X-linked Charcot-Marie-Tooth disease after SARS-CoV-2 vaccination mimicked stroke-like episodes: A case report

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vaccinations on individuals with Xlinked Charcot-Marie-Tooth disease type 1(CMTX1) is unclear. Patients with CMTX1 can have stroke-like episodes with posterior reversible encephalopathy syndrome on magnetic resonance imaging(MRI), although this is rare.CASE SUMMARY A 39-year-old man was admitted with episodic aphasia and dysphagia for 2 d. He received SARS-CoV-2 vaccination 39 d before admission. Physical examination showed pes cavus and reduced tendon reflexes. Brain MRI showed bilateral, symmetrical, restricted diffusion with T2 hyperintensities in the cerebral hemispheres. Nerve conduction studies revealed peripheral nerve damage. He was diagnosed with Charcot-Marie-Tooth disease, and a hemizygous mutation in the GJB1 gene on the X chromosome, known to be pathogenic for CMTX1, was identified. Initially, we suspected transient ischemic attack or demyelinating leukoencephalopathy. We initiated treatment with antithrombotic therapy and immunotherapy. At 1.5 mo after discharge, brain MRI showed complete resolution of lesions, with no recurrence.CONCLUSION SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.

Chronology of the Tungsten Deposits in Southern Jiangxi Province, and Episodes and Zonation of the Regional W-Sn Mineralization-Evidence from High-precision Zircon U-Pb, Molybdenite Re-Os and Muscovite Ar-Ar Ages

Previous studies have obtained some petrogenetic and metallogenic chronological data with SHRIMP （sensitive high-resolution ion microprobe） zircon U-Pb, zircon LA-ICPMS （laser-ablation-inductively coupled plasma mass spectroscopy） U-Pb, molybdenite Re-Os isochron and muscovite Ar-Ar methods in southern Jiangxi Province and its adjacent areas. Based on these, the purpose of this paper is to study the petrogenetic and metallogenic ages and their time gap for different genetic types of W-Sn deposits, and thus to research their numerous episodes, zonal arrangement and their geodynamic background. The result shows that the large-scale W-Sn mineralization in southern Jiangxi Province occurred in the middle to late Jurassic （170-150 Ma）, the skarn W-Sn-polymetallic deposits formed much earlier （170-161 Ma）, and all of the wolframite-quartz vein type, greisen type, altered granite type and fractured zone type tungsten deposits formed in the late Jurassic （160-150 Ma）. In one ore field or ore district, greisen type tungsten deposits formed earlier than quartz vein type ones hosted in the endoor exo-contact zone; and quartz vein type hosted in the endocontact zone formed earlier than that of exocontact zone. There is no significant time difference between tungstentin mineralization and its intimately associated parent granite emplacement （1-6 Ma）. They all formed in the same rock-forming and ore-forming system and under the same geodynamic setting. Regionally, rock-forming and ore-forming processes of the W-Sn deposits in the Nanling region （include southern Jiangxi Province, southern Hunan Province, northern Guangdong Province and eastern Guangxi Zhuang Autonomous Region） exhibit numerous episodes. The mineralization in the Nanling region mainly occurred at （240-210） Ma, （170-150） Ma and （130-90） Ma. The tungsten-tin deposits in this region are centered by the largest scale in southern Jiangxi Province and southern Hunan Province, and become small in the east, west, south and north directions. This displays a zonal arrangement and temporal and spatial distribution regularity. Integrated with the latest research results, it is concluded that the W-Sn mineralization in southern Jiangxi Province and its adjacent areas corresponds to the second large-scale mineralization in South China. The Indosinian W-Sn mineralization formed under the extensional tectonic regime between collisional compressional stages, while the Yanshanian large-scale petrogenetic and metallogenic processes occurred in the Jurassic intraplate extensional geodynamic setting of lithosphere extension.

Delayed Impacts of the El Nio Episodes in the Central Pacific on the Summertime Climate Anomalies of Eastern China in 2003 and 2007

In the summers of 2003 and 2007, eastern China suffered similar climate disasters with severe flooding in the Huaihe River valley and heat waves in the southern Yangtze River delta and South China. Using SST data and outgoing longwave radiation （OLR） data from NOAA along with reanalysis data from NCEP/NCAR, the 2002/03 and 2006/07 E1 Nifio episodes in the central Pacific and their delayed impacts on the following early summertime climate anomalies of eastern China were analyzed. The possible physical progresses behaved as follows： Both of the moderate E1 Ninio episodes matured in the central equatorial Pacific during the early winter. The zonal wind anomalies near the sea surface of the west-central equatorial Pacific excited equatorial Kelvin waves propagating eastward and affected the evolution of the E1 Nifio episodes. From spring to early summer, the concurring anomalous easterly winds in the central equatorial Pacific and the end of upwelling Kelvin waves propagating eastward in the western equatorial Pacific, favored the equatorial warm water both of the SST and the subsurface temperature in the western Pacific. These conditions favored the warm state of the western equatorial Pacific in the early summer for both cases of 2003 and 2007. Due to the active convection in the western equatorial Pacific in the early summer and the weak warm SST anomalies in the tropical western Pacific from spring to early summer, the convective activities in the western Pacific warm pool showed the pattern in which the anomalous strong convection only appeared over the southern regions of the tropical western Pacific warm pool, which effects the meridional shift of the western Pacific subtropical high in the summer. The physical progress of the delayed impacts of the E1 Nino episodes in the central equatorial Pacific and their decaying evolution on the climate anomalies in eastern China were interpreted through the key role of special pattern for the heat convection in the tropical western Pacific warm pool and the response of the western North Pacific anomalous anticyclone.

Episodes of Cenozoic Gold Mineralization on the Eastern Margin of the Qinghai-Tibet Plateau:40Ar/39Ar Dating and Implication for Geodynamic Events

A lot of new gold deposits have been found on the eastern margin of the Qinghai-Tibet Plateau during the past two decades. Among them, three main types of gold deposits have been recognized, including quartz-vein-type, shear- zone-type and porphyry-type. The former two types of gold deposits are mainly hosted within metamorphic rocks, while the latter is related to Cenozoic magmatism. Although all of these gold deposits are believed to have been formed during the uplift process of the Qinghai-Tibet Plateau in the Cenozoic era (Wang et al., 2002b), precise isotopic age constraints have still been lacking until quite recently. This paper presents new 40Ar/39Ar data of some gold deposits on the eastern margin of the Qinghai-Tibet Plateau, which indicate that gold mineralization in the region occurred in response to the episodic stages of the orogenies. Recently obtained 40Ar/39Ar data on quartz and feldspars from several gold deposits, such as the Sandiao deposit, the Baijintaizi deposit, the Pusagang deposits, provide new constraints on gold mineralization on the eastern margin of the Qinghai-Tibet Plateau. Geochronological studies of gold deposits along the Daduhe River indicate that there are three stages of gold mineralization. The early two stages occurred as early as 65.1 Ma in the Shuibaiyang deposit and 58.95 Ma in the Ruoji deposit, while the latter stage occurred as late as 25.35 Ma in Baijintaizi and 24.70 Ma in Sandiao. Isotopic dating of three plagioclases from the Beiya deposit, Zhifanggou deposit and Luobodi deposit and a K-feldspar from the Jinchangqing deposit in Yunnan Province indicates that these deposits were formed at two stages. The Zhifanggou and Jinchangqing deposits have early stage records as old as 58.82 Ma in Zhifanggou and 55.49 Ma in Jinchangqing, but all of the above four deposits in Yunnan have late stage records of 23.18 Ma in Jinchangqing, 24.54 Ma in Zhifanggou, 24.60 Ma in Luobodi and 24.56 Ma in Hongnitang. The above results suggest that the gold deposits on the eastern margin of the Qinghai-Tibet Plateau were formed concentratedly at two main episodes, i.e. the end of the Paleocene (about 58 Ma) and the boundary between the Paleogene and the Neogene (about 25 Ma). The later episode appears to be looks like more important and was coupled with the Sichuan movement, which was extensively activated at that period. The beginning of the Cenozoic Era (about 65 Ma) might be another episode of gold mineralization, but only one deposit (Shuibaiyang) in this study has been proved to have been be formed at this stage and might be earlier than the initial collision between the Indian Plate and the Eurasia Plate. In view of geology, the above three episodes of gold mineralization are associated with three events of tectonic- magmatism and/or fluid events. Even though the gold deposits (for example, the Shuibaiyang deposit, Ruoji deposit and Pusagang deposit) were formed at different episodes, all of them are genetically related to tectonic movements in large- scale shear zones. It looks like theat tectonic events (including large-scale strike-slip) between Paleogene and Neogene had a wide influence upon gold mineralization, with new deposits formed and old deposits enriched or superimposed to be a higher grade by new stage of mineralization. The above data suggest that gold deposits were not only concentrated in some areas, but also formed mainly at different boundaries of geological times, indicating that there existed some peak stages of gold mineralization (metallogenic episodes), and that the gold deposits were formed mainly by episodic mineralization.

Tectonic evolution of structures in Southern Sindh Monocline,Indus Basin,Pakistan formed in multi-extensional tectonic episodes of Indian Plate

There are a number of structures and structural styles found in extensional tectonic settings of the world,and it is a big challenge to study the evolution of these structures. Evolution of structures formed in extensional tectonic settings have been studied by researchers on different extensional basins of the world. Southern Sindh Monocline lies on the western corner of Indian Plate and the tectonic history of Indian plate has also experienced different extensional episodes, and its journey rifted from Gondwanaland to its final welding to Asia. The aim of this study is to figure out the evolution of structures in the subsurface of Southern Sindh Monocline, Pakistan using the seismic data interpretation and flattening of horizons approach. Structures within the subsurface of Southern Sindh Monocline have been characterized by different tectonic episodes of Indian plate while rifting from Gondwanaland, rifting from other plates at different geological times and to its collision with the Asia. Basic structures within study area are classified into nine types while the structural styles have been classified into six types as horst and grabens, dominos, crotch, synthetic and antithetic, negative and flashlight structural style. The structures within the study area revealed evidence for three major structural episodes which can be characterized as Episode 1: Structures associated with rifting of Indian plate from Gondwanaland during Late Jurassic to Early Cretaceous, Episode 2: Modification and reactivation of previous structures while Madagascar rifted from Indian Plate during the Middle Cretaceous and during Episode 3: Inversion and reactivation of structures occurred when Indian Plate collided with Asia during Early Eocene.

Modeling Arctic Ocean heat transport and warming episodes in the 20th century caused by the intruding Atlantic Water

This study investigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observations. The model, with no flux adjustment, reproduces well the Atlantic Water core temperature （AWCT） in the Arctic Ocean and shows that four largest decadalscale warming episodes occurred in the 1930s, 70s, 80s, and 90s, in agreement with the hydrographic observational data. The difference is that there was no pre-warming prior to the 1930s episode, while there were two pre-warming episodes in the 1970s and 80s prior to the 1990s, leading the 1990s into the largest and prolonged warming in the 20th century. Over the last century, the simulated heat transport via Fram Strait and the Barents Sea was estimated to be, on average, 31.32 TW and 14.82 TW, respectively, while the Bering Strait also provides 15.94 TW heat into the west- ern Arctic Ocean. Heat transport into the Arctic Ocean by the Atlantic Water via Fram Strait and the Barents Sea correlates significantly with AWCT （ C = 0.75 ） at 0- lag. The modeled North Atlantic Oscillation （NAO） index has a significant correlation with the heat transport （ C = 0.37 ）. The observed AWCT has a significant correlation with both the modeled AWCT （ C =0.49） and the heat transport （ C =0.41 ）. However, the modeled NAO index does not significantly correlate with either the observed AWCT （ C = 0.03 ） or modeled AWCT （ C = 0.16 ） at a zero-lag, indicating that the Arctic climate system is far more complex than expected.

Health Risk Impacts of Exposure to Airborne Metals and Benzo(a)Pyrene during Episodes of High PM10 Concentrations in Poland

Objective To check whether health risk impacts of exposure to airborne metals and Benzo（a） Pyrene during episodes of high PM10 concentrations lead to an increased number of lung cancer cases in Poland. Methods In this work, we gathered data from 2002 to 2014 concerning the ambient concentrations of PM10 and PM10-bound carcinogenic Benzo（a）pyrene [B（a）P] and As, Cd, Pb, and Ni. With the use of the criterion of the exceedance in the daily PM10 mass concentration on at least 50% of all the analyzed stations, the PM10 maxima’s were selected. Lung cancer occurrences in periods with and without the episodes were further compared. Results During a 12-year period, 348 large-scale smog episodes occurred in Poland. A total of 307 of these episodes occurred in the winter season, which is characterized by increased emissions from residential heating. The occurrence of episodes significantly （P 〈 0.05） increased the concentrations of PM10-bound carcinogenic As, Cd, Pb, Ni, and B（a）P. During these events, a significant increase in the overall health risk from those PM10-related compounds was also observed. The highest probability of lung cancer occurrences was found in cities, and the smallest probability was found in the remaining areas outside the cities and agglomerations. Conclusion The link between PM pollution and cancer risk in Poland is a serious public health threat that needs further investigation.

Nature of Three Episodes of Magmatism(2181 Ma, 2115 Ma and 1891 Ma) in the Liaohe Rift of North China: Implications for Tectonic Evolution

To define a tectonic environment switching from rifting to subduction and their respective duration time are usually largely debated.Such case occurs for the Liaohe rift:whether it went through a long subduction from 2100to 1850 Ma or there were two different events in different

Neoproteroic Magmatism Related to Lithospheric Delamination: Implications from Three Episodes of Mafic Dykes and Associated Granitoids in the Pengguan Complex, Western Sichuan Province, Yangtze Block

The research on dyke swarms is very important,for it can not only shed light on within-plate geological processes of some regions but also contribute to our understanding on evolution of a specific orogenic belt.The Yangtze Block,

The Personality Beauty Thought in New Accounts of Old Episodes

“New Accounts of Old Episodes”is a classic handed down in China,which reflects the personality image and charm of the scholars in the Wei and Jin dynasties with the original ecological narrative technique.The scholars of the Wei and Jin Dynasties were detached,facing the world with an aesthetic attitude beyond secular utilitarianism,etiquette,and real life,establish a graceful social stage of vulgarity,create a unique personality beauty,providing valuable ideological wealth for the cultivation of poetic spirit,poetic dwelling,aesthetic style,transcend personality,and wisdom.

Subgrouping time-dependent prescribing patterns of first-onset major depressive episodes by psychotropics dissection

BACKGROUND Subgrouping patients with major depressive disorder is a promising solution for the issue of heterogeneity.However,the link between available subtypes and distinct pathological mechanisms is weak and yields disappointing results in clinical application.AIM To develop a novel approach for classification of patients with time-dependent prescription patterns at first onset in real-world settings.METHODS Drug-naive patients experiencing their first major depressive episode(n=105)participated in this study.Psychotropic agents prescribed in the first 24 mo following disease onset were recorded monthly and categorized as antidepressants,augmentation agents,and hypnosedatives.Monthly cumulative doses of agents in each category were converted into relevant equivalents.Four parameters were used to summarize the time-dependent prescription patterns for each psychotropic load:Stability,amount,frequency,and the time trend of monthly prescriptions.A K-means cluster analysis was used to derive subgroups of participants based on these input parameters of psychotropic agents across 24 mo.Clinical validity of the resulting data-driven clusters was compared using relevant severity indicators.RESULTS Four distinct clusters were derived from K-means analysis,which matches experts’consent:"Short-term antidepressants use","long-term antidepressants use","long-term antidepressants and sedatives use",and"long-term antidepressants,sedatives,and augmentation use".At the first 2 years of disease course,the four clusters differed on the number of antidepressants used at adequate dosage and duration,frequency of outpatient service use,and number of psychiatric admissions.After the first 2 years following disease onset,depression severity was differed in the four subgroups.CONCLUSION Our findings suggested a new approach to optimize the subgrouping of patients with major depressive disorder,which may assist future etiological and treatment response studies.

Atmospheric oxidizing capacity in autumn Beijing:Analysis of the O_(3) and PM_(2.5) episodes based on observation-based model

Atmospheric oxidizing capacity(AOC)is the fundamental driving factors of chemistry process(e.g.,the formation of ozone(O_(3))and secondary organic aerosols(SOA))in the troposphere.However,accurate quantification of AOC still remains uncertainty.In this study,a comprehensive field campaign was conducted during autumn 2019 in downtown of Beijing,where O_(3) and PM_(2.5) episodes had been experienced successively.The observation-based model(OBM)is used to quantify the AOC at O_(3) and PM_(2.5) episodes.The strong intensity of AOC is found at O_(3) and PM2.5 episodes,and hydroxyl radical(OH)is the dominating daytime oxidant for both episodes.The photolysis of O_(3) is main source of OH at O_(3) episode;the photolysis of nitrous acid(HONO)and formaldehyde(HCHO)plays important role in OH formation at PM_(2.5) episode.The radicals loss routines vary according to precursor pollutants,resulting in different types of air pollution.O_(3) budgets and sensitivity analysis indicates that O_(3) production is transition regime(both VOC and NOx-limited)at O3 episode.The heterogeneous reaction of hydroperoxy radicals(HO_(2))on aerosol surfaces has significant influence on OH and O_(3) production rates.The HO_(2) uptake coefficient(γHO_(2))is the determining factor and required accurate measurement in real atmospheric environment.Our findings could provide the important bases for coordinated control of PM_(2.5) and O_(3) pollution.

Progress in Diagnosing Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes

Objective： Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes （MELAS） is a progressive, multisystem affected mitochondrial disease associated with a number of disease-related defective genes. M ELAS has unpredictable presentations and clinical course, and it can be commonly misdiagnosed as encephalitis, cerebral infarction, or brain neoplasms. This review aimed to update the diagnosis progress in MELAS, which may provide better understanding of the disease nature and help make the right diagnosis as well. Data Sources： The data used in this review came fi-om published peer review articles from October 1984 to October 2014, which were obtained fiom PubMed. The search term is ＂MELAS＂, Study Selection： lnfornmtion selected from those reported studies is mainly based on the progress on clinical tkatures, blood biochemistry, neuroimaging, muscle biopsy, and genetics in diagnosing MELAS. Results： MELAS has a wide heterogeneity in genetics and clinical manifestations. The relationship between mutations and phenotypes remains unclear. Advanced serial functional magnetic resonance imaging （MRI） can provide directional information on this disease. Muscle biopsy has meaningflil value in diagnosing MELAS, which shows the presence of ragged red fibers and mosaic appearance of cytochrome oxidase negative fibers. Genetic studies have reported that approximately 80% of MELAS cases are caused by the lnutation in.3243A〉G of the mitochondrial transfer RNA （Leu （UU R）） gene （MT-TLI）. Conclusions： MELAS involves multiple systems with variable clinical symptoms and recurrent episodes. The prognosis of MELAS patients depends on timely diagnosis. Therefore, overall diagnosis of MELAS should be based on the maternal inheritance family history, clinical manifestation, and findings from serial MR1, muscle biopsy, and genetics.

White matter connection's damage,not cortical activation, leading to language dysfunction of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes

Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS) is a metabolic disorder characterized by hyperlactic acidemia and stroke-like symptoms.

Intensified wintertime secondary inorganic aerosol formation during heavy haze pollution episodes(HPEs) in Beijing,China

Air pollution in China is complex,and the formation mechanism of chemical components in particulate matter is still unclear.This study selected three consecutive heavy haze pollution episodes(HPEs)during winter in Beijing for continuous field observation,including an episode with heavy air pollution under red alert.Clean days during the observation period were selected for comparison.The HPE characteristics of Beijing in winter were:under the influence of adverse meteorological conditions such as high relative humidity,temperature inversion and low wind speed;and strengthening of secondary transformation reactions,which further intensified the accumulation of secondary aerosols and other pollutants,promoting the explosive growth of PM_(2.5).PM_(2.5)/CO values,as indicators of the contribution of secondary transformation in PM_(2.5),were approximately 2 times higher in the HPEs than the average PM_(2.5)/CO during the clean period.The secondary inorganic aerosols(sulfate nitrate and ammonium salt)were significantly enhanced during the HPEs,and the conversion coefficients were remarkably improved.In addition,it is interesting to observe that the production of sulfate tended to exceed that of nitrate in the late stage of all three HPEs.The existence of aqueous phase reactions led to the explosive growth sulfur oxidation ratio(SOR)and rapid generation of sulfate under high relative humidity(RH>70%).

Characteristics and formation mechanism of regional haze episodes in the Pearl River Delta of China

To investigate the characteristics and the specific mechanism of continuous haze,comprehensive measurements were conducted from 15 October to 19 November in the Atmospheric Environment Monitoring Super-Station in Heshan of Guangdong province.Five haze episodes occurred in October and November 2014 in the Pearl River Delta（PRD）region. The meteorological parameters, gas data, chemical compositions, and optical parameters of the aerosols were obtained. Among these events, the second haze episode,with the highest concentration of PM2.5 of 187.51 μg/m^3, was the most severe. NO^3-was always higher than SO_4^（2-）, which indicated that motor vehicles played an important role in the haze, even though the oxidation rate from SO_2 to SO_4^（2-）was faster than that of NOXto NO_3^-. The difference between the hourly averages of Na＋and K＋during the haze episode and clean days was small, implying that straw combustion and sea salt had no significant effect on the occurrence of haze, and the backward trajectories of the air masses also conformed with this result. The air pollutants were difficult to disperse because of the significant decrease in the planetary boundary layer（PBL） height. Relative humidity played a crucial role in the formation of haze by leading to hygroscopic growth of the diameter of aerosols.

Comparisons of two serious air pollution episodes in winter and summer in Beijing

Characteristics of two serious air pollution episodes（9–15 January, as the winter case; and30 June to 1 July, as the summer case）, which occurred in Beijing in 2013 were investigated and compared using multi-method observations and numerical simulations. During these two air pollution episodes, PM2.5 concentrations varied significantly within Beijing, with PM2.5 concentrations in southern parts of Beijing being significantly higher than in northern areas. Typically, heavy air pollution episodes begin in the southern parts and disperse towards the northern parts of Beijing. Clearly, synoptic patterns and the stability of atmospheric circulation patterns were the main factors controlling air pollution in Beijing.During the winter case, a warm center above 900 h Pa occurred over Beijing. Meanwhile, in the summer case, although there was only a weak inversion, the convective inhibition energy was strong（over 200 J/k G）. This clearly influenced the duration of the air pollution event. Except for the local accumulation and secondary atmospheric reactions in both cases, regional straw burnings contributed a lot to the PM2.5 concentrations in summer case.Using the CAMxmodel, we established that regional transport contributed almost 59% to the PM2.5 averaged concentration in Beijing in the winter case, but only 31% in the summer case. Thus, the winter case was a typical regional air pollution episode, while the summer case resulted from local accumulation straw burnings transportation and strong secondary atmospheric reactions. Given that air pollution is a regional problem in China, consistent and simultaneous implementation of regional prevention and control strategies is necessary to improve regional air quality.

Photochemical properties and source of pollutants during continuous pollution episodes in Beijing, October, 2011

Beijing suffered from serious air pollution in October, 2011 with the occurrence of three continuous episodes. Here we analyze the pollution status of particulate matter, the relationship between the gaseous pollutants, physical and chemical properties of single particles, and the profile of water-soluble ions in PM2.5 during the three episodes. Regional and photochemically aged air masses, which were characterized as having high values of O3 and SO2, were hypothesized to have played a dominant role in the first episode. After mixing local air masses with freshly-emitted primary pollutants, the concentration of NOx continued to increase and the size of SO42-, NO3- and NH4＋ in the particle population continued to become smaller. The amount of elemental carbon-rich and organic carbonrich particles in the scaled single particles （0.2-2 μm） and water-soluble K＋ in PM2.s also increased in the episodes. All the available information suggests that the biomass or fuel burning sources in or around Beijing may have had a huge impact on the last two episodes.

Volcanically Driven Terrestrial Environmental Perturbations during the Carnian Pluvial Episode in the Eastern Tethys

The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlation between terrestrial environmental changes and Wrangellia volcanism in the Ordos Basin during the CPE remains poorly understood.Records of negative carbon isotopic excursions(NCIEs),mercury(Hg),Hg/TOC,and Hg enrichment factor(HgEF)from oil shales in a large-scale terrestrial Ordos Basin in the Eastern Tethys were correlated with marine and other terrestrial successions.The three significant NCIEs in the study section were consistently correlated with those in the CPE successions of Europe,the UK,and South and North China.The U-Pb geochronology indicates a Ladinian-Carnian age for the Chang 7 Member.A comprehensive overview of the geochronology,NCIE correlation,and previous bio-and chronostratigraphic frameworks shows that the Ladinian-Carnian boundary is located in the lower part of Chang 7 in the Yishicun section.HgEF may be a more reliable proxy for tracing volcanic eruptions than the Hg/TOC ratio because the accumulation rates of TOC content largely vary in terrestrial and marine successions.The records of Hg,Hg/TOC,HgEF,and NCIEs in the Ordos Basin aligned with Carnian successions worldwide and were marked by similar anomalies,indicating a global response to the Wrangellia LIP during the CPE.Anoxia,a warm-humid climate,enhancement of detrital input,and NCIEs are synchronous with the CPE interval in the Ordos Basin,which suggests that the CPE combined with the regional Qinling Orogeny should dominate the enhanced rate of terrigenous input and paleoenvironmental evolution in the Ordos Basin.