Hepatocellular carcinoma(HCC)is a leading cause of death worldwide.Current therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to chem...Hepatocellular carcinoma(HCC)is a leading cause of death worldwide.Current therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to chemotherapy.Therefore,new therapeutic targets are needed.We analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly different.The analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC patients.In vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell lines.Knockdown of AKR1C3 in Huh7 cells reduced tumor growth in vivo.To explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target genes.Suppression of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 cells.Knockdown of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC growth.We showed that indomethacin potentiated the sensitivity of Huh7 cells to sorafenib.In summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC growth.Therefore,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.展开更多
In order to restore noisy fractal Brownian motion(FBM),discrete fractional gaussiannoise(DFGN) combined with noise increments is decomposed by Haar wavelets based on Mallatalgorithm.Considering the correlation of deta...In order to restore noisy fractal Brownian motion(FBM),discrete fractional gaussiannoise(DFGN) combined with noise increments is decomposed by Haar wavelets based on Mallatalgorithm.Considering the correlation of detail coefficients,a bank of Wiener filters are used to estimatethe detail coefficients to reconstruct DFGN considering the estimated approximation coefficients in thecoarsest scale in the minimum mean square sense.Then,the reconstructed DFGN is used to restore FBM.In the digital simulation,in light of the restoration mean square error,we show that the suppose that thecorrelation of detail coefficients and the approximation coefficients in the coarsest scale for any Hurstcould be avoided is unrealistic.Moreover,we calculate the estimation root mean square error of the hurstparameter of the restored FBM to show the validity of our algorithm.展开更多
This paper analyzes the family factor in the construction of new socialist countryside. It is believed that the family plays both the positive role and negative role in new socialist countryside construction. Based on...This paper analyzes the family factor in the construction of new socialist countryside. It is believed that the family plays both the positive role and negative role in new socialist countryside construction. Based on this analysis,it puts forward corresponding countermeasures,including bringing into play the effect of family in promoting production and carrying forward excellent factors of family culture.展开更多
For a given triangulation Δ of a region R of interest, let S_8~2(Δ): = {s∈C^2(R): s|_1∈P_8,l∈Δ} be the space of all splines of degree 8 and smoothness 2, where t denotes any triangle of Δ and P_8 the space of ...For a given triangulation Δ of a region R of interest, let S_8~2(Δ): = {s∈C^2(R): s|_1∈P_8,l∈Δ} be the space of all splines of degree 8 and smoothness 2, where t denotes any triangle of Δ and P_8 the space of polynomials of total degree≤8. Furthermore, let S_8~2(Δ):={s∈S_8~3(Δ):s∈C^3 at v, v∈Δ} be a super spline subspace of S_8~2(Δ). We construel a collection of locally supported splines in S_8~2(Δ) which can be used to achieve lhe full approximation order of S_8~2(Δ) and its cardinalily is less than the di- mension of super spline space space S_8~2(Δ).展开更多
We analyze the periodic orbits of “f” family (simply symmetric retrograde periodic orbits) and the regions of quasi-periodic motion around Saturn in the photo gravitational Sun-Saturn system in the framework of plan...We analyze the periodic orbits of “f” family (simply symmetric retrograde periodic orbits) and the regions of quasi-periodic motion around Saturn in the photo gravitational Sun-Saturn system in the framework of planar circular restricted three-body problem with oblateness. The location, nature and size of these orbits are studied using the numerical technique of Poincare surface of sections (PSS). In this paper we analyze these orbits for different solar radiation pressure (q) and actual oblateness coefficient of Sun Saturn system. It is observed that as Jacobi constant (C) increases, the number of islands in the PSS and consequently the number of periodic and quasi-periodic orbits increase. The periodic orbits around Saturn move towards the Sun with decrease in solar radiation pressure for given value of “C”. It is observed that as the perturbation due to solar radiation pressure decreases, the two separatrices come closer to each other and also come closer to Saturn. It is found that the eccentricity and semi major axis of periodic orbits at both separatrices are increased by perturbation due to solar radiation pressure.展开更多
目的:梳理家属ICU后综合征相关文献,以界定该概念。方法:以Arksey和O′Malley的范围综述框架为方法学指导,系统检索PubMed、Web of Science、the Cochrane Library等14个中英文数据库,并辅以手工检索,检索时限为2010年1月1日-2023年4月1...目的:梳理家属ICU后综合征相关文献,以界定该概念。方法:以Arksey和O′Malley的范围综述框架为方法学指导,系统检索PubMed、Web of Science、the Cochrane Library等14个中英文数据库,并辅以手工检索,检索时限为2010年1月1日-2023年4月18日。2名研究者独立筛选文献和提取数据。采用内容分析法分析数据,专家会议讨论并确定概念相关内容。结果:纳入13篇文献,经数据分析和专家讨论后确定了家属ICU后综合征的6个概念关键组成部分和描述性定义。结论:本研究初步阐明了家属ICU后综合征的概念,为该概念的发展和测量提供了一定的参考依据。展开更多
基金National Yang Ming Chiao Tung University Far Eastern Memorial Hospital Joint Research Programs(NYCU-FEMH 109DN03,110DN06,111DN04,112DN05).
文摘Hepatocellular carcinoma(HCC)is a leading cause of death worldwide.Current therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to chemotherapy.Therefore,new therapeutic targets are needed.We analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly different.The analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC patients.In vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell lines.Knockdown of AKR1C3 in Huh7 cells reduced tumor growth in vivo.To explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target genes.Suppression of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 cells.Knockdown of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC growth.We showed that indomethacin potentiated the sensitivity of Huh7 cells to sorafenib.In summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC growth.Therefore,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.
基金Supported by The "Fondazione Cassa di Risparmio of Triestethe "Fondazione Benefica Kathleen Foreman Casali of Trieste"the Italian Minister of Instruction,University and Research(MIUR),PRIN 2010-11,No.20109PLMH2(in part)
文摘AIM: To evaluate the effects of the proteasome inhibitor bortezomib (BZB) on E2Fs and related genes in hepatocellular carcinoma (HCC) cells.
文摘In order to restore noisy fractal Brownian motion(FBM),discrete fractional gaussiannoise(DFGN) combined with noise increments is decomposed by Haar wavelets based on Mallatalgorithm.Considering the correlation of detail coefficients,a bank of Wiener filters are used to estimatethe detail coefficients to reconstruct DFGN considering the estimated approximation coefficients in thecoarsest scale in the minimum mean square sense.Then,the reconstructed DFGN is used to restore FBM.In the digital simulation,in light of the restoration mean square error,we show that the suppose that thecorrelation of detail coefficients and the approximation coefficients in the coarsest scale for any Hurstcould be avoided is unrealistic.Moreover,we calculate the estimation root mean square error of the hurstparameter of the restored FBM to show the validity of our algorithm.
文摘This paper analyzes the family factor in the construction of new socialist countryside. It is believed that the family plays both the positive role and negative role in new socialist countryside construction. Based on this analysis,it puts forward corresponding countermeasures,including bringing into play the effect of family in promoting production and carrying forward excellent factors of family culture.
文摘For a given triangulation Δ of a region R of interest, let S_8~2(Δ): = {s∈C^2(R): s|_1∈P_8,l∈Δ} be the space of all splines of degree 8 and smoothness 2, where t denotes any triangle of Δ and P_8 the space of polynomials of total degree≤8. Furthermore, let S_8~2(Δ):={s∈S_8~3(Δ):s∈C^3 at v, v∈Δ} be a super spline subspace of S_8~2(Δ). We construel a collection of locally supported splines in S_8~2(Δ) which can be used to achieve lhe full approximation order of S_8~2(Δ) and its cardinalily is less than the di- mension of super spline space space S_8~2(Δ).
文摘We analyze the periodic orbits of “f” family (simply symmetric retrograde periodic orbits) and the regions of quasi-periodic motion around Saturn in the photo gravitational Sun-Saturn system in the framework of planar circular restricted three-body problem with oblateness. The location, nature and size of these orbits are studied using the numerical technique of Poincare surface of sections (PSS). In this paper we analyze these orbits for different solar radiation pressure (q) and actual oblateness coefficient of Sun Saturn system. It is observed that as Jacobi constant (C) increases, the number of islands in the PSS and consequently the number of periodic and quasi-periodic orbits increase. The periodic orbits around Saturn move towards the Sun with decrease in solar radiation pressure for given value of “C”. It is observed that as the perturbation due to solar radiation pressure decreases, the two separatrices come closer to each other and also come closer to Saturn. It is found that the eccentricity and semi major axis of periodic orbits at both separatrices are increased by perturbation due to solar radiation pressure.
文摘目的:梳理家属ICU后综合征相关文献,以界定该概念。方法:以Arksey和O′Malley的范围综述框架为方法学指导,系统检索PubMed、Web of Science、the Cochrane Library等14个中英文数据库,并辅以手工检索,检索时限为2010年1月1日-2023年4月18日。2名研究者独立筛选文献和提取数据。采用内容分析法分析数据,专家会议讨论并确定概念相关内容。结果:纳入13篇文献,经数据分析和专家讨论后确定了家属ICU后综合征的6个概念关键组成部分和描述性定义。结论:本研究初步阐明了家属ICU后综合征的概念,为该概念的发展和测量提供了一定的参考依据。
