BACKGROUND Congenital infantile fibrosarcoma(CIF)and congenital hemangioma(CH)have similarities on prenatal ultrasound and are rare.CASE SUMMARY We report 3 cases of fetuses with superficial hypervascular tumors,confi...BACKGROUND Congenital infantile fibrosarcoma(CIF)and congenital hemangioma(CH)have similarities on prenatal ultrasound and are rare.CASE SUMMARY We report 3 cases of fetuses with superficial hypervascular tumors,confirmed by postnatal pathology as CIF(1 case)and CH(2 cases,including 1 in a twin fetus).In Case 1,a mass with a rich blood supply in the fetal axilla was discovered by prenatal ultrasound at 28+0 wk of gestation.The postpartum pathological diagnosis was CIF,the mass was surgically removed,and the prognosis of the child was good.In Case 2,at 23+1 wk of gestation,a mass was discovered at the base of the fetus’s thigh on prenatal ultrasound.The postpartum pathological diagnosis was CH.After conservative treatment,the mass shrank significantly.Case 3 occurred in a twin fetus.At 30+0 wk of gestation,prenatal ultrasound revealed a bulging mass with a rich blood supply on the abdominal wall of one of the fetuses.Three weeks later,the affected fetus died,and the unaffected baby was successfully delivered by emergency cesarean section.The affected fetus was pathologically diagnosed with CH.CONCLUSION Prenatal ultrasound can provide accurate information,such as the location,size and blood supply of a surface mass in a fetus.We found similarities between CIF and CH in prenatal ultrasound findings.Although it is difficult to distinguish these conditions by prenatal ultrasound alone,for superficial hypervascular tumors that rapidly increase in size in a short period,close ultrasound monitoring of the fetus is required to quickly address possible adverse outcomes.展开更多
BACKGROUND A sclerosing epithelioid fibrosarcoma(SEF)is a rare malignant fibroblastic soft tissue tumor that rarely occurs in intra-abdominal organs.A case of a SEF in the pancreatic head is reported herein,including ...BACKGROUND A sclerosing epithelioid fibrosarcoma(SEF)is a rare malignant fibroblastic soft tissue tumor that rarely occurs in intra-abdominal organs.A case of a SEF in the pancreatic head is reported herein,including its clinical manifestations,preoperative imaging features,gross specimen and pathological findings.CASE SUMMARY A 33-year-old male patient was admitted to Peking Union Medical College Hospital in December 2023 due to a one-year history of intermittent upper abdominal pain and the discovery of a pancreatic mass.The patient underwent an enhanced computed tomography scan of the abdomen,which revealed a welldefined,round mass with clear borders and calcifications in the pancreatic head.The mass exhibited progressive,uneven mild enhancement,measuring approximately 6.6 cm×6.3 cm.The patient underwent laparoscopic pylorus-preserving pancreaticoduodenectomy.Postoperative pathological examination revealed that the lesion was consistent with a SEF.At the 3-month postoperative follow-up,the patient did not report any short-term complications,and there were no signs of tumor recurrence.CONCLUSION SEFs are rare malignant fibrous soft tissue tumors.SEFs rarely develop in the pancreas,and its preoperative diagnosis depends on imaging findings,with confirmation depending on pathological examination and immunohistochemistry.Currently,only four cases of pancreatic SEF have been reported in studies written in English.This case is the first reported case of a pancreatic SEF by a clinical physician.展开更多
Objective:To explore the molecular mechanisms of antitumor properties of triptolide,a bioactive component isolated from the Chinese herb Tripterygium wolfordii Hook F.Methods:Human fibrosarcoma HT-1080 cells were trea...Objective:To explore the molecular mechanisms of antitumor properties of triptolide,a bioactive component isolated from the Chinese herb Tripterygium wolfordii Hook F.Methods:Human fibrosarcoma HT-1080 cells were treated with different doses of triptolide for 72 h.Then the expression and activity of matrix metalloproteinase(MMP)-2 and -9 were measured and the invasiveness of triptolide-treated HT-1080 cells was compared with that of anti-MMP-9- treated HT-1080 cells.Results:18 nmol/L triptolide inhibited the gene expression and activity of MMP-9,but not those of MMP-2,in HT-1080 cells.In addition,both 18 nmol/L triptolide and 3μg/mL anti-MMP-9 significantly reduced the invasive potential of HT-1080 cells,by about 50%and 35%, respectively,compared with the control.Whereas there was no significant difference between the effect of 18 nmol/L triptolide and that of anti-MMP-9 on invasive potential of HT-1080 cells. Conclusions:These data suggest that triptolide inhibits tumor cell invasion partly by reducing MMP-9 gene expression and activity.展开更多
Sclerosing epithelioid fibrosarcoma （SEF） is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matr...Sclerosing epithelioid fibrosarcoma （SEF） is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matrix. We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava （IVC）. The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEE Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findings to those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC.展开更多
BACKGROUND In general,malignant tumors metastasize to the pancreas in<1%of cases.Most patients miss the opportunity for further surgery due to distant metastases;however,for fibrosarcomas,aggressive surgery may be ...BACKGROUND In general,malignant tumors metastasize to the pancreas in<1%of cases.Most patients miss the opportunity for further surgery due to distant metastases;however,for fibrosarcomas,aggressive surgery may be helpful even if distant metastases occur.Hence,we report such a case and share some valuable information about the disease.CASE SUMMARY A 45-year-old man was admitted with recurrent epigastric pain for 10 days.The abdominal pain was mainly related to bloating with nausea,but no other associated symptoms.No particular signs were found on abdominal examination or laboratory testing.In 2003,a local distal expanded resection of the primary fibrosarcoma in the left chest wall was performed.Then,a left pneumonectomy was performed in 2017 due to diffuse metastases from the fibrosarcoma to the left lung.Enhanced computed tomography(CT)and magnetic resonance imaging of the upper abdomen suggested multiple masses of different sizes involving the head and tail of the pancreas;no local lymph node enlargement was noted.The postoperative pathologic diagnosis revealed a fibrosarcoma of the pancreas.A CT re-examination 6 mo postoperatively showed no local recurrence or distant metastases.CONCLUSION A fibrosarcoma is a rare low-grade malignant tumor,and metastases to the pancreas are even rarer.Patients with a history of a fibrosarcoma should consider the possibility of metastasis when a pancreatic neoplasm is demonstrated.Surgical resection is the preferred treatment.展开更多
Sclerosing epithelioid fibrosarcoma （SEF） is a rare and poorly defined variant of fibrosarcoma, but generally insensitive to chemotherapy and progresses with poor prognosis. We report the marvelous effect of irinote...Sclerosing epithelioid fibrosarcoma （SEF） is a rare and poorly defined variant of fibrosarcoma, but generally insensitive to chemotherapy and progresses with poor prognosis. We report the marvelous effect of irinotecan hydrochloride （CPT-11） chemotherapy in rescuing a patient with atypical SEF from emergent condition, who underwent recurrences after several treatment methods. Small dose of CPT-11 was administered to the patient, with which, the size of superficial mass （cervical lymph node） gradually decreased observed by the naked eyes in 5 days. X-ray and CT image proved a marked reduction in the size of the tumor. CPT-11 is valuable for the treatment of this aggressive sarcoma. In condition of emergency caused by sarcoma oppression, administering a tolerable small dose of topoisomerase I-inhibiting drug could be a beneficial choice.展开更多
In this paper,a sliding mode observer scheme of sensor fault diagnosis is proposed for a class of time delay nonlinear systems with input uncertainty based on neural network.The sensor fault and the system input uncer...In this paper,a sliding mode observer scheme of sensor fault diagnosis is proposed for a class of time delay nonlinear systems with input uncertainty based on neural network.The sensor fault and the system input uncertainty are assumed to be unknown but bounded.The radial basis function (RBF) neural network is used to approximate the sensor fault.Based on the output of the RBF neural network,the sliding mode observer is presented.Using the Lyapunov method,a criterion for stability is given in terms of matrix inequality.Finally,an example is given for illustrating the availability of the fault diagnosis based on the proposed sliding mode observer.展开更多
It has been shown that some parasites interfere with malignant tumor cells growth in vivo or in vitro. In this work anticancer activity of three live protozoan parasites;Toxoplasma gondii, Trichomonas vaginalis and Le...It has been shown that some parasites interfere with malignant tumor cells growth in vivo or in vitro. In this work anticancer activity of three live protozoan parasites;Toxoplasma gondii, Trichomonas vaginalis and Leishmania major on fibrosarcoma cells growth has been investigated in cell culture medium. In this experimental study, WEHI-164 fibrosarcoma cells treated with alive Toxoplasma gondii tachyzoite, Trichomonas vaginalis trophozoite or Leishmania major promastigote as case groups or left intact as control groups. Following 24 hours incubation the number of cells, lactate dehydrogenase (LDH) and apoptosis were determined in case and control groups. Toxoplasma gondii tachyzoite decreased cell proliferation and increased cell lyses’ but it did not induce apoptosis. Trichomonas vaginalis or Leishmania major didn’t show any effects on cell proliferation, cell lyses or apoptosis. Therefore Toxoplasma gondii may have anticancer activity and further works is recommended to understand the mechanisms of action.展开更多
A new time-resolved shifted dual transmission grating spectrometer （SDTGS） is designed and fabricated in this work. This SDTGS uses a new shifted dual transmission grating （SDTG） as its dispersive component, which...A new time-resolved shifted dual transmission grating spectrometer （SDTGS） is designed and fabricated in this work. This SDTGS uses a new shifted dual transmission grating （SDTG） as its dispersive component, which has two sub transmission gratings with different line densities, of 2000 lines/mm and 5000 lines/mm. The axes of the two sub transmission gratings in SDTG are horizontally and vertically shifted a certain distance to measure a broad range of 0.1-5 keV time-resolved X-ray spectra. The SDTG has been calibrated with a soft X-ray beam of the synchrotron radiation facility and its diffraction efficiency is also measured. The designed SDTGS can take full use of the space on a record panel and improve the precision for measuring spatial and temporal spectrum simultaneously. It will be a promising application for accurate diagnosis of the soft X-ray spectrum in inertial confinement fusion.展开更多
This report describes the clinical manifestations and pathological findings in a 4-year-old neutered male dwarf rabbit diagnosed with a mandibular fibrosarcoma. The rabbit was evaluated for a unilateral mandibular swe...This report describes the clinical manifestations and pathological findings in a 4-year-old neutered male dwarf rabbit diagnosed with a mandibular fibrosarcoma. The rabbit was evaluated for a unilateral mandibular swelling and an acute onset of oral blood loss. Physical examination confirmed a marked facial asymmetry with a swollen painful left mandible. Radiographic projections of the skull revealed a left mandibular mass extending into the oral cavity. Tissue biopsies demonstrated severe bone destruction and a presumptive pathological diagnosis of a mandibular osteosarcoma were made. A helical CT (computed tomography) study of the skull confirmed the severe mandibular bone destruction and the oral extension of the mass. The patient was treated palliative with oral meloxicam and subcutaneous penicillin injections. Six months later, the rabbit died in a natural way. Postmortem examination led to final diagnosis of severe left facial malformation due to mandibular fibrosarcoma. A bile duct adenoma was found in the liver. To the author’s knowledge, this is the first description of a spontaneous mandibular fibrosarcoma in a pet rabbit.展开更多
BACKGROUND Neurofibromatosis(NF)is a genetic disease consisting of seven types,of which types 1 to 4 are caused by a dominant autosomal gene mutation;such disease sometimes arises in patients with NF type 1.However,it...BACKGROUND Neurofibromatosis(NF)is a genetic disease consisting of seven types,of which types 1 to 4 are caused by a dominant autosomal gene mutation;such disease sometimes arises in patients with NF type 1.However,it remains unclear whether the origin of neurofibrosarcoma is directly linked to the incidence of NF type 1,as no reports have been published on this issue.Here,we report a case of NF1-positive multiple neurofibromas with malignant fibrosarcomatous transformation in the pleural cavity.CASE SUMMARY A 51-year-old male was admitted to our hospital due to fever accompanied by coughing,chest tightness and asthma for more than one month.The preliminary diagnosis was NF type 1,which was pathologically confirmed by a subsequent thoracoabdominal subcutaneous biopsy.The definitive diagnosis was neurofibrosarcoma with a pathogenic NF1 gene.The patient refused surgery and chemoradiotherapy,and died two months later.NF is a genetic disease consisting of seven types,of which types 1 to 4 are caused by a dominant autosomal gene mutation.The case reported belongs to the class of NF1-positive dominant inheritance.Neurofibrosarcoma is a malignant tumor derived from cells surrounding the peripheral nerves.However,due to the lack of previous reports,it remains unclear whether the origin of neurofibrosarcoma is directly linked to the incidence of NF type 1.CONCLUSION We report the first case of NF1-positive multiple neurofibromas with malignant fibrosarcomatous transformation in the pleural cavity.展开更多
The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence;...The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgGl could not. The data from this study did not show that IgE, IgG or IgGl had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.展开更多
Background:Fibrosarcoma is a malignant soft tissue tumor of mesenchymal origin.Gekko sulfated glycopeptide(GSPP),an anticancer drug in traditional Chinese medicine,could inhibited the tumor angiogenesis by targeting b...Background:Fibrosarcoma is a malignant soft tissue tumor of mesenchymal origin.Gekko sulfated glycopeptide(GSPP),an anticancer drug in traditional Chinese medicine,could inhibited the tumor angiogenesis by targeting basic fibroblast growth factor(bFGF).bFGF promoted the proliferation of fibroblasts.Both fibrosarcoma and fibroblasts derived from fibrous connective tissue.This study investigated whether GSPP has the inhibitory effects on human fibrosarcoma HT1080 cells.Materials and methods:The trypan blue exclusion assay was used to determine cell viability and cell numbers.Cells migration was observed by wound-healing and transwell.Results:From the first day to seventh day,HT1080 cells number of GSPP,bFGF,GSPP combined bFGF groups had not change compared with control.HT1080 cells migration distance and the number of migrating cells of GSPP,bFGF,GSPP combined bFGF groups were not significantly reduced.Conclusions:GSPP did not have inhibitory effects on the proliferation and migration of human fibrosarcoma HT1080 cells.Thus further research should be carried out in order to study the mechanism of GSPP and bFGF acting on the tumor stroma.展开更多
A new approach is advanced based on wavelet transform in tandem with autoregressive technique. Wavelets and wavelet packets decompose dynamic signal into different bands and pro- vide multiresolution or multiscale vie...A new approach is advanced based on wavelet transform in tandem with autoregressive technique. Wavelets and wavelet packets decompose dynamic signal into different bands and pro- vide multiresolution or multiscale view of signal. Autoregressive technique possesses effective function for short data processing. The approach is abopted to analyse nonstationary vibration sig- nals of mining excavator. The results indicate that nonstationary operating condition can be moni- tored and diagnosed. Transient toothmeshing frequency and rotating speed are measured. Weak vibration signal of defective ball bearing is extracted from strong vibration of gearbox and diag- nosed successfully. This approach is effective for nonstationary condition monitoring and early di- agnosis of latent fault.展开更多
文摘BACKGROUND Congenital infantile fibrosarcoma(CIF)and congenital hemangioma(CH)have similarities on prenatal ultrasound and are rare.CASE SUMMARY We report 3 cases of fetuses with superficial hypervascular tumors,confirmed by postnatal pathology as CIF(1 case)and CH(2 cases,including 1 in a twin fetus).In Case 1,a mass with a rich blood supply in the fetal axilla was discovered by prenatal ultrasound at 28+0 wk of gestation.The postpartum pathological diagnosis was CIF,the mass was surgically removed,and the prognosis of the child was good.In Case 2,at 23+1 wk of gestation,a mass was discovered at the base of the fetus’s thigh on prenatal ultrasound.The postpartum pathological diagnosis was CH.After conservative treatment,the mass shrank significantly.Case 3 occurred in a twin fetus.At 30+0 wk of gestation,prenatal ultrasound revealed a bulging mass with a rich blood supply on the abdominal wall of one of the fetuses.Three weeks later,the affected fetus died,and the unaffected baby was successfully delivered by emergency cesarean section.The affected fetus was pathologically diagnosed with CH.CONCLUSION Prenatal ultrasound can provide accurate information,such as the location,size and blood supply of a surface mass in a fetus.We found similarities between CIF and CH in prenatal ultrasound findings.Although it is difficult to distinguish these conditions by prenatal ultrasound alone,for superficial hypervascular tumors that rapidly increase in size in a short period,close ultrasound monitoring of the fetus is required to quickly address possible adverse outcomes.
基金Supported by National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-003National Multidisciplinary Cooperative Diagnosis and Treatment Capacity Building Project for Major Diseases.
文摘BACKGROUND A sclerosing epithelioid fibrosarcoma(SEF)is a rare malignant fibroblastic soft tissue tumor that rarely occurs in intra-abdominal organs.A case of a SEF in the pancreatic head is reported herein,including its clinical manifestations,preoperative imaging features,gross specimen and pathological findings.CASE SUMMARY A 33-year-old male patient was admitted to Peking Union Medical College Hospital in December 2023 due to a one-year history of intermittent upper abdominal pain and the discovery of a pancreatic mass.The patient underwent an enhanced computed tomography scan of the abdomen,which revealed a welldefined,round mass with clear borders and calcifications in the pancreatic head.The mass exhibited progressive,uneven mild enhancement,measuring approximately 6.6 cm×6.3 cm.The patient underwent laparoscopic pylorus-preserving pancreaticoduodenectomy.Postoperative pathological examination revealed that the lesion was consistent with a SEF.At the 3-month postoperative follow-up,the patient did not report any short-term complications,and there were no signs of tumor recurrence.CONCLUSION SEFs are rare malignant fibrous soft tissue tumors.SEFs rarely develop in the pancreas,and its preoperative diagnosis depends on imaging findings,with confirmation depending on pathological examination and immunohistochemistry.Currently,only four cases of pancreatic SEF have been reported in studies written in English.This case is the first reported case of a pancreatic SEF by a clinical physician.
文摘Objective:To explore the molecular mechanisms of antitumor properties of triptolide,a bioactive component isolated from the Chinese herb Tripterygium wolfordii Hook F.Methods:Human fibrosarcoma HT-1080 cells were treated with different doses of triptolide for 72 h.Then the expression and activity of matrix metalloproteinase(MMP)-2 and -9 were measured and the invasiveness of triptolide-treated HT-1080 cells was compared with that of anti-MMP-9- treated HT-1080 cells.Results:18 nmol/L triptolide inhibited the gene expression and activity of MMP-9,but not those of MMP-2,in HT-1080 cells.In addition,both 18 nmol/L triptolide and 3μg/mL anti-MMP-9 significantly reduced the invasive potential of HT-1080 cells,by about 50%and 35%, respectively,compared with the control.Whereas there was no significant difference between the effect of 18 nmol/L triptolide and that of anti-MMP-9 on invasive potential of HT-1080 cells. Conclusions:These data suggest that triptolide inhibits tumor cell invasion partly by reducing MMP-9 gene expression and activity.
文摘Sclerosing epithelioid fibrosarcoma （SEF） is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matrix. We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava （IVC）. The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEE Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findings to those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC.
文摘BACKGROUND In general,malignant tumors metastasize to the pancreas in<1%of cases.Most patients miss the opportunity for further surgery due to distant metastases;however,for fibrosarcomas,aggressive surgery may be helpful even if distant metastases occur.Hence,we report such a case and share some valuable information about the disease.CASE SUMMARY A 45-year-old man was admitted with recurrent epigastric pain for 10 days.The abdominal pain was mainly related to bloating with nausea,but no other associated symptoms.No particular signs were found on abdominal examination or laboratory testing.In 2003,a local distal expanded resection of the primary fibrosarcoma in the left chest wall was performed.Then,a left pneumonectomy was performed in 2017 due to diffuse metastases from the fibrosarcoma to the left lung.Enhanced computed tomography(CT)and magnetic resonance imaging of the upper abdomen suggested multiple masses of different sizes involving the head and tail of the pancreas;no local lymph node enlargement was noted.The postoperative pathologic diagnosis revealed a fibrosarcoma of the pancreas.A CT re-examination 6 mo postoperatively showed no local recurrence or distant metastases.CONCLUSION A fibrosarcoma is a rare low-grade malignant tumor,and metastases to the pancreas are even rarer.Patients with a history of a fibrosarcoma should consider the possibility of metastasis when a pancreatic neoplasm is demonstrated.Surgical resection is the preferred treatment.
基金supported by a grant from Science and Technology Committee of Guangdong (No.2010B060900093)a grant from Educational Commission of Guangzhou (No.10A196)
文摘Sclerosing epithelioid fibrosarcoma （SEF） is a rare and poorly defined variant of fibrosarcoma, but generally insensitive to chemotherapy and progresses with poor prognosis. We report the marvelous effect of irinotecan hydrochloride （CPT-11） chemotherapy in rescuing a patient with atypical SEF from emergent condition, who underwent recurrences after several treatment methods. Small dose of CPT-11 was administered to the patient, with which, the size of superficial mass （cervical lymph node） gradually decreased observed by the naked eyes in 5 days. X-ray and CT image proved a marked reduction in the size of the tumor. CPT-11 is valuable for the treatment of this aggressive sarcoma. In condition of emergency caused by sarcoma oppression, administering a tolerable small dose of topoisomerase I-inhibiting drug could be a beneficial choice.
基金Natural Science Foundation of Jiangsu Province (No.SBK20082815)Aeronautical Science Foundation of China (No.20075152014)
文摘In this paper,a sliding mode observer scheme of sensor fault diagnosis is proposed for a class of time delay nonlinear systems with input uncertainty based on neural network.The sensor fault and the system input uncertainty are assumed to be unknown but bounded.The radial basis function (RBF) neural network is used to approximate the sensor fault.Based on the output of the RBF neural network,the sliding mode observer is presented.Using the Lyapunov method,a criterion for stability is given in terms of matrix inequality.Finally,an example is given for illustrating the availability of the fault diagnosis based on the proposed sliding mode observer.
文摘It has been shown that some parasites interfere with malignant tumor cells growth in vivo or in vitro. In this work anticancer activity of three live protozoan parasites;Toxoplasma gondii, Trichomonas vaginalis and Leishmania major on fibrosarcoma cells growth has been investigated in cell culture medium. In this experimental study, WEHI-164 fibrosarcoma cells treated with alive Toxoplasma gondii tachyzoite, Trichomonas vaginalis trophozoite or Leishmania major promastigote as case groups or left intact as control groups. Following 24 hours incubation the number of cells, lactate dehydrogenase (LDH) and apoptosis were determined in case and control groups. Toxoplasma gondii tachyzoite decreased cell proliferation and increased cell lyses’ but it did not induce apoptosis. Trichomonas vaginalis or Leishmania major didn’t show any effects on cell proliferation, cell lyses or apoptosis. Therefore Toxoplasma gondii may have anticancer activity and further works is recommended to understand the mechanisms of action.
基金supported by National Natural Science Foundation of China(Nos.11405158 and 11435011)Development Foundation of China Academy of Engineering Physics(Nos.2014B0102011 and 2014B0102012)
文摘A new time-resolved shifted dual transmission grating spectrometer （SDTGS） is designed and fabricated in this work. This SDTGS uses a new shifted dual transmission grating （SDTG） as its dispersive component, which has two sub transmission gratings with different line densities, of 2000 lines/mm and 5000 lines/mm. The axes of the two sub transmission gratings in SDTG are horizontally and vertically shifted a certain distance to measure a broad range of 0.1-5 keV time-resolved X-ray spectra. The SDTG has been calibrated with a soft X-ray beam of the synchrotron radiation facility and its diffraction efficiency is also measured. The designed SDTGS can take full use of the space on a record panel and improve the precision for measuring spatial and temporal spectrum simultaneously. It will be a promising application for accurate diagnosis of the soft X-ray spectrum in inertial confinement fusion.
文摘This report describes the clinical manifestations and pathological findings in a 4-year-old neutered male dwarf rabbit diagnosed with a mandibular fibrosarcoma. The rabbit was evaluated for a unilateral mandibular swelling and an acute onset of oral blood loss. Physical examination confirmed a marked facial asymmetry with a swollen painful left mandible. Radiographic projections of the skull revealed a left mandibular mass extending into the oral cavity. Tissue biopsies demonstrated severe bone destruction and a presumptive pathological diagnosis of a mandibular osteosarcoma were made. A helical CT (computed tomography) study of the skull confirmed the severe mandibular bone destruction and the oral extension of the mass. The patient was treated palliative with oral meloxicam and subcutaneous penicillin injections. Six months later, the rabbit died in a natural way. Postmortem examination led to final diagnosis of severe left facial malformation due to mandibular fibrosarcoma. A bile duct adenoma was found in the liver. To the author’s knowledge, this is the first description of a spontaneous mandibular fibrosarcoma in a pet rabbit.
文摘BACKGROUND Neurofibromatosis(NF)is a genetic disease consisting of seven types,of which types 1 to 4 are caused by a dominant autosomal gene mutation;such disease sometimes arises in patients with NF type 1.However,it remains unclear whether the origin of neurofibrosarcoma is directly linked to the incidence of NF type 1,as no reports have been published on this issue.Here,we report a case of NF1-positive multiple neurofibromas with malignant fibrosarcomatous transformation in the pleural cavity.CASE SUMMARY A 51-year-old male was admitted to our hospital due to fever accompanied by coughing,chest tightness and asthma for more than one month.The preliminary diagnosis was NF type 1,which was pathologically confirmed by a subsequent thoracoabdominal subcutaneous biopsy.The definitive diagnosis was neurofibrosarcoma with a pathogenic NF1 gene.The patient refused surgery and chemoradiotherapy,and died two months later.NF is a genetic disease consisting of seven types,of which types 1 to 4 are caused by a dominant autosomal gene mutation.The case reported belongs to the class of NF1-positive dominant inheritance.Neurofibrosarcoma is a malignant tumor derived from cells surrounding the peripheral nerves.However,due to the lack of previous reports,it remains unclear whether the origin of neurofibrosarcoma is directly linked to the incidence of NF type 1.CONCLUSION We report the first case of NF1-positive multiple neurofibromas with malignant fibrosarcomatous transformation in the pleural cavity.
文摘The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgGl could not. The data from this study did not show that IgE, IgG or IgGl had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.
基金This work was supported by grants from the New Century Excellent Talent(NCET-11-1068)National Science Foundation of China(No.81173376).
文摘Background:Fibrosarcoma is a malignant soft tissue tumor of mesenchymal origin.Gekko sulfated glycopeptide(GSPP),an anticancer drug in traditional Chinese medicine,could inhibited the tumor angiogenesis by targeting basic fibroblast growth factor(bFGF).bFGF promoted the proliferation of fibroblasts.Both fibrosarcoma and fibroblasts derived from fibrous connective tissue.This study investigated whether GSPP has the inhibitory effects on human fibrosarcoma HT1080 cells.Materials and methods:The trypan blue exclusion assay was used to determine cell viability and cell numbers.Cells migration was observed by wound-healing and transwell.Results:From the first day to seventh day,HT1080 cells number of GSPP,bFGF,GSPP combined bFGF groups had not change compared with control.HT1080 cells migration distance and the number of migrating cells of GSPP,bFGF,GSPP combined bFGF groups were not significantly reduced.Conclusions:GSPP did not have inhibitory effects on the proliferation and migration of human fibrosarcoma HT1080 cells.Thus further research should be carried out in order to study the mechanism of GSPP and bFGF acting on the tumor stroma.
文摘A new approach is advanced based on wavelet transform in tandem with autoregressive technique. Wavelets and wavelet packets decompose dynamic signal into different bands and pro- vide multiresolution or multiscale view of signal. Autoregressive technique possesses effective function for short data processing. The approach is abopted to analyse nonstationary vibration sig- nals of mining excavator. The results indicate that nonstationary operating condition can be moni- tored and diagnosed. Transient toothmeshing frequency and rotating speed are measured. Weak vibration signal of defective ball bearing is extracted from strong vibration of gearbox and diag- nosed successfully. This approach is effective for nonstationary condition monitoring and early di- agnosis of latent fault.
