Novel milestones for early esophageal carcinoma:From bench to bed

Esophageal cancer(EC)is the seventh most common cancer worldwide,and esophageal squamous cell carcinoma(ESCC)accounts for the majority of cases of EC.To effectively diagnose and treat ESCC and improve patient prognosis,timely diagnosis in the initial phase of the illness is necessary.This article offers a detailed summary of the latest advancements and emerging technologies in the timely identification of ECs.Molecular biology and epigenetics approaches involve the use of molecular mechanisms combined with fluorescence quanti-tative polymerase chain reaction(qPCR),high-throughput sequencing technology(next-generation sequencing),and digital PCR technology to study endogenous or exogenous biomolecular changes in the human body and provide a decision-making basis for the diagnosis,treatment,and prognosis of diseases.The invest-igation of the microbiome is a swiftly progressing area in human cancer research,and microorganisms with complex functions are potential components of the tumor microenvironment.The intratumoral microbiota was also found to be connected to tumor progression.The application of endoscopy as a crucial technique for the early identification of ESCC has been essential,and with ongoing advancements in technology,endoscopy has continuously improved.With the advancement of artificial intelligence(AI)technology,the utilization of AI in the detection of gastrointestinal tumors has become increasingly prevalent.The implementation of AI can effectively resolve the discrepancies among observers,improve the detection rate,assist in predicting the depth of invasion and differentiation status,guide the pericancerous margins,and aid in a more accurate diagnosis of ESCC.

Yellow Vein Mosaic Disease in Okra(Abelmoschus esculentus L.):An Overview on Causal Agent,Vector and Management

Okra(Abelmoschus esculentus L.)belongs to the Malvaceae family and is one of the most essential and popular vegetables globally.It is rich in proteins,carbohydrates,and vitamins.Abiotic and biotic factors threaten okra productivity.Okra yellow vein mosaic disease(OYVMD)is the most destructive disease of okra.The causal agent,[i.e.,Okra yellow vein mosaic virus(OYVMV)]of this disease belongs to the family Geminiviridae and genus Begomovirus.OYVMV is a monopartite with additional ssDNA molecule.This virus has two components DNA-A for protein coding and DNA-B for symptoms induction.Whitefly transmits OYVMV in persistent manner.Characteristic symptoms of OYVMV infected okra plants are chlorosis,dwarfing,and yellowing of veins and fruits.High temperatures with moderate rainfall enhance the development of OYVMV disease and the whitefly population.However,high humidity with low temperature and rainfall has no significant role in developing the OYVMD and whitefly population.Moreover,the virus also affects the secondary metabolites in the infected okra plants.The virus can be managed through various strategies including the application of plant defense activators,the development of resistant varieties and by controlling its vector via pesticides and plant extracts.Various plant defense activators such as monopotassium phosphate(KH2PO),salicylic acid,benzoic acid,and citric acid enhance resistance in okra against OYMVD.In addition,the resistance to OYMVD can also be achieved by successfully incorporating high yielding but resistant cultivars of acceptable quality.In this review,we have discussed history,economic impact,symptomology,disease development under a natural environment,genetics and management of OYVMV.