Euodiae Fructus,referred to as“Wuzhuyu”in Chinese,has been used as local and traditional herbal medicines in many regions,especially in China,Japan and Korea,for the treatment of gastrointestinal disorders,headache,...Euodiae Fructus,referred to as“Wuzhuyu”in Chinese,has been used as local and traditional herbal medicines in many regions,especially in China,Japan and Korea,for the treatment of gastrointestinal disorders,headache,emesis,aphtha,dermatophytosis,dysentery,etc.Substantial investigations into their chemical and pharmacological properties have been performed.Recently,interest in this plant has been focused on the different structural types of alkaloids like evodiamine,rutaecarpine,dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone,which exhibit a wide range of pharmacological activities in preclinical models,such as anticancer,antibacterial,anti-inflammatory,anti-cardiovascular disease,etc.This review summarizes the up-to-date and comprehensive information concerning the botany,traditional uses,phytochemistry,pharmacology of Euodiae Fructus together with the toxicology and quality control,and discusses the possible direction and scope for future research on this plant.展开更多
Alkaloids are the main active constituents of the nearly ripe fruits of Euodia rutaecarpa(Juss.)Benth.,which possesses antitumor,anti-inflammatory,analgesic and antimicrobial activities.In this study,we aimed to asses...Alkaloids are the main active constituents of the nearly ripe fruits of Euodia rutaecarpa(Juss.)Benth.,which possesses antitumor,anti-inflammatory,analgesic and antimicrobial activities.In this study,we aimed to assess the potential anti-inflammatory effects of six main components,evodiamine,rutaecarpine,dehydroevodiamine,evocarpine,dihydroevocarpine and 1-methyl-2-undecyl-4-(1H)-quinolone,in the nearly ripe fruits of E.rutaecarpa.In the co-culture system consisting of the human colorectal adenocarcinoma(Caco-2)cells and RAW264.7 macrophages,inflammation was induced in RAW264.7 cells with 2μg/mL lipopolysaccharide.The results indicated that evodiamine,rutaecarpine,and dehydroevodiamine significantly down-regulated the mRNA expressions of pro-inflammatory cytokines(Il-6,Il-1βand Tnf-α)and inflammatory mediators,such as cyclooxygenase-2(Cox-2)and inducible nitric oxide synthase(iNos).Besides,the drug administration group showed a higher transepithelial electrical resistance and a lower tight junction permeability compared with the model group.Taken together,the tested compounds possessed anti-inflammatory effects.Our findings laid the foundation for further research on the anti-inflammatory mechanism of the nearly ripe fruits of E.rutaecarpa.展开更多
基金the National Natural Science Foundation of China(82004215,82173704,31870327,82003624,82004003)the Key Research and Development Program of China(2019YFC1711006,2017YFC1702002)+4 种基金the National Major Project of China(2018ZX09731016-005)Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(16DZ2280200)Shanghai Municipal Health Commission Project(20204Y0326)Science and Technology Commission of Shanghai Municipality(20YF1459000,20YF1458700)Sailing Program of Naval Medical University。
文摘Euodiae Fructus,referred to as“Wuzhuyu”in Chinese,has been used as local and traditional herbal medicines in many regions,especially in China,Japan and Korea,for the treatment of gastrointestinal disorders,headache,emesis,aphtha,dermatophytosis,dysentery,etc.Substantial investigations into their chemical and pharmacological properties have been performed.Recently,interest in this plant has been focused on the different structural types of alkaloids like evodiamine,rutaecarpine,dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone,which exhibit a wide range of pharmacological activities in preclinical models,such as anticancer,antibacterial,anti-inflammatory,anti-cardiovascular disease,etc.This review summarizes the up-to-date and comprehensive information concerning the botany,traditional uses,phytochemistry,pharmacology of Euodiae Fructus together with the toxicology and quality control,and discusses the possible direction and scope for future research on this plant.
基金National Key R&D Program of China(Grant No.2018YFC1704500,2018YFC1704506)the National Natural Science Foundation of China(Grant No.81773865)。
文摘Alkaloids are the main active constituents of the nearly ripe fruits of Euodia rutaecarpa(Juss.)Benth.,which possesses antitumor,anti-inflammatory,analgesic and antimicrobial activities.In this study,we aimed to assess the potential anti-inflammatory effects of six main components,evodiamine,rutaecarpine,dehydroevodiamine,evocarpine,dihydroevocarpine and 1-methyl-2-undecyl-4-(1H)-quinolone,in the nearly ripe fruits of E.rutaecarpa.In the co-culture system consisting of the human colorectal adenocarcinoma(Caco-2)cells and RAW264.7 macrophages,inflammation was induced in RAW264.7 cells with 2μg/mL lipopolysaccharide.The results indicated that evodiamine,rutaecarpine,and dehydroevodiamine significantly down-regulated the mRNA expressions of pro-inflammatory cytokines(Il-6,Il-1βand Tnf-α)and inflammatory mediators,such as cyclooxygenase-2(Cox-2)and inducible nitric oxide synthase(iNos).Besides,the drug administration group showed a higher transepithelial electrical resistance and a lower tight junction permeability compared with the model group.Taken together,the tested compounds possessed anti-inflammatory effects.Our findings laid the foundation for further research on the anti-inflammatory mechanism of the nearly ripe fruits of E.rutaecarpa.
基金supported by Major Program of National Natural Science Foundation of China (82192910)the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202009 and ZYYCXTD-D-202207)。
