Comparison of the Development Model of DTP Pharmacy between China and the United States and Its Enlightenment

Objective To systematically analyze the development status of DTP pharmacy in the United States and China,and to find out the problems in China’s DTP pharmacy and put forward some countermeasures and suggestions.Methods Relevant literature was searched and reviewed to study the history,market scale and development trend of DTP pharmacy in the United States and China.Then,the problems in China’s DTP pharmacy were found out.Results and Conclusion DTP pharmacy model in the U.S.has taken shape and is maturing.The high degree of industry concentration is an important feature of the U.S.pharmacy.In contrast,China’s DTP pharmacy started late,and the industry pattern has not yet been finalized.There are still some problems in the DTP pharmacy certification and quality management.It is recommended to promote the rapid development of DTP pharmacies in China by encouraging the outflow of prescription drugs,establishing a third-party pharmacy accreditation organization and strengthening the team of licensed pharmacists and other personnel.

Comparison of the Development of CDMO at Home and Abroad and Its Enlightment to China

Objective To analyze the development status of contract development manufacturing organization(CDMO)at home and abroad,and to make some suggestions for the development of CDMO in China.Methods The relevant literature was searched and reviewed,and the development status of CDMOs in the United States,France,Japan and China was compared from the aspects of market scale,development process,development focus,advantages and disadvantages,and policy support.Then,some suggestions for the development of CDMO enterprises in China were summarized.Results and Conclusion Through the comparison of CDMO development at home and abroad,it can be seen that China started CDMO late,there were many technical barriers and its globalization layout were not sufficient.However,the development trend was good and it focused on the field of chemical drugs and biological drugs to constantly develop innovative drugs.China needs to continuously improve its own technical capabilities to carry out innovative research.Therefore,cost reduction and efficiency increase will be the key elements for the development of CDMOs,and they are expected to have a rapid and comprehensive development in the future.

Implications of periostin in the development of subarachnoid hemorrhage-induced brain injuries

Target of research in subarachnoid hemorrhage（SAH）：The outcome of aneurysmal SAH remains poor despite advances in the diagnosis and treatment.Although many factors related to patients,aneurysms,and institutions,as well as physiological parameters and medical complications were reported as prognostic factors,

A Study of Culture： Features, Classes, Development and Implications for ELT

It proves to be a tough job to define culture and to draw characteristics of culture or work out the categories of culture. Based on some influential definitions, and achievements made in sociology and anthropology, this paper makes an attempt to summarize and discuss some characteristics of culture. With regard to the categorization of culture, we put forward the idea that it is closely related to the definition and features of culture, and also that it is closely related with human cognition and different perspectives, and thus culture category is an open system just as culture in general. Cultural development as product of human evolution and development is both a need and reality, going on through cultural transmission. In the process, it is human nature to encounter cultural conflicts like culture shock, the solution of which partially depends on cultural studies, on a close relationship with the main school of culture or dominating culture and on seeking similarities and accepting differences, and in a word, on friendly and cordial contacts and understanding through linguistic communication.

China's CDM Policies and Their Development Implications:Major Concerns for CDM Implementation

Most CDM (Clean Development Mechanism) opportunities exist in some large industrializing developing countries. For instance, China is estimated to take 48% of the world potential for CDM project activities. In reality, however, the share by China over the CDM projects registered and CDM projects in the pipeline is less than 10% as of Auguest 2005. This paper will examine the reasons behind, as reflected in China's CDM policies. Further investigation will be made into the use of these policies to boost the country's sustainable development, the sustainable development implications and effects of these policies. In addition, it is noted that incompatibility of some other Chinese laws and policies can be responsible for the low level and slow pace of CDM implementation in China and some suggestions are offered for promoting CDM project activities in China. There also exist barriers at the international level that impedes implementation of CDM project activities. A conclusion is drawn that CDM policies in a developing country like China aim mainly at promotion of sustainable development and to a lesser extent the generation of CERs.

Ethical Implication of Spatial Design of Hakka Enclosed-castled-houses in Southern Jiangxi

The Hakka enclosed-castled-houses in southern Jiangxi are the historical treasure of Hakka culture,and are the material carrier of Hakka traditional excellent ethics.This article combs the historical development of Hakka enclosed-castled-houses from the perspective of design,and explores the ethical implication of respecting ancestors,respecting social rank,and valuing harmony in space design,in order to provide new ideas and basic theoretical support for the protection and inheritance of Hakka enclosed-castled-houses in southern Jiangxi.

Narrative Judgments and Its Ethical Implication in Ian McEwan＇s The Child in Time

As a newly developed theory, narrative ethics has its reasonability and advantages in that it can not only analyze either the contents or the forms of the texts, but also make an analysis of the combination of both contents and forms. This article, supported by James Phelan＇s rhetorical narrative theory as the theoretical base, attempts to explore and interpret narrative judgments and its implied ethics existing in The Child in Time by Ian McEwan so as to observe the hidden aesthetic orientation, the value judgments and the ethical intentions of the text and help to reveal the author＇s views of narrative ethics and aesthetics of the novel.

Development and psychometric evaluation of the Ethical Behavior for Thai Nurses Scale

Background:Ethical problems in the nursing profession are mostly found in the undesirable ethical behavior(EBE)of nurses.If there is no concern about these problems,it may negatively affect the quality of nursing care,patients’safety,and trust in the nursing profession.In assessing nurses’EBE,it is important to develop an instrument that reflects the actual EBE of nurses.Objectives:To develop and evaluate the psychometric properties of the Ethical Behavior for Thai Nurses Scale(EBTNS).Methods:The construct definition,5 sub-constructs,43 items,and the hypothesized model were synthesized and generated from a comprehensive literature review and existing research instruments by using document analysis.The EBTNS was verified for content validity by 4 experts.Of the 43 items,37 items were retained for psychometric testing.The construct validity was tested by using second-order confirmatory factor analysis(CFA).The EBTNS was tested on 1500 professional nurses working at tertiary,secondary,and primary hospitals in 6 regions(the central,northern,northeast,eastern,western,and southern)of Thailand.Proportional quota sampling was applied to recruit participants.Results:The hypothesized model fitted the empirical data.All 37 first-order indicators and 5 second-order sub-constructs showed significantly standardized factor loadings and effect sizes.The standardized factor loadings of 37 first-order indicators ranged from 0.58 to 0.89,and the construct reliabilities were moderate to substantial(R2=0.34-0.79).The 5 second-order sub-constructs displayed the standardized effect sizes,ranging from 0.81 to 0.96,and accounted for 65%-96%of the total explained variance.In addition,the construct validity was supported by convergent validity and discriminant validity.It also satisfied Cronbach’s alpha coefficients of 5 sub-constructs from 0.87 to 0.94,and a full scale was 0.97.Conclusions:The psychometric properties of the EBTNS are acceptable.This instrument has the potential to be used for evaluating and monitoring to prevent ethical problems of Thai nurses.

Melastatin-related transient receptor potential 2 channel in Aβ_(42)-induced neuroinflammation: implications to Alzheimer's disease mechanism and development of therapeutics

Alzheimer’s disease （AD） is an age-related eurodegenerative disease that represents the most common cause of dementia among the elderly people. With the increasingly aging population, AD has presented an overwhelming healthcare challenge to modern society; the World Alzheimer Report 2015 has estimated that 46.8 million people worldwide lived with dementia in 2015 and this number will rise to 74.7 million in 2030 and that the total cost of dementia was 818 billion in US$ in 2015 and will reach two trillion in 2030. Post-mortem studies have identified two histopathological hallmarks in the brains of AD patients; extracellular senile plaque with elevated deposition of amyloid β （Aβ） peptides, and intracellular neurofibrillary tangle composed of hyper-phosphorylated microtubule-associated protein tau.Etiologically, progressive neuronal loss within the cerebral cortex and hippocampus regions of the brain leads to irreversible decline in, and eventually complete loss of, memory and other cognitive functions that afflict AD patients. The widely-accepted amyloid cascade hypothesis for AD pathogenesis holds that accumulation and aggregation of neurotoxic Aβ peptides, due to imbalance of their generation and clearance as a result of changes in genetic makeup, aging and/or exposure to environmental risk factors, is a major and early trigger of AD. This hypothesis has continuously gained support by preclinical and clinical studies （Selkoe and Hardy, 2016）. However, the intensive and costly drug discovery efforts over the past decades based on such a hypothesis have proved extremely frustrating in developing effective therapeutics to treat or slow down the progress of AD, highlighting the need for more research to improve our understanding towards the cellular and molecular mechanisms by which Aβ peptides bring about neurotoxicity and cognitive dysfunction.

Present Status of Clinical Decision Support System （CDSS） and Proposal of Ethical Guideline for Artificial Intelligence Development in Medical Field

This paper is looking at the trends of future medicine focusing on IBM Watson, Microsoft Intelligent Network for Eye care （MINE）, and Google’s AI Eye Doctor. Microsoft’s Mine, an artificial intelligence assistant program, and Google’s Eye Doctor, were created because of the two characteristics of eye disease. The disease of the eye significantly reduces the quality of human life, but it can be prevented if the illness is discovered in advance. Therefore, prevention of these diseases is important. Through the development of the Google eye Doctor Program shown in the article of “Retinopathy Algorithm”, we obtained the implications for the ethical guidelines that can be applied to other artificial intelligence development programs. At the heart of these guidelines is the efficient and safe treatment of patient illnesses for medical purposes.

On Tourism Ethics and Sustainable Development

The correlation between tourism ethics and sustainable development was put forward,and the practical significance of constructing tourism significance was proposed.Tourism ethics is the product of tourism based on the thought that how human beings perfect themselves and create new civilization in the 21st century,which is adaptable to the emphasis on harmonious development among human beings,between human and nature as well as the self-perfection of human beings,and moreover,tourism ethics would greatly promote and guide the sustainable development.

Challenges Brought about by Rapid Changes in Chinese Diets: Comparison with Developed Countries and Implications for Further Improvement

Given developments in urbanization, agricultural, and technological practices, the diet and lifestyle of developed countries has changed dramatically over the course of the last century[1].

Discussion on Ecological Ethics Implication of Youyu Spirit

Ecological ethics is a kind of ethics code adjusting relationship between human and nature. Ecological ethics implication of Youyu spirit reflects in four aspects： eco-value concept of ＂nature and human unifying, revering nature＂, eco-politics concept of ＂persisting greening, diligently working for people＂, eco-obligation concept of ＂predecessor planting, descendant cooling＂ and eco-culture concept of ＂public participation, harmonious development＂. It has important value for constructing beautiful Shanxi and realizing ecological civilization to excavate and carry forward ecological ethics implication of Youyu spirit.

Building up the concept of green development by infiltrating ecological ethics into ideological education for university students

University student education is the main part of higher education in China. Therefore, the comprehensive quality of university students shows the level of higher education. Ecological literacy is the basic literacy of college students under the background of green development to build socialism with Chinese characteristics. The green development education is based on the research idea of the relationship between the individual and the surrounding environment in ecology, which requires respecting the subjectivity of the active object, paying attention to the integrity and connection of the object. Compared with the traditional education, green development education pays more attention to the cultivation of moral quality and sound personality of the educated, and it can make the students understand the ecological environment. Under the premise of ecological system and the mechanism of biological growth and development, respect and love of life are formed naturally, and then the universal concern for environment and others is formed. College students, as advanced groups of young people, are leading the social fashion and influencing the social ethical environment. Ecological literacy is the new requirement of the times for college students. We should integrate the education of green development into the ideological education,make great efforts to shape the ecological ethical system of college students, and cultivate their ecological consciousness, ecological thinking and behavior habits. It is an important issue for ideological education to improve the quality of green development in an all-round way.

Informed consent process: ethical and practical challenges in clinical trials regarding subject enrollment, protection, and informed consent in developing countries (India, Pakistan & Iran)

In this study,we are discussing the rationale behind informed consent in clinical trials in developing countries.It elaborates how informed consent has remained an ethical and practical issue.Poverty,endemic diseases,and a lack of investment in healthcare systems influence the ease of conducting and selecting trials that can benefit the people of developing countries.Differences in cultural perspectives,religious beliefs,a lack of formal training for clinical staff,children,time zone difference,literacy,vulnerable population,and language barriers for subject enrollment,protection,and informed are also challenges.This report doesn’t only highlight the right the wrongs of the past or reiterate cases where clinical trials have hurt subjects in developing countries.The current study investigates the conditions of human research in developing countries to make them more ethically sound.The extends proposals to investigators,scientists,governments,sponsors,and other groups who are interested where appropriate.

The Intemal Implication of the Economic Ethics in the Alienated Labor Theory of Economic and Philosophical Manuscripts of 1844

Alienated labor, also known as labor alienation, was a concept with historical creativity, which was first raised in Marx＇ s Economic and Philosophical Manuscripts of 1844. The Manuscripts was important works of Marx, in which the social relations of capitalism private ownership were analyzed by Marx using the concept of alienated labor. A deep analysis was conducted by Marx from the specific historical facts, in which the rational kernel of the alienated problem in the social relations of capitalism was mentioned. Specifically, the alienated labor theory was analyzed from the relationship of laborers with their labor products and labor itself, human＇ s essence, and other people under the condition of the capitalist private ownership; the ＂ought to be＂ ethical characteristics of labors were expounded from the perspective of ethics, and the abnormal labor relations in the process of capitalist production were ethically reviewed and criticized. Therefore, rich economic ethics thoughts were contained in Marx＇ s analysis of the alienated labor theory.

Green Development and the Land Ethic

Attempts to understand and respond to the threat of anthropogenic climate change,the defining challenge of our era,increasingly reveal the inadequacy of the dominant conceptual systems of thought.Recognizing the need for a fundamental change in the dominant models of industrial development,the concept of sustainability has quickly become the idea around which contemporary environmentalism is centered.This essay argues that while the concept of sustainability is important,it ultimately does not address the root of the ecological crisis.With Aldo Leopold(1887-1948),I argue that it is an"evolutionary possibility and an ecological necessity"that we develop what he calls a"land ethic."If we are truly to address the root causes of the ecological crisis,humanity must stop conceiving of proper land use merely in terms of economic expedience and recognize that we are ultimately a member and citizen of the wider"biotic community."In the end,green development is development which is compatible with the integrity,stability,and beauty of the nature.

Discussions about Gardening Craft of Japanese Gardens and Implications for China

Japanese gardens were developed under the influence of China.In the process of development,the Japanese gardens studied the modern Western gardening craft,and developed unique gardening craft with local regional characteristics and national style in accordance with local conditions.This paper analyzed Japanese gardens through the development of Japanese gardens,the development process,the types of gardens and gardening elements,the characteristics of garden design and the implications for modern and contemporary Chinese garden design.In addition,through an in-depth understanding of Japanese gardens and exploring their intrinsic value,this paper summarized their development experience,in the hope of applying them into the future garden landscape design.

A Critical Review on the Sustainable Development Future

Government managements in every country, at each stage and from all parts of the world are beginning to classify the criticality of highlighting the challenges of sustainability. The high demand of the philosophy of sustainability is being developed in public policy debates. Analyzing the chances of sustainability is an essential element which goes beyond the nation’s local plans. It is hard for any nation to practice sustainability if their own government systems which run the organizations of different sectors are unsustainable. In other words, it is impossible for several industries to easily generate economic, environmental and social significances by updating their strategy or pioneering applications when international marketing motivations exist in the opposite dimension. However, as a result of the high demand of sustainable products in the industry, many of the governments have found themselves to be obligated to align with green strategy and policy to facilitate the shift to a sustainable economy which is more resourceful and reasonable for all the stake holders. The vital role of governments consists of setting robust and sustainable policies to regulate the business mechanism for the individuals and industries. The authors give an example of environmental performers to support their claim. This review paper will highlight the role of the three main players in the Sustainable Development Future: government, industry, and society from a new and integrated perspective.

Ethical Issues and Politics in Research for Sustainable Resource Management in Tanzania

Understanding Research ethics is the key for producing sound findings to guide management of resource in any community. Through in-depth interview, observation and documentary search, it was noted that most of the studies are not self-driven and lack ethical integrity. People are hired to produce report without clear and streamlined methodology. Nature of the community and the way it is organised poses challenge in acquiring information. In principle, culture of the people to expression is an important aspect in getting liable findings. The conflicts over resources in Namawala and Magaiduru villages have led to the loss of trust and rejects on researchers as they are discovered to provide villagers with false information. Some findings are fabricated to convince the donors＇ interests to call for more funds for personal interests. Other decision makers would commission researcher to produce false data to suit their interests. This causes academic and researchers being classified as a tool of politician to pacify the public in order to maintain the status quo. The problem is caused by lack of sufficient research fund and understanding on the research essence, and importance of ethical consideration for good research. The situation causes multiple sided effects in the community. Generally, lack of research ethics and presence of greed politicians jeopardise resource management, peace and security. There is need to build the culture of truth and integrity for community development. Research methods need to be taught rigorously in order to build capacity in tools and principles.