating angiogenic cells endothelial cell erectile dysfunction TADALAFIL
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Endothelial dysfunction: The contribution of diabetes mellitus to the risk factor burden in a high risk population
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作者 Muluemebet Ketete Rabia Cherqaoui +3 位作者 Abid R. Maqbool John Kwagyan Shichen Xu Otelio S. Randall 《Journal of Biomedical Science and Engineering》 2013年第6期593-597,共5页
Background: Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in Western societies and are rapidly becoming a worldwide health problem. African-Americans have increased morbidity and morta... Background: Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in Western societies and are rapidly becoming a worldwide health problem. African-Americans have increased morbidity and mortality rates from CVD. Our study aimed to assess the effects of the CVD risk factors burden alone versus with diabetes mellitus in a high riskCVDpopulation. Methods: The two study groups consisted of thirty seven diabetics and thirty seven non-diabetic African-Americans aged ≥55 years without clinical atherosclerosis having similar cardiovascular risk factors (age, hypertension, hypercholesterolemia, smoking, and body mass index) except for diabetes mellitus. Brachial artery flow-mediated dilation (FMD), Nitroglycerin-mediated dilatation (NMD) and carotid intima-media thickness (IMT) were recorded in all subjects. Results: Endothelial function as assessed by the brachial artery FMD was significantly impaired in the diabetic group compared to the non-diabetic group (7.8 ± 5 vs 3.3 ± 4;p = 0.0001). There were no differences in neither Nitroglycerin-mediated dilatation (NMD) nor carotid intima-media thickness (IMT) in the diabetic and non-diabetic groups. Conclusion: The contribution of diabetes to the development of endothelial dysfunction in subjects with clustering of CVD risk factors may be early as indicated by significant functional changes preceeding structural vascular changes.. 展开更多
关键词 Diabetes endothelial dysfunction cardiovascular Risk Factors
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Risk of cardiovascular,cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease 被引量:58
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作者 Stefano Ballestri Amedeo Lonardo +3 位作者 Stefano Bonapace Christopher D Byrne Paola Loria Giovanni Targher 《World Journal of Gastroenterology》 SCIE CAS 2014年第7期1724-1745,共22页
Non-alcoholic fatty liver disease(NAFLD)has emerged as a public health problem of epidemic proportions worldwide.Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with live... Non-alcoholic fatty liver disease(NAFLD)has emerged as a public health problem of epidemic proportions worldwide.Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease(CHD),abnormalities of cardiac function and structure(e.g.,left ventricular dysfunction and hypertrophy,and heart failure),valvular heart disease(e.g.,aortic valve sclerosis)and arrhythmias(e.g.,atrial fibrillation).Experimental evidence suggests that NAFLD itself,especially in its more severe forms,exacerbates systemic/hepatic insulin resistance,causes atherogenic dyslipidemia,and releases a variety of pro-inflammatory,pro-coagulant and pro-fibrogenic mediators that may play important roles in the pathophysiology of cardiac and arrhythmic complications.Collectively,these findings suggest that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions to decrease the risk for CHD and other cardiac/arrhythmic complications.The purpose of this clinical review is to summarize the rapidly expanding body of evidence that supports a strong association between NAFLD and cardiovascular,cardiac and arrhythmic complications,to briefly examine the putative biological mechanisms underlying this association,and to discuss some of the current treatment options that may influence both NAFLD and its related cardiac and arrhythmic complications. 展开更多
关键词 Non-alcoholic fatty liver disease cardiovascular disease Cardiac complications Coronary heart disease Myocardial dysfunction Valvular heart disease ARRHYTHMIAS Arrhythmic complications
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Excess cardiovascular mortality in men with non-alcoholic fatty liver disease:A cause for concern! 被引量:3
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作者 Akash Batta Juniali Hatwal 《World Journal of Cardiology》 2024年第7期380-384,共5页
Non-alcoholic fatty liver disease(NAFLD)has emerged as the commonest cause of chronic liver disease worldwide in recent years.With time,our understanding of NAFLD has evolved from an isolated liver condition to a syst... Non-alcoholic fatty liver disease(NAFLD)has emerged as the commonest cause of chronic liver disease worldwide in recent years.With time,our understanding of NAFLD has evolved from an isolated liver condition to a systemic disease with significant manifestations beyond the liver.Amongst them,cardiovascular diseases(CVDs)are the most important and clinically relevant.Recent research supports a strong independent link between NALFD and CVD beyond the shared risk factors and pathophysiology.Female sex hormones are well known to not only protect against CVD in pre-menopausal females,but also contribute to improved adipose tissue function and preventing its systemic deposition.Recent research highlights the increased risk of major adverse cardiovascular-cerebral events(MACCE)amongst male with NAFLD compared to females.Further,racial variation was observed in MACCE outcomes in NAFLD,with excess mortality in the Native Americans and Asian Pacific Islanders compared to the other races. 展开更多
关键词 Non-alcoholic fatty liver disease cardiovascular diseases Male sex Major adverse cardiovascular-cerebral events Inflammation endothelial dysfunction
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Maternal Vascular Dysfunction in Congenital Heart Defects
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作者 Yanli Liu Fengzhen Han +6 位作者 Jian Zhuang Yanqiu Ou Yanji Qu Yanyan Lin Weina Zhang Haiping Wang Liping Huang 《Congenital Heart Disease》 SCIE 2023年第5期561-570,共10页
Background:Research on fetal congenital heart defect(CHD)mostly focuses on etiology and mechanisms.However,studies on maternal complications or pathophysiology are limited.Our objective was to determine whether vascul... Background:Research on fetal congenital heart defect(CHD)mostly focuses on etiology and mechanisms.However,studies on maternal complications or pathophysiology are limited.Our objective was to determine whether vascular dysfunction exists in pregnant women carrying a fetus with congenital heart defects.Methods:We conducted a case-control study.27 cases of pregnant women carrying a fetus with major CHD admitted to our hospital for delivery between April 2021 and August 2022 were selected.Every case was matched with about 2 pregnant complication-free controls without fetal abnormalities.The proangiogenic and anti-angiogenic factors and pregnancy outcomes were compared.Results:The proangiogenic factors include vascular endothelial growth factor(VEGF)and placental growth factor(PlGF).The anti-angiogenic factors involve soluble fms-like tyrosine kinase 1(sFlt-1)and soluble endoglin(sEng).No differences were found in maternal plasma concentrations of PlGF,VEGF,and sFlt-1 between case-control groups when analyzed at 36 weeks≤gestational age(GA)<39 weeks and 39 weeks≤GA≤41 weeks.The concentrations of sEng in maternal plasma in the fetal CHD group were significantly higher than those in the control group:0.60(0.77)vs.0.32(0.26)ng/ml at 36 weeks≤GA<39 weeks,p=0.001 and 0.75(0.55)vs.0.28(0.27)ng/ml at 39 weeks≤GA≤41 weeks,p<0.001.Conclusion:Vascular dysfunction exists in pregnant women with fetal congenital heart defects,manifesting significantly elevated sEng concentration at delivery. 展开更多
关键词 Congenital heart defects vascular dysfunction placental growth factor soluble fms-like tyrosine kinase 1 vascular endothelial growth factor soluble endoglin FETUS PREGNANCY maternal complication
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Cardiovascular implications of inflammatory bowel disease: An updated review
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作者 Arshia Bhardwaj Arshdeep Singh +4 位作者 Vandana Midha Ajit Sood Gurpreet Singh Wander Bishav Mohan Akash Batta 《World Journal of Cardiology》 2023年第11期553-570,共18页
Emerging data highlights the heightened risk of atherosclerotic cardiovascular diseases(ASCVD)in patients with chronic inflammatory disorders,particularly those afflicted with inflammatory bowel disease(IBD).This revi... Emerging data highlights the heightened risk of atherosclerotic cardiovascular diseases(ASCVD)in patients with chronic inflammatory disorders,particularly those afflicted with inflammatory bowel disease(IBD).This review delves into the epidemiological connections between IBD and ASCVD,elucidating potential underlying mechanisms.Furthermore,it discusses the impact of current IBD treatments on cardiovascular risk.Additionally,the cardiovascular adverse effects of novel small molecule drugs used in moderate-to-severe IBD are investigated,drawing parallels with observations in patients with rheumatoid arthritis.This article aims to comprehensively evaluate the existing evidence supporting these associations.To achieve this,we conducted a meticulous search of PubMed,spanning from inception to August 2023,using a carefully selected set of keywords.The search encompassed topics related to IBD,such as Crohn’s disease and ulcerative colitis,as well as ASCVD,including coronary artery disease,cardiovascular disease,atrial fibrillation,heart failure,conduction abnormalities,heart blocks,and premature coronary artery disease.This review encompasses various types of literature,including retrospective and prospective cohort studies,clinical trials,meta-analyses,and relevant guidelines,with the objective of providing a comprehensive overview of this critical intersection of inflammatory bowel disease and cardiovascular health. 展开更多
关键词 Inflammatory bowel diseases cardiovascular disorders PERICARDITIS MYOCARDITIS THROMBOEMBOLISM Chronic inflammation Oxidative stress endothelial dysfunction
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冠状动脉微循环障碍的发病机制及诊治现状 被引量:1
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作者 张杭 郭航远 《临床医学研究与实践》 2024年第6期190-193,共4页
冠状动脉微循环在全身血流灌注和阻力调节方面起重要作用。冠状动脉微循环障碍(CMD)是由冠状动脉管壁狭窄、微血管重构、内皮功能障碍等结构和功能改变引起的,与许多心血管不良事件的发生有关,且广泛存在于心血管疾病患者中。本文回顾CM... 冠状动脉微循环在全身血流灌注和阻力调节方面起重要作用。冠状动脉微循环障碍(CMD)是由冠状动脉管壁狭窄、微血管重构、内皮功能障碍等结构和功能改变引起的,与许多心血管不良事件的发生有关,且广泛存在于心血管疾病患者中。本文回顾CMD的相关研究,并总结近年来关于CMD的发病机制、诊断技术以及治疗策略。 展开更多
关键词 冠状动脉微循环障碍 心血管疾病 内皮功能障碍
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硝基化修饰蛋白质在心血管内皮功能障碍中的作用 被引量:1
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作者 朱诗瑶 贺雪珂 +2 位作者 陈豪 赵小梅 姜淼 《中国动脉硬化杂志》 CAS 2024年第1期65-71,共7页
内皮功能障碍作为多种心血管疾病共同的特征之一,与过量表达的活性氧(ROS)/活性氮(RNS)密切相关。超氧阴离子与一氧化氮(NO)反应可以生成氧化能力更强的过氧亚硝酸盐,可以通过氧化多种蛋白质耗竭NO,导致内皮收缩与舒张功能障碍,在多种... 内皮功能障碍作为多种心血管疾病共同的特征之一,与过量表达的活性氧(ROS)/活性氮(RNS)密切相关。超氧阴离子与一氧化氮(NO)反应可以生成氧化能力更强的过氧亚硝酸盐,可以通过氧化多种蛋白质耗竭NO,导致内皮收缩与舒张功能障碍,在多种心血管疾病中发挥了重要的作用。该文通过综述硝基化修饰蛋白质产生的途径及其在心血管疾病中促进内皮功能紊乱的可能机制,讨论了ROS/RNS介导的硝基化修饰与内皮功能障碍之间相互促进,共同推动心血管疾病进程的关系。该文还讨论了清除过氧亚硝酸盐、抑制ROS产生途径以及直接增强内皮细胞功能的治疗策略在内皮功能障碍相关的心血管疾病中的应用,可以为进一步研究蛋白质硝基化修饰这一蛋白质翻译后修饰作为干预靶点在心血管疾病中的作用提供参考。 展开更多
关键词 蛋白质硝基化修饰 活性氧 活性氮 内皮功能障碍 动脉粥样硬化 心血管疾病
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Link between periodontitis and diabetic retinopathy:Inflammatory pathways and clinical implications
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作者 Yu Zhao Quan-Quan Shen 《World Journal of Diabetes》 SCIE 2024年第9期1842-1846,共5页
The bidirectional relationship between periodontitis and type 2 diabetes mellitus has been well-established.However,the underlying molecular mechanisms remain unclear.Diabetic retinopathy(DR)is an important complicati... The bidirectional relationship between periodontitis and type 2 diabetes mellitus has been well-established.However,the underlying molecular mechanisms remain unclear.Diabetic retinopathy(DR)is an important complication of diabetes,but there are few studies on the relationship between DR and periodontitis,especially on the intrinsic inflammatory pathway mechanism.This article reviews the latest clinical data on how diabetes promotes susceptibility to periodontitis from the epidemiological and molecular perspectives,with a special focus on the key roles of systemic inflammation and endothelial dysfunction in the interplay between DR and periodontitis.Comprehension of the intertwined pathogenesis of DR and periodontitis can better guide the development of comprehensive management strategies for glycemic control and periodontal health,with the aim of mitigating the progression of DR and enhancing overall well-being. 展开更多
关键词 Type 2 diabetes mellitus Diabetic retinopathy Microvascular complications PERIODONTITIS Systemic inflammation endothelial dysfunction
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血管老化对心血管疾病的影响及中药干预机制
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作者 余嗣澳 陈铭 +4 位作者 陈聪 廖菁 杨漾 付桔 蒋其成 《湖南中医药大学学报》 CAS 2024年第5期896-903,共8页
血管老化是人体各器官、各系统衰老的重要病理基础,对高血压、动脉粥样硬化、心肌缺血再灌注损伤、冠心病等常见心血管疾病的发生产生重要影响。血管老化的病理机制主要为细胞衰老、氧化应激、线粒体功能障碍、慢性低度炎症、内皮功能... 血管老化是人体各器官、各系统衰老的重要病理基础,对高血压、动脉粥样硬化、心肌缺血再灌注损伤、冠心病等常见心血管疾病的发生产生重要影响。血管老化的病理机制主要为细胞衰老、氧化应激、线粒体功能障碍、慢性低度炎症、内皮功能障碍、端粒功能障碍、表观遗传改变等。中医药研究以中药单体和复方研究较多,主要通过调控TLR4/MyD88/NF-κB、NLRP3/Caspase-1、MAPK/ERK1、TNF-α/NF-κB、PI3K/AKT等信号通路,抑制细胞衰老、抗氧化应激、抗炎等,从而延缓血管老化。系统梳理血管老化相关机制及其在心血管疾病中的作用,以及中医药延缓血管老化的药理研究进展,以期为心血管疾病的预防和诊治提供新思路。 展开更多
关键词 血管老化 衰老 心血管疾病 细胞衰老 氧化应激 线粒体功能障碍 慢性低度炎症 内皮功能障碍
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沉默Salusin-β对糖尿病大鼠内皮功能障碍的影响及机制研究
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作者 左宪宏 张婷婷 +1 位作者 李月琴 赵佳琪 《天津医药》 CAS 北大核心 2023年第5期491-497,共7页
目的分析短发夹RNA(shRNA)沉默心血管调节肽(Salusin-β)对糖尿病(DM)大鼠内皮功能障碍的影响及其潜在的机制。方法52只SD大鼠随机抽取12只为正常对照组(NC组),其余大鼠采用喂食高糖高脂饲料和腹腔注射链脲佐菌素的方法制备DM模型。将3... 目的分析短发夹RNA(shRNA)沉默心血管调节肽(Salusin-β)对糖尿病(DM)大鼠内皮功能障碍的影响及其潜在的机制。方法52只SD大鼠随机抽取12只为正常对照组(NC组),其余大鼠采用喂食高糖高脂饲料和腹腔注射链脲佐菌素的方法制备DM模型。将36只建模成功的大鼠分为DM组、Ad-Scr shRNA组和Ad-Salusin-βshRNA组,每组12只。Ad-Scr shRNA组大鼠尾静脉注射腺病毒空载体(Ad-scramble shRNA),Ad-Salusin-βshRNA组大鼠尾静脉注射编码Salusin-βshRNA的腺病毒载体(Ad-Salusin-βshRNA)。每2周注射1次,NC组和DM组注射等量生理盐水。4周后,检测大鼠空腹血糖(FBG)和血清Salusin-β水平以及胸主动脉血管舒张功能;酶联免疫吸附试验检测大鼠胸主动脉肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-1β、丙二醛(MDA)、超氧化物歧化酶(SOD)水平;二氢乙锭(DHE)染色检测胸主动脉中活性氧(ROS)水平;苏木精-伊红染色观察大鼠胸主动脉组织病理学变化;荧光定量PCR检测大鼠胸主动脉Salusin-β和还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶2(NOX2)mRNA表达水平;Western blot法检测大鼠胸主动脉NOX2、核因子κB p65(NF-κB p65)蛋白表达。结果与NC组相比,DM组大鼠FBG、血清Salusin-β水平升高,胸主动脉TNF-α、IL-6、IL-1β、MDA、ROS水平升高,胸主动脉内膜-中膜厚度增厚,Salusin-βmRNA、NOX2 mRNA和蛋白、细胞核NF-κB p65蛋白水平升高,Ach诱发的内皮依赖性血管舒张功能下降,胸主动脉SOD和细胞质NF-κB p65蛋白表达水平降低(P<0.05)。与DM组和Ad-Scr shRNA组相比,Ad-Salusin-βshRNA组大鼠FBG和血清Salusin-β表达下降,胸主动脉TNF-α、IL-6、IL-1β、MDA、ROS表达下降,胸主动脉内膜-中膜厚度变薄,Salusin-βmRNA、NOX2 mRNA和蛋白、细胞核NF-κB p65蛋白表达水平降低,Ach诱发的内皮依赖性血管舒张功能升高,胸主动脉SOD和细胞质NF-κB p65蛋白表达水平升高(P<0.05)。结论shRNA沉默Salusin-β可减轻DM大鼠内皮功能障碍,其作用机制可能与抑制NOX2/ROS/NF-κB信号通路活化有关。 展开更多
关键词 糖尿病 2型 疾病模型 动物 心血管调节肽 内皮功能障碍 还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶2 活性氧 核因子ΚB
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复发性流产史对母体远期心脑血管疾病发生风险研究进展
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作者 池铭偲 唐嘉伟 +2 位作者 伍曼玉 刘丹 黄启涛 《妇产与遗传(电子版)》 2023年第2期45-50,共6页
复发性流产(recurrent spontaneous abortion,RSA)是常见的严重妊娠并发症之一,其患者在妊娠期或产后存在代谢紊乱、内皮功能障碍、易栓症和免疫失衡等问题。近年来,RSA患者远期心脑血管疾病(如心肌梗死、冠心病、脑卒中、血管性痴呆)... 复发性流产(recurrent spontaneous abortion,RSA)是常见的严重妊娠并发症之一,其患者在妊娠期或产后存在代谢紊乱、内皮功能障碍、易栓症和免疫失衡等问题。近年来,RSA患者远期心脑血管疾病(如心肌梗死、冠心病、脑卒中、血管性痴呆)的发生风险明显增加,复发性流产患者产后心脑血管健康逐渐受到关注。本文就复发性流产史对母体远期心脑血管疾病发生风险研究进展进行相关综述,以提高临床对该类患者的关注并为早期干预提供可能的时机。 展开更多
关键词 复发性流产 心血管疾病 代谢紊乱 内皮功能障碍 易栓症 免疫失衡
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老年慢性肾病患者危险因素分析 被引量:5
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作者 沈展 汪思阳 +2 位作者 沈婷婷 邱凌 曲毅 《医学综述》 2014年第14期2670-2672,共3页
目的 探讨老年慢性肾脏疾病(CKD)的相关危险因素,为老年CKD患者的早期评估与治疗提供依据.方法 选取2011年1月至2013年12月在上海市徐汇区中心医院老年科住院的100例CKD患者(CKD组)和100例非CKD患者(非CKD组),记录两组患者的动脉... 目的 探讨老年慢性肾脏疾病(CKD)的相关危险因素,为老年CKD患者的早期评估与治疗提供依据.方法 选取2011年1月至2013年12月在上海市徐汇区中心医院老年科住院的100例CKD患者(CKD组)和100例非CKD患者(非CKD组),记录两组患者的动脉硬化程度(脉搏波速度,踝臂指数)、内皮功能(一氧化氮、内皮素)指标数据,收集患者的心血管危险因素和心血管事件的发生情况.结果 CKD组脉搏波速度显著高于非CKD组[(1955.12±254.48) cm/s vs(1480.46±235.12)c m/s](P<0.05),踝臂指数显著低于非CKD组[(1.005±0.114) vs(1.297±0.112)](P <0.05);CKD组血浆一氧化氮水平显著低于非CKD纽(49.7±5.5) μmol/L vs(58.1±7.9) μmol/L](P<0.05),内皮素水平显著高于非CKD组[(66.2±9.6) ng/L vs(51.3±10.2)ng/L](P<0.05).Logistic回归分析结果显示CKD的危险因素包括动脉硬化(OR =2.233,95%CI1.706~2.551)、内皮功能紊乱(OR =1.761,95% CI0.913~3.217)、心血管事件(OR =3.067,95% CI1.388~6.431).结论 CKD患者心血管事件发生率高,动脉硬化程度重且多合并有内皮功能紊乱,需提早发现及干预. 展开更多
关键词 慢性肾脏疾病 动脉硬化 内皮功能紊乱 心血管并发症
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子痫前期患者血管内皮祖细胞数量及生物学功能的变化 被引量:5
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作者 周燕 邹丽 +1 位作者 朱剑文 王娟 《现代妇产科进展》 CSCD 北大核心 2009年第3期208-211,共4页
目的:观察子痫前期患者血管内皮祖细胞(endothelial progenitor cells,EPCs)数量与功能的变化。方法:选取孕28~40周子痫前期孕妇、健康孕妇各20例,抽取外周静脉血20ml,经密度梯度离心法分离单个核细胞,通过CD133/CD34双荧光标记及... 目的:观察子痫前期患者血管内皮祖细胞(endothelial progenitor cells,EPCs)数量与功能的变化。方法:选取孕28~40周子痫前期孕妇、健康孕妇各20例,抽取外周静脉血20ml,经密度梯度离心法分离单个核细胞,通过CD133/CD34双荧光标记及Ⅷ因子鉴定细胞;用流式细胞仪检测细胞数量,用MTT比色法、改良Boyden小室法、黏附能力测定实验,分别观察EPCs的增殖、迁移及黏附功能的变化。结果:与健康孕妇相比,子痫前期患者外周血EPCs数量明显减少(4.29%±1.21%vs15.32%±2.00%,P〈0.01),其增殖能力(增殖率13.45%±1.68%vs 18.45%±1.67%)、迁移能力[迁移细胞(37.25±7.28)个/视野vs(67.10±9.55)个/视野]、黏附能力[黏附细胞(20.65±5.19)个/视野vs(34.40±6.72)个/视野]明显受损。结论:子痫前期患者外周血EPCs数量减少、生物学功能减退。 展开更多
关键词 子痫前期 血管内皮祖细胞 妊娠并发症 心血管 高血压
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波动性高血糖与心血管并发症关系 被引量:7
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作者 夏城东 殷惠军 陈可冀 《心血管病学进展》 CAS 2009年第1期99-101,共3页
2型糖尿病是冠心病的等危症,内皮功能异常是糖尿病心血管并发症发生发展的重要病理生理基础。除高血糖可导致内皮功能损伤外,波动性高血糖具有更为明显的作用,包括促进内皮细胞凋亡,诱导氧化应激,增加细胞间黏附分子合成等。对血糖波动... 2型糖尿病是冠心病的等危症,内皮功能异常是糖尿病心血管并发症发生发展的重要病理生理基础。除高血糖可导致内皮功能损伤外,波动性高血糖具有更为明显的作用,包括促进内皮细胞凋亡,诱导氧化应激,增加细胞间黏附分子合成等。对血糖波动的正确认识、评价和治疗可能对糖尿病合并心血管并发症的研究具有重要意义。 展开更多
关键词 糖尿病 血糖波动性 内皮功能异常 心血管并发症
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动脉顺应性的研究进展 被引量:17
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作者 高磊 李卫华 《心血管病学进展》 CAS 2007年第1期74-76,共3页
动脉顺应性是动脉血管壁的内在弹性特性,顺应性的降低为血管性疾病发生、发展的早期表现。现就动脉顺应性的定义、影响因素、检测方法、临床意义作一综述。
关键词 动脉顺应性 内皮功能障碍 高血压 心血管事件
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