Application of external treatment of traditional Chinese medicine in the treatment of cancer-related fatigue

External treatment of traditional Chinese medicine(TCM),also known as external treatment of internal diseases,has many advantages,such as simple,easy to operate,cost-effective and so on.Therefore,external treatment of TCM is favored by the majority of medical workers.By consulting the domestic literature reports on the treatment of cancer-related fatigue(CRF),it is found that the external treatment of TCM has a significant effect on the intervention of CRF,and has a good effect on reducing fatigue,improving the quality of life and prolonging the survival time.The purpose of this paper is to summarize the application of several external treatments in this disease,and to provide a variety of references for clinical treatment of CRF.

China Association of Chinese Medicine Paper notice for seminar on clinical application of TCM classic prescriptions and herbs in the treatment of emotional diseases

Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of TCM classic prescriptions and herbs in the treatment of emotional diseaseis planned to be held in Yichang,Hubei province from June 22nd to 24th.

Kinematic improvement after the external-application herbs combine rehabilitation in upper-limb spasticity due to stroke

Background: Spasm is one of the most serious physical impairment after stroke. the external-application herbs have showed some effects on the spasm. This study was conducted to evaluate the comparative effectiveness of the external-application herbs and physical therapy in upper limb spasticity after stroke. Methods: A total of 100 patients with upper limb spasm after stroke (stroke time less than 1 month), have been recruited in Shun-yi Hospital of Beijing Traditional Chinese Medicine Hospital. Patients will be randomly allotted to one of two groups (N = 50, respectively): the TCM external application group, and the usual rehab (conventional physical therapy and medication treatment) group. The two groups will be administered once a month for three months. The primary outcome will be Modified Athworth Scale (MAS) and the simplified scale (Fugl-Meyer assessment, FMA) for upper limb. Results: Muscle tension and motor function were evaluated before and 4 weeks after treatments. There was a significant improvement in muscle tension and motor function in patients with stroke after the external-application herbs and physical therapy (P < 0.05). Conclusion: There was a significant improvement in kinematics in patients with stroke.

The latest research progress of traditional Chinese medicine in the treatment of early and middle femoral head necrosis

At present,the development of orthopedics,the conservative treatment of femoral head necrosis in the early and middle stages is still a difficult problem.With the progress of osteonecrosis,it may deteriorate into irreversible bone destruction,affecting the hip joint and even causing severe disability of the hip.In traditional medicine,femoral head necrosis belongs to the category of"bone erosion"and"bone erosion".As a common disease in orthopedics,the treatment difficulty is relatively large.In the view of Chinese medicine,the pathogenesis of femoral head necrosis is kidney deficiency,stagnation and so on.Clinically,most doctors use the principle of promoting blood circulation,tonifying kidney and strengthening spleen.In the early and middle femoral head necrosis,traditional Chinese medicine treatment methods are more diverse and economical,and have always been valued by the modern medical community.This study reviews the latest research progress of traditional Chinese medicine in the treatment of early and mid-stage femoral head necrosis,in order to provide more basis for clinical medical research and related disease treatment.

Study on Early Application of Chinese Medicinal Herbs after Total Gastrectomy

Objective: To evaluate the effect of Chinese medicinal herbs on digestive function, nutritional status, immune function and complication rate in patients after total gastrectomy. Methods: Thirty-nine patients performed total gastrectomy were divided into two groups and had their small intestine intubated for administering medicine postoperatively. Twenty-one of them belonged to the treated group and had Chinese medicinal herbs dripped into their small intestine intraluminally during the early postoperative stage, while the 18 cases in the control group were dripped with 0.9% sodium chloride. Results: The digestive function of the treated group recovered rapidly, and the nutritional status and immune function improved markedly as compared with those of the control group (P<0.01-0.05). Conclusion: Early application of Chinese medicinal herbs after total gastrectomy could promote the digestive function to recover to normal, and improve the nutritional status and immune function. And occurrence of complication was reduced.

基于“骨正筋柔”理论探讨踝关节扭伤中医治疗

“骨正筋柔”理论中,“骨正”指骨骼结构和功能正常,“筋柔”则指筋脉的柔韧性和伸展性正常,“骨正”与“筋柔”相互依赖,骨不正会导致筋脉紧张和僵硬,而筋脉紧张和僵硬又会影响骨骼的正常排列和功能。急慢性踝关节扭伤主要因外力或未及时、正确治疗,使踝关节“骨失正,筋失柔”。基于“骨正筋柔”理论,在急性踝关节扭伤的治疗中,可通过调整骨骼结构、促进筋脉恢复,缓解疼痛和肿胀;在慢性踝关节扭伤的治疗中,可通过筋脉调理和骨骼养护,改善关节功能,减少复发率。治疗方法有物理治疗、手法复位、穴位按摩、中药敷贴等,常多法联用,综合治疗。另外,中药内服、食疗以及调整生活习惯等方法可促进患者气血运行,保障经络通畅,加快踝关节损伤的修复。

Efficacy and safety of external application of Traditional Chinese Medicine for the treatment of acute gouty arthritis: a systematic review and Meta-analysis

OBJECTIVE:To evaluate the clinical efficacy and safety of external application of Traditional Chinese Medicine (EATCM) on acute gouty arthritis (AGA).METHODS:Six electronic data bases were retrieved from their inception to march 2017.15 randomized controlled clinical trials (RCTs) were included.The quality of the literatures was assessed according to Cochrane review criteria by using RevMan5.3 software;and related data was counted using Stata14.0 software.RESULTS:There was no significant difference in C-reactiveprotein (CRP) between experimental intervention group and control group [(WMD =1.093,95% C/(-2.514,4.701);P =0.553)].In terms of overall efficacy,the EATCM's treatment group was significantly superior to control group [(OR =3.692;95% CI (2.408,5.661);P <0.001)].The EATCM was better than western medicine treatments or other interventions in reducing the adverse reactions [(OR =0.135;95% CI (0.067,0.274);P < 0.001)].All these funnel plots showed unlikelihood of publishing bias.But due to excessive heterogeneity,the statistical results of serum uric acid and visual analogue scale and CRP between the two groups became uncertain.CONCLUSION:The results indicate that EATCM may have greater overall efficacy with fewer adverse drug reactions,although the evidence is weak owing to the low methodological quality and the small number of the included trials.

Effects of External Application of Chinese Medicine on Diabetic Ulcers and the Expressions of β-catenin,c-myc and K6

Objective：To observe the clinical efficacy of Chinese medicine（CM） treatment of Hongyou Ointment（红油膏） and Shengji Powder（生肌散） on diabetic ulcers,and to observe the influence of CM treatment on the expressions of proteins associated with the Wnt signaling pathway,such asβ-catenin,c-myc and K6.Methods：sixty-two patients fitting the registration standards were randomly divided into the CM group（31 patients） and the Western medicine（WM） group（31 patients） by a random number table.The patients in the CM group were treated with Hongyou Ointment and Shengji Powder externally.The patients in the WM group were treated with mupirocin ointment,growth factor（bFGF）,and Vaseline gauze for external use and with basic therapies.Wound-healing time and four-week healing rate were recorded.The wounds were measured by digital photography and ImageJ software.Skin biopsies were obtained from 24 patients before CM treatment and 20 patients after CM treatment.Immunohistochemical tests and semi-quantitative imaging with NIH ImageJ 1.42 software were used to analyze the changes in protein expression ofβ-catenin,c-myc,and K6.Results：Fifty-three patients completed the trial;four patients in the CM treatment group and five patients in the WM group dropped out.Among them,four were dissatisfied with the treatment process,two could not continue because of their jobs,two failed to complete the course of follow-up appointments,and one was diagnosed with squamous cell carcinoma during treatment.The comparison of ulcer healing rates between the two groups showed insignificant differences（P=0.77）.The ulcer healing rates were 33.33%（9/27） in the CM group and 26.92%（7/26） in the WM group.However,the effective rate was significantly higher in the CM group（81.48%,22/27） than in the WM group（57.69%,15/26,P=0.04）.The mean wound healing time was shorter in the CM group（22.71±5.46 days） than in the WM group（26.56±7.56 days,P=0.04）.CM treatment was well tolerated,and there was no withdrawal due to adverse reactions.Immunohistochemical analysis in the refractory wound indicated higher expressions ofβ-catenin,c-myc and K6 compared with the normal skin.β-catenin was abnormally expressed in the nuclei of the keratinocytes and fibroblasts at the wound margins,and the expressions of c-myc and K6 were highly expressed in the full hyperplastic epidermis,especially in the granular layer（P0.05）.The expressions of these proteins decreased after CM treatment.The expression levels ofβ-catenin,c-myc,and K6 proteins before and after the treatment were 101.88±10.76 vs.140.42±8.45;113.27±16.75 vs.153.79±8.32; 90.39±11.07 vs.151.29±7.39,respectively.Conclusions：CM treatment using Hongyou Ointment and Shengji Powder was efficient in the management of diabetic skin ulcers.The mechanism of action might be related to the inhibition of the Wnt signaling pathway.

External Application of Chinese Medcine Qu Tong Ling（去痛灵）in Trealing 144 Cases of Cancer Pain

One hundred forty-four patients of cancer pain were treated with external application of QuTong Ling, and the effect of pain remission was observed. The total remission rate was 79. 2% with themaintaining time of 6. 42 1 . 24 hours, proving it was superior to butycinnamyl pyrazirum.

散结透脓方外敷联合消肿清热解毒汤内服治疗泛发性肛周脓肿术后的效果及对创面愈合时间、肛门功能的影响

目的观察散结透脓方外敷联合消肿清热解毒汤内服在泛发性肛周脓肿术后的应用效果及对创面愈合时间、肛门功能的影响。方法将102例热毒炽盛型泛发性肛周脓肿术后患者按照随机数字表法分为2组,对照组51例术后予以抗感染及对症支持等治疗方法,治疗组51例在对照组基础上予以散结透脓方外敷联合消肿清热解毒汤内服治疗,2组均治疗4周。比较2组治疗后创面愈合情况(创面腐肉脱落时间、创面愈合时间、治疗2周创面回缩率)、治疗前后中医证候评分、治疗前和治疗2周疼痛视觉模拟评分(VAS)、治疗前和术后2个月肛门失禁Wexner评分量表评分、治疗前和治疗2周炎症相关指标[白细胞计数(WBC)、C反应蛋白(CRP)、白细胞介素6(IL-6)],并统计2组临床疗效,记录治疗期间不良反应发生情况。结果治疗组总有效率90.20%(46/51),对照组总有效率74.51%(38/51),治疗组临床疗效优于对照组(P<0.05)。2组治疗后中医证候各项评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。治疗组创面腐肉脱落时间、愈合时间均低于对照组(P<0.05),治疗2周时创面回缩率高于对照组(P<0.05)。2组治疗2周时疼痛VAS均较本组治疗前降低(P<0.05),且治疗组治疗2周时疼痛VAS低于对照组同期(P<0.05)。2组术后2个月Wexner评分均较本组治疗前降低(P<0.05),且治疗组术后2个月Wexner评分低于对照组同期(P<0.05)。2组治疗2周后外周血WBC、CRP、IL-6水平均较本组治疗前降低(P<0.05),且治疗组治疗2周后均低于对照组同期(P<0.05)。结论散结透脓方外敷联合消肿清热解毒汤内服可提高泛发性肛周脓肿术后疗效,缩短愈合时间,减轻术后疼痛,缓解炎症反应,有利于改善患者肛门功能。

中药保留灌肠联合芒硝外敷的辨证施护治疗急性胰腺炎的效果

目的探讨中药保留灌肠联合芒硝外敷的中医辨证施护在急性胰腺炎患者中的应用效果。方法将80例急性胰腺炎患者随机分为观察组与对照组,对照组给予常规治疗护理,观察组在对照组基础上给予中药保留灌肠联合芒硝外敷的中医辨证施护治疗,观察两组的治疗效果及临床症状改善时间。结果观察组总有效率为97.5%(39/40),高于对照组的70.0%(28/40)(P<0.05)。经治疗,观察组临床症状改善时间均短于对照组(P<0.05)。结论中药保留灌肠联合芒硝外敷的中医辨证施护在急性胰腺炎患者中的应用效果显著,预后良好,患者乐意接受此项操作,可行推广。

中药外敷联合复合超声关节治疗仪治疗膝骨关节炎的临床效果

目的探究中药外敷联合复合超声关节治疗仪在膝骨关节炎(KOA)中的应用效果。方法选取2022年8月至2023年8月就诊于安阳市中医院的99例KOA患者为研究对象,随机分为3组,每组33例。超声组接受超声关节治疗仪治疗,中药组接受中药外敷治疗,联合组接受中药外敷联合超声关节治疗仪治疗。对比3组疗效及治疗前后西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、视觉模拟评分法(VAS)、奎森功能演算(Lequesne)指数评分、成纤维细胞生长因子2(FGF-2)、Ⅰ型胶原C-末端肽(CTX-I)、软骨寡聚基质蛋白(COMP)及不良反应。结果联合组总有效率[93.94%(31/33)]高于超声组[75.76%(25/33)]、中药组[72.73%(24/33)](P<0.05),超声组与中药组总有效率对比,差异无统计学意义(P>0.05);治疗3个疗程后联合组FGF-2高于超声组、中药组,CTX-1、COMP、Lequesne、WOMAC评分低于超声组、中药组(P<0.05),超声组、中药组组间对比,差异无统计学意义(P>0.05);治疗3个疗程后联合组静态、动态VAS评分<中药组<超声组(P<0.05);治疗期间3组均未出现不良反应。结论中药外敷与复合超声关节治疗仪联合治疗KOA患者效果确切,可有效调节骨代谢指标,有助于缓解患者疼痛感,恢复膝关节功能。

益肾逐瘀汤联合中药外敷治疗前列腺增生伴膀胱过度活动症的疗效及机制研究

目的研究益肾逐瘀汤联合中药外敷治疗前列腺增生伴膀胱过度活动症的疗效及机制。方法选取2022年7月—2023年4月广西中医药大学第一附属医院泌尿外科收治的前列腺增生伴膀胱过度活动症患者90例,随机分为常规药物组、中药外敷组与益肾逐瘀汤组,每组30例。3组均给予常规药物(托特罗定)治疗,中药外敷组在托特罗定治疗的基础上给予中药敷贴于神阙关元穴,益肾逐瘀汤组在托特罗定治疗的基础上给予中药外敷联合益肾逐瘀汤浓缩丸剂口服治疗。治疗2周后比较3组患者治疗有效率,治疗前后的最大尿流率(maximum flow rate,Qmax)、尿量(urine volume,VV),国际前列腺症状评分(international prostate symptom score,IPSS)、膀胱活动过度症评分(overactive bladder syndrome score,OABSS),前列腺小体外泄蛋白(prostatic exosomal potein,PSEP)、血液流变学[全血高切黏度(high blood viscosity,HBV)、全血低切黏度(low blood viscosity,LBV)]和血清性激素[促黄体生成素(Luteinizing hormone,LH)、睾酮(testosterone,T)]的水平。结果常规药物组、中药外敷组与益肾逐瘀汤组治疗总有效率分别为73.33%(22/30)、90.00%(27/30)、96.67%(29/30),益肾逐瘀汤组显著高于常规药物组(P<0.05)。治疗后3组患者Qmax、VV均显著升高,并且益肾逐瘀汤组显著高于常规药物组、中药外敷组(P<0.05)。治疗后3组患者IPS、OABSS评分均显著降低,并且益肾逐瘀汤组显著低于常规药物组、中药外敷组(P<0.05)。治疗后3组患者PSEP、HBV、LBV、LH水平均显著下降,T水平显著升高,益肾逐瘀汤组PSEP、HBV、LBV、LH水平显著低于常规药物组、中药外敷组,T水平显著高于常规药物组、中药外敷组,差异均有统计学意义(P<0.05)。结论益肾逐瘀汤联合中药外敷治疗前列腺增生伴膀胱过度活动症效果满意,可提高治疗总有效率,并改善患者血流流变学、促进性激素水平处于平衡状态,促进患者康复。

火针联合黄连膏包敷治疗慢性湿疹血虚风燥证的临床观察

目的观察火针联合黄连膏包敷治疗慢性湿疹血虚风燥证的临床疗效。方法将100例慢性湿疹血虚风燥证患者按照随机数字表法分为2组,对照组50例予局部火针方法治疗,治疗组50例在对照组基础上予黄连膏包敷方法治疗。2组均治疗4周。比较2组治疗前后湿疹面积及严重程度指数(EASI)评分、瘙痒程度评分、瘙痒频率评分,并统计2组疗效及复发率。结果治疗组总有效率96.00%(48/50),对照组总有效率82.00%(41/50),治疗组临床疗效优于对照组(P<0.05)。2组治疗后EASI各项评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后瘙痒程度评分、瘙痒频率评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。治疗组复发率低于对照组(P<0.05)。结论火针联合黄连膏包敷治疗慢性湿疹血虚风燥证患者效果显著,能够减轻患者的瘙痒症状,降低复发率,值得推广应用。

新型特色水药罐的设计和应用

目的:研制一种新型特色水药罐,以提高水药罐的操作便利性、密封性、保温性及牢固性。方法:新型特色水药罐材质为树脂类,由双层保温罐体、单向排气阀、调节开关、活塞、风琴软管和弹簧组成。其中双层保温罐体的罐壁为内部中空的双层结构;调节开关的中部设有长方形滑动孔;活塞由活塞杆、尾座和活塞头组成;弹簧位于开关底座旁,上端和调节开关连接,下端和双层保温罐体连接。结果:相较于传统特色水药罐,新型特色水药罐用于拔罐所需时间更短,药液洒漏量更少,拔罐前后药液温差更小。结论:新型特色水药罐临床操作简便、密封性强、保温性能良好、不易破碎,是一种适合临床推广使用的拔罐器具。

中医外治单元疗法治疗胡蜂蜇伤的疗效观察

目的观察中医外治单元疗法对胡蜂蜇伤急诊患者的疗效。方法将2021年4月至2023年9月安徽中医药大学第一附属医院急诊科收治的70例胡蜂蜇伤患者采用随机数字表法分为观察组与对照组,各35例。对照组采用基础治疗方法,观察组在对照组基础上加用中医外治单元疗法,疗程为5 d。比较两组患者治疗前后疗效、数字疼痛评分(NRS)和毒效应指标[天门冬氨酸氨基转移酶/丙氨酸氨基转移酶(AST/ALT)、总胆红素(TBIL)、肌酐(SCr)、部分凝血酶原时间(APTT)、超敏C反应蛋白(hs-CRP)],并记录两组蜇伤处肿胀开始消退时间。结果观察组总有效率(85.71%)高于对照组(62.86%),肿胀消退时间短于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后NRS评分、AST/ALT、TBIL、SCr、APTT、hs-CRP差值比较,差异均有统计学意义(P<0.05)。结论中医外治单元疗法能加速胡蜂蜇伤局部肿胀消退,缓解疼痛,降低毒效应指标,促进炎症吸收,加速患者康复。

针刺联合循经按摩及中药外敷治疗哺乳期急性乳腺炎患者的疗效观察

目的探讨针刺联合循经按摩、中药外敷治疗哺乳期急性乳腺炎患者的临床疗效。方法回顾性分析2021年1月—2022年12月期间唐山市妇幼保健院中医科门诊收治的360例早期哺乳期急性乳腺炎患者,按随机数字表法分为对照A组(循经按摩+中药外敷)77例、对照B组(针刺+循经按摩)82例、对照C组(针刺+中药外敷)98例、治疗组(针刺+循经按摩+中药外敷)113例。对照A组患者循经按摩+中药外敷治疗,对照B组患者针刺+循经按摩治疗,对照C组患者针刺+中药外敷治疗,治疗组患者针刺+循经按摩+中药外敷治疗。治疗2个疗程后,观察比较4组患者临床疗效、临床症状、体征消退时间、疼痛及体温变化及复发率,治疗前后血清炎性指标[白细胞计数(White blood cell,WBC)、中性粒细胞百分比(Neutrophilicgranulocyte,NE%)、C-反应蛋白(Creactiveprotein,CRP)]水平。结果治疗后治疗组患者临床总有效率68.14%(77/113)明显高于对照A组患者53.25%(41/77)、对照B组患者51.22%(42/82)、对照C组患者53.06(52/98),差异有统计学意义(P<0.05)。治疗后治疗组患者疼痛消退时间、肿块消失时间、皮肤发红消退时间、体温恢复时间均明显优于对照A组、对照B组、对照C组患者,差异有统计学意义(P<0.05)。治疗后4组患者外周血WBC、NE%、CRP水平均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组患者外周血WBC、NE%、CRP水平均明显低于对照A组、对照B组、对照C组患者,差异有统计学意义(P<0.05)。治疗后治疗组患者哺乳意愿、哺乳行为率明显高于对照A组、对照B组、对照C组患者,差异有统计学意义(P<0.05);复发率明显低于对照A组、对照B组、对照C组患者,差异有统计学意义(P<0.05)。结论针刺联合循经按摩、中药外敷治疗哺乳期急性乳腺炎患者能有效提高临床疗效,降低患者炎症因子水平及疼痛感,增加哺乳意愿及哺乳行为,降低复发率。

止疼膏1号外敷治疗肺癌癌痛患者的临床观察

目的 观察止疼膏1号外敷痛点及穴位治疗肺癌癌痛患者的临床疗效。方法 选取2022年1月—2022年12月期间山东省昌乐人民医院收治的80例肺癌患者作为研究对象,按随机数字表法分为对照组和观察组,每组各40例。对照组仅采用规范的三阶梯止痛方案,观察组在接受三阶梯止痛方案治疗的基础上,采用止疼膏1号外敷痛点及穴位。治疗2周后,观察比较两组患者临床疗效、不良反应情况,治疗前后疼痛程度[数字疼痛分级法(Numberical rating scale, NRS)]、生活质量[肺癌治疗功能评价系统(Functional Assessment of Cancer Therapy-Lungcancer, FACT-L)]评分。结果 治疗后观察组总有效率87.50%(35/40)高于对照组67.50%(27/40),差异有统计学意义(P<0.05)。治疗后两组患者NRS评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组NRS评分均较对照组同期明显降低,差异有统计学意义(P<0.05)。治疗后两组患者FACT-L评分均较治疗前升高,差异有统计学意义(P<0.05);且观察组FACT-L评分明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 止疼膏1号外敷治疗具有协同止痛作用,能够有效减轻肺癌癌痛患者的疼痛程度,提高肺癌患者的生活质量。

中药膏药外敷治疗类风湿关节炎的研究进展

清代医家吴师机提出“外治之理即内治之理,外治之药即内治之药”,为中药膏药外治法奠定了基础。文章就近10年来中药膏药外敷治疗类风湿关节炎相关文献进行梳理总结,并对其用药特点、中医证型及作用机制进行探讨和分析,以期为中药膏药外敷治疗类风湿关节炎的挖掘与应用研究提供依据。

活血类膏药外敷治疗膝关节炎及中医药对其认识的进展

膝关节炎具有发病率高、治疗相对困难、易复发等特点,且与多种因素密切相关,严重威胁中老年的生活质量与身体健康。对于膝关节炎患者,目前可采用止痛治疗、激素治疗、物理治疗、手术治疗、中医药治疗等。近年来,中医药对膝关节炎认识越来越深入,这对于提高中老年膝关节炎的关注度,提升膝关节炎的治疗效果,促进中老年膝关节炎患者疾病的恢复与生活健康有重要的参考意义。本文从膝关节炎的特点、中医药治疗膝关节炎相关研究方面进行综述,重点叙述活血类膏药外敷治疗及相关疗法的作用。