Objective: To investigate whether magnetic resonance imaging (MRI) can be used to directly assess olfactory bulb (OB) lesions and quantify the associated morphological changes of olfactory filaments (OF), also known a...Objective: To investigate whether magnetic resonance imaging (MRI) can be used to directly assess olfactory bulb (OB) lesions and quantify the associated morphological changes of olfactory filaments (OF), also known as fila, in an in vivo OB-lesion rat model of the brain. Methods: A surgical group (n = 5) of male Sprague-Dawley rats was subjected to the unilat-eral damage of the OB by a steel needle. The control group (n = 5) did not receive surgery. To assess olfactory system injury in vivo, T2-weighted MRI images were acquired in an oblique plane at a 30° angle from transverse plane one day after surgery. These brain regions were also assessed in the controls. The olfactory function was evaluated using the buried food pellet test (BFPT) 5 days before and after surgery. Results: The OF could be clearly observed on the MRI images from all animals. The left and right OF mean lengths (mm) were similar in the control group (0.81 ± 0.18 vs 0.89 ± 0.17, P > 0.05). In the surgical group, the OB was partially injured in all rats. These rats did not show differences in OF length between left- and right-side (0.83 ± 0.18 vs 0.93 ± 0.24, P > 0.05) at the time of measurement. The time (sec) required to find the food pellets in the BFPT was longer after than before the surgery (83.80 ± 34.37 vs 231.44 ± 53.23, P < 0.05). Conclusions: MicroMRI may be a feasible tool to evaluate the OF and OBs in rat models. The unilateral partial OB lesion model appears to be an effective post-traumatic olfactory dysfunc-tion model.展开更多
In early February 2008 the Ministry of Science and Technology said China put more attention to supporting the research project for special engineering plastic dur-ing the period from 2006 to 2010.The Ministry will all...In early February 2008 the Ministry of Science and Technology said China put more attention to supporting the research project for special engineering plastic dur-ing the period from 2006 to 2010.The Ministry will allocate RMB50.0 million to support the research and development of related technologies.The target of the project is as follow:(a) In light of the development trends of engineering plastic and special polymer material sectors both at home and展开更多
基金This study was supported by the National Natural Science Foundation, Government of China(81670903)%the High End Foreign Expert Program(20151100504)
文摘Objective: To investigate whether magnetic resonance imaging (MRI) can be used to directly assess olfactory bulb (OB) lesions and quantify the associated morphological changes of olfactory filaments (OF), also known as fila, in an in vivo OB-lesion rat model of the brain. Methods: A surgical group (n = 5) of male Sprague-Dawley rats was subjected to the unilat-eral damage of the OB by a steel needle. The control group (n = 5) did not receive surgery. To assess olfactory system injury in vivo, T2-weighted MRI images were acquired in an oblique plane at a 30° angle from transverse plane one day after surgery. These brain regions were also assessed in the controls. The olfactory function was evaluated using the buried food pellet test (BFPT) 5 days before and after surgery. Results: The OF could be clearly observed on the MRI images from all animals. The left and right OF mean lengths (mm) were similar in the control group (0.81 ± 0.18 vs 0.89 ± 0.17, P > 0.05). In the surgical group, the OB was partially injured in all rats. These rats did not show differences in OF length between left- and right-side (0.83 ± 0.18 vs 0.93 ± 0.24, P > 0.05) at the time of measurement. The time (sec) required to find the food pellets in the BFPT was longer after than before the surgery (83.80 ± 34.37 vs 231.44 ± 53.23, P < 0.05). Conclusions: MicroMRI may be a feasible tool to evaluate the OF and OBs in rat models. The unilateral partial OB lesion model appears to be an effective post-traumatic olfactory dysfunc-tion model.
文摘In early February 2008 the Ministry of Science and Technology said China put more attention to supporting the research project for special engineering plastic dur-ing the period from 2006 to 2010.The Ministry will allocate RMB50.0 million to support the research and development of related technologies.The target of the project is as follow:(a) In light of the development trends of engineering plastic and special polymer material sectors both at home and
