Background:Botulinum toxin type A injection,a noninvasive alternative method for treating masseteric hypertrophy,is inadequate for treating patients with a round lower face.This study aimed to investigate the operativ...Background:Botulinum toxin type A injection,a noninvasive alternative method for treating masseteric hypertrophy,is inadequate for treating patients with a round lower face.This study aimed to investigate the operative technique and clinical results of liposuction followed by botulinum toxin type A injections in patients with masseteric hypertrophy and excessive subcutaneous fat.Methods:Sixty-five patients(50 women and 15 men)were treated using this technique between May 2014 and January 2019.Their mean age was 26.3 years(range,18–35 years)and the mean follow-up period was 13 months(range,8–18 months).Results:All patients achieved slimmer lower cheeks with improved jaw definitions after the procedure.Among the 65 patients,61(94%)expressed satisfaction with the results and believed that the procedure produced their desired face shape.No major complications were observed.The effect of this combination treatment remained stable for 12 months after the procedure.Conclusion:The authors believe that liposuction followed by botulinum toxin type A injections is an effective technique for the treatment of masseteric hypertrophy and excessive subcutaneous fat.It is also a relatively simple and safe treatment approach.展开更多
Background: The US FDA has recently approved autologous cultured fibroblast cells (ACF) as treatment for cutaneous contour defects. ACF provides an alternative to synthetic fillers or fat grafting with the significant...Background: The US FDA has recently approved autologous cultured fibroblast cells (ACF) as treatment for cutaneous contour defects. ACF provides an alternative to synthetic fillers or fat grafting with the significant advantage of producing longer lasting effect. Methods: This was a prospective open label single group clinical study to demonstrate the clinical efficacy of ACF that we have replicated in our lab. The study enrolled 18 patients with nasolabial folds from 2 centres in Malaysia in 2011-2012. ACF at dose of 23 or 92 million cells were injected on 3 occasions at 4 weeks interval. Efficacy at 6- and 12-month post treatment was assessed using a standardized 7-point scale which was performed by the 2 investigators as well as a panel of 7 independent evaluators. Results: We obtained a successful outcome (primary endpoint), defined as improvement in the appearance of the nasolabial fold of at least 2 points on the 7-point scale, in 33% of patients as assessed by investigators at 12-month follow-up and in 22% of patients assessed by independent evaluators. Investigators also found 78% of patients having had a 1-point improvement from baseline while independent evaluators found 83% of patients having improved by as much. Patients were uniformly (100%) satisfied with the improvement in their appearance. No treatment-related adverse event was reported. Baseline score and follow-up duration had significant effect on treatment response. The greater the baseline severity and the longer the post-treatment follow-up, the better the response to ACF. Larger dose of cells (92 million cells) has little additional effect suggesting that the 1 mL dose (23 million cells) is near optimal. Older patients showed a trend towards poorer response but this was not statistically significant. Conclusions: We have successfully replicated the laboratory method and clinical procedure to perform ACF treatment which was effective in improving the appearance of nasolabial folds in some patients.展开更多
<b><span style="font-family:Verdana;">Background</span></b><span style="font-family:Verdana;"><strong></strong></span><strong><b><span...<b><span style="font-family:Verdana;">Background</span></b><span style="font-family:Verdana;"><strong></strong></span><strong><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"></span></strong><b><span style="font-family:;" "=""> </span></b><span style="font-family:Verdana;">There are often situations that require the correction of facial defects. Local fasciocutaneous flaps provide a reasonable option for reconstruction of facial defects with good colour and texture match and good success rate. Among the various options of local flaps is the use of a rotation flap. </span><span style="font-family:Verdana;"><strong></strong></span><strong><b><span style="font-family:Verdana;">Aim</span></b></strong><strong><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"></span></strong><b><span style="font-family:;" "=""> </span></b><span style="font-family:Verdana;">The aim of this work is to demonstrate the reliability of the rotation flap in the correction of facial defects and its ability to achieve a good aesthetic outcome by applying the knowledge of facial aesthetic units. </span><span style="font-family:Verdana;"><strong></strong></span><strong><b><span style="font-family:Verdana;">Case </span></b><span style="font-family:Verdana;"></span></strong><strong><b><span style="font-family:Verdana;">Presentation</span></b><span style="font-family:Verdana;"></span></strong> <strong><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> <strong></strong></span><strong><b><span style="font-family:;" "=""> </span></b></strong></strong><span style="font-family:Verdana;"></span><span style="font-family:Verdana;"></span><span style="font-family:;" "=""></span><span style="font-family:Verdana;">This is a case report of a 28-year-old woman who suffered an avulsion injury to the face with loss of facial tissue resulting in exposure of the left zygomatic bone. The defect measured 5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm </span><span style="font-family:;" "=""><span style="font-family:Verdana;">×</span><span style="font-family:Verdana;"> 6</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm. A rotation flap was used to cover the defect after the wound had been previously irrigated and debrided. Her wounds healed well. She suffered no facial nerve injury. The rotation flap resulted in a good colour match with no disruption of facial contour. </span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;"><strong>Conclusion</strong></span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;"><strong>:</strong></span><span style="font-family:Verdana;"></span><span style="font-family:;" "=""><span style="font-family:Verdana;"> The Rotation</span> <span style="font-family:Verdana;">flap provides a reasonable option for reconstruction of facial defects with good colour and texture match.</span></span>展开更多
基金the National Natural Science Foundation of China(grant no.81671964,2017/01–2020/12).
文摘Background:Botulinum toxin type A injection,a noninvasive alternative method for treating masseteric hypertrophy,is inadequate for treating patients with a round lower face.This study aimed to investigate the operative technique and clinical results of liposuction followed by botulinum toxin type A injections in patients with masseteric hypertrophy and excessive subcutaneous fat.Methods:Sixty-five patients(50 women and 15 men)were treated using this technique between May 2014 and January 2019.Their mean age was 26.3 years(range,18–35 years)and the mean follow-up period was 13 months(range,8–18 months).Results:All patients achieved slimmer lower cheeks with improved jaw definitions after the procedure.Among the 65 patients,61(94%)expressed satisfaction with the results and believed that the procedure produced their desired face shape.No major complications were observed.The effect of this combination treatment remained stable for 12 months after the procedure.Conclusion:The authors believe that liposuction followed by botulinum toxin type A injections is an effective technique for the treatment of masseteric hypertrophy and excessive subcutaneous fat.It is also a relatively simple and safe treatment approach.
文摘Background: The US FDA has recently approved autologous cultured fibroblast cells (ACF) as treatment for cutaneous contour defects. ACF provides an alternative to synthetic fillers or fat grafting with the significant advantage of producing longer lasting effect. Methods: This was a prospective open label single group clinical study to demonstrate the clinical efficacy of ACF that we have replicated in our lab. The study enrolled 18 patients with nasolabial folds from 2 centres in Malaysia in 2011-2012. ACF at dose of 23 or 92 million cells were injected on 3 occasions at 4 weeks interval. Efficacy at 6- and 12-month post treatment was assessed using a standardized 7-point scale which was performed by the 2 investigators as well as a panel of 7 independent evaluators. Results: We obtained a successful outcome (primary endpoint), defined as improvement in the appearance of the nasolabial fold of at least 2 points on the 7-point scale, in 33% of patients as assessed by investigators at 12-month follow-up and in 22% of patients assessed by independent evaluators. Investigators also found 78% of patients having had a 1-point improvement from baseline while independent evaluators found 83% of patients having improved by as much. Patients were uniformly (100%) satisfied with the improvement in their appearance. No treatment-related adverse event was reported. Baseline score and follow-up duration had significant effect on treatment response. The greater the baseline severity and the longer the post-treatment follow-up, the better the response to ACF. Larger dose of cells (92 million cells) has little additional effect suggesting that the 1 mL dose (23 million cells) is near optimal. Older patients showed a trend towards poorer response but this was not statistically significant. Conclusions: We have successfully replicated the laboratory method and clinical procedure to perform ACF treatment which was effective in improving the appearance of nasolabial folds in some patients.
文摘<b><span style="font-family:Verdana;">Background</span></b><span style="font-family:Verdana;"><strong></strong></span><strong><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"></span></strong><b><span style="font-family:;" "=""> </span></b><span style="font-family:Verdana;">There are often situations that require the correction of facial defects. Local fasciocutaneous flaps provide a reasonable option for reconstruction of facial defects with good colour and texture match and good success rate. Among the various options of local flaps is the use of a rotation flap. </span><span style="font-family:Verdana;"><strong></strong></span><strong><b><span style="font-family:Verdana;">Aim</span></b></strong><strong><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"></span></strong><b><span style="font-family:;" "=""> </span></b><span style="font-family:Verdana;">The aim of this work is to demonstrate the reliability of the rotation flap in the correction of facial defects and its ability to achieve a good aesthetic outcome by applying the knowledge of facial aesthetic units. </span><span style="font-family:Verdana;"><strong></strong></span><strong><b><span style="font-family:Verdana;">Case </span></b><span style="font-family:Verdana;"></span></strong><strong><b><span style="font-family:Verdana;">Presentation</span></b><span style="font-family:Verdana;"></span></strong> <strong><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> <strong></strong></span><strong><b><span style="font-family:;" "=""> </span></b></strong></strong><span style="font-family:Verdana;"></span><span style="font-family:Verdana;"></span><span style="font-family:;" "=""></span><span style="font-family:Verdana;">This is a case report of a 28-year-old woman who suffered an avulsion injury to the face with loss of facial tissue resulting in exposure of the left zygomatic bone. The defect measured 5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm </span><span style="font-family:;" "=""><span style="font-family:Verdana;">×</span><span style="font-family:Verdana;"> 6</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm. A rotation flap was used to cover the defect after the wound had been previously irrigated and debrided. Her wounds healed well. She suffered no facial nerve injury. The rotation flap resulted in a good colour match with no disruption of facial contour. </span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;"><strong>Conclusion</strong></span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;"><strong>:</strong></span><span style="font-family:Verdana;"></span><span style="font-family:;" "=""><span style="font-family:Verdana;"> The Rotation</span> <span style="font-family:Verdana;">flap provides a reasonable option for reconstruction of facial defects with good colour and texture match.</span></span>