The Role of RNA Epitranscriptomics and the RNA Fat Mass and Obesity-Associated Demethylase in Triple Negative Breast Cancer

Breast cancer is one of the most commonly diagnosed cancers and one of the most significant sources of cancer mortality. Triple negative breast cancer (TNBC) is a particularly aggressive subtype that has proven difficult to treat with standard chemotherapies. Obesity has also been shown to exacerbate breast cancer, and diagnoses of these two diseases frequently overlap. Both conditions are regulated in part by the fat mass and obesity-associated (FTO) demethylase, an RNA demethylase which may drive breast cancers through epigenetic alterations to gene expression. Methods of inhibiting FTO have been researched in vitro and in vivo as an alternative or adjunct to chemotherapies in multiple cancers, including breast cancer. Translating knowledge of the role of FTO in breast cancer and the development of novel agents may allow for improvements in the treatment of this refractory cancer. This review therefore aims to provide an overview of existing and developing chemical inhibitors of FTO that could be innovatively studied for the treatment of TNBC and associated comorbidity.

Expression and significance of fat mass and obesity associated gene and forkhead transcription factor O1 in non-alcoholic fatty liver disease

Background Non-alcoholic fatty liver disease （NAFLD） is a complex disorder and has been closely linked to obesity.The fat mass and obesity-associated （FTO） gene is a newly discovered gene related to obesity,which enhances oxidative stress and tipogenesis in NAFLD.The forkhead transcription factor O1 （FoxO1） is another important gene involved in NAFLD,which causes lipid disorders when insulin resistance appears in the liver.However,the interactions between FTO and FoxO1 during the pathogenesis of NAFLD have not been fully elucidated.This study was designed to identify the relationship between these two factors that are involved in the development of NAFLD.Methods This study includes two parts referred to as animal and cell experiments.Twelve female SPF C57BL/6 mice were fed a high-fat diet to serve as an NAFLD animal model.Aspartate aminotransferase （AST）,alanine aminotransferase （ALT）,total triglyceride （TG）,total cholesterol （TC）,alkaline phosphatase （ALP）,high-density lipoprotein （HDL）,and low-density lipoprotein （LDL） were measured.Immunohistochemical analysis was used to detect the expression and histological localization of FTO,FoxO1,and adenosine monophosphate （AMP）-activated protein kinase （AMPK）.The L02 cells were exposed to high fat for 24,48,or 72 hours.Oil red O staining was used to detect intracellular lipid droplets.Reverse transcription-polymerase chain reaction was used for analyzing the levels of FTO and FoxO1 mRNA.Results At the end of 10 weeks,ALP,ALT,AST,and LDL were significantly increased （P ＜0.01）,while TC and TG were also significantly higher （P ＜0.05）.In addition,HDL was significantly decreased （P ＜0.05）.The FTO and FoxO1 proteins were weakly expressed in the control group,but both FTO and FoxO1 were expressed significantly higher （P ＜0.01） in the experimental group,and the expression of the two factors was significantly correlated.AMPK in the high-fat group showed a low level of correlation with FTO,but not with FoxO1.Oil Red O staining results showed that the cells cultured in 50％ fetal bovine serum for 24,48,or 72 hours exhibited steatosis.FTO and FoxO1 mRNA were increased in the high-fat group compared with the normal group （P ＜0.01）.The expression levels of FTO and FoxO1 mRNA were the highest at 48 hours （P ＜0.05）.Conclusions A high-fat diet leads to higher expression of FTO,phosphorylation of FoxO1,and decreased phosphorylation of AMPK.These results suggest that the interactions between FTO and FoxO1 are closely related to the pathogenesis of NAFLD.

Association between IGF-2 gene and fat-free mass in response to resistance training

BACKGROUND: It is well established that the human aging process is associated with a significant decline in neuromuscular function and performance. Twin studies demonstrate that genetic factors partially explain the inter-individual variation of fat-free mass (FFM) and muscle strength. PURPOSE: To examine the association between the polymorphism of the gene IGF-2 with phenotypes strength and muscle mass of elderly women pre and post resistance training. METHODS: 76 elderly women participated in this analysis. These volunteers, who should be sedentary for at least 6 months before the study, were assigned four groups in relation to allele GAGG, AA, GAAA and GG. The first analysis compared 60 elderly women with GG and GA allele (GAGG) versus 16 elderly women with AA allele. The second analysis compared 54 elderly women with GA and AA (GAAA) versus 22 elderly women GG allele. The Body mass index, fat free mass, fat mass and Isokinetic Muscle Peak Torque were measured. All volunteers were participating in the Resistance Training program. The DNA was extracted from peripheral venous blood leukocytes using a salting out protocol. The primer for IGF-II gene exon 9 was 5’-GTCCCTGAACCAGCAAAGAG-3’ 0.5 μM (0.625 μl) Primer R-5’-TGATGGAAAAGGGAGTGAGG-3’ 0.5 μM (0.625 μl), Taq DNA Polimerase enzime 0.5 U (0.1 μl), água milli-Q (3.8 μl) 5 hg de DNA (3 μl). PCR amplification was performed in a programmable thermal cycler GeneAmp? PCR System 9700. RESULTS: The results of the first analysis GAGG × AA versus the group AA showed the relative increase in knee extensor peak torque relative and also in the fat-free mass and showed a decrease in the fat mass percentage in the GAGG group. The second analysis considered the group GAAA versus group GG showed decreases in the fat-free mass percentage in the GAAA group, also showed the relative increase in the fat-free mass in the GG group and decrease in the fat mass percentage in the GG group. CONCLUSIONS: The results of this study show that 24 weeks of the resistance training improved strength and muscle mass and decreased the fat mass. The results confirm this assertion and suggest the G allele presents more influence over the A allele, in relation to phenotypes strength and muscle mass in elderly women after resistance training.

Bivariate whole-genome linkage scan for bone geometry and total body fat mass

To quantify the genetic correlations between total body fat mass （TBFM） and femoral neck geometric parameters （FNGPs） and, if pos- sible, to detect the specific genomic regions shared by them, bivariate genetic analysis and bivariate whole-genome linkage scan were carried out in a large Caucasian population. All the phenotypes studied were significantly controlled by genetic factors （P 〈 0.001） with the heritabilities ranging from 0.45 to 0.68. Significantly genetic correlations were found between TBFM and CSA （cross-section area）, W （sub-periosteal diameter）, Z （section modulus） and CT （cortical thickness） except between TBFM and BR （buckling ratio）. The peak bivariate LOD scores were 3.23 （20q12）, 2.47 （20p11）, 3.19 （6q27）, 1.68 （20p12）, and 2.47 （7q11） for the five pairs of TBFM and BR, CSA, CT, W, and Z in the entire sample, respectively. Gender-specific bivariate linkage evidences were also found for the five pairs. 6p25 had complete pleiotropic effects on the variations of TBFM ＆ Z in the female sub-population, and 6q27 and 17q11 had coincident link- ages for TBFM ＆ CSA and TBFM ＆ Z in the entire population. We identified moderate genetic correlations and several shared genomic regions between TBFM and FNGPs in a large Caucasian population.

Muscle Mass Is Associated with Depression in Adolescents and Young Adults

Background and Aims: The study aims to explore the association between body composition and depression in adolescents and young adults. Methods: A random cluster sampling method was used to select 41 age-matched indi-viduals (aged 11 - 30) as a non-depressive control group. The Department of Psychology at the Affiliated Hospital of Youjiang Medical University for Na-tionalities recruited 27 depressive patients within the same age range. Bioelec-trical impedance analysis measured body composition, while SCL-90, SAS, and SDS were employed for depression diagnosis. Logistic regression analysis was conducted to assess the relationship between body composition and de-pression scores. Results: The Depression Group exhibited higher levels of fat mass (p Conclusion: Depression is associated with age, gender, and muscle mass in adolescents and young people. Proper exercise and a healthy diet can increase muscle mass, thereby reducing fat mass and, as a result, reducing the prevalence of depression.

The relationship between body mass index, thickness of subcutaneous fat, and the gluteus muscle as the intramuscular injection site

An intramuscular injection (IMI) is an injection given directly into the central area of a specific muscle. Certain medicines need to be administered by the gluteal route for these to be effective. The aim of this study was to determine the influence of body mass index (BMI), subcutaneous fat, and muscular thickness of the dorsogluteal IMI site among healthy Japanese women. There were 39 healthy female subjects who volunteered and met the criteria. Their ages ranged from 40s to 60s (50.82 ± 6.04). With the data collected using the B-mode ultrasound images of the dorsogluteal site, it was found that the distance from the epidermis to the under-fascia (DEUF) of the gluteus maximus was dissimilar between the subject’s right and left buttocks. It was found that the distance from the epidermis to the iliac bone (DEI) was significantly more on the right than on the left buttocks. In the case of an adult Japanese woman with a BMI of 21 or more, the DEUF of the gluteus medius was found to be about 30 mm, and the DEI was approximately 50 mm or more. Based on these findings, it is recommended that a needle length of 38 mm (1.5 inches) can be safely used to administer IMIs to the gluteus medius muscle to effectively and efficiently deliver medications through the IMI route.

Body Mass Index and Body Fat Percentage in Assessment of Obesity Prevalence in Saudi Adults

Objective To assess the obesity prevalence in body mass index （BMI） and body fat percentage Saudi adults according to the international standards of （BF%）. Methods Five hundred and thirty healthy Saudi adults aged 18-72 years （mean 36.91＋15.22 years） were enrolled in this study. Their body composition was assessed by bioelectrical impendence analysis with a commercially available body composition analyzer. Standard BMI and BF% values were used to define obesity. Results The prevalence of underweight, normal underweight, overweight and obesity in Saudi adults according to the BMI criteria （〈18.5 kg/mz, 18.5-24.4 kg/m2, 25-29.9 kg/m2, 30 k＆/m2 and above, respectively） was 2.5%, 30.2%, 33.6%, and 33.8%, respectively, whereas the obesity prevalence was 60% （n=31g） in Saudi adults according to the BF% criteria （25% for males and 30% for females）, which was significantly higher than that according to BMI criteria. However, it was 50.6% （n=268） when the BMI cutoff point was 27.5 kg/m2, proposed by WHO for the Asian population. Kappa analysis showed that the obesity prevalence defined by BMI and BF% was higher in females than in males （k=0.530 vs k=0.418, P〈O.O001）. The sensitivity and specificity of BMI （30 kg/m2 and 27.5 kg/m2） were 54.1% and 96.7% and 76.4% and 88.2%, respectively, for obesity. A lower BMI cutoff point （26.60 kg/m2） was proposed in this study, which gave the maximum sensitivity （84.3%） and specificity （85.4%）, with a moderate kappa agreement （k=0.686）. Moreover, the obesity prevalence at this cutoff point （56.4%） was significantly higher than that recommended by WHO. Conclusion The specificity of BMI for obesity is high and its sensitivity is low in both sexes. Its sensitivity can be increased by changing BMI cutoff to a lower value. The choice of BF% reference is of great influence for the assessment of obesity prevalence according to the BMI.

Impact of Lifestyle Intervention on the Estimated Visceral Fat Area and Skeletal Muscle Mass in Men with Obesity

Background: The lifestyle modification remains the fundamental approach for the obesity treatment. The aim of this study is to demonstrate the effect of the multimodal lifestyle intervention on the estimated visceral fat area versus changes in musculoskeletal mass in a cohort of adult men with obesity. Subjects and Methods: A retrospective cohort study in which the file of eighty-two male subjects, aged 20 - 60 years, was studied for three months. Patients had been instructed to follow a balanced-hypocaloric diet, physical activity plan and general advice for combating the unhealthy lifestyle habits through the study period. Those who succeeded to loss > 5% of their body weight were classified as weight loser (WL) group, while others as weight resistant (WR) group. The results of In Body-720 bioelectric impedance analysis were used to report the fat mass (FM), visceral fat area (VFA), skeletal muscle mass (SMM), SMM/VFA ratio, osseous mass (OM), and basal metabolic rate (BMR) before and after the study period. Anthropometric measures, glucose, and lipid profile were also analyzed. Paired t-test was used to detect the significance of change between before and after measures, independent sample t-test was used to compare WL vs. WR groups. Results: There were significant decreases in weight, FM (p 0.05) and VFA (p 0.001), in addition to a significant rise of SMM/VFA ratio (p 0.05), together with insignificant changes of osseous mass, SMM and BMR after 3 months. Additionally, total cholesterol, low-density lipoprotein, and triglycerides were significantly reduced (P 0.05). The percentages of reduction in weight, FM and VFA in WL vs. WR groups were highly significant (p 0.001), while the percentages of change in SMM, SMM/VFA ratio and BMR were significant (p 0.05). Conclusion: Lifestyle modification might be effective in production of positive changes in the body composition of patients with obesity. These changes were more significant in weight losers.

Effects of Weight Loss on Pericardial Fat and Left Ventricular Mass Assessed with Cardiac Magnetic Resonance Imaging in Morbid Obesity

Background: Obesity is a risk factor for cardiovascular disease and mortality. Significant weight loss has beneficial effects on left ventricular structure, in particular on regression of left ventricular hypertrophy (LVH). We therefore evaluated the consequences of significant weight loss on left ventricular morphology, hemodynamics and pericardial fat. Methods: We performed volumetric cardiac magnetic resonance (CMR) imaging before and after significant weight loss due to laparoscopic adjustable gastric banding (LAGB). CMR was used to measure cardiac mass, volume and function, as well as to quantify pericardial fat. Results: Eleven patients (age 40.5 ± 10 yrs, body mass index 42.5 ± 3.9 kg/m2) underwent CMR imaging before and a median 15.4 months after gastric banding. The BMI declined by 9.3 ± 3.3 kg/m2 (p Discussion: Significant weight loss in obesity is accompanied by a marked regression of LVH, with no apparent change in cardiac volume or function. The local effect of a diminished amount of pericardiac fat tissue may be more important than absolute weight loss with respect to the regression of LVH in obesity.

Body Mass Index and Percentage Body Fat Determination in Cancer Patients

Body Mass Index (BMI) and Percentage Body Fat (%BF) values have been determined in cancer patients. In the study, 83 adult cancer patients were assessed of which 15 (18.1%) were males and 68 (81.9%) females. Body weight and height of individual patients were used in calculating their respective BMI values. The respective %BF values were determined taking into consideration of the age, gender and BMI. Maximum values of BMI (34.71 kg/m2) and %BF (46.37%) were obtained, for which they were females and the minimum values of BMI (12.08 kg/m2) and %BF (12.35%) respectively. The patient with the minimum %BF value was male and that of BMI was female. It was observed from the results that females have higher values of both BMI and %BF than their male counterparts. The study reveals higher rate of female cancer incidence than males.

Correlations of Body Mass Index, Japan-Defined and IDF-Defined Waist Circumference, Visceral and Subcutaneous Fat Area with Metabolic Parameters in Japanese Patients with Type 2 Diabetes

Obesity is included in the definition of metabolic syndrome. However, there are many controversies surrounding the evaluation of obesity such as body mass index (BMI) and waist circumference (WC) in the definition of metabolic syndrome among various populations. To understand precisely how various anthropometric indices of obesity influence metabolic parameters, we studied the correlations of BMI, WC (Japanese criteria), WC (IDF criteria), visceral fat area (VFA), subcutaneous fat area (SFA) and the VFA/SFA ratio with metabolic parameters in patients with type 2 diabetes. The influences of BMI and WC on diastolic blood pressure and HDL-cholesterol were larger than VFA, whereas the influences of visceral fat area on triglyceride, very low-density lipoprotein-cholesterol, C-peptide and high-sensitivity C-reactive protein were larger than BMI and WC. WC (IDF) was the strongest determinant of adiponectin among anthropometric indices. Present study showed significant different associations of BMI, Japan- and IDF-defined WC, VFA, SFA and the VFA/SFA ratio with blood pressure, glucose and lipid metabolism, and adipocytokines in Japanese patients with type 2 diabetes.

Mediation role of cardiorespiratory fitness on the association between fatness and cardiometabolic risk in European adolescents: The HELENA study

Purpose:This study was aimed to analyze the mediation role of cardiorespiratory fitness(CRF)on the association between fatness and cardiometabolic risk scores(CMRs)in European adolescents.Methods:A cross-sectional study was conducted in adolescents(n=525;46%boys;14.1±1.1 years old,mean ±SD)from 10 European cities involved in the Healthy Lifestyle in Europe by Nutrition in Adolescence study.CRF was measured by means of the shuttle run test,while fatness measures included body mass index(BMI),waist to height ratio,and fat mass index estimated from skinfold thicknesses.A clustered CMRs was computed by summing the standardized values of homeostasis model assessment,systolic blood pressure,triglycerides,total cholesterol/highdensity lipoprotein cholesterol ratio,and leptin.Results:Linear regression models indicated that CRF acted as an important and partial mediator in the association between fatness and CMRs in 1217-year-old adolescents(for BMI:coefficients of the indirect role b=0.058(95%confidence interval(95%CI):0.023-0.101),Sobel test z=3.11(10.0%mediation);for waist to height ratio:b=4.279(95%CI:2.242-7.059),z=3.86(11.5%mediation);and for fat mass index:b=0.060(95%CI:0.020-0.106),z=2.85(9.4%mediation);all p<0.01).Conclusion:In adolescents,the association between fatness and CMRs could be partially decreased with improvements to fitness levels;therefore,CRF contribution both in the clinical field and public health could be important to consider and promote in adolescents independently of their fatness levels.

基于ARM9和FAT的高速海量数据采集系统

针对一些控制系统,为了能够快速获取实时数据,并借助上位机系统进行离线分析,提出了移植FAT文件系统到ARM中,将实时采集的海量数据保存到SD卡的设计方案;该方案以S3C2440 ARM9为嵌入式平台,结合文件系统和SD卡存储技术设计了数据采集系统,应用MATLAB等软件对数据进行分析处理,实现了对控制系统模型的矫正;经飞思卡尔智能车系统的设计证明,这种方案在系统建模和系统特性分析上具有较强的应用价值。

精简FAT文件系统在数据采集中的应用

针对控制系统为了能够获取实时海量数据,并借助上位机系统对获取的数据进行离线统计、分析,提出了精简FAT文件系统的方法,并将其移植到控制系统的微处理器中,把实时采集的数据保存到SD卡的设计方案。该方案具有占用系统空间小、运行效率高、海量数据存储、可移植于各种单片机系统的特点。经智能车系统的设计证明,该方案具有较强的应用价值。

Prediction of Abdominal Visceral Obesity From Body Mass Index,Waist Circumference and Waist-hip Ratio in Chinese Adults:Receiver Operating Characteristic Curves Analysis

Objective To evaluate the sensitivity and specificity of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) measurements in diagnosing abdominal visceral obesity. Methods BMI, WC, and WHR were assessed in 690 Chinese adults (305 men and 385 women) and compared with magnetic resonance imaging (MRI) measurements of abdominal visceral adipose tissue (VA). Receiver operating characteristic (ROC) curves were generated and used to determine the threshold point for each anthropometric parameter. Results 1) MRI showed that 61.7% of overweight/obese individuals (BMI≥25 kg/m2) and 14.2% of normal weight (BMI<25 kg/m2) individuals had abdominal visceral obesity (VA≥100 cm2). 2) VA was positively correlated with each anthropometric variable, of which WC showed the highest correlation (r=0.73-0.77, P<0.001). 3) The best cut-off points for assessing abdominal visceral obesity were as followed: BMI of 26 kg/m2, WC of 90 cm, and WHR of 0.93, with WC being the most sensitive and specific factor. 4) Among subjects with BMI≥28 kg/m2 or WC≥95 cm, 95% of men and 90% of women appeared to have abdominal visceral obesity. Conclusion Measurements of BMI, WC, and WHR can be used in the prediction of abdominal visceral obesity, of which WC was the one with better accuracy.

穴位埋线辅助温针灸治疗单纯性肥胖症的效果及患者BMI与FAT的变化研究

目的:研究穴位埋线辅助温针灸治疗单纯性肥胖症的效果及患者体重指数(BMI)、体脂百分比(FAT)的变化情况。方法:选择笔者科室2017年10月-2018年3月收治的60例单纯性肥胖症患者,根据随机数字法分为对照组(温针灸治疗)和观察组(穴位埋线辅助温针灸治疗),分析两组患者治疗后的临床疗效。结果:治疗前,两组BMI、FAT、内脏脂肪交叉估计指数(VFA)、腰臀比(WHR)水平组间比较,差异无统计学意义(P>0.05)。治疗后,观察组BMI、FAT、VFA、WHR水平低于对照组(P<0.05);治疗前,两组血脂指标、C反应蛋白(CRP)、白介素-6(IL-6)、脂联素(Adiponeetin)水平组间比较,差异无统计学意义(P>0.05)。治疗后,观察组高密度脂蛋白胆固醇(HDL-C)、Adiponeetin水平高于对照组,甘油三酯(TG)、高总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、CRP、IL-6水平低于对照组(P<0.05),观察组不良反应率为13.33%,对照组为6.67%,两组比较无统计学意义(P>0.05)。结论:穴位埋线辅助温针灸治疗单纯性肥胖症可降低患者BMI、FAT、WHR水平,抑制炎症因子的表达,改善血脂指标,且并未增加不良反应风险,安全性高。

Dietary Fat Intake, Micronutritient and Obesity among Adolescent in Tlemcen (Western Algeria)

Background: A number of epidemiological studies around the world have shown that the occurred and the high prevalence of some chronic diseases such as diabetes, obesity, cardiovascular disease, etc. are mainly caused by a high calorie and unbalanced diet associate with reduced physical activity. In Algeria, as in many emerging countries to improve the standard of living of the population and changes in lifestyle, more westernized characterized by abundant food and sedentary lifestyle especially among young people contribute to the increased incidence of these chronic diseases. Objectives: This work consists of a dietary survey conducted among adolescent boys and girls in Tlemcen (Algeria). Subject and Methods: This is a descriptive cross-sectional study of dietary intake of adolescent aged 10 - 17 years and anthropometric parameters: weight, height, body mass index. Results: Increased fat intake was associated with increased body mass index in both sexes, increased obesity and abdominal obesity in girls, boys are more active than girls and we observed decreased intake of sugar, the nutritient adequacy ratio of folate, niacin, vitamin B6, iron, magnesium. Conclusion: The early prevention of obesity in children and adolescents is essential in the prevention of chronic diseases in adults. We recommended adolescent by healthy diets towards helps regulate their body weight and reduces the risk of cardiovascular disease and some types of cancer and especially the girls by lifestyle more active.

婴儿体脂指数的影响因素分析

目的探究不同性别婴儿体脂指数(FMI)的影响因素。方法于2021年10月至2022年12月,在山东省开展婴儿体成分的横断面研究,对研究对象进行电子问卷调查和体成分测量获取研究数据,最终纳入9291份有效数据,应用多因素线性回归分析不同性别婴儿FMI的影响因素。结果不同性别婴儿月龄与FMI具有显著正相关。与适于胎龄儿相比,大于胎龄儿的FMI增加(β值分别为0.086、0.078,P<0.001),小于胎龄儿的FMI降低(β值分别为-0.088、-0.072,P<0.001)。与6月龄以后添加辅食相比,4~6月龄添加辅食男女婴儿FMI均增加,差异均具有统计学意义(β值分别为0.099、0.053,P<0.001)。与父母亲体重正常相比、父母亲肥胖与婴儿FMI的增加显著相关(β值分别为0.058、0.070和0.054、0.058,P<0.001),母亲体重过低与婴儿FMI降低显著相关(β值分别为-0.039、-0.046,P=0.005、0.002)。妊娠期糖尿病与婴儿FMI降低显著相关(β值分别为-0.039、-0.046,P=0.005、0.002),妊娠期高血压与男婴FMI升高显著相关(β=0.028,P=0.038)。纯配方奶喂养对女婴FMI存在显著正向影响(β=0.029,P=0.046)。孕期增重不足对女婴FMI存在显著负向影响(β=-0.033,P=0.032)。结论影响婴儿身体成分的因素有胎龄别体重、喂养方式、辅食添加时间、母亲孕期增重及孕期疾病等,应在生命早期采取干预措施进行控制,预防子代代谢性疾病的发生。

身体成分与儿童血压关系的系统评价/Meta分析

背景身体成分是体内各种成分的含量,其与儿童血压的关联存在争议。目的探讨身体成分与儿童血压的关联性。设计系统综述/Meta分析。方法计算机检索中国生物医学数据库、维普中文科技期刊数据库、中国知网期刊数据库、万方数据在线知识服务平台4个中文数据库和PubMed、Web of Science和EBSCO 4个外文数据库,检索起止时间均为各数据库建库至2023年8月8日。纳入身体成分与儿童血压关系的队列研究。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,对结果进行定量和定性归纳总结。主要结局指标身体成分与儿童高血压的相关性。结果共纳入9项身体成分与儿童舒张压和收缩压的纵向队列研究,其中7个队列报告了脂肪质量相关指标与儿童舒张压和收缩压的相关性,儿童期脂肪质量百分比与儿童舒张压和收缩压呈正相关,其他脂肪质量指标研究结论仍不一致。2个队列报告了非脂肪质量指标与儿童血压的相关性,研究结论不统一。3个队列报告了脂肪质量与儿童期血压偏高和高血压的发生呈正相关,但新生儿脂肪质量与6岁时高血压的风险可能为负相关。结论儿童期脂肪质量百分比与儿童舒张压和收缩压呈正相关,身体成分对儿童血压有一定影响。

老年肥胖病人顺式阿曲库铵按去脂体质量给药对其95%有效剂量的影响

目的观察老年肥胖病人顺式阿曲库铵按去脂体质量(FFM)给药对其95%有效剂量(ED95)的影响。方法选择2020年9月20日至2021年9月30日在秦皇岛市第一医院择期行全麻手术老年(年龄≥65岁)肥胖病人40例。根据随机数字表法分为OF1~OF4组,每组10例(男女各5例),采用单次剂量法按FFM分别给予40、50、60、70μg/kg的顺式阿曲库铵,给药后使用Mindray BeneVision N17型监护仪进行肌松监测,记录拇内收肌第1个肌颤搐反应(T1)最大抑制值及起效时间,对顺式阿曲库铵单次剂量进行对数转换,将T1最大抑制值进行概率单位转换,用直线回归方法建立量效曲线,计算其ED95。结果T1最大抑制值随剂量的增加而增大(P<0.05),得出ED95为70.5μg/kg。结论老年肥胖病人按FFM给予顺式阿曲库铵的ED95为70.5μg/kg。