The removal of Ni2+ and Cd2+ ions by Eupenicillium ludwigii biomass was studied in a batch system. The optimum pH for the biosorption was 6 for Ni2+ and 5 for Cd2+. Temperature changes in the range from 15oC to 40oC a...The removal of Ni2+ and Cd2+ ions by Eupenicillium ludwigii biomass was studied in a batch system. The optimum pH for the biosorption was 6 for Ni2+ and 5 for Cd2+. Temperature changes in the range from 15oC to 40oC affected the biosorption capacity, and the nature of the reaction was found to be endothermic for both metal ions. HCl was the best desorbing agent for the desorption of both metals. Chemical modifications of the biomass demonstrated that carboxyl and amine groups played an important role in Ni2+ and Cd2+ biosorption. Ion exchange mechanism was also suggested in the biosorption process.展开更多
One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isola...One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isolated from the solid cultures of the endophytic fungus,Penicillium brefeidianum.The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism（CD） exciton chirality method.All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines.Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC（50） values of 14.1 μmol/L and 35.5μmol/L,respectively.Compound 3 showed moderate activity against HepG2 cells with IC（50） values of 36.6 μmol/L.展开更多
基金supported by the funds of national major programs on new drug creation during the 11th Five-Year Plan Period(2010ZX09401-403)Science and Technology Planning Project of Fujian Province(2009R10003-3)
文摘The removal of Ni2+ and Cd2+ ions by Eupenicillium ludwigii biomass was studied in a batch system. The optimum pH for the biosorption was 6 for Ni2+ and 5 for Cd2+. Temperature changes in the range from 15oC to 40oC affected the biosorption capacity, and the nature of the reaction was found to be endothermic for both metal ions. HCl was the best desorbing agent for the desorption of both metals. Chemical modifications of the biomass demonstrated that carboxyl and amine groups played an important role in Ni2+ and Cd2+ biosorption. Ion exchange mechanism was also suggested in the biosorption process.
基金This study was supported by the Knowledge Innovation Program of theChinese Academy of Sciences and National Natural Science Foundation of China(no．30230020)．
基金funded by the National Natural Science Foundation of China(No.81503218)the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Fundamental Research Funds for the Central Universities(No.2016ZZD010)
文摘One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isolated from the solid cultures of the endophytic fungus,Penicillium brefeidianum.The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism（CD） exciton chirality method.All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines.Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC（50） values of 14.1 μmol/L and 35.5μmol/L,respectively.Compound 3 showed moderate activity against HepG2 cells with IC（50） values of 36.6 μmol/L.
