Effects of Darbepoetin-<i>α</i>on Oxidative Stress Marker in Patients with Chronic Renal Failure

Objective: Long-acting darbepoetin-α (DA) has recently been used to treat renal anemia in patients with chronic renal failure. It is considered clinically useful because its duration of action is longer than that of conventional epoetin-α. In this study, we investigated changes in the levels of the oxidative stress marker malondialdehyde-modified low density lipoprotein (MDA-LDL), renal anemia, and renal function when patients were treated for chronic renal failure switched from epoetin-α to DA. Materials and Methods: The subjects included nine patients with chronic renal failure and renal anemia who were treated with epoetin-α on an outpatient basis at our department. Blood was sampled prior to the switch and at 3, 6, and 12 months after the switch. We then investigated changes in MDA-LDL, hemoglobin (Hb), and creatinine (Cr) levels. Results: There were no significant changes in MDA-LDL and Hb levels after switching to DA. A significant increase was observed in Cr levels after 12 months compared with those prior to switching. Conclusion: Once-a-month administration of DA did not result in an increase in oxidative stress, and therefore, DA is considered capable of controlling renal anemia.

轻度贫血患者全膝关节置换术前使用α-红细胞生成素的作用研究

目的:观察轻度贫血患者全膝关节置换术(total knee arthroplasty,TKA)前使用α-红细胞生成素(erythropoietin-α)对其输血发生情况的作用。方法 :收集本院2010-2012年60例轻度贫血的TKA患者,其中30例作为干预组在TKA术前以40 000 U Epoetin-α处理3次(术前3周,1周1次),并补充铁剂、VB12和叶酸等造血物质,另外30例作为对照组不作Epoetin-α处理。观察和比较TKA患者手术前后血红蛋白含量、输血率、住院时间和手术时间等指标。结果:TKA患者术前使用Epoetin-α可使血红蛋白的量从11.5 g/dL增加至14.3 g/dL(P<0.01)。以Epoetin-α处理的患者输血率减少(96.7%vs.56.6%P=0.013),但干预组和对照组的住院时间相似。结论:轻度贫血患者在TKA术前3周连续使用Epoetin-α可以减少输血的发生率,但不会影响住院时间。