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Stereoselective Synthesis of (+)-△~5-Dehydrosugiyl Methyl Ether
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作者 An Pai LI Xiao Shui PENG +1 位作者 Yong Hong GAN Xin Fu PAN 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第2期111-112,共2页
A stereoselective synthetic route to △~5-dehydrosugiyl methyl ether was developed from (S)-(-)-α-cyclocitral, DDQ as a better oxidant for enone was used.
关键词 SYNTHESIS DITERPENOIDS geranic (+)-△~5-dehydrosugiyl methyl ether.
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Systematic pharmacology analysis of Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate
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作者 Ze-Ping Luo Li-Wei Pan +1 位作者 Hai-Lin Chen Jun-Yu Lu 《Drug Combination Therapy》 2019年第4期186-198,共13页
The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the mo... The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the molecule was analyzed by using a series of Systematic pharmacology methods.The results show that the M molecule has a higher drug-like DL value of 0.59 and better molecular property parameters,namely Hdon=4,Hacc=10 and AlogP=0.94;A total of 11 M molecules related targets,namely F2,ESR1,AR,F10,CA2,DPP4,CCNA2,PRSS1,CDK2,GSK3B and PTPN1;A total of 140 diseases are associated with M molecule targets,and these diseases are mainly related to cancer and cardiovascular diseases;A total of 52 pathways involve the pharmacological mechanisms of M molecules,which are mainly related to cancer and other related diseases;GO-enriched analysis showed that these targets are closely related to the regulation of peptidase activity and biological processes such as blood coagulation and hemostasis.This article clearly demonstrated the pharmacological mechanism of M molecule,which provides references for exploring the pharmacological mechanism of new compounds. 展开更多
关键词 Sodium 8-(((carboxymethyl)amino)methyl)-4' 7-bishydroxy-isoflavone-3'-sulfonate Systematic PHARMACOLOGY analysis
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The Synthesis of Some Novel N-[α-(Isoflavone-7-O-) Acetyl]Amino Acid Derivatives 被引量:1
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作者 Peng LIU Jun Biao CHANG +2 位作者 Rong Feng CHEN Qiang WANG Jing Xi XIE (Henan Institute of Chemistry, Henan Academy of Science, Zhengzhou 450002 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) 《Chinese Chemical Letters》 SCIE CAS CSCD 2000年第5期391-394,共4页
A series of novel N-[α-(isoflavone-7-O-)acetyl] amino acid methyl esters were prepared from the efficient and regioselective alkylation of isoflavones with chloroacetyl amino acid derivatives under mild condition.
关键词 Isoflavone analogues N--(isoflavone-7-O-)acetyl] amino acid methyl ester synthesis.
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Synthesis and Adsorption Property of Two Polymeric Adsorbents with Pendent Ether Bonds 被引量:4
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作者 JianGouHUANG ManCaiXU +1 位作者 HaiTaoLI ZuoQingSHI 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第9期914-916,共3页
Two polymeric adsorbents, poly(methyl p-vinylbenzyl ether) and poly(phenyl p-vinylbenzyl ether), were synthesized from chloromethylated polystyrene. Their adsorption property for phenol in hexane solution was investig... Two polymeric adsorbents, poly(methyl p-vinylbenzyl ether) and poly(phenyl p-vinylbenzyl ether), were synthesized from chloromethylated polystyrene. Their adsorption property for phenol in hexane solution was investigated. The results showed that the two adsorbents adsorb phenol from hexane solution through hydrogen-bonding and π-π stacking interaction. 展开更多
关键词 Poly(methyl p-vinylbenzyl ether) poly(phenyl p-vinylbenzyl ether) adsorption HYDROGEN-BONDING π-π stacking interaction.
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Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo 被引量:1
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作者 Qidong Ren Xinni Xie +2 位作者 Yue Tang Qing Hu Yuguo Du 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2021年第3期236-247,共12页
The biosafety of methyl tertiary-butyl ether(MTBE),mainly used as a gasoline additive,has long been a contentious topic.In addition to its routine toxicities,MTBE has been demonstrated to disrupt glucose and lipid met... The biosafety of methyl tertiary-butyl ether(MTBE),mainly used as a gasoline additive,has long been a contentious topic.In addition to its routine toxicities,MTBE has been demonstrated to disrupt glucose and lipid metabolism and contribute to the development of type2 diabetes as well as obesity.As one of the morbidities related to dyslipidemia,atherosclerosis is worthy of being investigated under MTBE exposure.Since foam cells derived from macrophages play pivotal roles during atherosclerosis development,we studied the effects of MTBE on macrophages in vitro and assessed the effect of MTBE on atherosclerosis plaque formation with the ApoE^(-/-)mouse model in uiuo for the first time.Our results demonstrated that exposure to MTBE at environmentally relevant concentrations decreased the expression of ABCA1 and ABCG1,which are responsible for macrophage cholesterol efflux,at both mRNA and protein levels in THP-1 macrophages.Consequently,treatment with MTBE inhibited the transport of cholesterol from macrophages to High-density lipoprotein.ApoE^(-/-)mice exposed to MTBE at environmentally relevant concentrations(100,1000μg/kg)displayed significant increases in lesion area in the aorta and aortic root compared to vehicletreated ones.Further analysis indicated that MTBE exposure enhanced the macrophagespecific marker Mac-2 contents within plaques in the aortic root,implying that MTBE could promote macrophage-derived foam cell formation and thus accelerate atherosclerosis plaque formation.We for the first time demonstrated the pro-atherogenic effect of MTBE via eliciting disruption of macrophage cholesterol efflux and accelerating foam cell formation and atherosclerosis plaque development. 展开更多
关键词 methyl tertiary–butyl ether(MTBE) MACROPHAGE cholesterol efflux ApoE^(-/-)mouse ATHEROSCLEROSIS
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不同产地差不嘎蒿的质量对比研究
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作者 王琰 刘辉 +2 位作者 辛艳 黄胜阳 周海燕 《中国民族民间医药》 2015年第17期27-30,共4页
目的:考察不同产地差不嘎蒿药材的各项质量指标,为其质量标准建立及优质产地的筛选提供一定的实验依据。方法:采用HPLC法,流动相:乙腈-0.2%甲酸水(35∶65)流量:0.8ml/min;检测波长:288nm;柱温:30℃,测定指标性成分异樱花素、圣草酚-7-... 目的:考察不同产地差不嘎蒿药材的各项质量指标,为其质量标准建立及优质产地的筛选提供一定的实验依据。方法:采用HPLC法,流动相:乙腈-0.2%甲酸水(35∶65)流量:0.8ml/min;检测波长:288nm;柱温:30℃,测定指标性成分异樱花素、圣草酚-7-甲醚的含量;按照2010年版《中国药典》(一部)附录方法测定其醇溶性浸出物、水分、杂质、灰分含量及其酸败度,综合评定药材质量。结果:不同产地的药材之间有一定的差异,其中异樱花素、圣草酚-7-甲醚含量差异较为明显,水分随保藏年份的增加而减少,其他项的差异保持在一定范围内。结论:不同产地的差不嘎蒿药材的质量有所不同,内蒙古自治区赤峰市可作为优质种源。 展开更多
关键词 差不嘎蒿 不同产地 质量对比 异樱花素 圣草酚-7-甲醚
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