目的研究慢性阻塞性肺疾病(COPD)患者支气管舒张试验后FEV_1与FVC改变值和改变率及改善率的比较,以更准确地评估其对COPD的临床意义。方法选择248例COPD患者,均行肺功能和支气管舒张试验,观察支气管舒张试验前后FEV_1和FVC的变化,对支...目的研究慢性阻塞性肺疾病(COPD)患者支气管舒张试验后FEV_1与FVC改变值和改变率及改善率的比较,以更准确地评估其对COPD的临床意义。方法选择248例COPD患者,均行肺功能和支气管舒张试验,观察支气管舒张试验前后FEV_1和FVC的变化,对支气管舒张后FEV_1和FVC的改变值和改变率进行比较。结果支气管舒张试验后,COPD患者的FEV_1改变值平均增加133.9 m L,较基础值提高(改变率)6.93%,改善率为52.2%;FVC改变值平均增加336.7 m L,较基础值提高(改变率)11.36%,改善率为73.1%。FEV_1与FVC的改变值和改变率差异均有统计学意义(P均<0.01)。结论 COPD患者吸入支气管舒张剂后FEV_1和FVC均有所增加,但FVC的改善较FEV_1更为显著,FVC的变化较FEV_1敏感,提示FVC应作为诊断COPD的重要指标。展开更多
Bronchial asthma is a chronic inflammatory disease. Allergies are intensely related to bronchial asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Treatment c...Bronchial asthma is a chronic inflammatory disease. Allergies are intensely related to bronchial asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Treatment can vary from inhalers to oral medications to drugs delivered in a nebulizer or breathing machine. Besides, dietary involvement was a significant tool to reduce the severity of many chronic inflammatory diseases including asthma. Randomly assigned, double blind, and placebo controlled 290 adults with mild to moderately persistent bronchial asthma concluded in this study, were subjected to alternating phases of supplementation with omega-3 fatty acids, vitamin C and Zn either singly or in combination. Subjective symptom improvement, pulmonary function, and biochemical tests were carried out at the beginning of the study and at the end of each therapeutic phase. The study findings showed that nearly half of the cases were in age between 18 years to 40 years followed by 29.6 of the cases that fall in age range between 40 years and 60 years. It was clear that all the four supplements (ogema-3 fatty acids, vitamin C and Zn, and combination) contributed more than placebo in reducing the severity of bronchial asthma. However, omega 3 fatty acids and combined supplement significantly contributed in symptomatic improvement (p < 0.05). There was a significant improvement of pulmonary function and sputum inflammatory markers with diet supplementation (p < 0.05). So, the subjects with mild and moderately persistent bronchial asthma may get benefit from their dietary supplementation with omega 3 fatty acids, Zinc and vitamin C. It is evident from this study that omega 3 fatty acids and combined supplementation significantly improved the severity of bronchial asthma.展开更多
文摘目的研究慢性阻塞性肺疾病(COPD)患者支气管舒张试验后FEV_1与FVC改变值和改变率及改善率的比较,以更准确地评估其对COPD的临床意义。方法选择248例COPD患者,均行肺功能和支气管舒张试验,观察支气管舒张试验前后FEV_1和FVC的变化,对支气管舒张后FEV_1和FVC的改变值和改变率进行比较。结果支气管舒张试验后,COPD患者的FEV_1改变值平均增加133.9 m L,较基础值提高(改变率)6.93%,改善率为52.2%;FVC改变值平均增加336.7 m L,较基础值提高(改变率)11.36%,改善率为73.1%。FEV_1与FVC的改变值和改变率差异均有统计学意义(P均<0.01)。结论 COPD患者吸入支气管舒张剂后FEV_1和FVC均有所增加,但FVC的改善较FEV_1更为显著,FVC的变化较FEV_1敏感,提示FVC应作为诊断COPD的重要指标。
文摘Bronchial asthma is a chronic inflammatory disease. Allergies are intensely related to bronchial asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Treatment can vary from inhalers to oral medications to drugs delivered in a nebulizer or breathing machine. Besides, dietary involvement was a significant tool to reduce the severity of many chronic inflammatory diseases including asthma. Randomly assigned, double blind, and placebo controlled 290 adults with mild to moderately persistent bronchial asthma concluded in this study, were subjected to alternating phases of supplementation with omega-3 fatty acids, vitamin C and Zn either singly or in combination. Subjective symptom improvement, pulmonary function, and biochemical tests were carried out at the beginning of the study and at the end of each therapeutic phase. The study findings showed that nearly half of the cases were in age between 18 years to 40 years followed by 29.6 of the cases that fall in age range between 40 years and 60 years. It was clear that all the four supplements (ogema-3 fatty acids, vitamin C and Zn, and combination) contributed more than placebo in reducing the severity of bronchial asthma. However, omega 3 fatty acids and combined supplement significantly contributed in symptomatic improvement (p < 0.05). There was a significant improvement of pulmonary function and sputum inflammatory markers with diet supplementation (p < 0.05). So, the subjects with mild and moderately persistent bronchial asthma may get benefit from their dietary supplementation with omega 3 fatty acids, Zinc and vitamin C. It is evident from this study that omega 3 fatty acids and combined supplementation significantly improved the severity of bronchial asthma.
