Comparative experiments show that ultrasonic irradiation reduces the reaction times and improves the yields in the di-alkylation and cyclo-di-alkylation of ethyl cyanoacetate under solid-liquid phase transfer conditions.
The title compound ethyl 2-(2-amino-3-ethoxycarbonyl-4H-benzopyran-4-yl) cyanoacetate(C17H18N2O5, Mr=330.33) was obtained by the reaction of salicylaldehyde with ethyl cyanoacetate in DMF at room temperature catalyzed...The title compound ethyl 2-(2-amino-3-ethoxycarbonyl-4H-benzopyran-4-yl) cyanoacetate(C17H18N2O5, Mr=330.33) was obtained by the reaction of salicylaldehyde with ethyl cyanoacetate in DMF at room temperature catalyzed by KF-Al2O3. The crystal is monoclinic, space group P21/n, with unit cell constants a =9.277(3), b =8.521(2), c =21.320(2)? b =93.72(2)? Z =4, V =1681.8(7)?, Dc =1.305g/cm3, m (MoKa) =0.097mm-1, F(000) =696, R =0.0426, Rw =0.0970 for 3042 observed reflections(I>2s(I)). X-ray analysis reveals that interatomic distance for C(8)C(9) is 1.359(3)? which shows that it is C=C double bond. In addition, there are hydrogen bonds in the molecule.展开更多
The conjugate hydrocyanation of chalcone derivatives using ethyl cyanoacetate as an organic cyanide source at room temperature under open air and transition metal-free conditions was described. The protocol has advant...The conjugate hydrocyanation of chalcone derivatives using ethyl cyanoacetate as an organic cyanide source at room temperature under open air and transition metal-free conditions was described. The protocol has advantages of using relatively cheap, less toxic, stable and easy-to-handle cyanating reagent, high yield, and mild reaction condi- tion.展开更多
文摘Comparative experiments show that ultrasonic irradiation reduces the reaction times and improves the yields in the di-alkylation and cyclo-di-alkylation of ethyl cyanoacetate under solid-liquid phase transfer conditions.
基金supported by the Foundation of the Surpassing Project of Jiangsu Province
文摘The title compound ethyl 2-(2-amino-3-ethoxycarbonyl-4H-benzopyran-4-yl) cyanoacetate(C17H18N2O5, Mr=330.33) was obtained by the reaction of salicylaldehyde with ethyl cyanoacetate in DMF at room temperature catalyzed by KF-Al2O3. The crystal is monoclinic, space group P21/n, with unit cell constants a =9.277(3), b =8.521(2), c =21.320(2)? b =93.72(2)? Z =4, V =1681.8(7)?, Dc =1.305g/cm3, m (MoKa) =0.097mm-1, F(000) =696, R =0.0426, Rw =0.0970 for 3042 observed reflections(I>2s(I)). X-ray analysis reveals that interatomic distance for C(8)C(9) is 1.359(3)? which shows that it is C=C double bond. In addition, there are hydrogen bonds in the molecule.
基金The authors thank the National Natural Science Foundation of China （Nos. 21462038, 21362034） and Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education for the financial support of this work.
文摘The conjugate hydrocyanation of chalcone derivatives using ethyl cyanoacetate as an organic cyanide source at room temperature under open air and transition metal-free conditions was described. The protocol has advantages of using relatively cheap, less toxic, stable and easy-to-handle cyanating reagent, high yield, and mild reaction condi- tion.
