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Usefulness of the epicardial fat tissue thickness as a diagnostic criterion for geriatric patients with metabolic syndrome 被引量:1
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作者 Bema Kaya Bedri Caner Kaya +7 位作者 Emel Yigit Karakas Sadettin Selcuk Baysal Dursun Cadirci Emre Erkus Ibrahim Halil Altiparmak Emin Savik Hatice Sezen Tttrgay Ulas 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2015年第4期373-377,共5页
Objective To evaluate the epicardial fat tissue thickness (EFTT) as a diagnostic criterion for geriatric patients with metabolic syn- drome (MetS). Methods Sixty geriatric patients over 65 years of age were recrui... Objective To evaluate the epicardial fat tissue thickness (EFTT) as a diagnostic criterion for geriatric patients with metabolic syn- drome (MetS). Methods Sixty geriatric patients over 65 years of age were recruited for the study. Patients were divided into two groups: Group 1 (n = 30) consisted of patients with MetS; Group 2 (n = 30) consisted of patients without MetS. Echocardiography was used to measure EFTT in all patients, and blood samples were analyzed for biochemical parameters. Results Compared to Group 2, EFTT levels of Group 1 were statistically higher (P 〈 0.05). In a binary logistic regression analysis, EFTT levels served as the independent factor for meta- bolic syndrome 03 = 17.35, SE = 4.93, Wald = 12.36, P 〈 0.001). Receivers operating characteristic Curve (ROC-curve) analysis revealed that EFTT predicted MetS with 96.7% sensitivity and 86.7% specificity above the level of 7.3 mm [area under the curve = 0.969; 95% con- fidence interval (CI): 0.928-1.00]. Conclusions The present study demonstrated that serum EFTT levels were higher in geriatric patients with MetS and can therefore be used as a diagnostic criterion for MetS. 展开更多
关键词 Epieardial fat tissue thickness GERIATRICS Metabolic syndrome
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Isolation, Cloning, and Identification of Expressed Sequence Tags from the Backfat Tissue in Duroc and Tongcheng Pigs by mRNA Differential Display
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作者 REN Zhu-qing XIONG Yuan-zhu DENG Chang-yan LEI Ming-gang ZUO Bo LI Feng-e ZHENG Rong XU De-quan 《Agricultural Sciences in China》 CAS CSCD 2006年第2期141-145,共5页
mRNA differential display technique was performed to discuss the differential expression of genes in fat tissue between introduced European and Chinese indigenous pigs. Four anchor primers in combination with five arb... mRNA differential display technique was performed to discuss the differential expression of genes in fat tissue between introduced European and Chinese indigenous pigs. Four anchor primers in combination with five arbitrary primers (20 sets in total) were used and nearly 300 bands were observed in polyacrylamide gel, among which 29 differential display bands were obtained. Twelve of 29 cDNA fragments were identified using reverse Northern dot blot, and subsequently cloned and sequenced. Eight of 12 cDNAs had no matches in GenBank and were submitted to GenBank, and the other 4 showed similarity to identified genes from GenBank. Three among 8 novel ESTs were selected to be further identified by semiquantitative RT-PCR. In our experiment, silver staining DDRT-PCR and DIG primer DNA labeling reverse Northern dot blot were used to avoid radioactive pollution. The result showed that the expressions of 5 among 8 novel ESTs were stronger in the backfat of Tongcheng pigs and the others were weaker than that in Duroc pigs. These novel ESTs were prepared for selecting genes related to adipose cells. 展开更多
关键词 ESTS fat tissue reverse Northern dot blot semi-quantitative RT-PCR mRNA differential display
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Shifting perspectives-interplay between non-alcoholic fatty liver disease and insulin resistance in lean individuals 被引量:2
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作者 Ines Bilic-Curcic Maja Cigrovski Berkovic +1 位作者 Lucija Virovic-Jukic Anna Mrzljak 《World Journal of Hepatology》 2021年第1期80-93,共14页
Non-alcoholic fatty liver disease(NAFLD)has become a significant public health burden affecting not only obese individuals but also people with normal weight.As opposed to previous beliefs,this particular subset of pa... Non-alcoholic fatty liver disease(NAFLD)has become a significant public health burden affecting not only obese individuals but also people with normal weight.As opposed to previous beliefs,this particular subset of patients has an increased risk of all-cause mortality and worse outcomes than their obese counterparts.The development of NAFLD in lean subjects seems to be interconnected with metabolic phenotype,precisely visceral fat tissue,sarcopenia,and insulin resistance.Here,we summarize available data focusing on the co-dependent relationship between metabolic phenotype,insulin resistance,and development of NAFLD in lean individuals,suggesting more appropriate tools for measuring body fat distribution for the screening of patients at risk. 展开更多
关键词 Non-alcoholic fatty liver disease Metabolic phenotype Lean individuals Insulin resistance Visceral fat tissue SARCOPENIA
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Epigenomic features associated with body temperature stabilize tissues during cold exposure in cold-resistant pigs
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作者 Yaping Guo Mingyang Hu +14 位作者 Hao Peng Yan Zhang Renzhuo Kuang Zheyu Han Daoyuan Wang Yinlong Liao Ruixian Ma Zhixiang Xu Jiahao Sun Yu Shen Changzhi Zhao Hong Ma Di Liu Shuhong Zhao Yunxia Zhao 《Journal of Genetics and Genomics》 SCIE CAS 2024年第11期1252-1264,共13页
Cold stress in low-temperature environments can trigger changes in gene expression,but epigenomics regulation of temperature stability in vital tissues,including the fat and diencephalon,is still unclear.Here,we explo... Cold stress in low-temperature environments can trigger changes in gene expression,but epigenomics regulation of temperature stability in vital tissues,including the fat and diencephalon,is still unclear.Here,we explore the cold-induced changes in epigenomic features in the diencephalon and fat tissues of two cold-resistant Chinese pig breeds,Min and Enshi black(ES)pigs,utilizing H3K27ac CUT&Tag,RNA-seq,and selective signature analysis.Our results show significant alterations in H3K27ac modifications in the diencephalon of Min pigs and the fat of ES pigs after cold exposure.Dramatic changes in H3K27ac modifications in the diencephalon of Min pig are primarily associated with genes involved in energy metabolism and hormone regulation,whereas those in the fat of ES pig are primarily associated with immunity-related genes.Moreover,transcription factors PRDM1 and HSF1,which show evidence of selection,are enriched in genomic regions presenting cold-responsive alterations in H3K27ac modification in the Min pig diencephalon and ES pig fat,respectively.Our results indicate the diversity of epigenomic response mechanisms to cold exposure between Min and ES pigs,providing unique epigenetic resources for studies of low-temperature adaptation in large mammals. 展开更多
关键词 Cold exposure Diencephalon tissue fat tissue H3K27ac modification Breed difference Multi-omics
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Extraluminal factors contributing to inflammatory bowel disease 被引量:3
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作者 Arvind Batra Thorsten Stroh Britta Siegmund 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第5期572-577,共6页
Many identified and yet unknown factors contribute to the pathogenesis of inflammatory bowel disease(IBD).The genome-wide association studies clearly support the earlier developed concept that IBD occurs in geneticall... Many identified and yet unknown factors contribute to the pathogenesis of inflammatory bowel disease(IBD).The genome-wide association studies clearly support the earlier developed concept that IBD occurs in genetically predisposed individuals who are exposed to distinct environmental factors,which together result in dysregulation of the mucosal immune system.Thus,the majority of previous studies have focused on the immune response within the intestinal wall.The present review aims to emphasize the contribution of three extraluminal structures to this inflammatory process,namely the mesenteric fat tissue,the lymphatics and the microvasculature.Broadening our view across the intestinal wall will not only facilitate our understanding of the disease,but will also us to identify future therapeutic targets. 展开更多
关键词 Inflammatory bowel disease Extraluminalstructures Mesenteric fat tissue LYMPHATICS Microvas-culature
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BmPLA2 containing conserved domain WD40 affects the metabolic functions of fat body tissue in silkworm, Bombyx moil
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作者 Chabungbam Orville Singh Hu-Hu Xin +5 位作者 Rui-Ting Chen Mei-Xian Wang Shuang Liang Yan Lu Zi-Zheng Cai Yun-Gen Miao 《Insect Science》 SCIE CAS CSCD 2016年第1期28-36,共9页
PLA2 enzyme hydrolyzes arachidonic acid, and other polyunsaturated fatty acids, from the sn-2 position to release free arachidonic acid and a lysophospholipid. Previous studies reported that the PLA2 in invertebrate o... PLA2 enzyme hydrolyzes arachidonic acid, and other polyunsaturated fatty acids, from the sn-2 position to release free arachidonic acid and a lysophospholipid. Previous studies reported that the PLA2 in invertebrate organisms participates in lipid signaling molecules like arachidonic acid release in immune-associated tissues like hemo- cytes and fat bodies. In the present study, we cloned the BmPLA2 gene from fat body tissue of silkworm Bombyx mori, which has a total sequence of 1.031 kb with a 31.90 kDa pro- tein. In silico results of BmPLA2 indicated that the protein has a putative WD40 conserved domain and its phylogeny tree clustered with Danaus plexippus species. We investigated the transcriptional expression in development stages and tissues. The highest expression of BmPLA2 was screened in fat body among the studied tissues of third day fifth instar larva, with a high expression on third day fifth instar larva followed by a depression of expression in the wandering stage of the fifth instar larva. The expression of BmPLA2 in female pupa was higher than that of male pupa. Our RNAi-mediated gene silencing results showed highest reduction of BmPLA2 expression in post-24 h followed by post-48 and post-72 h. The BmPLA2-RNAi larvae and pupa could be characterized by pharate adult lethality and underdevelopment. The phenotypic characters of fat body cells in RNAi-induced larva im- plied that BmPLA2 affects the metabolic functions of fat body tissue in silkworm Bombyx mori. 展开更多
关键词 BmPLA2 cloning and expression dsRNA interference fat body tissue SILKWORM
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Antiapoptotic activity of 30 kDa lipoproteins family from fat body tissue of silkworm, Bombyx moil
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作者 Britto Cathrin Pakkianathan Nitin Kumar Singh +1 位作者 Simone Konig Muthukalingan Krishnan 《Insect Science》 SCIE CAS CSCD 2015年第5期629-638,共10页
The family of 30kDa lipoproteins (LP1-5) is abundant in silkworm pupa fat body (FB) and hemolymph. One of its members, the 29 kDa protein decreased in concentration from peripheral (PP) FB tissue but was sustain... The family of 30kDa lipoproteins (LP1-5) is abundant in silkworm pupa fat body (FB) and hemolymph. One of its members, the 29 kDa protein decreased in concentration from peripheral (PP) FB tissue but was sustained in perivisceral (PV) FB tissue at the time of apoptosis. This study investigated the correlation of the 30kDa proteins with FB apoptosis. Two protein fractions were purified, a 29 and a 30/31 kDa protein fraction, and they were used to test for activity against actinomycin D-induced apoptosis in the FB tissues. Concentrations as little as 50/zg/mL of the 29 kDa protein fraction efficiently inhibited apoptosis. Less antiapoptotie activity was detected for the higher MW fraction; DNA fragmentation was observed in FB tissue treated with 50 #g/mL of the 30/31 kDa fraction. The viability of the cells in the 29 kDa protein-supplemented culture was 40% higher than in the 31 kDa protein-supplemented culture. However, the 30 kDa lipoproteins were not able to prevent scheduled FB degeneration during silkworm metamorphosis. Thus, it is hypothesized that the antiapoptotic 29 kDa protein needs to be proteolytically degraded by a regulatory mechanism to allow programmed cell death of FB tissue. 展开更多
关键词 actinomycin D apoptosis Bombyx mori fat body tissue 30 kDa proteins
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Tissue engineering in burn scar reconstruction
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作者 PPM van Zuijlen KLM Gardien +4 位作者 MEH Jaspers EJ Bos DC Baas AJM van Trier E Middelkoop 《Burns & Trauma》 SCIE 2015年第3期122-132,共11页
Nowadays,most patients with severe burns will survive their injury.This evolution is accompanied by the challenge to cover a large percentage of total body surface area burned.Consequently,more and more patients have ... Nowadays,most patients with severe burns will survive their injury.This evolution is accompanied by the challenge to cover a large percentage of total body surface area burned.Consequently,more and more patients have to deal with the sequelae of burn scars and require(multiple)reconstructions.This review provides a gross overview of developments in the field of tissue engineering for permanent burn wound coverage and reconstructive burn surgery,focusing on usage and clinical effectiveness.Not only skin substitutes will be discussed but also the replacement of subcutaneous fat tissue and cartilage. 展开更多
关键词 BURNS tissue engineering Scar CONTRACTURE SUBSTITUTE Subcutaneous fat tissue Cartilage RECONSTRUCTION
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