Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer＇s dis- ease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese her...Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer＇s dis- ease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer＇s disease patients. An APPs,~JPSI^E9 double transgenic mouse model of Alzheimer＇s disease was used. The intragas- tric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer＇s disease. These com- pounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer＇s disease.展开更多
目的观察补肾中药淫羊藿对哮喘大鼠肺组织调节激活正常T细胞表达和分泌因子(regulated on activation,normal T cell expressed and secreted,RANTES)、单核细胞趋化蛋白3(monocyte chemotactic pro- tein-3,MCP-3)表达的影响,进一步探...目的观察补肾中药淫羊藿对哮喘大鼠肺组织调节激活正常T细胞表达和分泌因子(regulated on activation,normal T cell expressed and secreted,RANTES)、单核细胞趋化蛋白3(monocyte chemotactic pro- tein-3,MCP-3)表达的影响,进一步探讨淫羊藿防治哮喘的作用机制。方法将挪威大鼠随机分成6组:正常组、模型组、阳性药组(给地塞米松)、淫羊藿低、中、高剂量组(分别给淫羊藿0.125、0.5、2.0 g/mL)。用Re- al-time PCR法检测肺组织RANTES、MCP-3 mRNA的表达,EUSA法检测各组血清中肿瘤坏死因子α(TNF-α)、白细胞介素(IL)4、5的含量。结果与模型组比较,各用药组大鼠肺组织RANTEs、MCP-3 mRNA的表达下调(P<0.05或P<0.01),TNF-α水平均明显降低(P=0.000),阳性药组和淫羊藿中、高剂量组IL-4水平均明显下降(P=0.007,P=0.047,P=0.033),IL-5水平仅见阳性药组和淫羊藿高剂量组显著下降(P= 0.003,P=0.005)。结论哮喘发作期给予淫羊藿可减轻哮喘气道炎症,并且其与抑制肺组织RANTES、MCP-3表达有关。展开更多
基金supported by the National Natural Science Foundation of China,No.81273983the Natural Science Foundation of Hebei Province in China,No.C2010001471+1 种基金the Scientific and Technological Research Youth Foundation of Colleges and Universities in Hebei Province of China,No.Q2012036the Hebei Provincial Food and Drug Administration in China,No.PT2014053
文摘Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer＇s dis- ease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer＇s disease patients. An APPs,~JPSI^E9 double transgenic mouse model of Alzheimer＇s disease was used. The intragas- tric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer＇s disease. These com- pounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer＇s disease.
