A algorithm for prediction of exudative retinal detachment risk of patients with pregnancy-induced hypertension

AIM:To investigate the risk of exudative retinal detachment(ERD)morbidity in patients with pregnancyinduced hypertension(PIH)by using the logistic regression combined with the receiver operating characteristic(ROC)curve.METHODS:A total of 46 patients with ERD and 142 patients with non-ERD were diagnosed as PIH from January 2017 to February 2020.A retrospective comparison of the clinical manifestations and laboratory tests were conducted.The risk of ERD morbidity with PIH was predicted by using logistic regression combined with an ROC curve model.RESULTS:There was no significant difference in age and body mass index between the two groups before pregnancy(P>0.05).However,significant differences were found in gestational weeks,duration of hypertension,maximum and minimum systolic and diastolic blood pressure(BP),and plasma total protein(PTP)concentration between the two groups(P<0.05).Binary logistic regression analysis showed that the maximum systolic BP(OR=1.050,95%CI:1.016-1.085)and PTP concentration(OR=0.764,95%CI:0.702-0.832)were independent prediction risks of ERD in PIH.The sensitivities of maximum systolic BP,PTP concentration and combined diagnosis were 0.717,0.870,and 0.870,respectively;the specificities were 0.617,0.837,and 0.908,respectively;the area under the curve(AUC)was 0.707(95%CI:0.622-0.792),0.917(95%CI:0.868-0.967),and 0.933(95%CI:0.890-0.975),respectively;the AUC of combined diagnosis was higher than that of single diagnosis(P<0.01).CONCLUSION:Logistic regression and ROC curve model combined with maximum systolic BP and PTP can improve the early identification of high-risk PIH patients in the hospital.

血浆总同型半胱氨酸测量值升高在AMD诊断中的意义

目的探讨血浆总同型半胱氨酸水平在渗出性老年性黄斑变性发病机制中的作用。方法设立实验组及正常对照组,分别测定血浆总同型半胱氨酸、叶酸、维生素B12水平及血糖、血压、血脂水平。结果渗出性老年性黄斑变性病例血浆总同型半胱氨酸水平升高,叶酸水平下降。结论血浆总同型半胱氨酸升高通过参与微血管内皮细胞的破坏特异性促进渗出性老年性黄斑变性的病程进展。

脑出血血肿周围水肿的病理生理研究

脑出血后血肿周围水肿的机制还不十分清楚。大量的研究表明,血液成分(溶解的红细胞、血浆蛋白的渗出、活化的血小板)血肿周围局部血流量的减少、脑出血后的炎性反应和凝血酶均和脑出血血肿周围水肿的形成有关。

细胞膜H^(+)-ATP酶在植物矿质营养中的作用

细胞膜H^(+)-ATP酶是植物体内一类重要的质子泵,也是一种极其关键的转运蛋白,在植物各种生命活动中具有重要的功能。本文综述了细胞膜H^(+)-ATP酶的活性调控机制,及其在植物根系吸收与利用矿质营养中的生理作用。细胞膜H^(+)-ATP酶通过消耗ATP将细胞质中的H^(+)排出,为养分离子的跨膜转运,以及有机酸和生物硝化抑制剂等物质的分泌提供细胞膜电位和质子驱动力。在缺磷、缺铁和铝毒等营养逆境下,细胞膜H+-ATP酶在受诱导后通过分泌H^(+)使根际酸化,从而提高磷和铁的有效性,还通过促进有机酸分泌来活化土壤中的矿物态磷,并且可以降低铝离子的毒害。此外,细胞膜H^(+)-ATP酶还参与调节植物根系的生长以及植物与丛枝菌根真菌的共生。通过遗传途径调节细胞膜H^(+)-ATP酶及其上游调节因子,如蛋白激酶和磷酸酶等基因的表达,以及对细胞膜H^(+)-ATP酶的特定氨基酸位点进行突变,可以改良作物细胞膜H^(+)-ATP酶的活性。这是一种提高作物养分利用效率、增强作物抵抗营养逆境的有效策略。

睡莲花露主要成分及抗氧化作用

以‘蓝鸟’睡莲(Nymphaea ‘Blue Bird’)花露为材料,采用液相色谱-质谱(liquid chromatograph-mass spectrometer,LC-MS)法,分析睡莲花露的主要成分,同时采用1,1-二苯基-2-三硝基苯肼(1,1-dipheny1-2-picrylhydrazyl,DPPH)法、铁离子还原/抗氧化能力(ferric reducing ability of plasma,FRAP)法、总抗氧化能力(total peroxyl radical-trapping antioxidant parameter,TRAP)法测定睡莲花露的抗氧化能力。代谢成分分析结果表明,睡莲花露的主要成份有葡萄糖酸、马来酸甲麦角新碱,单半乳糖甘油二酯,硫代异鼠李糖甘油二酯、1-十六酰-SN-丙三醇-磷酸胆碱、东莨菪内酯、威严仙皂苷C、葡萄糖醛酸、槲皮素、肌醇半乳糖苷和香豆素等多种物质。抗氧化能力测试表明,DPPH法中350μL睡莲花露的自由基清除率为(85.19±1.55)%;FRAP法中测定的睡莲花露抗氧化能力相当于6.35 mmol/L的FeSO_4的抗氧化能力;TRAP法中花露加入量与TRAP值呈线性相关,5μL的睡莲花露加入量其抗氧化能力相当于1.425 2 mmol/L的抗坏血酸钠。