OBJECTIVE：The aims of this study were to investigate the changes of the total intensity of transient evoked otoacoustic emission（TEOAE） and signal-to-noise ratio in various frequency bands as a function of aging,an...OBJECTIVE：The aims of this study were to investigate the changes of the total intensity of transient evoked otoacoustic emission（TEOAE） and signal-to-noise ratio in various frequency bands as a function of aging,and to explore the role of age-related decline of cochlear outer hair cells.DATA SOURCES：The literature was searched using the PubMed database using ＇transient-evoked otoacoustic emissions＇ as a keyword.Articles were limited as follows：Species was ＇Humans＇;languages were ＇English and Chinese＇;publication date between 1990-01-01 and 2010-12-31.The references of the found were also searched to obtain additional articles.DATA SELECTION：Inclusion criteria：（1） Articles should involve the total TEOAE level or signal-to-noise ratio.（2） The measurement and analysis system used was Otodynamics ILO analysis system（ILO88,ILO92,ILO96 or ILO292）.（3） Studies involved groups of greater than 10 subjects and TEOAE results were from normally hearing ears.（4） If more papers from the same author or laboratory analyzed the same subjects,only one was used.MAIN OUTCOME MEASURES：The correlations of the age scale with the total level and signal-to-noise ratio of TEOAE was determined,respectively.RESULTS：（1） TEOAE total level gradually increased until 2 months of age,and then decreased with increasing age.Significant negative correlations between total TEOAE level and age were found（r =-0.885,P = 0.000）.（2） The most rapid decrease of TEOAE amplitude occurred at 1 year old.The total TEOAE level decreased about 4.25 dB SPL between 2 months to 1 year old,then about 0.26-0.52 dB SPL from 1 year to 10 years old,about 0.23 dB SPL from 11 years to 25 years old,and about 0.14 dB SPL from 26 years to 60 years old.（3） The signal-to-noise ratio in the frequency bands centered at 1.5,2,3 and 4 kHz decreased with increasing age after 2 months of age.Significant negative correlations between the signal-to-noise ratio and age were found for frequency bands ranging from 1.5 kHz to 4 kHz,with the highest correlations at 4 kHz（r =-0.890,P 〈 0.01）,then at 3 kHz（r =-0.889,P 〈 0.01）,at 2 kHz（r =-0.850,P 〈 0.01） and at 1.5 kHz（r =-0.705,P 〈 0.05）.Conversely,a positive correlation between the signal-to-noise ratio centered at 1 kHz and age was found,but was not statistically significant（r = 0.298,P = 0.374）.CONCLUSION：The total TEOAE response level decreased with increasing age after the first 2 months of age.The signal-to-noise ratio also decreased with increasing age in frequency bands above 1.5 kHz.The signal-to-noise ratio in higher frequencies decreased faster than in lower frequencies,leading to the maximum signal-to-noise ratio shift form 3.2-4.0 kHz in neonates to 1.5 kHz in adults,and further decreasing the total TEOAE response level.The age-related TEOAE spectrum peak shift is most likely because the outer hair cells functioning in higher frequencies are more prone to damage than those for lower frequencies.展开更多
We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between b...We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between bilirubin serum levels and auditory dysfunction. Eleven infants born at-term with BFJ were selected for the study. We studied also 11 control age- and gender matched healthy at-term infants without signs of jaundice. T-EOAE studies were performed between 5-7 days after birth, and 3 months later. BAEP studies were performed once. BFJ group infants exhibited lower amplitudes in T-EOE than infants in the control group. These differences disappear at the 3-month evaluation. In BAEP, we observed a significant latency delay of waves I and V in Breast-feeding jaundice group infants. All infants in both groups demonstrated reproducible wave V response at 30 decibels. No significant correlation values were observed between bilirubin serum levels and T-EOE and BAEP variables. Our data suggest that BFJ can result in transient peripheral and central auditory dysfunction. Dysfunction is reversible after treatment of infants with BFJ.展开更多
Objective: To determine the proportion of neonates with referral result on testing with transient evoked otoacoustic emission (TEOAE) and the associated risk factors. Method: Prospective evaluation of all neonates bor...Objective: To determine the proportion of neonates with referral result on testing with transient evoked otoacoustic emission (TEOAE) and the associated risk factors. Method: Prospective evaluation of all neonates born in the Hospital within 6 months using the TEOAE. A hand-held Etymotic Research Otoacoustic Emission Scanner (Ero-scan Combo) was used with the child sleeping in the cot or the mother’s hand. Right and left ears were tested separately and the result was displayed automatically as “pass” when 100% of the in-built criteria were met and “refer” if otherwise. The subjects that passed in both ears were regarded as passes, while those with a refer in either the right/left ears or both ears were regarded as referrals and were thus subjected to rescreening in six weeks or on discharge from the special care baby unit. Analysis was done to find association between the outcome of TEOAE and the clinical and epidemiological risk factors. Result: TEOAE was carried out on 386 neonates, (194 males (50.3%) and 192 females (49.7%)). The mean age at screening was 2.3 days (SD = 1.5), the mean gestational age was 38.0 weeks (SD = 2.7) while the mean birth weight was 2.9 kg (SD = 0.7) and the mean Apgar score at 1 and 5 minute were 8.3 (SD = 1.0) and 9.8 (SD = 0.6). At the first step hearing screening, referral rate was 112 (29.0%);at the second stage, 31 (8.5%) neonates had referral in one or both ears. Fisher’s exact test showed that prematurity, multiple births, jaundice and small birth weight were significantly associated with a referral outcome. However, logistic regression revealed prematurity as a significant predictor of referral outcome with a negative predictive value of 12.61. Conclusion: The referral rate is high with prematurity as a significant predictor. This study calls for commencement of newborn hearing screening and strengthening of the public health measures in the developing countries.展开更多
Biometrics,which has become integrated with our daily lives,could fall prey to falsification attacks,leading to security concerns.In our paper,we use Transient Evoked Otoacoustic Emissions(TEOAE)that are generated by ...Biometrics,which has become integrated with our daily lives,could fall prey to falsification attacks,leading to security concerns.In our paper,we use Transient Evoked Otoacoustic Emissions(TEOAE)that are generated by the human cochlea in response to an external sound stimulus,as a biometric modality.TEOAE are robust to falsification attacks,as the uniqueness of an individual’s inner ear cannot be impersonated.In this study,we use both the raw 1D TEOAE signals,as well as the 2D time-frequency representation of the signal using Continuous Wavelet Transform(CWT).We use 1D and 2D Convolutional Neural Networks(CNN)for the former and latter,respectively,to derive the feature maps.The corresponding lower-dimensional feature maps are obtained using principal component analysis,which is then used as features to build classifiers using machine learning techniques for the task of person identification.T-SNE plots of these feature maps show that they discriminate well among the subjects.Among the various architectures explored,we achieve a best-performing accuracy of 98.95%and 100%using the feature maps of the 1D-CNN and 2D-CNN,respectively,with the latter performance being an improvement over all the earlier works.This performance makes the TEOAE based person identification systems deployable in real-world situations,along with the added advantage of robustness to falsification attacks.展开更多
Objectives:This study aimed to determine the prognostic value of otoacoustic emissions(OAEs)in idiopathic sudden sensorineural hearing loss patients.Methods:The study included 30 subjects with unilateral idiopathic su...Objectives:This study aimed to determine the prognostic value of otoacoustic emissions(OAEs)in idiopathic sudden sensorineural hearing loss patients.Methods:The study included 30 subjects with unilateral idiopathic sudden sensorineural hearing loss(ISSNHL).Each patient was evaluated four times:at baseline and after one week,one month,and three months of treatment.During each visit,each patient was subjected to full audiological history,otoscopic examination,basic audiological evaluations,and transiently evoked and distortion product otoacoustic emission(TEOAEs&DEOAEs).Results:The hearing thresholds(frequency range 250e8000 Hz)and word recognition scores of patients with detectable TEOAEs and DPOAEs improved significantly,whereas no significant improvements were observed in those with no response.Conclusion:Hearing improvement is better in patients with detectable TEOAEs and DPOAEs.As a result,TEOAEs and DPOAEs are recommended as routine tests in all SSNHL patients to predict outcomes and monitor treatment as TEOAEs and DPOAEs reflect the cochlear OHCs activity.展开更多
In 35 adult human subjects (58 ears) thresholds of rarefaction click evoked otoacoustic emission (EOAE), behavioral response (BR) and auditory brainstem response (ABR) were measured and compared, and correlation coeff...In 35 adult human subjects (58 ears) thresholds of rarefaction click evoked otoacoustic emission (EOAE), behavioral response (BR) and auditory brainstem response (ABR) were measured and compared, and correlation coefficients (r) among them calculated. The results revealed that 86 % of the measured thresholds were in the range from 10 to 45 dB (nHL) for EOAE, 88 % from 10 to 25 dB for BR and 88 % from 10 to 35 for ABR. The correlation coefficients for the whole threshold sample were 0.415 (p< 0.002) for EOAE vs. BR, 0.501 (p< 0.001) for EOAE vs. ABR and 0.702 (p< 0.001) for ABR vs. BR, all indicating highly significant correlation. However, for those ears whose BR, ABR or EOAE thresholds were elevated, equaling to or exceeding 25 dB, there is no significant correlation between thresholds of EOAE and BR and of EOAE and ABR (r range: 0.176-0.310, p>0.05). In contrast, significant correlation between BR and ABR thresholds in the same conditions still remained (r: 0.533-0.720, p<0.05). The experimental results indicate that the correlation between EOAE and hearing thresholds is significant only for subjects with normal or slightly lost hearing. EOAE is valuable in audiometry only as an accessory tool.展开更多
Otoacoustic emissions (OAEs) has been considered as an excellent objective tool in clinics for diagnosing hearing loss. The signal-to-noise ratio (SNR) and correlation coefficient of OAEs are very important for the pu...Otoacoustic emissions (OAEs) has been considered as an excellent objective tool in clinics for diagnosing hearing loss. The signal-to-noise ratio (SNR) and correlation coefficient of OAEs are very important for the purpose of diagnosis. An adaptive signal enhancer (ASE) based on the Least Mean Square (LMS) algorithm is presented to detect transient evoked OAEs (TEOAEs). The TEOAEs detection results from 106 ears show that ASE reaches better estimation of TEOAEs than a conventional ensemble averaging (EA) technique. With the ASE, the improvement of SNR was increased faster than that with the EA and the number of sweeps required can be markedly reduced. The detection time with ASE could be shortened by about 50% in comparison with that of EA.展开更多
基金supported by the Natural Science Foundation of Beijing,No.7112055
文摘OBJECTIVE：The aims of this study were to investigate the changes of the total intensity of transient evoked otoacoustic emission（TEOAE） and signal-to-noise ratio in various frequency bands as a function of aging,and to explore the role of age-related decline of cochlear outer hair cells.DATA SOURCES：The literature was searched using the PubMed database using ＇transient-evoked otoacoustic emissions＇ as a keyword.Articles were limited as follows：Species was ＇Humans＇;languages were ＇English and Chinese＇;publication date between 1990-01-01 and 2010-12-31.The references of the found were also searched to obtain additional articles.DATA SELECTION：Inclusion criteria：（1） Articles should involve the total TEOAE level or signal-to-noise ratio.（2） The measurement and analysis system used was Otodynamics ILO analysis system（ILO88,ILO92,ILO96 or ILO292）.（3） Studies involved groups of greater than 10 subjects and TEOAE results were from normally hearing ears.（4） If more papers from the same author or laboratory analyzed the same subjects,only one was used.MAIN OUTCOME MEASURES：The correlations of the age scale with the total level and signal-to-noise ratio of TEOAE was determined,respectively.RESULTS：（1） TEOAE total level gradually increased until 2 months of age,and then decreased with increasing age.Significant negative correlations between total TEOAE level and age were found（r =-0.885,P = 0.000）.（2） The most rapid decrease of TEOAE amplitude occurred at 1 year old.The total TEOAE level decreased about 4.25 dB SPL between 2 months to 1 year old,then about 0.26-0.52 dB SPL from 1 year to 10 years old,about 0.23 dB SPL from 11 years to 25 years old,and about 0.14 dB SPL from 26 years to 60 years old.（3） The signal-to-noise ratio in the frequency bands centered at 1.5,2,3 and 4 kHz decreased with increasing age after 2 months of age.Significant negative correlations between the signal-to-noise ratio and age were found for frequency bands ranging from 1.5 kHz to 4 kHz,with the highest correlations at 4 kHz（r =-0.890,P 〈 0.01）,then at 3 kHz（r =-0.889,P 〈 0.01）,at 2 kHz（r =-0.850,P 〈 0.01） and at 1.5 kHz（r =-0.705,P 〈 0.05）.Conversely,a positive correlation between the signal-to-noise ratio centered at 1 kHz and age was found,but was not statistically significant（r = 0.298,P = 0.374）.CONCLUSION：The total TEOAE response level decreased with increasing age after the first 2 months of age.The signal-to-noise ratio also decreased with increasing age in frequency bands above 1.5 kHz.The signal-to-noise ratio in higher frequencies decreased faster than in lower frequencies,leading to the maximum signal-to-noise ratio shift form 3.2-4.0 kHz in neonates to 1.5 kHz in adults,and further decreasing the total TEOAE response level.The age-related TEOAE spectrum peak shift is most likely because the outer hair cells functioning in higher frequencies are more prone to damage than those for lower frequencies.
文摘We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between bilirubin serum levels and auditory dysfunction. Eleven infants born at-term with BFJ were selected for the study. We studied also 11 control age- and gender matched healthy at-term infants without signs of jaundice. T-EOAE studies were performed between 5-7 days after birth, and 3 months later. BAEP studies were performed once. BFJ group infants exhibited lower amplitudes in T-EOE than infants in the control group. These differences disappear at the 3-month evaluation. In BAEP, we observed a significant latency delay of waves I and V in Breast-feeding jaundice group infants. All infants in both groups demonstrated reproducible wave V response at 30 decibels. No significant correlation values were observed between bilirubin serum levels and T-EOE and BAEP variables. Our data suggest that BFJ can result in transient peripheral and central auditory dysfunction. Dysfunction is reversible after treatment of infants with BFJ.
文摘Objective: To determine the proportion of neonates with referral result on testing with transient evoked otoacoustic emission (TEOAE) and the associated risk factors. Method: Prospective evaluation of all neonates born in the Hospital within 6 months using the TEOAE. A hand-held Etymotic Research Otoacoustic Emission Scanner (Ero-scan Combo) was used with the child sleeping in the cot or the mother’s hand. Right and left ears were tested separately and the result was displayed automatically as “pass” when 100% of the in-built criteria were met and “refer” if otherwise. The subjects that passed in both ears were regarded as passes, while those with a refer in either the right/left ears or both ears were regarded as referrals and were thus subjected to rescreening in six weeks or on discharge from the special care baby unit. Analysis was done to find association between the outcome of TEOAE and the clinical and epidemiological risk factors. Result: TEOAE was carried out on 386 neonates, (194 males (50.3%) and 192 females (49.7%)). The mean age at screening was 2.3 days (SD = 1.5), the mean gestational age was 38.0 weeks (SD = 2.7) while the mean birth weight was 2.9 kg (SD = 0.7) and the mean Apgar score at 1 and 5 minute were 8.3 (SD = 1.0) and 9.8 (SD = 0.6). At the first step hearing screening, referral rate was 112 (29.0%);at the second stage, 31 (8.5%) neonates had referral in one or both ears. Fisher’s exact test showed that prematurity, multiple births, jaundice and small birth weight were significantly associated with a referral outcome. However, logistic regression revealed prematurity as a significant predictor of referral outcome with a negative predictive value of 12.61. Conclusion: The referral rate is high with prematurity as a significant predictor. This study calls for commencement of newborn hearing screening and strengthening of the public health measures in the developing countries.
基金The authors would like to thank the Biometrics Security Laboratory of the University of Toronto for providing the Transient Evoked Otoacoustic Emissions(TEOAE)dataset.
文摘Biometrics,which has become integrated with our daily lives,could fall prey to falsification attacks,leading to security concerns.In our paper,we use Transient Evoked Otoacoustic Emissions(TEOAE)that are generated by the human cochlea in response to an external sound stimulus,as a biometric modality.TEOAE are robust to falsification attacks,as the uniqueness of an individual’s inner ear cannot be impersonated.In this study,we use both the raw 1D TEOAE signals,as well as the 2D time-frequency representation of the signal using Continuous Wavelet Transform(CWT).We use 1D and 2D Convolutional Neural Networks(CNN)for the former and latter,respectively,to derive the feature maps.The corresponding lower-dimensional feature maps are obtained using principal component analysis,which is then used as features to build classifiers using machine learning techniques for the task of person identification.T-SNE plots of these feature maps show that they discriminate well among the subjects.Among the various architectures explored,we achieve a best-performing accuracy of 98.95%and 100%using the feature maps of the 1D-CNN and 2D-CNN,respectively,with the latter performance being an improvement over all the earlier works.This performance makes the TEOAE based person identification systems deployable in real-world situations,along with the added advantage of robustness to falsification attacks.
文摘Objectives:This study aimed to determine the prognostic value of otoacoustic emissions(OAEs)in idiopathic sudden sensorineural hearing loss patients.Methods:The study included 30 subjects with unilateral idiopathic sudden sensorineural hearing loss(ISSNHL).Each patient was evaluated four times:at baseline and after one week,one month,and three months of treatment.During each visit,each patient was subjected to full audiological history,otoscopic examination,basic audiological evaluations,and transiently evoked and distortion product otoacoustic emission(TEOAEs&DEOAEs).Results:The hearing thresholds(frequency range 250e8000 Hz)and word recognition scores of patients with detectable TEOAEs and DPOAEs improved significantly,whereas no significant improvements were observed in those with no response.Conclusion:Hearing improvement is better in patients with detectable TEOAEs and DPOAEs.As a result,TEOAEs and DPOAEs are recommended as routine tests in all SSNHL patients to predict outcomes and monitor treatment as TEOAEs and DPOAEs reflect the cochlear OHCs activity.
文摘In 35 adult human subjects (58 ears) thresholds of rarefaction click evoked otoacoustic emission (EOAE), behavioral response (BR) and auditory brainstem response (ABR) were measured and compared, and correlation coefficients (r) among them calculated. The results revealed that 86 % of the measured thresholds were in the range from 10 to 45 dB (nHL) for EOAE, 88 % from 10 to 25 dB for BR and 88 % from 10 to 35 for ABR. The correlation coefficients for the whole threshold sample were 0.415 (p< 0.002) for EOAE vs. BR, 0.501 (p< 0.001) for EOAE vs. ABR and 0.702 (p< 0.001) for ABR vs. BR, all indicating highly significant correlation. However, for those ears whose BR, ABR or EOAE thresholds were elevated, equaling to or exceeding 25 dB, there is no significant correlation between thresholds of EOAE and BR and of EOAE and ABR (r range: 0.176-0.310, p>0.05). In contrast, significant correlation between BR and ABR thresholds in the same conditions still remained (r: 0.533-0.720, p<0.05). The experimental results indicate that the correlation between EOAE and hearing thresholds is significant only for subjects with normal or slightly lost hearing. EOAE is valuable in audiometry only as an accessory tool.
基金This work was supported by the National Natural Science Foundation of China (No.39870212)
文摘Otoacoustic emissions (OAEs) has been considered as an excellent objective tool in clinics for diagnosing hearing loss. The signal-to-noise ratio (SNR) and correlation coefficient of OAEs are very important for the purpose of diagnosis. An adaptive signal enhancer (ASE) based on the Least Mean Square (LMS) algorithm is presented to detect transient evoked OAEs (TEOAEs). The TEOAEs detection results from 106 ears show that ASE reaches better estimation of TEOAEs than a conventional ensemble averaging (EA) technique. With the ASE, the improvement of SNR was increased faster than that with the EA and the number of sweeps required can be markedly reduced. The detection time with ASE could be shortened by about 50% in comparison with that of EA.
