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必压生和垂体后叶素治疗食管静脉曲张破裂出血临床对比研究
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作者 金瑞 于中麟 《北京医学》 CAS 北大核心 1999年第3期151-153,共3页
采用对照研究方法,比较必压生(Pitressin)和垂体后叶素控制食管静脉曲张破裂出血(EVB)的临床疗效。必压生6小时和12小时完全止血率分别为45.4%(10/22)和72.7%(16/20),垂体后叶素则为20%(4/20)和40%(8/20)(P<0... 采用对照研究方法,比较必压生(Pitressin)和垂体后叶素控制食管静脉曲张破裂出血(EVB)的临床疗效。必压生6小时和12小时完全止血率分别为45.4%(10/22)和72.7%(16/20),垂体后叶素则为20%(4/20)和40%(8/20)(P<0.05);前者起效时间为4.47小时,达到完全止血时为8.7小时;后者分别为8.8小时和22.2小时(P<0.05);24小时和36小时的输血量必压生组明显少于对照组(P<0.05)。结果表明,必压生能迅速有效地控制EVB,止血效果优于垂体后叶素,但两者在病死率、再出血方面无显著性差异。 展开更多
关键词 必压生 垂体后叶素 食管静脉曲张 药物疗法
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Portal hemodynamics in cirrhotics with portal hypertension using color Doppler velocity profile 被引量:1
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作者 黄洁夫 殷晓煜 +2 位作者 吕明德 陈俊伟 梁力建 《Chinese Medical Journal》 SCIE CAS CSCD 1999年第7期51-55,共5页
Objective To investigate portal hemodynamics and its correlation with e sophageal variceal bleeding (EVB) in cirrhotics with portal hypertension by usin g a newlydeveloped technique, color Doppler velocity profile (CD... Objective To investigate portal hemodynamics and its correlation with e sophageal variceal bleeding (EVB) in cirrhotics with portal hypertension by usin g a newlydeveloped technique, color Doppler velocity profile (CDVP) Methods Hemodynamics of portal trunk (PT), right anterior branch (RAB) and splenic vein (SV) were evaluated in 48 cirrhotics with portal hypertension a nd 35 normal volunteers by CDVP The parameters included maximum crosssection a l velocity (CSVmax), flow volume, congestion index (CI), profile parameter N a nd pattern of flow curve Stepwise logistic regression model was employed to de termine EVBrelating factors in cirrhotics Results CSVmax in PT and RAB was significantly lower in cirrhotic gro up than that of normal group, being 1491308?cm/s, 944270?cm/s vs 3 052 675?cm/s, 1282269?cm/s, respectively ( P <001 for both) Fl ow volume of PT and SV was significantly higher in cirrhotic group compared with that of normal group, being 25161048?mlmin1kg1, 15 8 3918?mlmin1kg1 vs 2043557?mlmin1kg 1, 581 204?mlmin1kg1, respectively ( P <001 for bo th) C I of PT,RAB and SV was significantly higher in cirrhotic group than in normal gr oup, being 014200654, 010500496, 0088400431 vs 003260014 2, 0075 700342, 0048300230, respectively ( P <001 for all) In d ynami c variation of flow volume over time, RAB and SV in cirrhotic group increasingly presented flat pattern and periodically changed pattern, respectively ( P <001 for both) Between cirrhotic subgroups without and with EVB histor y, there were significant differences in flow volume, CI and N value of SV, splenic size, degree of esophageal varices (EV) and portal hypertensive gastropathy (PH G), and stepwise logistic regression revealed that N value of SV, splenic size, degree of EV and PHG were four independent factors in relation to EVB EVB sco r es calculated from the regression equation had a close correlation with EVB I n patients with EVB score>0, 889% of them had EVB, and in those with EVB<0, 76 9% of them had no history of EVB Conclusion In cirrhotics with portal hypertension, portal venous system has the features of elevated vascular resistance and hyperdynamics, and the lat ter mainly results from increased blood flow in SV EVB score may become a val uable parameter in predicting occurrence of EVB 展开更多
关键词 portal hemodynamics color Doppler velocity profile esop hageal variceal bleeding
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