The branching ratios of ions and the angular distributions of electrons ejected from the Eu 4f^76p_（1/2）nd auto-ionizing states are investigated with the velocity-map-imaging technique.To populate the above auto-ion...The branching ratios of ions and the angular distributions of electrons ejected from the Eu 4f^76p_（1/2）nd auto-ionizing states are investigated with the velocity-map-imaging technique.To populate the above auto-ionizing states,the relevant bound Rydberg states have to be detected first.Two new bound Rydberg states are identified in the region between41150 cm^（-1）and 44580 cm^（-1）,from which auto-ionization spectra of the Eu 4f^76p_（1/2）nd states are observed with isolated core excitation method.With all preparations above,the branching ratios from the above auto-ionizing states to different final ionic states and the angular distributions of electrons ejected from these processes are measured systematically.Energy dependence of branching ratios and anisotropy parameters within the auto-ionization spectra are carefully analyzed,followed by a qualitative interpretation.展开更多
突触密度活体可视化评估与定量分析在神经和精神疾病的诊断、治疗监测和机制研究方面具有广阔的临床应用前景。突触前膜囊泡蛋白2A(synaptic vesicle protein 2A,SV2A)可反映突触密度情况并与神经元兴奋性改变、致痫网络形成和癫痫耐药...突触密度活体可视化评估与定量分析在神经和精神疾病的诊断、治疗监测和机制研究方面具有广阔的临床应用前景。突触前膜囊泡蛋白2A(synaptic vesicle protein 2A,SV2A)可反映突触密度情况并与神经元兴奋性改变、致痫网络形成和癫痫耐药密切相关。为可视化评估突触密度,本研究采用GE Tracerlab FXFN模块高效合成与标记特异性靶向SV2A新型PET核素分子探针^(18)F-SynVesT-1,通过理化性质、稳定性、比活度、细菌内毒素等检测技术进行质量控制,利用癫痫动物模型对^(18)F-SynVesT-1显像效果进行验证。结果显示,Tracerlab FXFN模块能实现^(18)F-SynVesT-1的高效合成,未校准放化产率为(11.4±2.6)%,且产品溶液满足临床及注射要求。本研究合成的^(18)F-SynVesT-1质控表现良好,可用于活体脑突触显像、突触密度定量评估及致痫灶异常检测分析。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.11174218)
文摘The branching ratios of ions and the angular distributions of electrons ejected from the Eu 4f^76p_（1/2）nd auto-ionizing states are investigated with the velocity-map-imaging technique.To populate the above auto-ionizing states,the relevant bound Rydberg states have to be detected first.Two new bound Rydberg states are identified in the region between41150 cm^（-1）and 44580 cm^（-1）,from which auto-ionization spectra of the Eu 4f^76p_（1/2）nd states are observed with isolated core excitation method.With all preparations above,the branching ratios from the above auto-ionizing states to different final ionic states and the angular distributions of electrons ejected from these processes are measured systematically.Energy dependence of branching ratios and anisotropy parameters within the auto-ionization spectra are carefully analyzed,followed by a qualitative interpretation.
