Validity and reliability of Chinese version of Fatigue Impact Scale in cerebral infarction patients

BACKGROUND： Post-stroke fatigue has received much attention recently. Three evaluation scales are available, including the Fatigue Impact Scale （FIS）. Yet none of these has been proven to be of use in the evaluation of psychological quality after post-stroke fatigue. OBJECTIVE： To introduce FIS into China, and to evaluate the validity and reliability of the Chinese Version in patients with cerebral infarction. DESIGN： Scale evaluation. SETTING： Department of Rehabilitation, Beijing Friendship Hospital, Capital Medical University. PARTICIPANTS： A total of 330 patients with cerebral infarction were selected from the Department of Neurology, Beijing Friendship Hospital, Capital Medical University from June 2005 to December 2006. All patients met diagnostic standards from the Fourth National Cerebrovascular Disease Academic Meeting of China Medical Association and were diagnosed with CT or MRI examination. Patients who were not willing to accept scale evaluation were excluded. METHODS： The English version of FIS was translated into Chinese and subsequently translated back to English again. FIS was given to the discharged patients, and they returned them upon completion. In-patients completed and immediately returned the FIS. Validity and reliability of the retrieved scales were ascertained with descriptive and inference analysis. MAIN OUTCOME MEASURES： Total scores and subscale scores of FIS. RESULTS： Out of 330 questionnaires, 214 valid questionnaires were deemed valid in total. Six components were extracted in factor analysis, and the total cumulative contribution was 73.919%, which suggested the questionnaire was valid. After correlation analysis, 6 components were divided into 3 subscales, including cognitive, physical, and social, which was the same as the English version. The Cronbach α value for the three subscales was 0.937 7, 0.918 8, and 0.940 6, respectively （〉 0.7）. CONCLUSION： The reliability and validity of the Chinese version of FIS met with satisfaction and appeared to be adaptable to cerebral infarction patients in China.

Research on Analytical Method of Fatigue Characteristics of Soft Yoke Mooring System Based on Full-Scale Measurement

By focusing on the vulnerability of the structure of marine equipments, together with considering the randomness of meta-ocean load in statistics, a kind of analytical method of fatigue characteristics of marine structure based on full- scale and actual measurement of prototype is proposed. On the basis of short-term field measurement results of structural response, research is carried out on the fatigue analysis of hinge joints at the upper part of the Soft Yoke single point Mooring System （SYMS） by simultaneously monitoring the environmental load and considering the design criteria of offshore structure. Through analysis of finite element modeling, the time-histories of typical stress response are obtained, and then the assessment of fatigue damage at key hinge joints is conducted. The simulation results indicate that the proposed method can accurately analyze the fatigue damage of offshore engineering structure caused by the effect of wave load. The present analytical method of fatigue characteristics can be extended on other offshore engineering structures subjected to meta-ocean load.

DIAGNOSTICS OF FATIGUE CRACK IN ULTERIOR PLACES OF LARGER-SCALE OVERLOADED SUPPORTING SHAFT BASED ON TIME SERIES AND NEURAL NETWORKS

To improve the diagnosis accuracy and self-adaptability of fatigue crack in ulterior place of the supporting shaft, time series and neural network are attempted to be applied in research on diag-nosing the fatigue crack’s degree based on analyzing the vibration characteristics of the supporting shaft. By analyzing the characteristic parameter which is easy to be detected from the supporting shaft’s exterior, the time series model parameter which is hypersensitive to the situation of fatigue crack in ulterior place of the supporting shaft is the target input of neural network, and the fatigue crack’s degree value of supporting shaft is the output. The BP network model can be built and net-work can be trained after the structural parameters of network are selected. Furthermore, choosing the other two different group data can test the network. The test result will verify the validity of the BP network model. The result of experiment shows that the method of time series and neural network are effective to diagnose the occurrence and the development of the fatigue crack’s degree in ulterior place of the supporting shaft.

Reliability and validity of the Chinese version of the PedsQL Multidimensional Fatigue Scale in children with acute leukemia

Background:The PedsQL Multidimensional Fatigue Scale(PedsQL^(TM)MFS)is widely used to rate fatigue in children living in English-speaking countries.However,insufficient instruments are available to conduct parallel assessment on fatigue in parents and children in China.In this regard,an appropriate measurement method must be developed.Objectives:This study aims to determine the reliability and validity of the Chinese-language PedsQL^(TM)MFS.Methods:Children with cancer(n=125)and their parents were surveyed in Guangzhou,China.The parents of children aged 2e4 years completed the PedsQL^(TM)MFS proxy reports,whereas the other children and their parents completed the questionnaires by themselves.Results:The PedsQL^(TM)MFS-Chinese version demonstrated satisfactory internal consistency reliability(child self-report Cronbach's a=0.87;parent self-report Cronbach's a=0.93).The factor loadings of the items ranged from 0.78 to 0.87 for general fatigue,0.56e0.78 for sleep/rest fatigue,and 0.62e0.89 for cognitive fatigue.Conclusion:This study proves that the PedsQL^(TM)MFS-Chinese version is an effective tool for screening fatigue in Chinese children with cancer.

Changes in mean cerebral blood flow velocity during cognitive task-induced cerebral fatigue in high performance fighter pilots

BACKGROUND： Several studies have demonstrated that sustained cognitive tasks can induce cognitive fatigue and that the mean cerebral blood flow velocity changes in some cerebral regions during cerebral fatigue. OBJECTIVE： To dynamically monitor the changes in mean cerebral blood flow velocity in different brain regions of high performance fighter pilots during mental arithmetic tasks and consecutive performance tasks. DESIGN, TIME AND SETTING： The present neurophysiological trial, based on controlled observation, was performed at the Laboratory of Neurophysiology, Institute of Aviation Medicine, Air Force of China between January 2003 and December 2005. PARTICIPANTS： Forty-five males, high performance fighter pilots, averaging （27.6±2.5） years, were recruited for this study. METHODS： The mean cerebral blood flow velocity in the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery of subjects was dynamically tested using transcranial Doppler during 5- hour mental arithmetic tasks and during 5- hour consecutive performance tasks. The neurobehavioral ability index was analyzed throughout each trial according to the number of correct responses, false responses, and lost responses. Simultaneously, cerebral cognitive fatigue-induced lethargy was assessed by the Stanford Sleepiness Scale. MAIN OUTCOME MEASURES： Changes in mean cerebral blood flow velocity in the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery; neurobehavioral ability index of mental arithmetic and consecutive performance tasks; Stanford Sleepiness Scale scores. RESULTS： During mental arithmetic tasks, the mean cerebral blood flow velocity in the anterior cerebral artery increased during hour 2 and decreased after hour 4. There was no significant change in mean cerebral blood flow velocity in the middle cerebral artery and posterior cerebral artery. During hour 4, cerebral cognitive fatigue was observed and, simultaneously, Stanford Sleepiness Scale scores demonstrated the presence of fatigue. During such a stage, the neurobehavioral ability index decreased, indicating a decline in performance ability. During consecutive performance tasks, the mean cerebral blood flow velocity declined earlier in the posterior cerebral artery compared to the middle cerebral artery. CONCLUSION： Five- hour mental arithmetic tasks have few effects on cerebral functions and do not lead to a significant change in mean cerebral blood flow velocity. Five-hour consecutive performance tasks can induce cerebral cognitive fatigue, and a marked decline in mean cerebral blood flow velocity.

Development of a Tool for Assessment of Post-Myocardial Infarction Fatigue

Introduction: After treatment for myocardial infarction (MI) quite a few persons will experience different symptoms, including fatigue, during the recovery phase. The aim of the present study was to construct the multidimensional Post-Myocardial Infarction Fatigue (PMIF) scale, based on empirical data gathered in coronary heart disease contexts. Methods: The construction of the post-MI fatigue scale was conducted in seven steps, ending in a psychometric evaluation of the internal structure of the scale, using confirmatory factor analysis, as well as testing of convergent and discriminant validity, using correlational analysis, in a sample of 141 persons treated for MI. Results: The results showed that the PMIF scale represents three dimensions: physical, cognitive and emotional fatigue. It was also found that the scale is suitable for summing the items to obtain a total score representing a post-MI global fatigue dimension. Conclusion: The PMIF is a brief and easily completed scale for identifying persons experiencing post-MI fatigue. Early identification of fatigue, together with health behavior support, might prevent progression toward a more severe state of fatigue.

Muscle fatigue in women with primary biliary cirrhosis:Spectral analysis of surface electromyography

AIM： To evaluate the myoelectric manifestations of peripheral fatigability in patients with primary biliary cirrhosis in comparison to healthy subjects. METHODS： Sixteen women with primary biliary cirrhosis without comorbidity and 13 healthy women matched for age and body mass index （BMI） completed the selfreported questionnaire fatigue impact scale. All subjects underwent surface electromyography assessment of peripheral fatigability. Anterior tibial muscle isometric voluntary contraction was executed for 20 s at 80% of maximal voluntary isometric contraction. During the exercise electromyographic signal series were recorded and root mean square （expression of central drive） as well as mean and median of electromyographic signal frequency spectrum （estimates of muscle fatigability） were com- puted. Each subject executed the trial two times. EMG parameters were normalized, then linear regression was applied and slopes were calculated. RESULTS： Seven patients were fatigued （median fatigue impact scale score： 38, range： 26-66） and 9 were not fatigued （median fatigue impact scale score： 7, range： 0-17）. The maximal voluntary isometric contraction was similar in patients （82, 54-115 N） and controls （87, 74-101 N）, and in patients with high （81, 54-115 N） and low fatigue impact scale scores （86, 65-106 N）. Root mean square as well as mean and median of frequency spectrum slopes were compared with the Mann-Whitney U test, and no significant difference was found between fatigued and non-fatigued patients and controls. CONCLUSION： No instrumental evidence of peripheral fatigability can be found in women with primary biliary cirrhosis but no comorbidity, suggesting that fatigue in such patients may be of central origin.

Moroccan Taxi Drivers Fatigue Using Pichot Questionnaire： A Cross-Sectional Survey

Studies conducted in many countries the world has shown that fatigued driving contributes to approximately 3%-30% of road accidents. We conducted this study to estimate the prevalence of fatigue among taxi drivers and to assess the determinant of fatigue among taxi drivers. In this cross-sectional study, 300 urban and rural taxi drivers from Fez, Morocco were enrolled from January to May 2013. The mean score of Pichot scale was 13.59 ± 8.23. The mean duration of sleep was 6.78 ±1.47 h per day. The mean rate of accident was 2.78 ± 1.12 per year. At the final model of the multiple linear regression we found an association statistically significant between Pichot scale and income, cardiovascular disorders, tobacco use, problems with colleagues, regularity of sleep and sleeping at the wheel. This study opened the door to many discussions about the professional drivers＇ conditions of work and we can argue that we should ameliorate the professional drivers conditions of work in Morocco.

Effect of Meridian Massage for Cancer Related Fatigue

Objectives:The purpose of this study is to investigate the effectiveness of meridian massage in lessening the fatigue and improving both physical and mental quality of life of cancer patients.Settings and design:This study was conducted at the East-West Cancer Center at Daejeon University;Using a single-arm,waiting list and non-treatment control research de- sign,we compared the results of control group and to that of the experimental group.Materials and methods:From July 2,2007 to July 28,2007,eighteen eligible cancer patients were recruited to participate in the experiment.Modified Chalder Fatigue Scale(CFS),Visual Analogue Scale(VAS)and active oxygen level were measured before and after treatment for both control and experimental groups.Lying on their back or stomach inside a room with a temperature of 18-22℃,the pa- tients received 30 minutes of meridian massages mainly around the trapezius muscles 5 times a week. Statistical analysis used:Data analysis was carried out using independent t-test,paired t-test and One-way ANOVA. Results:Data analysis of modified CFS showed statistically significant results for all groups between before and after treat- ment.Within CFS,results of physical and psychological analysis showed significant results for all groups except before and after no treatment and secondary treatment.In the analysis of VAS,the experimental group showed a greater decrease in score compared to that of the control group and the average difference was statistically significant(P<0.05).Although the results were not statistically significant(P>0.05),active oxygen levels for the control group showed little difference before and after no treatment(331.11 and 330.78,respectively)while the experimental group observed a decrease in active oxygen level before and after treatment(327.28 and 314.11,respectively).Conclusion:In conclusion,patients who received meridian massage showed decreased cancer related fatigue scores compared to the control.These results suggest that meridian massage may alleviate cancer-related fatigue and contribute to the improvement in quality of life among cancer patients.

下肢重复蹬伸至力竭过程中肌肉功能网络拓扑特性

背景:表面肌电已经被广泛用于监测肌肉疲劳,但传统肌电指标通常针对于单块肌肉,无法评价一组肌肉在疲劳过程中的变化。目的:建立肌肉功能网络,提取复杂网络参数,研究不同疲劳程度下的肌肉功能网络拓扑特性变化,为疲劳的监测、预防提供理论和方法依据。方法:11名受试者进行直到力竭的50%1RM单腿下肢蹬伸运动,同步采集股直肌、股外侧肌、股内侧肌、股二头肌长头、胫骨前肌、腓肠肌外侧肌、腓肠肌内侧肌7块肌肉的肌电信号,以及心电信号和Borg CR-10量表评分;根据Borg CR-10量表评分划分为轻度、中度和重度三个疲劳阶段,采用心率和心率变异性验证疲劳阶段划分的有效性;以7块肌肉为节点,使用肌肉信号的相干性构建肌肉功能网络,提取聚类系数、平均加权度、全局效率、特征向量中心性4个复杂网络参数;提取肌电信号的均方值振幅、中位频率、瞬时平均频率和共激活比4种指标,并在3种疲劳程度下进行比较。结果与结论:①3种疲劳阶段在心率及心率变异性上产生显著性差异,证明了疲劳阶段划分的有效性;②对于不同肌肉在3种疲劳程度下的肌电指标:均方值振幅和共激活比未表现出差异,中位频率在股外侧肌、股内侧肌和股二头肌长头表现出稳健的疲劳趋势,瞬时平均频率则在股直肌、股外侧肌、股内侧肌和股二头肌长头表现出稳健的疲劳趋势;瞬时平均频率的性能优于中位频率和均方值振幅,但三者仅在主要工作肌群能够获得较好的稳健趋势,共激活比不受疲劳因素的影响;③股外侧肌-股内侧肌、股外侧肌-股二头肌长头、股外侧肌-腓肠肌内侧肌和股内侧肌-股二头肌长头连接强度逐渐增加,平均加权度、聚类系数和全局效率在疲劳后表现出显著差异,并且与疲劳程度之间显著相关。结果表明:肌肉功能网络内的连通强度变化能够反映疲劳过程中肌肉间的协同性和互补性;聚类系数、平均加权度、全局效率可作为一组肌肉疲劳的监测指标。

Moroccan Taxi Drivers Sleepiness Using Epworth Scale： A Cross-sectional Survey

Many international studies found that fatigue can be a probable major cause of truck driver accidents. The primary goal of the current study was to assess the relation between sleep disorders and accidents by using Epworth sleepiness scale. In this cross-sectional study, 300 urban and rural taxi drivers from Fez, Morocco were enrolled from January to May 2013. All participants were male and their mean age was 42.51 ± 10.81 （range 18-74） years. Their experience in driving was 8.34± 3.56 years on average; which had no significant relationship with their crash history and was not found a confounding factor in this series. The mean duration of sleep was 6.78± 1.47 h per day. The mean rate of accident was 2.78 ± 1.12 per year. The mean Epworth index was 13.23 ± 5.59. The simple linear regression showed a significant correlation between the Epworth sleepiness scale and education （P = 0.030）, age （P = 0.017）, marital status （P = 0.011）, coffee consumption （P = 0.006）, and water pipe （chicha） use （P = 0.01 ）, but there was no significant correlation with history of crash in past years. The multivariate analysis （multiple linear regressions） found a significant association between Epworth scale and age （P = 0.024）, coffee consumption （P = 0.023） and water pipe use （P = 0.027）. In Morocco where road accidents are very frequent and number of serious injuries and death is very high. This is considered as one of the major public health problems and hence public health officials, legislators and the police should collaborate in multidisciplinary approach to have effective preventives measures. This study can be the start of many debates about the most efficient preventive measure to ameliorate professional drivers＇ work condition and to reduce road accident and hence save thousands of lives from the ＂traffic war＂ in Morocco.

多尺度聚丙烯纤维混凝土弯曲疲劳寿命试验及数值模拟

为研究多尺度聚丙烯纤维混凝土的弯曲疲劳性能,开展基准混凝土、聚丙烯粗纤维混凝土及多尺度聚丙烯纤维混凝土的静载试验及不同应力水平(0.75、0.80、0.85)下的弯曲疲劳试验,建立弯曲疲劳寿命方程,并结合ABAQUS与FE-SAFE软件建立纤维混凝土梁的三点弯曲疲劳有限元模型。结果表明:聚丙烯纤维的掺入,尤其是多尺度聚丙烯纤维混掺显著增强了混凝土基体的抗折、抗疲劳性能。双对数lgS-lgN疲劳方程能够较好地描述多尺度聚丙烯纤维混凝土的应力水平与疲劳寿命的相关性,使用lgS-lgN疲劳方程计算得到200万次循环荷载作用下多尺度聚丙烯纤维混凝土的疲劳强度最高,为3.91 MPa。三组试件疲劳寿命的数值模型预测值均介于实测疲劳寿命的最大值与最小值之间,并接近于疲劳寿命平均值,该模型为多尺度聚丙烯纤维混凝土的疲劳寿命预测提供了理论依据。

金属疲劳损伤全寿命过程及工程应用综述

金属疲劳损伤过程复杂,不同载荷类型与服役环境下金属疲劳损伤机理、变形特性和破坏模式存在较大差异。将疲劳损伤全寿命过程按照循环寿命周次划分为超高周、高周、低周和裂纹扩展4个类别,根据变形响应特性和变形机理特征阐述了各类别疲劳损伤的研究现状及发展趋势,涉及宏观尺度、微细观尺度和宏细微观多尺度理论体系。同时结合工程实际案例,以轧辊和燕尾榫作为代表性构件,分析其疲劳损伤行为与影响因素,探讨了目前疲劳理论在工程实践中的应用及挑战,旨在为金属疲劳损伤全寿命理论体系的完善和关键部件健康质量管控提供理论依据和技术指导。

沥青混合料弯曲疲劳损伤强度的多尺度研究

目的为了验证多尺度数值试验模拟方法在预测沥青混合料半圆弯曲试验疲劳损伤过程中弯拉强度参数变化规律的有效性问题。方法基于多尺度算法思想和半圆弯曲试验,通过对沥青混合料试件进行细观结构分析,得到内部集料颗粒的几何特征分布规律;在此基础上,对沥青混合料划分5个微观区域尺度,并构建相应尺度下半圆弯曲试件的有限元(FEM)数值模型,结合多尺度迭代运算来预测各级沥青混合料计算在0%Nf,20%Nf,50%Nf,65%Nf,80%Nf(Nf为疲劳寿命)不同半圆弯拉疲劳损伤程度下的弯拉强度。将室内半圆弯曲试验获得不同粒径的沥青混合料的弯拉强度参数作为宏观验证试验,与通过多尺度算法数值模拟试验所得的弯拉强度进行对比分析研究。结果结果表明:在沥青混合料的疲劳损伤过程中,前期材料的抗弯拉强度衰减速率较为缓慢,当在中后期时,抗弯拉强度进入了急剧衰减阶段,多尺度数值模拟试验与室内试验得到的衰减规律相吻合,且弯拉强度相对误差的绝对值控制在8%以内。结论多尺度数值模拟用于预测疲劳过程中沥青混合料的抗弯拉强度参数是有效的,该算法可以为类似的实际工程提供一定的参考意义。

补中益气汤加减联合灵龟八法治疗胃癌放疗后癌性疲乏临床研究

目的:观察补中益气汤加减联合灵龟八法治疗胃癌放疗后癌性疲乏的临床疗效。方法:选择胃癌放疗后癌性疲乏患者84例,按随机数字表法分为对照组和观察组各42例。对照组给予常规对症支持治疗,观察组给予补中益气汤加减联合灵龟八法治疗。2组均治疗8周。比较2组临床疗效、中医证候评分、相关癌性疲乏量表评分、生活质量评分、营养状况及炎症因子水平,并统计恶心呕吐分级情况。结果:观察组总有效率为92.86%,高于对照组78.57%(P<0.05)。治疗后,2组纳差乏力、面色萎黄、头晕气短、肢体倦怠评分均较治疗前降低(P<0.05),且观察组各项评分低于对照组(P<0.05)。治疗后,2组简短疲劳量表(BFI-C)、临床虚弱量表(CFS)评分较治疗前降低,Karnofsky功能状态评分、日常生活活动能力(ADL)评分较治疗前升高(P<0.05);且观察组BFI-C、CFS评分低于对照组,Karnofsky功能状态评分、ADL评分高于对照组(P<0.05)。治疗后,2组血清前白蛋白、白蛋白、转铁蛋白水平较治疗前升高,血清白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平较治疗前降低(P<0.05);且观察组血清前白蛋白、白蛋白、转铁蛋白水平高于对照组,血清IL-6、IL-1β、TNF-α水平低于对照组(P<0.05)。观察组呕吐总发生率为47.62%,低于对照组73.81%(P<0.05)。结论:补中益气汤加减联合灵龟八法治疗胃癌放疗后癌性疲乏患者临床疗效显著。

混凝土铺装层开裂对正交异性钢桥面疲劳性能劣化作用研究

为合理评估混凝土铺装层开裂对正交异性钢桥面板疲劳性能劣化的影响,开展足尺模型疲劳试验并进行数值仿真分析,得到铺装层开裂后钢桥面板典型易损细节疲劳应力,并提出疲劳应力增大系数量化分析裂缝尺寸对各细节疲劳应力的影响效应。结果表明:混凝土裂缝深度不超过其厚度20%时,正交异性钢桥面典型细节疲劳应力增幅很小;混凝土层正下方的横隔板-U肋-顶板及横隔板-U肋细节疲劳应力对混凝土裂缝长度、深度变化较敏感,混凝土开裂对横隔板弧形开口处及U肋圆弧处的影响较小;纵桥向裂缝对疲劳应力的影响比横桥向裂缝显著,且多裂缝会明显增大疲劳细节处应力水平,会加速桥面结构疲劳性能劣化,因此须设钢筋网阻滞裂缝扩展。

沥青混合料半圆弯曲试验疲劳剩余强度分析与预测

为揭示沥青混合料在弯拉作用下的疲劳剩余强度规律,基于半圆弯曲试验,对AC-13C型沥青混合料及含不同粒径集料的AC-9.5、AC-4.75、AC-2.36、AC-1.18型沥青混合料开展了疲劳试验、疲劳剩余强度试验等研究,结合多尺度算法建立的数值模型,预测了不同粒径沥青混合料在不同损伤程度下的抗弯拉剩余强度和剩余强度衰减规律。预测结果与沥青混合料半圆弯曲试验结果对比分析表明,利用多尺度算法建立的数值模型,能够较精确地预测沥青混合料的抗弯拉剩余强度,预测结果与半圆弯曲试验结果吻合良好。

全机疲劳试验几个问题的探讨

全机疲劳试验是规范要求的保障飞机结构完整性以及满足适航要求的大型、复杂以及持续时间长的地面验证试验。全机疲劳试验的几个重要问题,例如试验目的、载荷谱、持续时间和分散系数等,是飞机设计师/工程师非常关注和充分讨论的问题,其中的分散系数也是研究者研究较多的问题之一。针对近年来完成的多个飞机型号的全机疲劳试验,本文介绍了对上述几个问题的研究和认识,对比了国内外5种型号战斗机的疲劳设计与全机疲劳试验情况,提出了关于全机疲劳试验的工程实用的一些建议。本文的研究可以为其他飞机全机疲劳试验提供有益的参考。

肺癌化疗患者味觉改变与其营养状况及癌因性疲乏的相关性研究

目的探索肺癌化疗患者味觉改变与其营养状况及癌因性疲乏的相关性。方法回顾性分析苏州市中医医院2021年2月至2024年2月期间收集的137例肺癌化疗患者,应用化疗相关味觉改变量表(CiTAS)、营养风险筛查2002(NRS 2002)、癌因性疲乏(CFS)状态进行评估,经Pearson法和线性回归分析CiTAS评分、NRS 2002评分、CFS评分相关性,同时,经中介效应分析三者的关系。结果肺癌化疗患者的基本味觉改变评分(15.52±2.52)分、味觉异常和味幻觉(9.12±2.63)分、进食困扰(20.15±2.35)分、整体味觉改变(12.35±2.89)分、CiTAS总分(57.13±7.78)分,NRS 2002评分(4.89±2.22)分,躯体疲乏(24.86±2.84)分、情感疲乏(12.36±2.39)分、认知疲乏(11.78±2.55)分、CFS总分(49.01±6.60)分。经Pearson法分析,Ci-TAS总分与NRS 2002评分,躯体疲乏、情感疲乏、认知疲乏、CFS总分呈正相关;经线性回归分析,NRS 2002评分、CiTAS总分会影响CFS总分;经中介效应分析,NRS 2002评分(β=0.469,P<0.001)与CiTAS总分(β=1.105,P<0.001)均可以显著正向预测CFS总分;CiTAS总分在NRS 2002评分、CFS总分影响中起到部分中介作用,中介效应占总效应比例的21.17%。结论肺癌化疗患者味觉改变症状明显,处于中重度水平,且会直接影响营养状况及癌因性疲乏,味觉改变越严重,营养状态、癌因性疲乏越严重,呈正相关,对此需积极开展营养治疗,调整食物口味,适应患者味觉需求,以保证足够营养摄入,改善身心健康状态。

正交异性钢-钢纤维混凝土组合桥面板疲劳极限状态研究

为了解正交异性钢-钢纤维混凝土(Steel Fiber Reinforced Concrete,SFRC)组合桥面板的疲劳性能及失效机理,以川南城际铁路临港长江大桥为背景,设计、制作正交异性钢-SFRC组合桥面板足尺模型进行疲劳试验,采用ANSYS软件建立试件有限元模型,研究关键细节的疲劳应力和开裂等情况。基于有限元模型,分析不同设计参数(钢顶板厚度、栓钉布置、SFRC抗拉强度及层厚)下组合桥面板疲劳极限状态的失效模式,并提出了主要控制参数取值建议。结果表明:200万次疲劳加载后足尺模型的实测最大裂缝宽度为0.136 mm,出现在SFRC层上缘,钢结构未开裂,组合桥面板疲劳性能良好;组合桥面板疲劳极限状态主要由SFRC层开裂控制,钢顶板厚度、栓钉布置对组合桥面板疲劳性能的影响较小,SFRC抗拉强度和层厚对组合桥面板疲劳性能影响较大,为主要控制参数;在常规正交异性钢桥面板上铺设薄层(厚度不超过50 mm)SFRC时,SFRC抗拉强度不应小于5 MPa,在常规正交异性钢桥面板上铺设普通SFRC(钢纤维体积含量不高于1%,抗拉强度不高于3 MPa)时,SFRC层厚不宜低于100 mm。