Effects of Integrative Chinese and Western Medicine on Arterial Oxygen Saturation in Patients with Severe Acute Respiratory Syndrome

Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine (ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-randomized, controlled trial was conducted on 447 SARS patients treated synchronously with western conventional treatment (WM group, n = 171) alone and ICWM (ICWM group, n = 276). The changes of the cases with normal level (≥95% ) or abnormal level (<95% ) SaO2 were observed dynamically. Results: In the 3rd-14th day of the therapeutic course, the percentage of patients with normal SaO2 in the ICWM group was higher than that in the WM group (OR = 0.5178, P = 0.0038), and this tendency was more evident in patients of the severe type (OR = 0. 18, P = 0. 0001). However, the statistical significance of difference was only shown in patients for whom the ICWM treatment started in the early period after the onset (≤7 days after it, OR = 0.3803, P = 0.006), but not shown in those who received ICWM treatment later in the mid-late period of SARS ( P>0. 05). Conclusion: ICWM treatment, particularly when it is used for intervention in the early stage, is beneficial for maintaining normal SaO2 in SARS patients.

Therapeutic Effects of Integrated Traditional Chinese Medicine and Western Medicine in Treating Severe Acute Respiratory Syndrome

Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone.

Exploring the biological mechanism of qi deficiency syndrome with chronic obstructive pulmonary disease(COPD)based on integrated pharmacology

Objective:To explore the potential biological mechanism of chronic obstructive pulmonary disease(COPD)qi deficiency syndrome,we used the integrated pharmacology network computing platform and carried out experimental verification.Methods:Using an integrated pharmacology strategy to analyze the potential biological targets of COPD qi deficiency syndrome.Based on the established qi deficiency syndrome rat model of COPD,the biological targets of lung and skeletal muscle were detected by electron microscopy,adenosine triphosphate(ATP)content assays,and western blotting.Results:According to the integrated pharmacological results,it was found that the locations of cell components related to COPD qi deficiency syndrome were mainly mitochondria.Electron microscopy results using lung tissue showed that mitochondria in the lipopolysaccharide(LPS group)and pulmonary instillation of LPS combined with cigarette smoke(LPStCS group)were swollen,deformed,and fragmented,with disappearing or broken crista.Results also showed that the total content of ATP in the lung and skeletal muscle of both groups was significantly lower than that in the control group at the 12th week(P<.05).At the 12th week,the expression of dynamin-related protein 1(DRP1)and mitofusin 1(MFN1)protein was significantly difference than that of the control group(P<.05).At the 10th and 14th weeks,changes in fission and fusion proteins in mitochondria of the lung and skeletal muscle were further detected.There was also a significant difference in the expression between the two groups compared to that in the control group at the 10th week and 14th week(P<.05).Conclusion:These findings suggest that the changes in mitochondrial morphology and ATP content and the unbalanced expression of DRP1 and MFN1 might be the key mechanisms underlying qi deficiency syndrome in rats with COPD.

Exploring the mechanism of action of Danggui Shaoyao San in the treatment of polycystic ovary syndrome based on integrated pharmacology and molecular docking

Background:We used integrated pharmacology and molecular docking to investigate the mechanism of action of Danggui Shaoyao San(DSS)in the treatment of polycystic ovary syndrome(PCOS),and to provide a basis for subsequent systematic studies.Methods:The Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine(TCMIP)V2.0 was used for target prediction of the drugs within DSS.Relevant targets for PCOS were retrieved in the human gene database(GeneCards)and imported within TCMIP V2.0.Relying on the“Chinese medicine association network mining”module in the TCMIP V2.0 platform,the“drug target-disease target”interaction network is constructed.We continue to enrich and analyze the potential targets of the above drugs for disease intervention through the TCMIP V2.0 platform,draw a multidimensional network map of“Chinese herbal medicine–chemical composition–disease–potential target–pathway”and validate the intersection of chemical composition and drug with disease by molecular docking.Results:There are 88 potential targets and 28 potential core targets among the action targets of DSS and PCOS.Combined with protein-protein interaction network analysis,the potential core targets of disease and drug intersection are estrogen receptor 1 androgen receptor.The binding energies obtained by molecular docking were all≤-5.0 kJ/moL,indicating that the potentially active chemical components have good binding activity to the intersection targets.Conclusion:DSS has the potential to be a multi-target and multi-pathway treatment for PCOS.

Efficacy of Sensory Integration Therapy in Improving Gross Motor Coordination and Grip Control in Down Syndrome Children

This work was carried out to investigate the efficacy of sensory integration therapy in improving gross motor coordination and grip control in Down syndrome children. Thirty children were enrolled in this study and randomly assigned into two groups: group A received (sensory integration therapy program plus specific physiotherapy training) and group B received (specific physiotherapy training program only). Motor coordination test measures (Balancing backward, Hopping, Jumping from side to side and Transferring boxes) to test and follow gross motor coordination, handheld dynamometer to test and follow grip control ability and kinesthesia test to test and follow awareness of joint position and movement. These measurements were taken before initial treatment and after 12 weeks of treatment. The children parents in both groups A and B were instructed to complete 3 hours of the home routine program. Data analysis was available on the 30 Down syndrome children participating in the study. The difference between pre- and post-treatment results was more significant in Motor coordination test measures in the study group than the control group. Grip control ability and kinesthesia test demonstrate representative improvement in the study groups (p = 0.0001) while insignificant in the kinesthesia control group and significant in a grip control group. The addition of sensory integration therapy program to specific physiotherapy training is recommended in improving gross motor coordination and grip control abilities in Down syndrome, so this suggested approach may be used as a selective choice for improving posture control and hand functions in Down syndrome children.

Give Full Play the Role of Traditional Chinese Medicine to Prevent and Treat Severe Acute Respiratory Syndrome with Integrative Chinese and Western Medicine Approach

Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU

Exploration of the molecular mechanism of Indigo Naturalis in the treatment of myelodysplastic syndromes through integrated pharmacological study

Background:Oral administration of indigo naturalis(IN)is used as a complementary and alternative medicine(CAM)regimen for the treatment of myelodysplastic syndromes(MDS).However,its mechanism of action has not been fully elucidated and needs to be further explored.Methods:By searching the traditional Chinese medicine system and analyzing platforms(TCMSP),bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine(BATMAN-TCM),and Swiss Target Prediction network database,the main active components and potential targets of IN were obtained.Based on this,a component-target network was established by Cytoscape 3.6.1 software.Differentially expressed genes(DGEs)in MDS were obtained from three GEO(Gene Expression Omnibus)gene chips.Then,the protein-protein interaction(PPI)network of DGEs was constructed and analyzed by STRING database and Cytoscape 3.6.1 software.In addition,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)biological enrichment analysis were carried out using REVIGO and KEGG Orthology Based Annotation System(KOBAS)on DGEs,respectively.Identification of IN-MDS compound targets was performed by matching potential targets of active components with disease-related targets.The results of KEGG pathway enrichment analysis were combined with compound targets to screen key targets.In the end,molecular docking was performed by SYBYL-X2.1 to verify the key targets.Results:Nine active components of IN and 439 potential targets of IN were identified by analyzing TCMSP,BATMAN-TCM,and Swiss Target Prediction network databases.Three MDS disease-related gene microarray chips were obtained from the GEO databases:GSE4619,GSE19429,and GSE58831.Through this analysis,87 DEGs were finally obtained using the Venn diagram.A PPI network of DEGs was then constructed,in which 18 genes were upregulated and 69 genes were downregulated.After the GO enrichment results were de-redundant,the representative GO terms were obtained by using REVIGO semantic similarity measuremen.The KEGG biological pathway analysis using the KOBAS indicated that the Hippo signaling pathway is important in MDS.The Hippo signaling pathway involves four genes:AREG,LEF1,SMAD7,and TCF4.By matching and mapping DEGs with potential targets,six IN-MDS compound targets were obtained:PDE4B,PLAUR,ELANE,NR3C1,AREG,and LEF1.We found that AREG and LEF1 are consistent with the genes involved in the Hippo signaling pathway.Through molecular docking simulation,we found that the indican binds best to AREG and LEF1.Conclusion:Based on the integrated pharmacology model,the material basis of the efficacy and biological molecular mechanism of IN in the treatment of MDS was systematically studied,which provided a novel indication of the CAM regimen for the improvement of MDS management.

Treatment of irritable bowel syndrome in China:A review

Irritable bowel syndrome(IBS)is a common,chronic,functional gastrointestinal disorder with a high incidence rate in the general population,and it is common among the Chinese population.The pathophysiology,etiology and pathogenesis of IBS are poorly understood,with no evidence of inflammatory,anatomic,metabolic,or neoplastic factors to explain the symptoms.Treatment approaches are mainly focused on symptommanagement to maintain everyday functioning and to improve quality of life for patients with IBS.However,prescribed medications often result in significant side effects,and many IBS sufferers(particularly Chinese)do not improve.Instead of taking a variety of conventional medications,many have turned to taking traditional Chinese medicine or integrated Chinese and Western medicine for remedy.A number of clinical trials have shown that Chinese herbal,acupuncture or integrative therapies presented improved treatment outcomes and reduced side effects in IBS patients.The purpose of this review article is to examine the treatment approaches of IBS that have been published in recent years,especially in China,to assess the possible differences in treating IBS between China and other countries.This would provide some useful information of unique treatment approach in clinical practice for physicians in the management of IBS in China,thus offering more treatment options for IBS patients with potentially better treatment outcomes while reducing the medical cost burden.

Study on Treatment of Polycystic Ovarian Syndrome with Infertility by Combined Therapy of Chinese Herbal Medicine and Compound Cyproterone Acetate

Objective: To evaluate the effect of combined therapy of Chinese herbal medicine and compound cyproterone acetate (CPA) in treating non-obesity polycystic ovarian syndrome (PCOS) and to explore its mechanism in improving withdrawal ovulation. Methods: Eighty-six patients of non-obesity P-COS, typed as Shen-deficiency with blood stasis Syndrome or Shen-deficiency with Phlegm-Dampness Syndrome by Syndrome Differentiation in traditional Chines medicine, were randomly divided into three groups: (1) The TCM group (n = 26) was treated with Chinese drugs for 6 menstrual cycles; (2) The western medicine (WM) group (n=30) was treated with 1 tablet of CPA for 21 days, with the treatment beginning from the 5th day of menstruation. The treatment was given for 3 menstrual cycles by repetitious medication, which stopped and restarted on the 5th day of withdrawal bleeding. Then the ovulation promoting therapy was applied by using clomifene citrate and human chorionic gonadotropin (CC/hCG) for 3 menstrual cycles; (3) The TCM-WM group (n=30) was treated with the medications used for the above two groups. The menstrual cycle, the volume and duration of the menstruation, as well as the improvement of acne and pilosis [Ferriman-Gallway (F-G) scoring] were observed after 3 cycles ended. Moreover, condition of ovulation was monitored by B-ultrasonography at the 4th- 6th cycle and status of pregnancy was observed. Results: Compared with before treatment, the blood level of luteinizing hormone (LH) and testosterone (T) in all 3 groups after treatment significantly decreased (P<0. 05), with its ratio to follicle-stimulating hormone (LH/FSH) recovered to normal, but without markedly change in levels of FSH, estradiol (E2) and prolactin (PRL). The menstrual cycle in most patients got regular and acne significantly alleviated (P<0. 05), and the improvement of infrequent menstruation and acne was better in the WM group and the TCM-WM group than that in the TCM group, but pilosis showed no significant improvement in all three groups. The periodical ovulation rate in the TCM-WM group (73. 1%) and the WM group (68. 3%) was significantly higher than that in the TCM group (40%). The pregnancy rate in the TCM-WM group (53. 8%) was significantly higher than that in the other two groups (26.1% and 25% respectively, all P<0.05). Conclusion: Using combined therapy of TCM and composite CPA followed by o-vulation promoting agents of TCM and WM to treat patients of non-obesity PCOS could relieve the clinical symptoms, improve the abnormal blood level of sex hormones and significantly elevate the pregnancy rate.

Nursing Based on Syndrome Differentiation Combined with Auricular Plaster Therapy in Alleviating Insomnia

Objective:To observe the effect of auricular point pressing combined with nursing based on syndrome differentiation in the treatment of insomnia patients.Methods:Totally 92 patients with insomnia were randomly divided into the observation groupgiven auricular point pressing combined with nursing care based on syndrome differentiation and the control group treated with auricular point pressing alone.The improvement of Pittsburgh Sleep Quality Index(PSQI),TCM Syndrome Score and nursing satisfaction were compared between the 2 groups.Results:The time effect of PSQI total score and 6 factors in both groups were statistically significant(P<0.05).The time effect,interaction effect and inter-group effect of subjective sleep quality,PSQI total score were statistically significant(P<0.05);the 4 inter-group factors of sleep quality,sleep latency,sleep duration and daytime function were statistically significant(P<0.05).The total score of TCM syndromes in the observation group was lower than that in the control group(P<0.05),and the satisfaction rate in the observation group higher than that in the control group(80.43%vs.60.86%,P<0.05).Conclusion:Auricular point pressing combined withnursing based on syndrome differentiation can effectively improve the sleep quality of insomnia patients,and has significant advantages in improving TCM syndromes,as well as gained higher nursing satisfaction from patients.

Comparative evaluation in treating qi-yin deficiency and phlegm stasis syndrome of type 2 diabetes mellitus in a rat model

Objective:To compare the efficacy of traditional Chinese medicine (TCM),western medicine and integrative medicine in treating type 2 diabetes mellitus (T2DM) in a rat model.Methods:The T2DM rat model was established with a high-fat diet (HFD) for 35 days and a single injection of streptozotocin (STZ,30 mg/kg).The T2DM-induced rats were divided into three groups,and treated with Yiqi Yangyin Huatan (YQYYHT) granules (3.84 g/kg per day),pioglitazone (1.35 mg/kg per day) or YQYYHT granules + pioglitazone (3.84 g/kg per day+1.35 mg/kg per day) respectively for 14 days.Clinical features and behavioral changes,as well as T2DM indicators,were recorded to evaluate therapeutics effects in each treatment group.Results:The T2DM rat model expressed insulin resistance (IR),with features similar to qi-yin deficiency and phlegm stasis syndrome,including decreased cyclic adenosine monophosphate/cyclic guanosine monophosphate (cAMP/cGMP) ratio,decreased levels of Na+-K+-ATPase,superoxide dismutase (SOD) and high density lipoprotein-cholesterol (HDL-C),and increased levels of serum triglyceride (TG),total cholesterol (TC) and low density lipoprotein (LDL-C).All three treatment groups showed significant decreases in fasting blood glucose (FBG) and fasting insulin (Fins),and improvement of TCM syndrome to different degrees.Importantly,YQYYHT improved the most of the indicators of T2DM,followed by integrative medicine and pioglitazone alone.Conclusion:Compared with western medicine or integrative medicine,prescription of TCM based on syndrome differentiation may offer more advantages in the prevention and treatment of T2DM.

Traditional Chinese medicine combined with low-dose glucocorticoid for treating nephrotic syndrome: A case report

Nephrotic syndrome(NS)is a common refractory clinical disease that can develop into end-stage renal disease(ESRD)if cannot be controlled.At present,in Western medicine,glucocorticoid or immunosuppressant drugs with heavy dose and long course are used for the therapy of NS.There are still few reports on the combined treatment of traditional Chinese medicine and low-dose glucocorticoid for NS.Here,we reported a case of a 48-year-old man diagnosed with NS,accompanied by severe pulmonary infection,abundant proteinuria,and pleural effusion.Integrated traditional Chinese and Western medicine was used as the therapeutic regimen of this patient.Traditional Chinese medicine(TCM)mainly focused on invigorating spleen and kidney,promoting blood circulation,removing blood stasis and promoting diuresis,and Chinese patent medicines or TCM immunosuppressants were given to consolidate the treatment.In Western medicine,small dose and short course glucocorticoids combined with symptomatic treatment were adopted.Delightfully,proteinuria subsided after 5 months treatment with integrated TCM and Western medicine and all laboratory reports were negative after 10 months,which has been normal so far(July 2019).This case report indicates that the combination of TCM and low-dose glucocorticoid is effective in curing NS,with low recurrence rate and few side effects.

Exploring the Care Experience of a Comprehensive Geriatric Assessment Team in the Management of Debilitating Syndromes in Older People

This study was conducted to investigate the clinical effects of applying the integrated geriatric assessment team approach on the care of elderly patients with debilitating syndromes.This study was conducted in Xi’an Jiaotong University hospital from January 2021 to January 2022.Around 50 patients with the geriatric debilitating syndrome were selected and retrospectively were analyzed,and psychiatrists,geriatric nurses,pharmacists,medical specialists,physiotherapists,and dieticians were selected to form a comprehensive geriatric assessment team.The patients were then assessed,a treatment plan was developed,and care was provided according to the actual situation,and the effectiveness of the clinical intervention was analyzed.This study demonstrated that,of the 50 patients in this study,the longest hospital stay was 15 days,while the shortest was 4 days,and the average length of stay was 10.23±4.37 days.Around 40 of the patients were able to eat on their own and consume food as prescribed,with a compliance rate of 80%,showing the effectiveness rate of the geriatric assessment team.In summary,the use of a comprehensive geriatric assessment team to treat and care for patients with debilitating syndromes in the elderly is an effective way,and this can significantly improve the life quality of the patients.

基于中医证候与精液质量相关参数构建精子DNA碎片预测模型与验证

背景:中医证候与精液质量相关参数相结合,共同预测精子DNA碎片指数(DNA fragmentation index,DFI)异常增高的发生并绘制列线图,能显著提高临床的实操性与应用效能,为临床全面评估精液质量,采取积极干预措施以改善临床结局及制定个体化医疗方案提供依据。目的:探讨基于中医证候与精液质量相关参数构建精子DNA碎片的预测模型与验证。方法:回顾性分析2019年7月至2021年7月在广西壮族自治区南溪山医院中医男科接受中医证候诊断及精子DNA碎片率检查的不育患者共420例,据《人类精液检查与处理实验室手册》(第6版),将其中137例精子DFI>30%患者纳入精子DFI异常增高组,将283例精子DFI≤30%作为对照组;首先采用单因素分析筛选精子DFI异常增高的影响因素,然后采用套索算法(LASSO)校正因子共线性问题并筛选出最佳匹配因子后,将其纳入多因素向前逐步Logistic回归找出其独立影响因素并绘制列线图,最后采用受试者工作曲线、校准曲线、临床决策曲线、临床影响曲线对该预测模型进行区分度与准确度及临床应用效能验证。结果与结论:①单因素分析结果显示,年龄、体质量指数、前向运动率、精子总活率、精子浓度、精子形态学、肾阳虚衰证、湿热下注证、肾精不足证为引发精子DFI异常增高的影响因子(P<0.05);②通过LASSO回归进一步筛选出的最佳匹配因素为年龄、体质量指数、精子总活率、精子浓度、精子形态学、肾阳虚衰证、湿热下注证、肾精不足证(P<0.05);③多因素向前逐步Logistic回归结果显示年龄、体质量指数、精子浓度、精子总活率、湿热下注证、肾阳虚衰证共6项为引发精子DFI异常增高的独立影响因素;④受试者工作曲线显示,模型组曲线下面积为0.760(0.713,0.806),验证组曲线下面积为0.745(0.714,0.776),说明该预测模型具有较好的区分度;⑤校准曲线平均绝对误差0.040,Hosmer-Lemeshow检验P>0.05,表明该模型预测发生精子DFI异常增高的概率与实际发生精子DFI异常增高的概率无显著统计学差异,证实该模型具有较好的准确度;⑥临床决策曲线与临床影响曲线显示,模型组与验证组分别在阈概率值为0.08-0.84与0.09-0.78时具有临床最大净获益,且在该阈概率范围内具有较好的临床应用效能;⑦结果表明,年龄、体质量指数、精子浓度、精子总活率、湿热下注证、肾阳虚衰证为引发精子DFI异常增高的独立影响因素,通过其构建的临床预测模型列线图具有较好的临床预测价值与临床应用效能,可为临床全面评估精液质量、预后与干预及个体化医疗服务提供依据。

蒲地蓝消炎口服液治疗湿热蕴结证中度寻常痤疮的随机对照研究

目的观察蒲地蓝消炎口服液治疗湿热蕴结证中度寻常痤疮的有效性和安全性。方法采取多中心随机双盲对照研究设计,选取5家中心,筛选240例湿热蕴结证中度寻常痤疮受试者,随机分为试验组和对照组,每组各120例;试验组给予蒲地蓝消炎口服液,对照组给予蒲地蓝消炎口服液模拟剂;两组均联合外用克林霉素磷酸酯凝胶,每天2次,洁面后涂于患处。治疗4周,比较两组治疗前后皮损(丘疹、脓疱、粉刺)数量以及中医证候(面红、皮疹痒痛、舌苔厚腻、尿黄、便秘)积分变化,记录不良反应。结果229例受试者完成试验,其中试验组117例、对照组112例。与基线相比,用药4周的两组患者的丘疹计数、脓疱计数显著减少,试验组粉刺计数和中医证候积分显著减少,且试验组均优于对照组(P<0.05)。试验组痤疮皮损改善有效率为87.2%,高于对照组的58.0%(P<0.05)。试验组仅1例患者出现外用药膏刺激性反应。结论蒲地蓝消炎口服液可有效改善湿热蕴结证中度寻常痤疮患者皮损数量及中医证候,值得临床推广应用。

中西医结合诊治妊娠胚物残留专家共识(2024年版)

妊娠胚物残留(RPOC)是指流产或分娩后,胚胎组织或胎盘未能完全排出而残留子宫内,可引起出血、感染,甚至宫腔粘连等。目前RPOC的治疗策略主要分为药物治疗和手术治疗两类,但国内外对此尚未形成科学、规范的指导意见。中西医联合诊治一直是我国诊治RPOC的特色手段,为推广中西医结合协同诊疗理念,促进RPOC中西医结合诊疗技术发展,山东中医药学会妇科专业委员会、山东中西医结合学会生殖外科专业委员会、山东省疼痛医学会妇产科专业委员会共同牵头成立共识专家组,讨论形成《中西医结合诊治妊娠胚物残留专家共识(2024年版)》,从RPOC的高危因素、临床表现、诊断、治疗等方面阐述中西医结合协同诊疗理念,并提供专家共识,以改善RPOC患者预后,提高其生活质量。

符文彬从心胆论治慢性疲劳综合征临床经验

符文彬教授根据多年临床经验提出从心胆论治慢性疲劳综合征(CFS),运用“一针二灸三巩固”的针灸治疗方法,整合针刺、精灸、皮内针等针灸适宜技术,选取手太阴心经及足少阳胆经相关腧穴施治,可有效缓解CFS患者疲乏、疼痛及情绪障碍等躯体及心理相关症状。

活血通窍法治疗儿童过敏性鼻炎临床观察

目的:观察活血通窍方治疗儿童痰瘀互结型过敏性鼻炎的临床疗效。方法:将60例符合纳入标准的过敏性鼻炎患儿随机分为两组各30例。对照组予口服盐酸西替利嗪片及糠酸莫米松喷鼻,治疗组在对照组基础上予活血通窍方,疗程均为28天。观察两组治疗前后中医各证候积分、鼻腔检查评分、PLT、EOS水平。结果:治疗组、对照组总有效率分别为96.67%、76.67%,两组比较差异无统计学意义(P﹥0.05),治疗组愈显率为70.00%高于对照组的40.00%(P﹤0.05);治疗后,两组患儿各主症、鼻腔检查积分、EOS水平均较治疗前明显下降(P﹤0.01),治疗组各次症积分、PLT水平较治疗前明显下降(P﹤0.01),对照组面色口唇、睡眠质量积分较治疗前下降(P﹤0.05)。治疗组主症、次症、鼻腔检查积分、PLT、EOS水平明显低于对照组(P﹤0.01,P﹤0.05)。结论:活血通窍方联合盐酸西替利嗪片、糠酸莫米松喷雾剂能有效改善过敏性鼻炎患儿的临床症状,同时可降低PLT、EOS水平。

毫火针联合中药封包对腰椎间盘突出症患者腰椎功能及血清炎症指标的影响

目的探究毫火针联合中药封包对腰椎间盘突出症(LDH)患者腰椎功能及血清炎症指标的影响。方法选取2022年05月~2024年01月于河南省洛阳正骨医院收治的LDH患者152例,随机分为联合组和中药封包组,各76例,联合组予以毫火针联合中药封包干预,中药封包组仅采用中药封包干预。比较两组患者疗效、中医证候积分、腰椎功能[Oswestry功能障碍指数(ODI)量表、腰椎功能障碍问卷(RDQ)和日本骨科协会(JOA)腰痛评估问卷]、血清炎症指标[C反应蛋白(CRP)和白细胞介素1β(IL-1β)和白细胞介素-6(IL-6)]及耐受性。结果联合组疗效总有效性高于中药封包组(P<0.05)。干预后,联合组主症腰脊疼痛、俯仰不利及次症瘀斑、舌质暗紫中医证候积分均低于中药封包组(P<0.05)。干预后,联合组ODI、RDQ得分均低于中药封包组(P<0.05),JOA得分高于中药封包组(P<0.05)。干预后,联合组血清中CRP、IL-1β和IL-6水平均低于中药封包组(P<0.05)。两组均无明显不适症状,耐受性较强。结论毫火针联合中药封包治疗LDH疗效明显,能有效改善腰椎功能和血清炎症。

痰证积分与特应性皮炎相关性的研究

目的探讨中医痰证积分与特应性皮炎(atopicdermatitis,AD)的相关性,为临床诊治提供依据。方法选取2021年6月—2023年5月福建医科大学附属龙岩第一医院皮肤科诊治的155例AD患者为研究对象,根据年龄段分为婴儿组(n=32)、儿童组(n=43)、青年与成人组(n=47)及老年组(n=33)。均在入院就诊时接受中医痰证积分,并行特应性皮炎积分(severity scoring of atopic dermatitis,SCORAD)量表严重程度指数评分系统(eczema area and severity index,EASI)评测,测定免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG)、嗜酸粒细胞趋化因子(eotaxin)、白细胞介素-17(interleukin-17,IL-17)、白细胞介素-13(interleukin-13,IL-13)及CD4^(+)/CD8^(+)等指标水平,并通过单因素方差、直线回归分析中医痰证积分与其他指标的相关性。结果老年组的中医痰证积分、SCORAD评分、EASI分别为(16.39±2.42)分、(64.15±6.47)分、(48.52±6.55)分,幼儿组分别为(13.89±1.90)分、(59.44±6.20)分、(45.40±6.11)分,儿童组分别为(10.36±0.91)分、(57.26±5.06)分、(42.22±5.53)分,青年与成人组分别为(8.15±2.33)分、(52.10±5.45)分、(39.48±6.16)分,老年组均高于其他3组,差异有统计学意义(P<0.05),幼儿组、儿童组差异无统计学意义(P>0.05),但均高于青年与成人组,差异有统计学意义(P<0.05)。老年组IL-17、IL-13、Eotaxin、IgM及IgG分别为(38.15±5.22)pg/m L、(38.22±3.19)pg/m L、(79.22±4.32)×10^(9)/L、(2.43±0.25)mg/m L、(12.35±2.65)mg/m L,高于幼儿组的(36.30±5.23)pg/m L、(36.52±5.21)pg/m L、(75.40±6.12)×10^(9)/L、(2.28±0.33)mg/mL、(11.34±2.10)mg/mL;高于儿童组的(36.15±5.03)pg/m L、(36.31±4.89)pg/m L、(75.52±6.24)×10^(9)/L、(2.30±0.32)mg/m L、(11.23±2.08)mg/m L;高于青年与成人组的(34.65±4.85)pg/m L、(35.05±4.429)pg/m L、(73.18±5.22)×10^(9)/L、(2.14±0.28)mg/m L、(10.18±2.14)mg/m L,差异均有统计学意义(P<0.05);老年组、幼儿组、儿童组、青年与成人组CD4^(+)/CD8^(+)分别为(1.12±0.29)、(1.25±0.22)、(1.42±0.31)、(1.12±0.29),组间与其他指标相反,组间比较差异均有统计学意义(P<0.05)。通过分析,中医痰证积分与SCORAD评分、EASI、IL-17、IL-13、eotaxin、Ig M及Ig G呈正相关(P<0.05),与CD4^(+)/CD8^(+)呈负相关(P<0.05)。结论中医痰证积分与AD病情严重度密切相关,可为临床诊治提供依据。