Enhancing Cancer Classification through a Hybrid Bio-Inspired Evolutionary Algorithm for Biomarker Gene Selection

In this study,our aim is to address the problem of gene selection by proposing a hybrid bio-inspired evolutionary algorithm that combines Grey Wolf Optimization(GWO)with Harris Hawks Optimization(HHO)for feature selection.Themotivation for utilizingGWOandHHOstems fromtheir bio-inspired nature and their demonstrated success in optimization problems.We aimto leverage the strengths of these algorithms to enhance the effectiveness of feature selection in microarray-based cancer classification.We selected leave-one-out cross-validation(LOOCV)to evaluate the performance of both two widely used classifiers,k-nearest neighbors(KNN)and support vector machine(SVM),on high-dimensional cancer microarray data.The proposed method is extensively tested on six publicly available cancer microarray datasets,and a comprehensive comparison with recently published methods is conducted.Our hybrid algorithm demonstrates its effectiveness in improving classification performance,Surpassing alternative approaches in terms of precision.The outcomes confirm the capability of our method to substantially improve both the precision and efficiency of cancer classification,thereby advancing the development ofmore efficient treatment strategies.The proposed hybridmethod offers a promising solution to the gene selection problem in microarray-based cancer classification.It improves the accuracy and efficiency of cancer diagnosis and treatment,and its superior performance compared to other methods highlights its potential applicability in realworld cancer classification tasks.By harnessing the complementary search mechanisms of GWO and HHO,we leverage their bio-inspired behavior to identify informative genes relevant to cancer diagnosis and treatment.

Optimizing Deep Learning for Computer-Aided Diagnosis of Lung Diseases: An Automated Method Combining Evolutionary Algorithm, Transfer Learning, and Model Compression

Recent developments in Computer Vision have presented novel opportunities to tackle complex healthcare issues,particularly in the field of lung disease diagnosis.One promising avenue involves the use of chest X-Rays,which are commonly utilized in radiology.To fully exploit their potential,researchers have suggested utilizing deep learning methods to construct computer-aided diagnostic systems.However,constructing and compressing these systems presents a significant challenge,as it relies heavily on the expertise of data scientists.To tackle this issue,we propose an automated approach that utilizes an evolutionary algorithm(EA)to optimize the design and compression of a convolutional neural network(CNN)for X-Ray image classification.Our approach accurately classifies radiography images and detects potential chest abnormalities and infections,including COVID-19.Furthermore,our approach incorporates transfer learning,where a pre-trainedCNNmodel on a vast dataset of chest X-Ray images is fine-tuned for the specific task of detecting COVID-19.This method can help reduce the amount of labeled data required for the task and enhance the overall performance of the model.We have validated our method via a series of experiments against state-of-the-art architectures.

Enhancing Evolutionary Algorithms With Pattern Mining for Sparse Large-Scale Multi-Objective Optimization Problems

Sparse large-scale multi-objective optimization problems(SLMOPs)are common in science and engineering.However,the large-scale problem represents the high dimensionality of the decision space,requiring algorithms to traverse vast expanse with limited computational resources.Furthermore,in the context of sparse,most variables in Pareto optimal solutions are zero,making it difficult for algorithms to identify non-zero variables efficiently.This paper is dedicated to addressing the challenges posed by SLMOPs.To start,we introduce innovative objective functions customized to mine maximum and minimum candidate sets.This substantial enhancement dramatically improves the efficacy of frequent pattern mining.In this way,selecting candidate sets is no longer based on the quantity of nonzero variables they contain but on a higher proportion of nonzero variables within specific dimensions.Additionally,we unveil a novel approach to association rule mining,which delves into the intricate relationships between non-zero variables.This novel methodology aids in identifying sparse distributions that can potentially expedite reductions in the objective function value.We extensively tested our algorithm across eight benchmark problems and four real-world SLMOPs.The results demonstrate that our approach achieves competitive solutions across various challenges.

Simultaneous Identification of Thermophysical Properties of Semitransparent Media Using a Hybrid Model Based on Artificial Neural Network and Evolutionary Algorithm

A hybrid identification model based on multilayer artificial neural networks(ANNs) and particle swarm optimization(PSO) algorithm is developed to improve the simultaneous identification efficiency of thermal conductivity and effective absorption coefficient of semitransparent materials.For the direct model,the spherical harmonic method and the finite volume method are used to solve the coupled conduction-radiation heat transfer problem in an absorbing,emitting,and non-scattering 2D axisymmetric gray medium in the background of laser flash method.For the identification part,firstly,the temperature field and the incident radiation field in different positions are chosen as observables.Then,a traditional identification model based on PSO algorithm is established.Finally,multilayer ANNs are built to fit and replace the direct model in the traditional identification model to speed up the identification process.The results show that compared with the traditional identification model,the time cost of the hybrid identification model is reduced by about 1 000 times.Besides,the hybrid identification model remains a high level of accuracy even with measurement errors.

Hybrid evolutionary algorithm for no-wait flow shops to minimize makespan and total flowtime

The NP-hard no-wait flow shop scheduling problems with makespan and total flowtime minimization are considered. Objective increment properties of the problems are analyzed. A non-dominated classification method is introduced to class population individuals into Pareto fronts to improve searching efficiency. Besides investigating the crowding distance and the elitist solution strategy, two effective bi-criteria local search procedures based on objective increments are presented to improve searching effectiveness. Based on the properties and methods, a hybrid evolutionary algorithm is proposed for the considered problems and compared with the best existing algorithms. Experimental results show that the proposed algorithm is effective with high efficiency.

Lake Eutrophic Evaluation Based on Bee Immune Evolutionary Algorithm

In order to establish the lake eutrophic evaluation model for multiple indices,based on the gauge transformation,an index formula in the form of a logarithmic power function was proposed to design an eutrophic evaluation model for the ＂ normalized values＂ of multi-indexes.The parameters in the formula were also optimized by bee immune evolutionary algorithm（BEIEA）.The universal index formula was suitable to multiindices items for eutrophic evaluation.At the same time,the formula was applied to practical eutrophic evaluations in 10 regions of Dong Lake.The evaluation results were coincident with those obtained from the power function of weighted sums and also with actual conditions.It was shown that the bee immune evolutionary algorithm was suitable to the parameter optimization in the eutrophic evaluation model.

A new improved Alopex-based evolutionary algorithm and its application to parameter estimation

In this work, focusing on the demerit of AEA (Alopex-based evolutionary algorithm) algorithm, an improved AEA algorithm (AEA-C) which was fused AEA with clonal selection algorithm was proposed. Considering the irrationality of the method that generated candidate solutions at each iteration of AEA, clonal selection algorithm could be applied to improve the method. The performance of the proposed new algorithm was studied by using 22 benchmark functions and was compared with original AEA given the same conditions. The experimental results show that the AEA-C clearly outperforms the original AEA for almost all the 22 benchmark functions with 10, 30, 50 dimensions in success rates, solution quality and stability. Furthermore, AEA-C was applied to estimate 6 kinetics parameters of the fermentation dynamics models. The standard deviation of the objective function calculated by the AEA-C is 41.46 and is far less than that of other literatures' results, and the fitting curves obtained by AEA-C are more in line with the actual fermentation process curves.

Managing Software Testing Technical Debt Using Evolutionary Algorithms

Technical debt(TD)happens when project teams carry out technical decisions in favor of a short-term goal(s)in their projects,whether deliberately or unknowingly.TD must be properly managed to guarantee that its negative implications do not outweigh its advantages.A lot of research has been conducted to show that TD has evolved into a common problem with considerable financial burden.Test technical debt is the technical debt aspect of testing(or test debt).Test debt is a relatively new concept that has piqued the curiosity of the software industry in recent years.In this article,we assume that the organization selects the testing artifacts at the start of every sprint.Implementing the latest features in consideration of expected business value and repaying technical debt are among candidate tasks in terms of the testing process(test cases increments).To gain the maximum benefit for the organization in terms of software testing optimization,there is a need to select the artifacts(i.e.,test cases)with maximum feature coverage within the available resources.The management of testing optimization for large projects is complicated and can also be treated as a multi-objective problem that entails a trade-off between the agile software’s short-term and long-term value.In this article,we implement a multi-objective indicatorbased evolutionary algorithm(IBEA)for fixing such optimization issues.The capability of the algorithm is evidenced by adding it to a real case study of a university registration process.

Cell Evolutionary Algorithm: a New Optimization Method on Ground-State Energy of the Atomic

The purpose of this paper is to present a new general approach to solve ground-state energies of the double-electron systems in a uniform magnetic field, in which the basic element of evolution is the set in the solution space, rather than the point. The paper defines the Cell Evolutionary Algorithm, which implements such a view of the evolution mechanism. First, the optimal set in which the optimal solution may be obtained. Then this approach applies the embedded search method to get the optimal solution. We tested this approach on the atomic structure, and the results show that it can improve not only the efficiency but also the accuracy of the calculations as it relates to this specific problem.

Fuzzy traffic signal control with DNA evolutionary algorithm

In order to optimize the signal control system, this paper proposes a method to design an optimized fuzzy logic controller （FLC） with the DNA evolutionary algorithm. Inspired by the DNA molecular operation characteristics, the DNA evolutionary algorithm modifies the corresponding genetic operators. Compared with the traditional genetic algorithm （GA）, the DNA evolutionary algorithm can overcome weak local search capability and premature convergence. The parameters of membership functions are optimized by adopting the quaternary encoding method and performing corresponding DNA genetic operators. The relevant optimized parameters are combined with the FLC for single intersection traffic signal control. Simulation experiments shows the better performance of the FLC with the DNA evolutionary algorithm optimization. The experimental results demonstrate the efficiency of the nrotmsed method.

A Survey of Evolutionary Algorithms for Multi-Objective Optimization Problems With Irregular Pareto Fronts

Evolutionary algorithms have been shown to be very successful in solving multi-objective optimization problems(MOPs).However,their performance often deteriorates when solving MOPs with irregular Pareto fronts.To remedy this issue,a large body of research has been performed in recent years and many new algorithms have been proposed.This paper provides a comprehensive survey of the research on MOPs with irregular Pareto fronts.We start with a brief introduction to the basic concepts,followed by a summary of the benchmark test problems with irregular problems,an analysis of the causes of the irregularity,and real-world optimization problems with irregular Pareto fronts.Then,a taxonomy of the existing methodologies for handling irregular problems is given and representative algorithms are reviewed with a discussion of their strengths and weaknesses.Finally,open challenges are pointed out and a few promising future directions are suggested.

A New Evolutionary Algorithm for Function Optimization

A new algorithm based on genetic algorithm(GA) is developed for solving function optimization problems with inequality constraints. This algorithm has been used to a series of standard test problems and exhibited good performance. The computation results show that its generality, precision, robustness, simplicity and performance are all satisfactory.

Multi-objective Evolutionary Algorithms for MILP and MINLP in Process Synthesis

Steady-state non-dominated sorting genetic algorithm (SNSGA), a new form of multi-objective genetic algorithm, is implemented by combining the steady-state idea in steady-state genetic algorithms (SSGA) and the fitness assignment strategy of non-dominated sorting genetic algorithm (NSGA). The fitness assignment strategy is improved and a new self-adjustment scheme of is proposed. This algorithm is proved to be very efficient both computationally and in terms of the quality of the Pareto fronts produced with five test problems including GA difficult problem and GA deceptive one. Finally, SNSGA is introduced to solve multi-objective mixed integer linear programming (MILP) and mixed integer non-linear programming (MINLP) problems in process synthesis.

Solving material distribution routing problem in mixed manufacturing systems with a hybrid multi-objective evolutionary algorithm

The material distribution routing problem in the manufacturing system is a complex combinatorial optimization problem and its main task is to deliver materials to the working stations with low cost and high efficiency. A multi-objective model was presented for the material distribution routing problem in mixed manufacturing systems, and it was solved by a hybrid multi-objective evolutionary algorithm (HMOEA). The characteristics of the HMOEA are as follows: 1) A route pool is employed to preserve the best routes for the population initiation; 2) A specialized best?worst route crossover (BWRC) mode is designed to perform the crossover operators for selecting the best route from Chromosomes 1 to exchange with the worst one in Chromosomes 2, so that the better genes are inherited to the offspring; 3) A route swap mode is used to perform the mutation for improving the convergence speed and preserving the better gene; 4) Local heuristics search methods are applied in this algorithm. Computational study of a practical case shows that the proposed algorithm can decrease the total travel distance by 51.66%, enhance the average vehicle load rate by 37.85%, cut down 15 routes and reduce a deliver vehicle. The convergence speed of HMOEA is faster than that of famous NSGA-II.

Time Complexity of Evolutionary Algorithms for Combinatorial Optimization:A Decade of Results

Computational time complexity analyzes of evolutionary algorithms （EAs） have been performed since the mid-nineties. The first results were related to very simple algorithms, such as the （1＋1）-EA, on toy problems. These efforts produced a deeper understanding of how EAs perform on different kinds of fitness landscapes and general mathematical tools that may be extended to the analysis of more complicated EAs on more realistic problems. In fact, in recent years, it has been possible to analyze the （1＋1）-EA on combinatorial optimization problems with practical applications and more realistic population-based EAs on structured toy problems. This paper presents a survey of the results obtained in the last decade along these two research lines. The most common mathematical techniques are introduced, the basic ideas behind them are discussed and their elective applications are highlighted. Solved problems that were still open are enumerated as are those still awaiting for a solution. New questions and problems arisen in the meantime are also considered.

A Parallel Global-Local Mixed Evolutionary Algorithm for Multimodal Function Optimization Based on Domain Decomposition

This paper presents a parallel two-level evolutionary algorithm based on domain decomposition for solving function optimization problem containing multiple solutions. By combining the characteristics of the global search and local search in each sub-domain, the former enables individual to draw closer to each optima and keeps the diversity of individuals, while the latter selects local optimal solutions known as latent solutions in sub-domain. In the end, by selecting the global optimal solutions from latent solutions in each sub-domain, we can discover all the optimal solutions easily and quickly.

MULTIOBJECT OPTIMIZATION OF A CENTRIFUGAL IMPELLER USING EVOLUTIONARY ALGORITHMS

Application of the multiobjective evolutionary algorithms to the aerodynamicoptimization design of a centrifugal impeller is presented. The aerodynamic performance of acentrifugal impeller is evaluated by using the three-dimensional Navier-Stokes solutions. Thetypical centrifugal impeller is redesigned for maximization of the pressure rise and blade load andminimization of the rotational total pressure loss at the given flow conditions. The Bezier curvesare used to parameterize the three-dimensional impeller blade shape. The present method obtains manyreasonable Pareto optimal designs that outperform the original centrifugal impeller. Detailedobservation of the certain Pareto optimal design demonstrates the feasibility of the presentmultiobjective optimization method tool for turbomachinery design.

Two Aspects of Evolutionary Algorithms

In this paper we discuss the paradigm of evolutionary algorithms (EAs). We argue about the need for new heuristics in real-world problem solving, discussing reasons why some problems are difficult to solve. After introducing the main concepts of evolutionary algorithms, we concentrate on two issues: (1) self-adaptation of the parameters of EA, and (2) handling constraints.

Immune evolutionary algorithms with domain knowledge for simultaneous localization and mapping

Immune evolutionary algorithms with domain knowledge were presented to solve the problem of simultaneous localization and mapping for a mobile robot in unknown environments. Two operators with domain knowledge were designed in algorithms, where the feature of parallel line segments without the problem of data association was used to construct a vaccination operator, and the characters of convex vertices in polygonal obstacle were extended to develop a pulling operator of key point grid. The experimental results of a real mobile robot show that the computational expensiveness of algorithms designed is less than other evolutionary algorithms for simultaneous localization and mapping and the maps obtained are very accurate. Because immune evolutionary algorithms with domain knowledge have some advantages, the convergence rate of designed algorithms is about 44% higher than those of other algorithms.

A Two-Level Subspace Evolutionary Algorithm for Solving Multi-Modal Function Optimization Problems

In this paper, a new algorithm for solving multi-modal function optimization problems-two-level subspace evolutionary algorithm is proposed. In the first level, the improved GT algorithm is used to do global recombination search so that the whole population can be separated into several niches according to the position of solutions; then, in the second level, the niche evolutionary strategy is used for local search in the subspaces gotten in the first level till solutions of the problem are found. The new algorithm has been tested on some hard problems and some good results are obtained.