Immune response is known to develop against malignant tumours. Malignant tumours express newer antigen on their cell surface membrane which elicit immunological reaction in and around tumoural tissue. In early part of...Immune response is known to develop against malignant tumours. Malignant tumours express newer antigen on their cell surface membrane which elicit immunological reaction in and around tumoural tissue. In early part of immune reaction neutrophil, eosinophil migrates followed by monocyte-macrophage cell. Tumor associated tissue eosinophilia (TATE) is believed to play a significant role in the biological behavior of the carcinoma. Eosinophil infiltrate in association with the head and neck squamous cell carcinoma (SCC) have been reviewed from time-to-time. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of this study was to investigate and evaluate the possible role of the tumour associated tissue eosinophilia (TATE) as a predictive indicator for the grading and establishing prognosis of the upper aerodigestive tract squamous cell carcinoma (SCC).展开更多
目的探讨肺朗格汉斯细胞组织细胞增生症(pulmonary Langerhans cell histiocytosis,PLCH)的临床表现、影像学、病理及预后特征,以提高临床医生对该病的认识。方法回顾性分析广州医科大学附属第一医院2009年9月至2019年8月收治住院的PLC...目的探讨肺朗格汉斯细胞组织细胞增生症(pulmonary Langerhans cell histiocytosis,PLCH)的临床表现、影像学、病理及预后特征,以提高临床医生对该病的认识。方法回顾性分析广州医科大学附属第一医院2009年9月至2019年8月收治住院的PLCH患者36例,对其临床资料进行分析。根据Muller评分法进行评分,对结节状病灶、囊状病变及肺间质性病变的HRCT评分进行比较。根据患者第1次行气管镜肺活检(transbronchial lung biopsy,TBLB)是否获得阳性结果将患者分为两组:阳性组(11例)和阴性组(8例);根据确诊PLCH的肺病理中浸润组织的嗜酸粒细胞的量分为两组:较多嗜酸粒细胞浸润组(18例)和较少嗜酸粒细胞浸润组(13例);根据患者的预后分为:存活组(32例)和死亡组(4例)。对两组间的临床特征进行比较。结果36例PLCH患者发病中位年龄27.50(19.50,36.75)岁,55.56%(20/36)的患者出现过自发性气胸,36例PLCH患者的HRCT总评分平均数为(6.71±2.84)分;结节状病灶、囊状病变及肺间质性病变的HRCT评分中位数分别为2.67(0.67,4.33)分、3.67(1.75,4.33)分和0.00(0.00,1.92)分,且三者评分的差异具有统计学意义(χ^(2)=18.000,P<0.001)。囊状病变HRCT评分与第1秒用力呼气容积占预计值的百分比(the percentage of predicted value of forced expiratory volume in 1second,FEV1%pred)及第1秒用力呼气容积/用力肺活量(forced expiratory volume in 1second/forced vital capacity,FEV1/FVC)呈负相关(分别为:rs=-0.527,P=0.008;rs=-0.440,P=0.032)。19例患者进行TBLB,57.89%(11/19)第1次进行TBLB阳性组单次呼吸法肺一氧化碳弥散量占预计值的百分比(the percentage of predicted value of diffusion capacity for carbon monoxide of lung-single breath method,DLCO SB%pred)平均值为(75.19±11.91)%,明显优于阴性组[(55.43±17.10)%],差异有统计学意义(t=2.449,P=0.032);阳性组肺间质性病变HRCT评分均为0.00分,明显低于阴性组[4.50(0.00,4.92)],差异有统计学意义(Z=-2.932,P=0.020)。确诊的PLCH肺病理组织中,有较多嗜酸粒细胞浸润组有61.11%(11/18)发现结节病灶,明显多于较少嗜酸粒细胞浸润组(15.38%)(Fisher精确概率法,P=0.025)。4例(11.11%,4/36)患者死亡,死亡组(100.00%)为多系统受累的PLCH,明显多于存活组(31.25%,10/32),差异有统计学意义(Fisher精确概率法,P=0.017)。结论对于气胸为主要临床表现、囊状及结节状病变为主要影像学改变和/或伴有多系统受累的患者需考虑PLCH的可能;对于怀疑PLCH患者如弥散功能较好、HRCT中无间质性病变的表现,建议可尝试行TBLB确诊;多系统受累为预后不利因素。展开更多
嗜酸性粒细胞增多性血管淋巴样增生(angiolymphoid hyperplasia with eosinophilia,ALHE)是一种良性血管性损害,本病病因及发病机制不清,曾被称为非典型性化脓性肉芽肿、假性化脓性肉芽肿、炎症性动脉血管瘤、上皮样血管瘤等。我院收治...嗜酸性粒细胞增多性血管淋巴样增生(angiolymphoid hyperplasia with eosinophilia,ALHE)是一种良性血管性损害,本病病因及发病机制不清,曾被称为非典型性化脓性肉芽肿、假性化脓性肉芽肿、炎症性动脉血管瘤、上皮样血管瘤等。我院收治了1例ALHE患者,经组织病理检查表现为:表皮角化不全,棘层肥厚,真皮内血管增生,血管内皮细胞呈立方形,胞浆红染,可见空泡,间质中淋巴细胞、组织细胞和嗜酸性粒细胞浸润,并最终诊断为嗜酸性粒细胞增多性血管淋巴样增生。本文通过对此例病例的临床情况和病理检查结果进行总结分析,为临床诊断和治疗提供参考。展开更多
文摘Immune response is known to develop against malignant tumours. Malignant tumours express newer antigen on their cell surface membrane which elicit immunological reaction in and around tumoural tissue. In early part of immune reaction neutrophil, eosinophil migrates followed by monocyte-macrophage cell. Tumor associated tissue eosinophilia (TATE) is believed to play a significant role in the biological behavior of the carcinoma. Eosinophil infiltrate in association with the head and neck squamous cell carcinoma (SCC) have been reviewed from time-to-time. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of this study was to investigate and evaluate the possible role of the tumour associated tissue eosinophilia (TATE) as a predictive indicator for the grading and establishing prognosis of the upper aerodigestive tract squamous cell carcinoma (SCC).
文摘目的探讨肺朗格汉斯细胞组织细胞增生症(pulmonary Langerhans cell histiocytosis,PLCH)的临床表现、影像学、病理及预后特征,以提高临床医生对该病的认识。方法回顾性分析广州医科大学附属第一医院2009年9月至2019年8月收治住院的PLCH患者36例,对其临床资料进行分析。根据Muller评分法进行评分,对结节状病灶、囊状病变及肺间质性病变的HRCT评分进行比较。根据患者第1次行气管镜肺活检(transbronchial lung biopsy,TBLB)是否获得阳性结果将患者分为两组:阳性组(11例)和阴性组(8例);根据确诊PLCH的肺病理中浸润组织的嗜酸粒细胞的量分为两组:较多嗜酸粒细胞浸润组(18例)和较少嗜酸粒细胞浸润组(13例);根据患者的预后分为:存活组(32例)和死亡组(4例)。对两组间的临床特征进行比较。结果36例PLCH患者发病中位年龄27.50(19.50,36.75)岁,55.56%(20/36)的患者出现过自发性气胸,36例PLCH患者的HRCT总评分平均数为(6.71±2.84)分;结节状病灶、囊状病变及肺间质性病变的HRCT评分中位数分别为2.67(0.67,4.33)分、3.67(1.75,4.33)分和0.00(0.00,1.92)分,且三者评分的差异具有统计学意义(χ^(2)=18.000,P<0.001)。囊状病变HRCT评分与第1秒用力呼气容积占预计值的百分比(the percentage of predicted value of forced expiratory volume in 1second,FEV1%pred)及第1秒用力呼气容积/用力肺活量(forced expiratory volume in 1second/forced vital capacity,FEV1/FVC)呈负相关(分别为:rs=-0.527,P=0.008;rs=-0.440,P=0.032)。19例患者进行TBLB,57.89%(11/19)第1次进行TBLB阳性组单次呼吸法肺一氧化碳弥散量占预计值的百分比(the percentage of predicted value of diffusion capacity for carbon monoxide of lung-single breath method,DLCO SB%pred)平均值为(75.19±11.91)%,明显优于阴性组[(55.43±17.10)%],差异有统计学意义(t=2.449,P=0.032);阳性组肺间质性病变HRCT评分均为0.00分,明显低于阴性组[4.50(0.00,4.92)],差异有统计学意义(Z=-2.932,P=0.020)。确诊的PLCH肺病理组织中,有较多嗜酸粒细胞浸润组有61.11%(11/18)发现结节病灶,明显多于较少嗜酸粒细胞浸润组(15.38%)(Fisher精确概率法,P=0.025)。4例(11.11%,4/36)患者死亡,死亡组(100.00%)为多系统受累的PLCH,明显多于存活组(31.25%,10/32),差异有统计学意义(Fisher精确概率法,P=0.017)。结论对于气胸为主要临床表现、囊状及结节状病变为主要影像学改变和/或伴有多系统受累的患者需考虑PLCH的可能;对于怀疑PLCH患者如弥散功能较好、HRCT中无间质性病变的表现,建议可尝试行TBLB确诊;多系统受累为预后不利因素。
文摘嗜酸性粒细胞增多性血管淋巴样增生(angiolymphoid hyperplasia with eosinophilia,ALHE)是一种良性血管性损害,本病病因及发病机制不清,曾被称为非典型性化脓性肉芽肿、假性化脓性肉芽肿、炎症性动脉血管瘤、上皮样血管瘤等。我院收治了1例ALHE患者,经组织病理检查表现为:表皮角化不全,棘层肥厚,真皮内血管增生,血管内皮细胞呈立方形,胞浆红染,可见空泡,间质中淋巴细胞、组织细胞和嗜酸性粒细胞浸润,并最终诊断为嗜酸性粒细胞增多性血管淋巴样增生。本文通过对此例病例的临床情况和病理检查结果进行总结分析,为临床诊断和治疗提供参考。
