Analysis of the adverse reactions of atezolizumab: A real-world study based on FAERS database

Objective In this study,we aimed to determine the incidence of adverse drug reactions(ADRs)of atezolizumab,identify ADR signals that are significantly related to atezolizumab,and provide a reference for the rational use of atezolizumab in the clinic through the statistical analysis of its adverse drug events(ADEs)reported in the American Food and Drug Administration(FDA)Adverse Event Reporting System(FAERS)database.Methods In total,4796 cases of atezolizumab ADEs reported in the American FAERS database from 2017 to 2019 were retrospectively analyzed.Results The top three ADEs were febrile neutropenia(3.7%),anemia(2.9%),and acute renal failure(2.3%).In addition,the incidence rates of some ADEs were significantly different according to sex and age.The systematic organ classification of atezolizumab ADEs involved 32 systems,among which the top three were blood and lymphatic system disorders(585 cases,12.2%),gastrointestinal disorders(433 cases,9.0%),and infections and infestations(401 cases,8.4%).The reporting odds ratio(ROR)method was used to detect the ADR signals of atezolizumab.The ROR(95%confidence interval)of the top ADE,febrile neutropenia,was 39.236(33.757–45.604).In addition,we found 121 cases of complications associated with immune-related ADEs.Conclusion The ADRs of atezolizumab reported in the FAERS database were consistent with those mentioned in the instructions for atezolizumab use,suggesting that atezolizumab has an acceptable and controllable drug effect.

基于GDELT新闻大数据的东南亚地缘交互关系制图研究

地缘关系研究是地理学中的一个重要研究领域,基于大数据的地缘关系的定量研究是对传统定性地缘关系研究的必要补充。利用全球事件、语言与语调(global database of events,language,and tone,GDELT)新闻数据库获取中国与缅甸、老挝、越南、泰国和柬埔寨5个国家之间的交互事件,通过定量统计和空间制图、构建交互网络、时空热点分析等方法,对中国与这5个国家的地缘关系进行剖析。并以中缅为例分析两国地缘关系变化的原因,提出相应合作建议。结果表明,事件主要发生在各国政治经济文化较为活跃的地区;中国与越南和泰国的地缘交互较多,与越南的关系最为复杂;中国与五国的交互热点主要分布于越南、泰国、柬埔寨,除越南外,中国与另外4个国家的合作水平呈增强态势。