Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese me...Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese medicine effective ingredients include paclitaxel,arsenical trioxide,camptothecin and so on.However,poor water solubility and low bioavailability of these traditional Chinese medicine ingredients severely hindered their clinical application.The rapid development of nanotechnology provided a new platform,new opportunities and new challenges for their effective delivery in vitro and in vivo.This minireview provides a concentrated summary of the most recent progresses made in this emerging field,highlighting the“combination ancient traditional Chinese medicine ingredients and advanced nanotechnology”strategy for favoring the construction of next generation cancer nanomedicines.展开更多
[Objectives]To analyze the effect of Mongolian pharmaceutical Betel Shisanwei Ingredient Pills in the clinical treatment of patients with depression.[Methods]From June 2020 to May 2021,64 patients with depression who ...[Objectives]To analyze the effect of Mongolian pharmaceutical Betel Shisanwei Ingredient Pills in the clinical treatment of patients with depression.[Methods]From June 2020 to May 2021,64 patients with depression who received treatment in Inner Mongolia Minzu University were selected to participate in this study.These patients were randomly numbered from 1 to 64,and then divided into two groups according to the principle of odd or even number.Patients with odd number were regarded as the reference group,and treated by western medicine fluoxetine;patients with even number were regarded as the study group,and treated by Mongolian pharmaceutical Betel Shisanwei Ingredient Pills.The therapeutic effects of the two groups of patients were compared.[Results]Before treatment,there was no significant difference in the scores of patients'depressive syndromes between the two groups(P>0.05).After treatment,there were two significant changes in comprehensive score of depressive symptoms in both groups.Compared with before treatment,the data of the same group after treatment decreased significantly.Comparison between the two groups showed that the score of patients'depressive syndromes in the study group(13.28±5.49)was significantly lower than that in the reference group(18.46±6.51),and the overall response rate of treatment in the study group(96.88%,31/32)was obviously higher than that in the reference group(75.00%,24/32),showing statistically significant differences(P<0.05).[Conclusions]In the treatment of depression,Mongolian medicine therapy can significantly improve the depressive syndromes in patients,with more prominent curative effects,and is worthy of promotion and application.展开更多
The continuous increase in the incidence rate of various fatal malignant tumors in the recent years warrants an imperative search for medications or drugs with obvious anti-tumor eflects and reliable curative effects....The continuous increase in the incidence rate of various fatal malignant tumors in the recent years warrants an imperative search for medications or drugs with obvious anti-tumor eflects and reliable curative effects.Previous studies have found that Curcuma zedoaria and its active ingredients,such as turmeric oil,curcumol,and P-elemene,have obvious antitumor effects,and they do not have the adverse reactions and side effects seen in the anti-tumor drugs of Western medicine.Based on the review and inductive analysis of related literature,we summarize in the present article the results of some researchers who investigated the anti-tumor effects of Curcuma zedoaria and its active ingredients through the immune regulation mechanism.展开更多
目的:基于现代检测技术对怀牛膝有效制剂——牛膝醇提物的单体成分进行定性定量分析。方法:将怀牛膝醇提物液体制剂按照检测进样要求分别制备成烘干物和液体物,再应用核磁共振波谱(Nuclear Magnetic Resonance,NMR)、气相色谱质谱联用(G...目的:基于现代检测技术对怀牛膝有效制剂——牛膝醇提物的单体成分进行定性定量分析。方法:将怀牛膝醇提物液体制剂按照检测进样要求分别制备成烘干物和液体物,再应用核磁共振波谱(Nuclear Magnetic Resonance,NMR)、气相色谱质谱联用(Gas Chromatography-Mass Spectrometry,GC-MS)、顶空-气相色谱质谱联用(Headspace-Gas Chromatography-Mass Spectrometry,HS-GCMS)、液相色谱质谱联用(Liquid Chromatography-Mass Spectrometry,LC-MS)、三重串联四极杆液相质谱联用(Triple Series Quadrupole Liquid Mass Spectrometry,LC-MSMS)等技术对牛膝醇提物的化学成分进行鉴定分析。结果:共检测出23个单体成分,包括糖类1个,类黄酮类1个,黄酮类1个,甾酮类1个,三萜类1个,氨基酸类16个,果酸类2个,其中槲皮素含量为0.0021%,β-蜕皮甾酮含量为0.0210%,齐墩果酸含量为0.00017%,并根据分子片段信息预测出了4’,5,6,7-四甲氧基黄酮成分。结论:本实验为怀牛膝醇提物制剂的临床应用提供了有效单体成分参考,为进一步对其单体物质的“药物-疾病-靶点”进行验证研究和开发应用提供依据。展开更多
Background Recent studies have shown that effective ingredients of Chinese herbs are used more and more widely in the treatment or co-treatment of cancers, however, they are usually used separately and there has been ...Background Recent studies have shown that effective ingredients of Chinese herbs are used more and more widely in the treatment or co-treatment of cancers, however, they are usually used separately and there has been limited research about joint application of Chinese herbs in multi-modal treatment. The aim of this study was to screen a QHF （Q： Qingrejiedu, H： Huoxuehuayu and F： Fuzhengguben） formula for effective ingredients from Chinese medicines and assess its anti-hepatic cell cancer （HCC） effect in combination with chemotherapy.Methods Six effective ingredients from Chinese medicine were selected based on the previous literature and used in the study. The QHF formula and the best ratio of ingredients were evaluated in H22 mouse （KM） models with solid tumors and ascites tumors by uniform design and monitoring inhibition of tumor growth and survival. We then observed the anti-hepatic cell cancer （HCC） effect of QHF when combined with cisplatin （DDP） in H22 mouse （Balb/c） models with solid tumors and ascites tumors. Evaluating of the therapeutic effect included the general condition of the mice, inhibition of tumor growth, survival, changes in body weight, thymus index, spleen index and WBC counts.Results The optimal QHF dose ratio for anti-hepatic cell cancer treatment was： 800 mg/kg Cinobufotalin, 14 mg/kg Ginsenosides Rg3, 5.5 mg/kg PNS and 100 mg/kg Lentinan. Treatment was more efficient in inhibiting the growth of transplanted tumors in H22 mice when using the QHF formula （55.91%） than using Cinobufotalin （33.25%）, Ginsenosides Rg3 （35.11%）, PNS （27.12%） or Lentinan （4.97%） separately. QHF also prolonged the life of H22 ascites hepatic cancer mice more efficiently （38.13%） than Cinobufotalin （25.00%）, Ginsenosides Rg3 （27.27%）, PNS （23.30%） or Lentinan （24.43%）. QHF combined with DDP could reduce DDP-induced leucopenia, spleen and thymus atrophy and other toxic reactions. Combining QHF with DDP the tumor growth inhibition reached 82.54% with a 66.83% increase in survival. Conclusions QHF is more efficient in anti-hepatic cell caner treatment than the single drugs that constitute the formula. QHF combined with DDP can attenuate tumor growth and suppresses the DDP-induced toxic reactions.展开更多
Radix Astragali,a Chinese herbal medicine possessing important cardiovascular pharmacologic effects,is widely applied for the treatment of chronic heart failure（CHF） in clinical practice.This paper summarizes briefl...Radix Astragali,a Chinese herbal medicine possessing important cardiovascular pharmacologic effects,is widely applied for the treatment of chronic heart failure（CHF） in clinical practice.This paper summarizes briefly the researches in the last 10 years on its chemical compositions,effective ingredients for improving cardiac function,dose-effect relationship in treating CHF,and adverse reactions that occurred in clinical practice.展开更多
Alpinia oxyphylla,a traditional herb,is widely used for its neuroprotective,antioxidant and memory-improving effects.However,the neuroprotective mechanisms of action of its active ingredients are unclear.In this study...Alpinia oxyphylla,a traditional herb,is widely used for its neuroprotective,antioxidant and memory-improving effects.However,the neuroprotective mechanisms of action of its active ingredients are unclear.In this study,we investigated the neuroprotective effects of various organic extracts of Alpinia oxyphylla on PC12 cells exposed to hydrogen peroxide-induced oxidative injury in vitro.Alpinia oxyphylla was extracted three times with 95%ethanol(representing extracts 1–3).The third 95%ethanol extract was dried and resuspended in water,and then extracted successively with petroleum ether,ethyl acetate and n-butanol(representing extracts 4–6).The cell counting kit-8 assay and microscopy were used to evaluate cell viability and observe the morphology of PC12 cells.The protective effect of the three ethanol extracts(at tested concentrations of 50,100 and 200μg/mL)against cytotoxicity to PC12 cells increased in a concentration-dependent manner.The ethyl acetate,petroleum ether and n-butanol extracts(each tested at 100,150 and 200μg/mL)had neuroprotective effects as well.The optimum effective concentration ranged from 50–200μg/mL,and the protective effect of the ethyl acetate extract was comparatively robust.These results demonstrate that organic extracts of Alpinia oxyphylla protect PC12 cells against apoptosis induced by hydrogen peroxide.Our findings should help identify the bioactive neuroprotective components in Alpinia oxyphylla.展开更多
基金This research was funded by the Postdoctoral Research Grant in Henan Province(201901025)National Natural Science Foundation of China(82003298).
文摘Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese medicine effective ingredients include paclitaxel,arsenical trioxide,camptothecin and so on.However,poor water solubility and low bioavailability of these traditional Chinese medicine ingredients severely hindered their clinical application.The rapid development of nanotechnology provided a new platform,new opportunities and new challenges for their effective delivery in vitro and in vivo.This minireview provides a concentrated summary of the most recent progresses made in this emerging field,highlighting the“combination ancient traditional Chinese medicine ingredients and advanced nanotechnology”strategy for favoring the construction of next generation cancer nanomedicines.
文摘[Objectives]To analyze the effect of Mongolian pharmaceutical Betel Shisanwei Ingredient Pills in the clinical treatment of patients with depression.[Methods]From June 2020 to May 2021,64 patients with depression who received treatment in Inner Mongolia Minzu University were selected to participate in this study.These patients were randomly numbered from 1 to 64,and then divided into two groups according to the principle of odd or even number.Patients with odd number were regarded as the reference group,and treated by western medicine fluoxetine;patients with even number were regarded as the study group,and treated by Mongolian pharmaceutical Betel Shisanwei Ingredient Pills.The therapeutic effects of the two groups of patients were compared.[Results]Before treatment,there was no significant difference in the scores of patients'depressive syndromes between the two groups(P>0.05).After treatment,there were two significant changes in comprehensive score of depressive symptoms in both groups.Compared with before treatment,the data of the same group after treatment decreased significantly.Comparison between the two groups showed that the score of patients'depressive syndromes in the study group(13.28±5.49)was significantly lower than that in the reference group(18.46±6.51),and the overall response rate of treatment in the study group(96.88%,31/32)was obviously higher than that in the reference group(75.00%,24/32),showing statistically significant differences(P<0.05).[Conclusions]In the treatment of depression,Mongolian medicine therapy can significantly improve the depressive syndromes in patients,with more prominent curative effects,and is worthy of promotion and application.
基金Guangxi Natural Science Foundation Project(No.2018GXNSFAA294115)Guangxi Natural Science Foundation Project(No.2018GXNSFAA050064)Guangxi University of Traditional Chinese Medicine Guangxi First-Class Discipline Construction Open Project(No.2019XK038)。
文摘The continuous increase in the incidence rate of various fatal malignant tumors in the recent years warrants an imperative search for medications or drugs with obvious anti-tumor eflects and reliable curative effects.Previous studies have found that Curcuma zedoaria and its active ingredients,such as turmeric oil,curcumol,and P-elemene,have obvious antitumor effects,and they do not have the adverse reactions and side effects seen in the anti-tumor drugs of Western medicine.Based on the review and inductive analysis of related literature,we summarize in the present article the results of some researchers who investigated the anti-tumor effects of Curcuma zedoaria and its active ingredients through the immune regulation mechanism.
文摘目的:基于现代检测技术对怀牛膝有效制剂——牛膝醇提物的单体成分进行定性定量分析。方法:将怀牛膝醇提物液体制剂按照检测进样要求分别制备成烘干物和液体物,再应用核磁共振波谱(Nuclear Magnetic Resonance,NMR)、气相色谱质谱联用(Gas Chromatography-Mass Spectrometry,GC-MS)、顶空-气相色谱质谱联用(Headspace-Gas Chromatography-Mass Spectrometry,HS-GCMS)、液相色谱质谱联用(Liquid Chromatography-Mass Spectrometry,LC-MS)、三重串联四极杆液相质谱联用(Triple Series Quadrupole Liquid Mass Spectrometry,LC-MSMS)等技术对牛膝醇提物的化学成分进行鉴定分析。结果:共检测出23个单体成分,包括糖类1个,类黄酮类1个,黄酮类1个,甾酮类1个,三萜类1个,氨基酸类16个,果酸类2个,其中槲皮素含量为0.0021%,β-蜕皮甾酮含量为0.0210%,齐墩果酸含量为0.00017%,并根据分子片段信息预测出了4’,5,6,7-四甲氧基黄酮成分。结论:本实验为怀牛膝醇提物制剂的临床应用提供了有效单体成分参考,为进一步对其单体物质的“药物-疾病-靶点”进行验证研究和开发应用提供依据。
文摘Background Recent studies have shown that effective ingredients of Chinese herbs are used more and more widely in the treatment or co-treatment of cancers, however, they are usually used separately and there has been limited research about joint application of Chinese herbs in multi-modal treatment. The aim of this study was to screen a QHF （Q： Qingrejiedu, H： Huoxuehuayu and F： Fuzhengguben） formula for effective ingredients from Chinese medicines and assess its anti-hepatic cell cancer （HCC） effect in combination with chemotherapy.Methods Six effective ingredients from Chinese medicine were selected based on the previous literature and used in the study. The QHF formula and the best ratio of ingredients were evaluated in H22 mouse （KM） models with solid tumors and ascites tumors by uniform design and monitoring inhibition of tumor growth and survival. We then observed the anti-hepatic cell cancer （HCC） effect of QHF when combined with cisplatin （DDP） in H22 mouse （Balb/c） models with solid tumors and ascites tumors. Evaluating of the therapeutic effect included the general condition of the mice, inhibition of tumor growth, survival, changes in body weight, thymus index, spleen index and WBC counts.Results The optimal QHF dose ratio for anti-hepatic cell cancer treatment was： 800 mg/kg Cinobufotalin, 14 mg/kg Ginsenosides Rg3, 5.5 mg/kg PNS and 100 mg/kg Lentinan. Treatment was more efficient in inhibiting the growth of transplanted tumors in H22 mice when using the QHF formula （55.91%） than using Cinobufotalin （33.25%）, Ginsenosides Rg3 （35.11%）, PNS （27.12%） or Lentinan （4.97%） separately. QHF also prolonged the life of H22 ascites hepatic cancer mice more efficiently （38.13%） than Cinobufotalin （25.00%）, Ginsenosides Rg3 （27.27%）, PNS （23.30%） or Lentinan （24.43%）. QHF combined with DDP could reduce DDP-induced leucopenia, spleen and thymus atrophy and other toxic reactions. Combining QHF with DDP the tumor growth inhibition reached 82.54% with a 66.83% increase in survival. Conclusions QHF is more efficient in anti-hepatic cell caner treatment than the single drugs that constitute the formula. QHF combined with DDP can attenuate tumor growth and suppresses the DDP-induced toxic reactions.
文摘Radix Astragali,a Chinese herbal medicine possessing important cardiovascular pharmacologic effects,is widely applied for the treatment of chronic heart failure（CHF） in clinical practice.This paper summarizes briefly the researches in the last 10 years on its chemical compositions,effective ingredients for improving cardiac function,dose-effect relationship in treating CHF,and adverse reactions that occurred in clinical practice.
基金financially supported by the National Natural Science Foundation of China,No.81574038(to ZZW)the Natural Science Foundation of Guangdong Province of China,No.2017A030313842(to LHD)+1 种基金the Science and Technology Foundation of Guangdong Province of China,No.2017A050506007(to YHL)the Technology Research Foundation of Basic Research Project of Shenzhen City of China,No.JCYJ20170412161254416(to ZZW)
文摘Alpinia oxyphylla,a traditional herb,is widely used for its neuroprotective,antioxidant and memory-improving effects.However,the neuroprotective mechanisms of action of its active ingredients are unclear.In this study,we investigated the neuroprotective effects of various organic extracts of Alpinia oxyphylla on PC12 cells exposed to hydrogen peroxide-induced oxidative injury in vitro.Alpinia oxyphylla was extracted three times with 95%ethanol(representing extracts 1–3).The third 95%ethanol extract was dried and resuspended in water,and then extracted successively with petroleum ether,ethyl acetate and n-butanol(representing extracts 4–6).The cell counting kit-8 assay and microscopy were used to evaluate cell viability and observe the morphology of PC12 cells.The protective effect of the three ethanol extracts(at tested concentrations of 50,100 and 200μg/mL)against cytotoxicity to PC12 cells increased in a concentration-dependent manner.The ethyl acetate,petroleum ether and n-butanol extracts(each tested at 100,150 and 200μg/mL)had neuroprotective effects as well.The optimum effective concentration ranged from 50–200μg/mL,and the protective effect of the ethyl acetate extract was comparatively robust.These results demonstrate that organic extracts of Alpinia oxyphylla protect PC12 cells against apoptosis induced by hydrogen peroxide.Our findings should help identify the bioactive neuroprotective components in Alpinia oxyphylla.
