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A cooperative fast annealing coevolutionary algorithm for protein motif extraction 被引量:2
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作者 CHEN Chao TIAN YuanXin ZOU XiaoYong CAI PeiXiang MO JinYuan 《Chinese Science Bulletin》 SCIE EI CAS 2007年第3期318-323,共6页
By integrating the cooperative approach with the fast annealing coevolutionary algorithm (FAEA), a so-called cooperative fast annealing coevolutionary algorithm (CFACA) is presented in this paper for the purpose of so... By integrating the cooperative approach with the fast annealing coevolutionary algorithm (FAEA), a so-called cooperative fast annealing coevolutionary algorithm (CFACA) is presented in this paper for the purpose of solving high-dimensional problems. After the partition of the search space in CFACA, each smaller one is then searched by a separate FAEA. The fitness function is evaluated by combining sub-solutions found by each of the FAEAs. It demonstrates that the CFACA outperforms the FAEA in the domain of function optimization, especially in terms of convergence rate. The current algorithm is also applied to a real optimization problem of protein motif extraction. And a satisfactory result has been obtained with the accuracy of prediction achieving 67.0%, which is in agreement with the result in the PROSITE database. 展开更多
关键词 全局优化 合作法 快速退火 进化算法 蛋白质 超二级结构 功能域
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快速退火演化算法用于取代β-环糊精与氨基酸手性识别研究 被引量:3
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作者 夏保云 蔡文生 +1 位作者 潘忠孝 邵学广 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2002年第6期1122-1125,共4页
将快速退火演化算法用于研究单 -(β— NH+ 3) -β-环糊精、全 -(— NH+ 3) -β-环糊精及全 -(— SCH2 CO- 2 ) -β-环糊精与 R/S型乙酰化氨基酸和甲基化氨基酸之间的手性识别 .结果表明 ,以上 3种取代环糊精主体化合物对修饰的氨基酸... 将快速退火演化算法用于研究单 -(β— NH+ 3) -β-环糊精、全 -(— NH+ 3) -β-环糊精及全 -(— SCH2 CO- 2 ) -β-环糊精与 R/S型乙酰化氨基酸和甲基化氨基酸之间的手性识别 .结果表明 ,以上 3种取代环糊精主体化合物对修饰的氨基酸对映体表现出一定的手性识别能力 .进一步分析表明 ,形成此类包结物的主要驱动力来自静电相互作用和范德华相互作用 。 展开更多
关键词 取代β-环糊精 快速退火演化算法 氨基酸衍生物 手性识别 范德华力 分子力学
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